S Bjorklund

Summary

Country: Sweden

Publications

  1. pmc Functional studies of the yeast med5, med15 and med16 mediator tail subunits
    Miriam Larsson
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS ONE 8:e73137. 2013
  2. pmc Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes
    Jeanette Blomberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 40:5938-50. 2012
  3. ncbi request reprint Mediator of transcriptional regulation
    S Bjorklund
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Trends Biochem Sci 21:335-7. 1996
  4. ncbi request reprint The yeast Mediator complex and its regulation
    Stefan Bjorklund
    Department of Medical Biochemistry, Umea University, S 901 87 Umea, Sweden
    Trends Biochem Sci 30:240-4. 2005
  5. ncbi request reprint The yeast mediator
    S Bjorklund
    Department of Medical Biosciences, Medical Biochemistry, Umea University, Sweden
    Mol Cells 11:129-36. 2001
  6. ncbi request reprint Functional and physical interactions within the middle domain of the yeast mediator
    Magnus Hallberg
    Department of Medical Biochemistry and Biophysics, Umea University, 0187, Umea, Sweden
    Mol Genet Genomics 276:197-210. 2006
  7. ncbi request reprint Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit
    Stefan Bäckström
    Department of Medical Biochemistry and Biophysics, KBC, Umea University, SE 901 87 Umea, Sweden
    Mol Cell 26:717-29. 2007
  8. pmc Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid
    Magnus Hallberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:3370-5. 2004
  9. ncbi request reprint The mediator complex
    Stefan Bjorklund
    Department of Medical Biochemistry, Umea University, S 901 87 Umea, Sweden
    Adv Protein Chem 67:43-65. 2004
  10. pmc Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation
    Zaki Shaikhibrahim
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 106:20728-33. 2009

Collaborators

  • Pernilla Wittung-Stafshede
  • Magnus Hallberg
  • Zaki Shaikhibrahim
  • Miriam Larsson
  • Jeanette Blomberg
  • Stefan Bäckström
  • Hans Ronne
  • Guo Zhen Hu
  • Anna Lena Chabes
  • Lars Thelander
  • Irina Kotova
  • Luke A Selth
  • Patrik Ryden
  • Hanna Uvell
  • Jenny Sandström
  • Ximena Aguilar
  • Linn Rautio
  • Kristoffer Brannstrom
  • Anders Olofsson
  • Hamidur Rahaman
  • Robert Nilsson
  • Nils Elfving
  • Gunnar Wingsle
  • Susanna Tronnersjö
  • Darius Balciunas
  • Claes M Gustafsson
  • Gennady V Polozkov
  • Jenny Beve
  • Anna L Chabes
  • Sergei Lobov

Detail Information

Publications13

  1. pmc Functional studies of the yeast med5, med15 and med16 mediator tail subunits
    Miriam Larsson
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS ONE 8:e73137. 2013
    ..Supporting this observation, we demonstrate that loss of Med15 leads to a G1 arrest phenotype. Collectively, these findings provide insight into the function of the Mediator Tail module. ..
  2. pmc Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes
    Jeanette Blomberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Nucleic Acids Res 40:5938-50. 2012
    ..We conclude that transcription regulation is facilitated by small but distinct changes in energetic and structural parameters of the involved proteins...
  3. ncbi request reprint Mediator of transcriptional regulation
    S Bjorklund
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Trends Biochem Sci 21:335-7. 1996
    ..Mediator binds the carboxy-terminal domain of RNA polymerase II, forming a polymerase holoenzyme, whose possible association with additional proteins is a subject of some controversy...
  4. ncbi request reprint The yeast Mediator complex and its regulation
    Stefan Bjorklund
    Department of Medical Biochemistry, Umea University, S 901 87 Umea, Sweden
    Trends Biochem Sci 30:240-4. 2005
    ....
  5. ncbi request reprint The yeast mediator
    S Bjorklund
    Department of Medical Biosciences, Medical Biochemistry, Umea University, Sweden
    Mol Cells 11:129-36. 2001
    ..The recent description of Mediator-like complexes in metazoans identifies it as a key player in transcriptional regulation...
  6. ncbi request reprint Functional and physical interactions within the middle domain of the yeast mediator
    Magnus Hallberg
    Department of Medical Biochemistry and Biophysics, Umea University, 0187, Umea, Sweden
    Mol Genet Genomics 276:197-210. 2006
    ..These interactions, and the interactions of Med21 with Med6 and Tup1, suggest that Med21 may serve as a molecular switchboard that integrates different signals before they reach the core polymerase...
  7. ncbi request reprint Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit
    Stefan Bäckström
    Department of Medical Biochemistry and Biophysics, KBC, Umea University, SE 901 87 Umea, Sweden
    Mol Cell 26:717-29. 2007
    ..The identification of the plant Mediator will provide new tools and insights into the regulation of transcription in plants...
  8. pmc Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid
    Magnus Hallberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:3370-5. 2004
    ..Combined with previous studies on the effects of SRB10/SRB11 deletions, our data suggest that posttranslational modifications of Mediator subunits are important for regulation of gene expression...
  9. ncbi request reprint The mediator complex
    Stefan Bjorklund
    Department of Medical Biochemistry, Umea University, S 901 87 Umea, Sweden
    Adv Protein Chem 67:43-65. 2004
  10. pmc Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation
    Zaki Shaikhibrahim
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 106:20728-33. 2009
    ..However, the concurrent presence of all three protein subunits during the renaturation process is required for proper folding and trimer complex formation...
  11. pmc Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase
    S Bjorklund
    Department of Medical Biochemistry and Biophysics, University of Umea, Sweden
    Proc Natl Acad Sci U S A 90:11322-6. 1993
    ..One complex most likely contained Sp1, and another complex showed S-phase-specific binding, suggesting a direct role in the cell-cycle-dependent R1 gene expression...
  12. ncbi request reprint S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region
    Anna Lena Chabes
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    J Biol Chem 279:10796-807. 2004
    ..Therefore, E2F-dependent repression is essential for cell cycle-specific R2 transcription...
  13. ncbi request reprint Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription
    Irina Kotova
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Eur J Biochem 270:1791-801. 2003
    ..We report that this region contains a conserved palindrome sequence that interacts with TAFIIs. This interaction down-regulates basal transcription from the R2 promoter, both in the absence and in the presence of the TATA-box...