Jenny Felth

Summary

Affiliation: Biomedical Centre
Country: Sweden

Publications

  1. doi Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs
    Jenny Felth
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Box 574, SE 751 23 Uppsala, Sweden
    J Nat Prod 72:1969-74. 2009
  2. doi Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
    Jenny Felth
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden
    Invest New Drugs 31:587-98. 2013
  3. doi Novel activity of acriflavine against colorectal cancer tumor cells
    Saadia Hassan
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Cancer Sci 102:2206-13. 2011
  4. pmc Ex vivo activity of cardiac glycosides in acute leukaemia
    Helene Hallböök
    Department of Haematology, University Hospital, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e15718. 2011
  5. doi Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice
    Robert Burman
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, SE 751 23 Uppsala, Sweden
    Biopolymers 94:626-34. 2010
  6. ncbi Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa
    Lucia Renee Ruhaak
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Biol Pharm Bull 34:774-8. 2011
  7. doi Bioassays in Natural Product Research - Strategies and Methods in the Search for Anti-inflammatory and Antimicrobial Activity
    Adam A Strömstedt
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Box 574, 751 23, Uppsala, Sweden
    Phytochem Anal 25:13-28. 2014

Collaborators

Detail Information

Publications7

  1. doi Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs
    Jenny Felth
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Box 574, SE 751 23 Uppsala, Sweden
    J Nat Prod 72:1969-74. 2009
    ....
  2. doi Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
    Jenny Felth
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden
    Invest New Drugs 31:587-98. 2013
    ..In conclusion, our results show that GA and dihydro GA exert their cytotoxic activity through inhibition of the UPS, specifically by acting as inhibitors of the chymotrypsin activity of the 20S proteasome...
  3. doi Novel activity of acriflavine against colorectal cancer tumor cells
    Saadia Hassan
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Cancer Sci 102:2206-13. 2011
    ..Mechanistic studies indicated acriflavine to be a dual topoisomerase I and II inhibitor. In conclusion, the strategy used seems promising for identification of new diagnosis-specific cancer drugs...
  4. pmc Ex vivo activity of cardiac glycosides in acute leukaemia
    Helene Hallböök
    Department of Haematology, University Hospital, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e15718. 2011
    ..In addition, evidence of species differences of a magnitude sufficient to explain the results of many studies called for reconsideration of earlier results...
  5. doi Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice
    Robert Burman
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, SE 751 23 Uppsala, Sweden
    Biopolymers 94:626-34. 2010
    ..5 mg/kg. Repeated dosing of 1 mg/kg gave a local-inflammatory reaction at the site of injection after 2-3 days; lower doses were without complications...
  6. ncbi Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa
    Lucia Renee Ruhaak
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Biol Pharm Bull 34:774-8. 2011
    ..Cannabinoids inhibited cyclooxygenase enzyme activity with IC₅₀ values ranging from 1.7·10⁻³ to 2.0·10⁻⁴ M...
  7. doi Bioassays in Natural Product Research - Strategies and Methods in the Search for Anti-inflammatory and Antimicrobial Activity
    Adam A Strömstedt
    Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Box 574, 751 23, Uppsala, Sweden
    Phytochem Anal 25:13-28. 2014
    ..Identifying bioactive molecules from complex biomasses requires careful selection and execution of relevant bioassays in the various stages of the discovery process of potential leads and targets...