Glenn R Bjork

Summary

Country: Sweden

Publications

  1. pmc The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance
    Gunilla Jäger
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 8:e60246. 2013
  2. pmc Amino acid residues of the Escherichia coli tRNA(m5U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    Nucleic Acids Res 35:3297-305. 2007
  3. pmc 1-methylguanosine-deficient tRNA of Salmonella enterica serovar Typhimurium affects thiamine metabolism
    Glenn R Bjork
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    J Bacteriol 185:750-9. 2003
  4. pmc A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast
    Glenn R Bjork
    Department of Molecular Biology, Umea University, Umea, Sweden
    RNA 13:1245-55. 2007
  5. pmc Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, SE 90 187 Umeå, Sweden
    RNA 9:760-8. 2003
  6. pmc Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:758-66. 2004
  7. pmc A "gain of function" mutation in a protein mediates production of novel modified nucleosides
    Peng Chen
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    EMBO J 24:1842-51. 2005
  8. pmc Eukaryotic wobble uridine modifications promote a functionally redundant decoding system
    Marcus J O Johansson
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    Mol Cell Biol 28:3301-12. 2008
  9. doi request reprint The ribosomal grip of the peptidyl-tRNA is critical for reading frame maintenance
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Mol Biol 385:350-67. 2009
  10. ncbi request reprint A cytosolic tRNA with an unmodified adenosine in the wobble position reads a codon ending with the non-complementary nucleoside cytidine
    Peng Chen
    Department of Molecular Biology, Umea University, Umea, 901 87, Sweden
    J Mol Biol 317:481-92. 2002

Collaborators

  • Peng Chen
  • Guillaume Stahl
  • Ramune Leipuviene
  • S Joakim Nasvall
  • Gunilla Jäger
  • Jérôme M B Durand
  • Jaunius Urbonavicius
  • Kristina Nilsson
  • Ismaïl Moukadiri
  • Hans K Lundgren
  • Qiang Qian
  • Marcus J O Johansson
  • M Eugenia Armengod
  • M José Garzón
  • Anders S Byström
  • Anders Esberg
  • Bo Huang
  • Michael G Pollard
  • Philip J Farabaugh
  • Samia N Ben Salem
  • Tord G Hagervall

