Christer Betsholtz

Summary

Country: Sweden

Publications

  1. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  2. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
  3. ncbi Developmental roles of platelet-derived growth factors
    C Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Bioessays 23:494-507. 2001
  4. ncbi Insight into the physiological functions of PDGF through genetic studies in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, P O Box 440, SE 405 30 Goteborg, Sweden
    Cytokine Growth Factor Rev 15:215-28. 2004
  5. ncbi Biology of platelet-derived growth factors in development
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Birth Defects Res C Embryo Today 69:272-85. 2003
  6. ncbi Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Curr Opin Nephrol Hypertens 13:45-52. 2004
  7. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
  8. ncbi Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
    Mattias Bjarnegard
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 131:1847-57. 2004
  9. pmc Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    Alexandra Abramsson
    Department of Medical Biochemistry, Sahlgrenska Academy at Göteberg University, Goteborg, Sweden
    J Clin Invest 112:1142-51. 2003
  10. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004

Detail Information

Publications56

  1. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ....
  2. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..Subsequent angiogenic sprouting and vessel enlargement involves PDGF-B-dependent vSMC/PC progenitor co-migration and proliferation, and/or PDGF-B-independent new induction of vSMC/PC, depending on tissue context...
  3. ncbi Developmental roles of platelet-derived growth factors
    C Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Bioessays 23:494-507. 2001
    ..This suggests that ancestral PDGF and PDGFR expression patterns and functions may have been iterated in related sets of morphogenetic processes in the course of evolution...
  4. ncbi Insight into the physiological functions of PDGF through genetic studies in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, P O Box 440, SE 405 30 Goteborg, Sweden
    Cytokine Growth Factor Rev 15:215-28. 2004
    ..The present review summarizes these findings and discusses their implications for mammalian development and disease...
  5. ncbi Biology of platelet-derived growth factors in development
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Birth Defects Res C Embryo Today 69:272-85. 2003
    ....
  6. ncbi Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Curr Opin Nephrol Hypertens 13:45-52. 2004
    ....
  7. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
    ..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
  8. ncbi Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
    Mattias Bjarnegard
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 131:1847-57. 2004
    ..This spectrum of pathological changes is reminiscent of diabetic microangiopathy, suggesting that the endothelium-restricted Pdgfb knockouts may serve as models for some of the pathogenic events of vascular complications to diabetes...
  9. pmc Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    Alexandra Abramsson
    Department of Medical Biochemistry, Sahlgrenska Academy at Göteberg University, Goteborg, Sweden
    J Clin Invest 112:1142-51. 2003
    ..Our data support the notion that pericytes serve an important function in tumor vessels and highlight PDGF-B and PDGF-Rbeta as promising molecular targets for therapeutic intervention...
  10. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
  11. ncbi Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
    Henrik C Nystrom
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, and RCEM and Wallenberg Laboratory, Sahlgrenska University Hospital, Sweden
    Cardiovasc Res 71:557-65. 2006
    ..We used the PDGF-B retention motif knockout mouse (RetKO) to study the effects of retention motif deletion on development of micro- and macrovascular structure and function...
  12. pmc Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells
    Cecilia Bondjers
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Pathol 162:721-9. 2003
    ..With RGS5 as a proof-of-principle, our data demonstrate the usefulness of microarray analysis of mouse models for abnormal pericyte development in the identification of new pericyte-specific markers...
  13. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
    ..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
  14. pmc Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    Maria Enge
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    EMBO J 21:4307-16. 2002
    ..Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy...
  15. ncbi Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences
    Andrea Lundkvist
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Medicinaregatan 9C, SE 41390 Göteborg, Sweden
    J Cell Sci 117:3481-8. 2004
    ..Furthermore, the absence of IFs in Müller cells leads to an abnormal response of the vascular system to ischemia, specifically decreased ability of newly formed blood vessels to traverse the ILM...
  16. ncbi Endothelial-pericyte interactions in angiogenesis
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, PO Box 440, SE 405 30, Goteborg, Sweden
    Cell Tissue Res 314:15-23. 2003
    ..Genetic data demonstrate the critical importance of pericytes for vascular morphogenesis and function, and imply specific roles for the cell type in various aspects of angiogenesis...
  17. ncbi PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis
