Torbjorn Backstrom

Summary

Country: Sweden

Publications

  1. doi request reprint Allopregnanolone and mood disorders
    T Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Sciences, University of Umea, Sweden Electronic address
    Prog Neurobiol 113:88-94. 2014
  2. ncbi request reprint Pathogenesis in menstrual cycle-linked CNS disorders
    Torbjorn Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Sciences, Obstetrics and Gynecology, Norrlands University Hospital, SE 901 85 Umea, Sweden
    Ann N Y Acad Sci 1007:42-53. 2003
  3. ncbi request reprint The role of hormones and hormonal treatments in premenstrual syndrome
    Torbjorn Backstrom
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, Umea, Sweden
    CNS Drugs 17:325-42. 2003
  4. doi request reprint Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons
    T Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Sciences, University of Umea, SE 901 85 Umea, Sweden
    Neuroscience 191:46-54. 2011
  5. ncbi request reprint Isoallopregnanolone; an antagonist to the anaesthetic effect of allopregnanolone in male rats
    Torbjorn Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynaecology, Norrlands University Hospital, Umea University, Umea, Sweden
    Eur J Pharmacol 512:15-21. 2005
  6. ncbi request reprint 3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone
    Sahruh Turkmen
    Department of Clinical Science, Obstetrics and Gynecology, Umea Neurosteroid Research Center, 5B level 5, Umea University Hospital, SE 901 85 Umea, Sweden
    Eur J Neurosci 20:1604-12. 2004
  7. ncbi request reprint Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone
    Lotta Andreen
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Norrlands University Hospital, Umeå SE 901 85, Sweden
    Psychoneuroendocrinology 30:212-24. 2005
  8. ncbi request reprint The effect of a low dose of alcohol on allopregnanolone serum concentrations across the menstrual cycle in women with severe premenstrual syndrome and controls
    Sigrid Nyberg
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, Umea University, Sweden
    Psychoneuroendocrinology 30:892-901. 2005
  9. ncbi request reprint Allopregnanolone serum concentrations and neurosteroid sensitivity during withdrawal from postmenopausal hormone therapy
    Anna Carin Wihlbäck
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, Umea, Sweden
    Gynecol Endocrinol 23:590-6. 2007
  10. doi request reprint Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor
    Ming De Wang
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Sweden
    Eur J Pharmacol 586:67-73. 2008