Detail Information

Publications21

  1. pmc The phenotype of many independently isolated +1 frameshift suppressor mutants supports a pivotal role of the P-site in reading frame maintenance
    Gunilla Jäger
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 8:e60246. 2013
    ..The isolation and characterization of the S9 mutants gave strong support of our model that the ribosomal grip of the peptidyl-tRNA is pivotal for the reading frame maintenance...
  2. pmc Amino acid residues of the Escherichia coli tRNA(m5U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    Nucleic Acids Res 35:3297-305. 2007
    ..Our results are consistent with the modular evolution of RNA(m5U)methyltransferases, in which the specificity of the enzymatic reaction is achieved by combining the conserved catalytic domain with different RNA-binding domains...
  3. pmc 1-methylguanosine-deficient tRNA of Salmonella enterica serovar Typhimurium affects thiamine metabolism
    Glenn R Bjork
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    J Bacteriol 185:750-9. 2003
    ..We suggest that a slow decoding event at a codon(s) read by a tRNA(s) normally containing m(1)G37 is responsible for the PurF-independent thiamine synthesis and that this event causes a changed flux in the APB pathway...
  4. pmc A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast
    Glenn R Bjork
    Department of Molecular Biology, Umea University, Umea, Sweden
    RNA 13:1245-55. 2007
    ..Surprisingly, overexpression of the mcm(5)s(2)U-lacking tRNA(Lys) alone was sufficient to restore viability of the double mutant...
  5. pmc Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, SE 90 187 Umeå, Sweden
    RNA 9:760-8. 2003
    ..Possible mechanisms explaining these results are discussed...
  6. pmc Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:758-66. 2004
    ....
  7. pmc A "gain of function" mutation in a protein mediates production of novel modified nucleosides
    Peng Chen
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    EMBO J 24:1842-51. 2005
    ..The results are discussed in relation to the mechanism of reading frame maintenance and the evolution of modified nucleosides in tRNA...
  8. pmc Eukaryotic wobble uridine modifications promote a functionally redundant decoding system
    Marcus J O Johansson
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    Mol Cell Biol 28:3301-12. 2008
    ..Moreover, the observation that the mcm(5)U(34)- and some ncm(5)U(34)-containing tRNAs efficiently read G-ending codons challenges the notion that eukaryotes do not use U-G wobbling...
  9. doi request reprint The ribosomal grip of the peptidyl-tRNA is critical for reading frame maintenance
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Mol Biol 385:350-67. 2009
    ..We suggest that the "ribosomal grip" of the peptidyl-tRNA is pivotal for maintaining the reading frame...
  10. ncbi request reprint A cytosolic tRNA with an unmodified adenosine in the wobble position reads a codon ending with the non-complementary nucleoside cytidine
    Peng Chen
    Department of Molecular Biology, Umea University, Umea, 901 87, Sweden
    J Mol Biol 317:481-92. 2002
    ..We suggest that the decoding of the CCC codon by a 5'-AGG-3' anticodon occurs by a wobble base-pair between a protonated A34 and a C in the mRNA...
  11. ncbi request reprint Putrescine or a combination of methionine and arginine restores virulence gene expression in a tRNA modification-deficient mutant of Shigella flexneri: a possible role in adaptation of virulence
    Jérôme M B Durand
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    Mol Microbiol 47:519-27. 2003
    ..flexneri, but also demonstrate a strong and specific involvement of tRNA modifications, and especially oQ, in the adaptation of virulence gene expression to the nutritional quality of the growth medium...
  12. pmc Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation
    Hans K Lundgren
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    J Bacteriol 188:3052-62. 2006
    ..Our results suggest that IscS has an intrinsic substrate specificity in how it mediates sulfur mobilization and/or iron-sulfur cluster formation and maintenance required for thiolation of tRNA...
  13. pmc The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    RNA 13:2151-64. 2007
    ..Unexpectedly, cmo(5)U is critical for efficient decoding of G-ending Pro, Ala, and Val codons. Apparently, whereas G34 pairs with U in mRNA, the reverse pairing (U34-G) requires a modification of U34...
  14. pmc The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium
    Gunilla Jäger
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 186:750-7. 2004
    ..The presence of s(2)C32 in peptidyl- or in peptidyl- interfered with decoding in the A-site. The presence of s(2)C32 in decreased the rate of translation of the CGA codon but not that of the CGU codon...
  15. pmc Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri
    Jaunius Urbonavicius
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    J Bacteriol 184:5348-57. 2002
    ..Moreover, lack of Psi55 in tRNA of human pathogen Shigella flexneri leads to a reduced expression of several virulence-associated genes...
  16. pmc A reduced level of charged tRNAArgmnm5UCU triggers the wild-type peptidyl-tRNA to frameshift
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    RNA 11:796-807. 2005
    ..Similar frame-shifting events could be the main cause of various phenotypes associated with environmental or genetically induced changes in the levels of aminoacylated tRNA...
  17. pmc Alterations in the two globular domains or in the connecting alpha-helix of bacterial ribosomal protein L9 induces +1 frameshifts
    Ramune Leipuviene
    Department of Molecular Biology, Umea University, S 90187 Umea, Sweden
    J Bacteriol 189:7024-31. 2007
    ..The way rplI mutations suppress various frameshift mutations suggests that bypassing of many codons from several takeoff and landing sites occurred instead of a specific frameshift forward at overlapping codons...
  18. pmc The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo
    S Joakim Nasvall
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    RNA 10:1662-73. 2004
    ....
  19. pmc The output of the tRNA modification pathways controlled by the Escherichia coli MnmEG and MnmC enzymes depends on the growth conditions and the tRNA species
    Ismaïl Moukadiri
    Laboratory of RNA Modification and Mitochondrial Diseases, Príncipe Felipe Research Center, 46012 Valencia, Spain, Department of Molecular Biology, Umea University, S90187, Sweden and Biomedical Research Networking Centre for Rare Diseases CIBERER node U721, Spain
    Nucleic Acids Res 42:2602-23. 2014
    ..Strikingly, the net output of the MnmEG pathways in vivo depends on growth conditions and tRNA species. Loss of any MnmC activity has a biological cost under specific conditions...
  20. ncbi request reprint Metabolic control through ornithine and uracil of epithelial cell invasion by Shigella flexneri
    Jérôme M B Durand
    Department of Molecular Biology, Umea University, S 90 187 Umeå, Sweden
    Microbiology 155:2498-508. 2009
    ..The implications and practical application of this finding in prophylaxis and treatment of shigellosis are discussed...
  21. pmc The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium
    Kristina Nilsson
    Department of Molecular Biology, Umea University, Sweden
    J Bacteriol 184:6830-5. 2002
    ....