Glenn R Bjork

Summary

Country: Sweden

Publications

  1. pmc A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast
    Glenn R Bjork
    Department of Molecular Biology, Umea University, Umea, Sweden
    RNA 13:1245-55. 2007
  2. pmc 1-methylguanosine-deficient tRNA of Salmonella enterica serovar Typhimurium affects thiamine metabolism
    Glenn R Bjork
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    J Bacteriol 185:750-9. 2003
  3. pmc Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, SE 90 187 Umeå, Sweden
    RNA 9:760-8. 2003
  4. pmc Eukaryotic wobble uridine modifications promote a functionally redundant decoding system
    Marcus J O Johansson
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    Mol Cell Biol 28:3301-12. 2008
  5. ncbi request reprint Putrescine or a combination of methionine and arginine restores virulence gene expression in a tRNA modification-deficient mutant of Shigella flexneri: a possible role in adaptation of virulence
    Jérôme M B Durand
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    Mol Microbiol 47:519-27. 2003
  6. pmc Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation
    Hans K Lundgren
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Bacteriol 188:3052-62. 2006
  7. pmc Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:758-66. 2004
  8. pmc Amino acid residues of the Escherichia coli tRNA(m5U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    Nucleic Acids Res 35:3297-305. 2007
  9. pmc The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium
    Gunilla Jäger
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:750-7. 2004
  10. doi request reprint The ribosomal grip of the peptidyl-tRNA is critical for reading frame maintenance
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Mol Biol 385:350-67. 2009

Collaborators

  • Peng Chen
  • Guillaume Stahl
  • S Joakim Nasvall
  • Gunilla Jäger
  • Jérôme M B Durand
  • Jaunius Urbonavicius
  • Ramune Leipuviene
  • Kristina Nilsson
  • Hans K Lundgren
  • Qiang Qian
  • Marcus J O Johansson
  • Anders S Byström
  • Anders Esberg
  • Bo Huang
  • Michael G Pollard
  • Samia N Ben Salem
  • Philip J Farabaugh
  • Tord G Hagervall

Detail Information

Publications17

  1. pmc A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast
    Glenn R Bjork
    Department of Molecular Biology, Umea University, Umea, Sweden
    RNA 13:1245-55. 2007
    ..Surprisingly, overexpression of the mcm(5)s(2)U-lacking tRNA(Lys) alone was sufficient to restore viability of the double mutant...
  2. pmc 1-methylguanosine-deficient tRNA of Salmonella enterica serovar Typhimurium affects thiamine metabolism
    Glenn R Bjork
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    J Bacteriol 185:750-9. 2003
    ..We suggest that a slow decoding event at a codon(s) read by a tRNA(s) normally containing m(1)G37 is responsible for the PurF-independent thiamine synthesis and that this event causes a changed flux in the APB pathway...
  3. pmc Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, SE 90 187 Umeå, Sweden
    RNA 9:760-8. 2003
    ..Possible mechanisms explaining these results are discussed...
  4. pmc Eukaryotic wobble uridine modifications promote a functionally redundant decoding system
    Marcus J O Johansson
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    Mol Cell Biol 28:3301-12. 2008
    ..Moreover, the observation that the mcm(5)U(34)- and some ncm(5)U(34)-containing tRNAs efficiently read G-ending codons challenges the notion that eukaryotes do not use U-G wobbling...
  5. ncbi request reprint Putrescine or a combination of methionine and arginine restores virulence gene expression in a tRNA modification-deficient mutant of Shigella flexneri: a possible role in adaptation of virulence
    Jérôme M B Durand
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    Mol Microbiol 47:519-27. 2003
    ..flexneri, but also demonstrate a strong and specific involvement of tRNA modifications, and especially oQ, in the adaptation of virulence gene expression to the nutritional quality of the growth medium...
  6. pmc Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation
    Hans K Lundgren
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Bacteriol 188:3052-62. 2006
    ..Our results suggest that IscS has an intrinsic substrate specificity in how it mediates sulfur mobilization and/or iron-sulfur cluster formation and maintenance required for thiolation of tRNA...
  7. pmc Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:758-66. 2004
    ....
  8. pmc Amino acid residues of the Escherichia coli tRNA(m5U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    Nucleic Acids Res 35:3297-305. 2007
    ..Our results are consistent with the modular evolution of RNA(m5U)methyltransferases, in which the specificity of the enzymatic reaction is achieved by combining the conserved catalytic domain with different RNA-binding domains...
  9. pmc The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium
    Gunilla Jäger
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:750-7. 2004
    ..The presence of s(2)C32 in peptidyl- or in peptidyl- interfered with decoding in the A-site. The presence of s(2)C32 in decreased the rate of translation of the CGA codon but not that of the CGU codon...
  10. doi request reprint The ribosomal grip of the peptidyl-tRNA is critical for reading frame maintenance
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Mol Biol 385:350-67. 2009
    ..We suggest that the "ribosomal grip" of the peptidyl-tRNA is pivotal for maintaining the reading frame...
  11. pmc The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    RNA 13:2151-64. 2007
    ..Unexpectedly, cmo(5)U is critical for efficient decoding of G-ending Pro, Ala, and Val codons. Apparently, whereas G34 pairs with U in mRNA, the reverse pairing (U34-G) requires a modification of U34...
  12. pmc Alterations in the two globular domains or in the connecting alpha-helix of bacterial ribosomal protein L9 induces +1 frameshifts
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 189:7024-31. 2007
    ..The way rplI mutations suppress various frameshift mutations suggests that bypassing of many codons from several takeoff and landing sites occurred instead of a specific frameshift forward at overlapping codons...
  13. pmc The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    RNA 10:1662-73. 2004
    ....
  14. doi request reprint Metabolic control through ornithine and uracil of epithelial cell invasion by Shigella flexneri
    Jérôme M B Durand
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    Microbiology 155:2498-508. 2009
    ..The implications and practical application of this finding in prophylaxis and treatment of shigellosis are discussed...
  15. pmc The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance
    Gunilla Jäger
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 8:e60246. 2013
    ..The isolation and characterization of the S9 mutants gave strong support of our model that the ribosomal grip of the peptidyl-tRNA is pivotal for the reading frame maintenance...
  16. pmc The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium
    Kristina Nilsson
    Department of Molecular Biology, Umea University, Sweden
    J Bacteriol 184:6830-5. 2002
    ....
  17. pmc Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    J Bacteriol 184:5348-57. 2002
    ..Moreover, lack of Psi55 in tRNA of human pathogen Shigella flexneri leads to a reduced expression of several virulence-associated genes...