Collaborators

Detail Information

Publications47

  1. doi request reprint Allopregnanolone and mood disorders
    T Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Sciences, University of Umea, Sweden Electronic address
    Prog Neurobiol 113:88-94. 2014
    ..This agrees with findings in animals showing a relation between changes in alpha4 and delta subunits of the GABA-A receptor and anxiogenic effects of allopregnanolone...
  2. ncbi request reprint Pathogenesis in menstrual cycle-linked CNS disorders
    Torbjorn Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Sciences, Obstetrics and Gynecology, Norrlands University Hospital, SE 901 85 Umea, Sweden
    Ann N Y Acad Sci 1007:42-53. 2003
    ..An example of withdrawal effect is "catamenial epilepsy," when seizures increase during menstruation after the withdrawal of GABA steroids. Similar phenomena occur at stress since the adrenals produce GABA steroids during stress...
  3. ncbi request reprint The role of hormones and hormonal treatments in premenstrual syndrome
    Torbjorn Backstrom
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, Umea, Sweden
    CNS Drugs 17:325-42. 2003
    ..To avoid adverse effects when high dosages of GnRH agonists are used, add-back hormone replacement therapy is recommended. Spironolactone also has a beneficial effect, although not as much as SSRIs and GnRH agonists...
  4. doi request reprint Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons
    T Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Sciences, University of Umea, SE 901 85 Umea, Sweden
    Neuroscience 191:46-54. 2011
    ..This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  5. ncbi request reprint Isoallopregnanolone; an antagonist to the anaesthetic effect of allopregnanolone in male rats
    Torbjorn Backstrom
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynaecology, Norrlands University Hospital, Umea University, Umea, Sweden
    Eur J Pharmacol 512:15-21. 2005
    ..86, b=0.40, df=8, P<0.01). Thus isoallopregnanolone can antagonise the anaesthetic action of allopregnanolone...
  6. ncbi request reprint 3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone
    Sahruh Turkmen
    Department of Clinical Science, Obstetrics and Gynecology, Umea Neurosteroid Research Center, 5B level 5, Umea University Hospital, SE 901 85 Umea, Sweden
    Eur J Neurosci 20:1604-12. 2004
    ..01), in both cortical and hippocampal homogenates. In conclusion, UC1011 can via antagonism at the GABA-A receptor reduce the negative allopregnanolone effect on learning in the water maze...
  7. ncbi request reprint Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone
    Lotta Andreen
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Norrlands University Hospital, Umeå SE 901 85, Sweden
    Psychoneuroendocrinology 30:212-24. 2005
    ....
  8. ncbi request reprint The effect of a low dose of alcohol on allopregnanolone serum concentrations across the menstrual cycle in women with severe premenstrual syndrome and controls
    Sigrid Nyberg
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, Umea University, Sweden
    Psychoneuroendocrinology 30:892-901. 2005
    ..The primary aim of this study was to investigate possible alcohol-induced changes in allopregnanolone serum concentrations across different menstrual cycle phases in women with severe premenstrual syndrome (PMS) and controls...
  9. ncbi request reprint Allopregnanolone serum concentrations and neurosteroid sensitivity during withdrawal from postmenopausal hormone therapy
    Anna Carin Wihlbäck
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, Umea, Sweden
    Gynecol Endocrinol 23:590-6. 2007
    ..The aim of the present study was to evaluate the pharmacodynamic response to pregnanolone during withdrawal from E2-only treatment and during withdrawal from treatment with E2 + P...
  10. doi request reprint Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor
    Ming De Wang
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Sweden
    Eur J Pharmacol 586:67-73. 2008
    ..0+/-0.5 microM and 8.4+/-0.9 microM, respectively. These results suggest differential actions of PS and 3beta, 20(R/S)-pregnandiols on the offset time course of GABA-site activation...
  11. ncbi request reprint Progesterone withdrawal effects in the open field test can be predicted by elevated plus maze performance
    Magnus Löfgren
    Department of Clinical Science, Obstetrics and Gynecology, Umea Neurosteroid Research Center, Umea University Hospital, SE 901 85 Umea, Sweden
    Horm Behav 50:208-15. 2006
    ..The results indicate that the effects of PWD relate to individual exploration and risk taking. Furthermore, the possible analogy of PWD and PMS/PMDD in relation to individual traits is discussed...
  12. ncbi request reprint Estradiol and the addition of progesterone increase the sensitivity to a neurosteroid in postmenopausal women
    Anna Carin Wihlbäck
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, S 90185 Umea, Sweden
    Psychoneuroendocrinology 30:38-50. 2005
    ..Women expressing cyclicity in negative mood symptoms were more sensitive to pregnanolone than women without symptom cyclicity during HRT...