    Hans Bostrom
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    Dev Dyn 223:155-62. 2002
    ..We conclude that, although PDGF-AA signaling over PDGFR alpha may have direct or indirect roles in overall lung growth, it does not specifically control early branching of the lung epithelium...
  18. pmc A new method for large scale isolation of kidney glomeruli from mice
    Minoru Takemoto
    Department of Medical Biochemistry, Goteborg University, Sweden
    Am J Pathol 161:799-805. 2002
    ..This method makes feasible transcript profiling and proteomic analysis of the developing, healthy and diseased mouse glomerulus...
  19. ncbi Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury
    Maria Enge
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    Neurochem Res 28:271-9. 2003
    ..Alternatively, other and more specific analyses of CNS functions in the normal and injured states will be required to demonstrate such a role...
  20. ncbi Analysis of mural cell recruitment to tumor vessels
    Alexandra Abramsson
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    Circulation 105:112-7. 2002
    ..A limited support of mural cells may contribute to these abnormalities. Here, we characterized mural cell recruitment in 2 mouse tumor models and addressed the question of why tumor vessels fail to recruit a proper coat of mural cells...
  21. ncbi Nonradioactive in situ hybridization on frozen sections and whole mounts
    Julia Asp
    Department of Pathology, University of Goteborg, Goteborg, Sweden
    Methods Mol Biol 326:89-102. 2006
    ..The protocols included describe synthesis of a digoxigenin-labeled probe, tissue handling, hybridization of the probe to the mRNA expressed in the sample and signal detection...
  22. ncbi In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure
    Arianna Tocchetti
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Genomics 81:234-44. 2003
    ..The data obtained will be instrumental in directing further experimental functional characterization of these genes...
  23. doi PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 237:494-503. 2008
    ..This implies a role for PDGF-B/PDGFR-beta-signaling specifically in the contribution of these cell lineages to cardiac development...
  24. ncbi A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated...
  25. ncbi Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..The three new brain pericyte markers are signaling molecules implicated in ion transport and intercellular signaling, potentially opening new windows on pericyte function in brain microvessels...
  26. ncbi Expression analysis of PDGF-C in adult and developing mouse tissues
    Karin Aase
    Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S 17177 Stockholm, Sweden
    Mech Dev 110:187-91. 2002
    ..PDGF-C may therefore have unique functions during tissue development and maintenance...
  27. ncbi Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics
    Nina Offenhauser
    Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Cell 127:213-26. 2006
    ..In addition, Eps8 null neurons are resistant to the actin-remodeling activities of NMDA and ethanol. We propose that proper regulation of the actin cytoskeleton is a key determinant of cellular and behavioral responses to ethanol...
  28. ncbi Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
    Jaakko Patrakka
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
    J Am Soc Nephrol 18:689-97. 2007
    ..This study provides fresh insights into glomerular biology and uncovers new possibilities to explore the role of these novel proteins in the glomerular physiology and pathology...
  29. pmc Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
    Enming J Su
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor Michigan 48109 0644, USA
    Nat Med 14:731-7. 2008
    ..These data demonstrate that PDGF signaling regulates blood-brain barrier permeability and suggest potential new strategies for stroke treatment...
  30. doi Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature
    Elisabet Wallgard
    Department of Medical Biochemistry and Biophysics, KarolinskaInstitutet, Scheeles vag 2, A3, Floor 4, SE 171 77, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 28:1469-76. 2008
    ..Here we aimed at determining the endothelial cell-specific core transcriptome in vivo...
  31. pmc Role of platelet-derived growth factors in physiology and medicine
    Johanna Andrae
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Genes Dev 22:1276-312. 2008
    ....
  32. ncbi Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007
    ....
  33. pmc Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
    Alexandra Abramsson
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genes Dev 21:316-31. 2007
    ....
  34. ncbi Growth factor gradients in vascular patterning
    Andrea Lundkvist
    Vascular Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Novartis Found Symp 283:194-201; discussion 201-6, 238-41. 2007
    ..Disruption of VEGF-A gradients provides a novel concept for the mechanism underlying pathological patterning in ocular disease...
  35. ncbi The glomerular transcriptome and proteome
    Christer Betsholtz
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Nephron Exp Nephrol 106:e32-6. 2007
    ....
  36. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...
  37. pmc Generation and characterization of rgs5 mutant mice
    Maya H Nisancioglu
    Karolinska Institutet, Laboratory of Vascular Biology, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Scheelesväg 2, Plan4 A3, SE 171 77 Stockholm, Sweden
