J Bylund

Summary

Country: Sweden

Publications

  1. pmc Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori
    J Bylund
    The Phagocyte Research Laboratory, Department of Medical Microbiology and Immunology, University of Goteborg, Goteborg, Sweden
    Antimicrob Agents Chemother 45:1700-4. 2001
  2. ncbi request reprint NADPH-oxidase activation in murine neutrophils via formyl peptide receptors
    Johan Bylund
    Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    Exp Cell Res 282:70-7. 2003
  3. ncbi request reprint The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1
    A L Stenfeldt
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    Biochem Pharmacol 74:1050-6. 2007
  4. ncbi request reprint Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1
    Lena Björkman
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Leukoc Biol 83:245-53. 2008
  5. ncbi request reprint Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1
    Karin Christenson
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10, 413 46 Goteborg, Sweden
    J Leukoc Biol 83:139-48. 2008
  6. pmc Interleukin-8-derived peptide has antibacterial activity
    Ase Björstad
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Antimicrob Agents Chemother 49:3889-95. 2005
  7. ncbi request reprint A bactericidal cecropin-A peptide with a stabilized alpha-helical structure possess an increased killing capacity but no proinflammatory activity
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Göeborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Inflammation 28:337-43. 2004
  8. ncbi request reprint Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor
    Anna Lena Stenfeldt
    Department of Rheumatology and Inflammation Research, Guldhedsgatan 10, S 413 46, Goteborg, Sweden
    Inflammation 30:224-9. 2007
  9. ncbi request reprint The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptide receptor like 1 is blocked. A receptor switch with implications for signal transduction studies with inhibitors a
    Jennie Karlsson
    The Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Biochem Pharmacol 71:1488-96. 2006
  10. pmc Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
    Johan Bylund
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    BMC Cell Biol 5:21. 2004