  13. ncbi request reprint Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus
    David Haage
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea Neurosteroid Research Center, Umea University Hospital, SE 901 85 Umea, Sweden
    Brain Res 1033:58-67. 2005
    ..The main effects of AlloP and PregS on the sIPSC time course were mimicked by a simplified model with AlloP assumed to reduce the rate of GABA unbinding from the receptor and PregS assumed to increase the rate of desensitization...
  14. ncbi request reprint A comparison of the pharmacological properties of recombinant human and rat alpha(1)beta(2)gamma(2L) GABA(A) receptors in Xenopus oocytes
    Mozibur Rahman
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Umea University, Umea, Sweden
    Clin Exp Pharmacol Physiol 35:1002-11. 2008
    ....
  15. ncbi request reprint 3Beta-hydroxysteroids and pregnenolone sulfate inhibit recombinant rat GABA(A) receptor through different channel property
    Ming De Wang
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Umea University, S 901 85 Umea, Sweden
    Eur J Pharmacol 557:124-31. 2007
    ..These results are consistent with the hypothesis that pregnenolone sulfate-inhibition does not share with 3beta-hydroxysteroids the coincident channel property at the GABA(A) receptor...
  16. ncbi request reprint GABA(A) receptor changes in acute allopregnanolone tolerance
    Vita Birzniece
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University Hospital, SE 901 85, Sweden
    Eur J Pharmacol 535:125-34. 2006
    ..These changes in GABA(A) receptor subunits mRNA expression and protein (alpha4) might be of importance for the development of acute tolerance to allopregnanolone...
  17. ncbi request reprint The effect of the neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol on the time course of GABA evoked currents is different to that of pregnenolone sulphate
    Jessica Strömberg
    Department of Clinical Science, Umea Neurosteroid Research Center, Umea University, Norrlands University Hospital, Umea, Sweden
    Eur J Pharmacol 605:78-86. 2009
    ..In conclusion, the effect of 5beta-pregnane-3beta, 20(R)-diol on GABA-evoked currents is different to that of pregnenolone sulphate in medial preoptic nucleus neurons...
  18. ncbi request reprint Allopregnanolone concentration and mood--a bimodal association in postmenopausal women treated with oral progesterone
    Lotta Andreen
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Norrlands University Hospital, SE 901 85, Umea, Sweden
    Psychopharmacology (Berl) 187:209-21. 2006
    ..Allopregnanolone effects on mood in postmenopausal women are unclear thus far...
  19. ncbi request reprint Progesterone effects during sequential hormone replacement therapy
    Lotta Andreen
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, University Hospital, S 901 87 Umea, Sweden
    Eur J Endocrinol 148:571-7. 2003
    ..The aim was to investigate the effect on mood and the physical symptoms of two dosages of natural progesterone and a placebo in postmenopausal women with and without a history of premenstrual syndrome (PMS)...
  20. doi request reprint Withdrawal effects from progesterone and estradiol relate to individual risk-taking and explorative behavior in female rats
    Magnus Löfgren
    Department of Clinical Sciences, Division of Obstetrics and Gynecology, Umea Neurosteroid Research Center, Umea University Hospital, Umea, Sweden
    Physiol Behav 96:91-7. 2009
    ..These findings show that female rats with the trait of risk-taking and explorative behavior (HR) are more affected by PEWD...
  21. ncbi request reprint Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte
    Mozibur Rahman
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Umea University, S 901 85 Umea, Sweden
    Eur J Pharmacol 547:37-44. 2006
    ..Results from the current study revealed a different modulation pattern by neurosteroids between the alpha(1)beta(2)gamma(2L) and alpha(5)beta(2)gamma(2L) receptor...
  22. doi request reprint Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit
    Ming De Wang
    Department of Clinical Science, Umea Neurosteroid Research Center, Obstetrics and Gynecology, Umea University, Umea, Sweden
    Clin Exp Pharmacol Physiol 37:662-9. 2010
    ..The recombinant H alpha(4)beta(3)delta receptor is a less sensitive subunit composition in terms of agonist activation...
  23. ncbi request reprint Pharmacokinetic and behavioral effects of allopregnanolone in healthy women
    Erika Timby
    Department of Clinical Science, Obstetrics and Gynecology, Umea University, and Hospital Pharmacy, University Hospital, Umea, Sweden
    Psychopharmacology (Berl) 186:414-24. 2006
    ..The behavioral effects of allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) in women are not known...
  24. ncbi request reprint Brief but chronic increase in allopregnanolone cause accelerated AD pathology differently in two mouse models
    Sara K Bengtsson
    Umea University, Umeå Neurosteroid Research Centre, Department of Clinical Sciences, Obstetrics and Gynaecology, Umea, Sweden
