- Label-free kinetic binding data as a decisive element in drug discoveryKarl Andersson
Biacore AB, Rapsgatan 7 SE 75450 Uppsala, Sweden
Expert Opin Drug Discov 1:439-46. 2006..The promising results found in the literature indicate that kinetic data on drug-protein interactions may soon become a crucial decisive element in modern drug discovery...
- Optimizing the hit-to-lead process using SPR analysisStefan Lofas
Biacore International AB, Uppsala, Sweden
Assay Drug Dev Technol 2:407-15. 2004..A number of studies have used SPR biosensors in secondary screening, lead optimization, quantitative structure-activity relationship analysis, and predictive adsorption, distribution, metabolism, excretion, and/or toxicity evaluations...
- Flow-mediated on-surface reconstitution of G-protein coupled receptors for applications in surface plasmon resonance biosensorsOlof P Karlsson
Department of Biochemistry and Chemistry, Biacore AB, Rapsgatan 7, SE 754 50 Uppsala, Sweden
Anal Biochem 300:132-8. 2002..This method can also be used for the easy formation of pure supported lipid bilayers for use in model membrane interaction studies...