Collaborators

Detail Information

Publications27

  1. pmc Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori
    J Bylund
    The Phagocyte Research Laboratory, Department of Medical Microbiology and Immunology, University of Goteborg, Goteborg, Sweden
    Antimicrob Agents Chemother 45:1700-4. 2001
    ..Furthermore, we show that these effects are mediated through binding of Hp(2-20) to the promiscuous, G-protein-linked lipoxin A(4) receptor-formyl peptide-like receptor 1...
  2. ncbi request reprint NADPH-oxidase activation in murine neutrophils via formyl peptide receptors
    Johan Bylund
    Department of Rheumatology and Inflammation Research, Goteborg University, Sweden
    Exp Cell Res 282:70-7. 2003
    ..Finally, we show that a synthetic hexapeptide, WKYMVM, is a more potent stimulus than fMLF for murine neutrophils and that these two agonists probably act via nonidentical high-affinity receptors...
  3. ncbi request reprint The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like 1
    A L Stenfeldt
    Department of Rheumatology and Inflammation Research, Goteborg University, Goteborg, Sweden
    Biochem Pharmacol 74:1050-6. 2007
    ..We show that piroxicam inhibits the neutrophil responses triggered through FPR, but not through FPRL1 and this inhibition is due to a reduced binding of the activating ligand to its cell surface receptor...
  4. ncbi request reprint Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1
    Lena Björkman
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Leukoc Biol 83:245-53. 2008
    ..Future identification and characterization of the SAA receptor could lead to development of novel, therapeutic targets for treatment of RA...
  5. ncbi request reprint Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1
    Karin Christenson
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10, 413 46 Goteborg, Sweden
    J Leukoc Biol 83:139-48. 2008
    ....
  6. pmc Interleukin-8-derived peptide has antibacterial activity
    Ase Björstad
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Antimicrob Agents Chemother 49:3889-95. 2005
    ..The results presented are of special interest when put in the context of the suggested importance of antimicrobial peptides for microbial colonization of the gastric mucosa...
  7. ncbi request reprint A bactericidal cecropin-A peptide with a stabilized alpha-helical structure possess an increased killing capacity but no proinflammatory activity
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Göeborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Inflammation 28:337-43. 2004
    ....
  8. ncbi request reprint Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor
    Anna Lena Stenfeldt
    Department of Rheumatology and Inflammation Research, Guldhedsgatan 10, S 413 46, Goteborg, Sweden
    Inflammation 30:224-9. 2007
    ..Based on the difference in potency of cyclosporin H and the two Boc-peptides, we suggest using cyclosporin H as a specific inhibitor for FPR. To specifically inhibit the FPRL1 response the antagonist WRW(4) should be used...
  9. ncbi request reprint The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptide receptor like 1 is blocked. A receptor switch with implications for signal transduction studies with inhibitors a
    Jennie Karlsson
    The Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Biochem Pharmacol 71:1488-96. 2006
    ..The phenomenon described is of general importance for proper interpretation of results generated through the use of different "silencing technologies" in receptor operated signaling transduction research...
  10. pmc Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils
    Johan Bylund
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    BMC Cell Biol 5:21. 2004
    ..The receptor uncoupling results in respiratory burst activity when signals generated by reactivated formyl peptide receptors trigger the NADPH-oxidase to produce superoxide anions...
  11. pmc The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Immunology 112:201-10. 2004
    ..The data presented in this study provide support for two different signalling pathways to the neutrophil NADPH-oxidase, used by ligand binding to FPR/FPRL1 or CXCR, respectively...
  12. pmc Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapy
    Huamei Fu
    The Phagocyte Research Laboratory, Department for Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Antimicrob Agents Chemother 47:2545-50. 2003
    ..These findings could be potentially used as a new approach to antibacterial chemotherapy...
  13. ncbi request reprint Outer membrane protein A deficient Escherichia coli activates neutrophils to produce superoxide and shows increased susceptibility to antibacterial peptides
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Goteborg, Gothenburg, Sweden
    Microbes Infect 5:781-8. 2003
    ..Taken together, these data suggest an important role for OmpA in the context of bacteria vs. host interactions...
  14. ncbi request reprint Reactivation of formyl peptide receptors triggers the neutrophil NADPH-oxidase but not a transient rise in intracellular calcium
    Johan Bylund
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Biol Chem 278:30578-86. 2003
    ..Further, phosphatidylinositol 3-kinase, mitogen-activated protein kinase, and MEK all participated in the generation of second messengers from the reactivated receptors...
  15. doi request reprint Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils-a tool in analysing receptor specific events
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Goteborg, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    J Immunol Methods 331:50-8. 2008
    ....
  16. ncbi request reprint Immunostimulatory DNA induces degranulation and NADPH-oxidase activation in human neutrophils while concomitantly inhibiting chemotaxis and phagocytosis
    Johan Bylund
    Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10, SE 413 46 Goteborg, Sweden
    Eur J Immunol 32:2847-56. 2002
    ..These findings may have implications for the development of DNA-based immunotherapy and vaccination...
  17. pmc Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1
    Johan Bylund
    Phagocyte Research Laboratory, Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    Infect Immun 70:2908-14. 2002
    ..These results suggest that the mechanism behind the LPS-induced priming of FPRL1-mediated responses lies at the level of granule (receptor) mobilization...
  18. ncbi request reprint Problems in identifying microbial-derived neutrophil activators, focusing on Helicobacter pylori
    Johan Bylund
    Trends Microbiol 10:12-4; author reply 14. 2002
  19. ncbi request reprint Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B
    Johan Bylund
    Department of Pediatrics, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia, Canada
    Eur J Immunol 37:1087-96. 2007
    ..Furthermore, we show that the major steps involved in NF-kappaB activation were intact in human CGD cells. These data indicate that ROS were nonessential for activation of NF-kappaB and their production may even attenuate inflammation...
  20. ncbi request reprint Measurement of respiratory burst products generated by professional phagocytes
    Claes Dahlgren
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Methods Mol Biol 412:349-63. 2007
    ..These techniques can be valuable tools in research spanning from basic phagocyte biology to more clinically-oriented research on innate immune mechanisms and inflammation...
  21. ncbi request reprint Ligand recognition and activation of formyl peptide receptors in neutrophils
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Goteborg, Sweden
    J Leukoc Biol 79:247-56. 2006
  22. ncbi request reprint Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species
    Johan Bylund
    Department of Pediatrics, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada
    J Biol Chem 281:2526-32. 2006
    ..These properties could explain why the two bacterial species resist clearance from the infected cystic fibrosis lung...
  23. ncbi request reprint Chronic granulomatous disease: from genetic defect to clinical presentation
    Johan Bylund
    Department of Pediatrics, B C Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, Canada
    Adv Exp Med Biol 568:67-87. 2005
  24. ncbi request reprint Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease
    Johan Bylund
    Department of Pediatrics, University of British Columbia, British Columbia Research Institute for Children s and Women s Health, Vancouver, British Columbia, Canada
    J Immunol 174:3562-9. 2005
    ..cenocepacia. The extreme virulence of B. cepacia complex bacteria in CGD, but not in immunocompetent hosts, could be due to its necrotic potential in the absence of ROS...
  25. ncbi request reprint Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6
    Johan Bylund
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Arch Biochem Biophys 412:34-41. 2003
    ..CYP4F5 and CYP4F6, due to their capacities to metabolize LTB(4), may play important roles in modulating inflammatory response in these organs...
  26. ncbi request reprint Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes
    Debebe Gebremedhin
    Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
    J Neurosci 23:1678-87. 2003
    ....
  27. doi request reprint ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease
    Kelly L Brown
    Centre for Microbial Disease Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Immunol 129:90-102. 2008
    ..The results are consistent with the hypothesis that ROS are anti-inflammatory mediators that control gene expression and potentially limit the development of sterile inflammatory disorders...