    Mol Cell Biol 28:2324-31. 2008
    ..The GFP expression in pericytes of rgs5(GFP) mice allows detection and sorting of these cells, thereby providing a valuable novel tool for pericyte research...
  38. ncbi Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
    Charlotte Rolny
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    Blood 108:1877-86. 2006
    ..Moreover, enhanced vascular remodeling was evident in the Rosa26-PDGF-BB yolk sacs. We conclude that PDGFR-beta is expressed on early hemangioprecursor cells, regulating vascular/hematopoietic development...
  39. pmc Large-scale identification of genes implicated in kidney glomerulus development and function
    Minoru Takemoto
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    EMBO J 25:1160-74. 2006
    ..We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease...
  40. pmc Pericytes limit tumor cell metastasis
    Xiaojie Xian
    Stem Cell Center, Lund University, Lund, Sweden
    J Clin Invest 116:642-51. 2006
    ..These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions...
  41. ncbi Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1876, USA
    FASEB J 17:440-2. 2003
    ..Together these results indicate that RGS5 exerts control over PDGFR-beta and GPCR-mediated signaling pathways active during fetal vascular maturation...
  42. ncbi Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice
    Sabrina Basciani
    Department of Medical Pathophysiology, University of Rome La Sapienza, Policlinico Umberto I, 00161 Rome, Italy
    Biol Reprod 70:168-77. 2004
    ..Taken together, these data indicate that the PDGF system is highly expressed in the epididymis and suggest that PDGF could be involved in the maintenance of morphological structure and functional control of this organ...
  43. ncbi Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    Jody J Haigh
    Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
    Dev Biol 262:225-41. 2003
    ..VEGF-A dosage is therefore a critical parameter regulating the density of the vascular plexus in the developing CNS that is in turn a key determinant in the development and architectural organization of the nervous system...
  44. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  45. pmc Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice
    Koichi Kozaki
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 161:1395-407. 2002
    ..Thus, elimination of PDGF-B from circulating cells or blockade of PDGF receptors does not appear sufficient to prevent smooth muscle accumulation in advanced lesions of atherosclerosis...
  46. ncbi Pericytes and the pathogenesis of diabetic retinopathy
    Hans Peter Hammes
    Fifth Medical Clinic, Medical Faculty of the University of Heidelberg, Mannheim, Germany
    Diabetes 51:3107-12. 2002
    ..At high vascular endothelial growth factor levels, such as those in the retinopathy of prematurity model, pericyte deficiency leads to reduced inhibition of endothelial proliferation in vivo...
  47. ncbi Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
    Masao Furuhashi
    Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
    Cancer Res 64:2725-33. 2004
    ..Our findings thus demonstrate that paracrine PDGF production stimulates pericyte recruitment to tumor vessels and suggest that pericyte abundance influences tumor cell apoptosis and tumor growth...
  48. ncbi The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens
    Svetlana N Popova
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala, Sweden
    Dev Biol 270:427-42. 2004
    ....
  49. ncbi Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL
    Nilima Prakash
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Exp Cell Res 278:31-44. 2002
    ..These data show that Notch 3 expression is conserved between mouse and human and suggest that the mouse is a valid system for analysis of CADASIL...
  50. ncbi Identification of transcripts specific for physiological gene activation by platelet-derived growth factor (PDGF)-B in intact brain tissue
    Oliver Renner
    Experimental Therapeutics Programme, Spanish National Cancer Centre, E 28029 Madrid, Spain
    J Cell Biochem 95:859-67. 2005
    ....
  51. pmc The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice
    Jingjing Tang
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Pathol 167:901-12. 2005
    ..Thus, our studies identify two independent negative immune regulatory pathways-PDGF-B and SOCS-that may help limit lesion expansion...
  52. ncbi Endothelial/pericyte interactions
    Annika Armulik
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Circ Res 97:512-23. 2005
    ..We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema...
  53. ncbi Pericytes and vascular stability
    Desiree von Tell
    Vascular Biology Laboratory, Division of Matrix Biology, Department of Medical, Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Exp Cell Res 312:623-9. 2006
    ..Several ligand-receptor systems have been implicated in endothelial-pericyte interactions. Here, we discuss the role of some of these signaling systems in the regulation of vascular stability...
  54. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    ..Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development...
  55. ncbi Homeostatic functions of vascular endothelial growth factor in adult microvasculature
    Christer Betsholtz
    Am J Physiol Heart Circ Physiol 290:H509-11. 2006
  56. pmc The glomerular transcriptome and a predicted protein-protein interaction network
    Liqun He
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    J Am Soc Nephrol 19:260-8. 2008
    ....