    Curr Alzheimer Res 10:38-47. 2013
    ..Still, further studies are required to determine the mechanisms behind the cognitive impairment and the increased Aβ-levels caused by mildly elevated ALLO-levels...
  25. ncbi request reprint Allopregnanolone decrease with symptom improvement during placebo and gonadotropin-releasing hormone agonist treatment in women with severe premenstrual syndrome
    Sigrid Nyberg
    Department of Clinical Science, Obstetrics and Gynecology, Umea University Hospital, Umea, Sweden
    Gynecol Endocrinol 23:257-66. 2007
    ....
  26. ncbi request reprint Action by and sensitivity to neuroactive steroids in menstrual cycle related CNS disorders
    Anna Carin N-Wihlbäck
    Umea Neurosteroid Research Center, Department of Clinical Sciences, University of Umea, Norrlands University Hospital, Sweden
    Psychopharmacology (Berl) 186:388-401. 2006
    ....
  27. doi request reprint Women with acute intermittent porphyria have a defect in 5α-steroid production during the menstrual cycle
    Eva Innala
    Department of Clinical Science, Obstetrics and Gynecology, Umea University, Umea, Sweden
    Acta Obstet Gynecol Scand 91:1445-52. 2012
    ....
  28. doi request reprint Allopregnanolone, a GABAA receptor agonist, decreases gonadotropin levels in women. A preliminary study
    Erika Timby
    Department of Clinical Science, Obstetrics and Gynaecology, Umeå Neurosteroid Research Centre, Umea University, SE 901 85 Umea, Sweden
    Gynecol Endocrinol 27:1087-93. 2011
    ..Although the number of women was small, the results suggest a regulatory mechanism on the hypothalamic-pituitary-gonadal axis by allopregnanolon...
  29. doi request reprint Studies of pharmacokinetic and pharmacodynamic properties of isoallopregnanolone in healthy women
    Helena Hedström
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics, and Gynecology, Umea University, Umea, Sweden
    Psychopharmacology (Berl) 203:85-98. 2009
    ..The pharmacokinetics and behavioral effects of isoallopregnanolone (3beta-hydoxy-5alpha-pregnan-20-one) in women are not known...
  30. ncbi request reprint Sexuality and androgens in women with cyclical mood changes and pre-menstrual syndrome
    Ulla Britt Ekholm
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea Neurosteroid Research Center, Umea University, Umea, Sweden
    Acta Obstet Gynecol Scand 93:248-55. 2014
    ..To study the relation between androgen levels and sexual interest in women with different kinds of pre-menstrual syndrome (PMS)...
  31. ncbi request reprint Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems
    Vita Birzniece
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University Hospital, Sweden
    Brain Res Rev 51:212-39. 2006
    ..It would be important to find a substance that antagonizes allopregnanolone-induced adverse effects...
  32. ncbi request reprint Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone)
    Per Lundgren
    Department of Clinical Science, Section of Obstetrics and Gynecology, Umea Neurosteroid Research Center, Umea University, Bldg 5B, Level 5, SE 901 85 Umea, Sweden
    Brain Res 982:45-53. 2003
    ..These results indicate that ISO may be useful functional blocker of GABA(A) receptor potentiating steroid ALLO when used at concentrations that do not affect baseline GABAergic neurotransmission...
  33. doi request reprint The influence of social subordinate housing on the withdrawal effects from progesterone and estradiol in male rats
    Magnus Löfgren
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea Neurosteroid Research Center, Building 5B, Fifth Floor, Umea University Hospital, SE 901 85 Umea, Sweden
    Gen Comp Endocrinol 177:62-9. 2012
    ..The behavioral results indicate an interaction between the effects of the lasting social subordinate stress and PEWD...
  34. ncbi request reprint Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators
    Lotta Andreen
    Umea Neurosteroid Research Center, Umeå University Department of Clinical Science, Obstetrics and Gynaecology, Norrlands University Hospital, Umeå SE 901 85, Sweden
    Psychoneuroendocrinology 34:1121-32. 2009
    ..These findings suggest that negative mood symptoms in women with PMDD are caused by the paradoxical effect of allopregnanolone mediated via the GABA(A) receptor...
  35. ncbi request reprint Increase of estrogen dose deteriorates mood during progestin phase in sequential hormonal therapy
    Inger Björn
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, 90185 Umea, Sweden
    J Clin Endocrinol Metab 88:2026-30. 2003
    ..05). Our conclusion is that an increase of the estrogen dose accentuates negative mood and physical symptoms during the progestin phase of sequential hormonal therapy...
  36. ncbi request reprint Effects of continuous combined conjugated estrogen/medroxyprogesterone acetate and 17beta-estadiol/norethisterone acetate on lipids and lipoproteins
    Inga Stina Odmark
    Department of Clinical Science, Obstetrics and Gynecology, Umea University, S 901 85, Sweden
    Maturitas 48:137-46. 2004
    ..This motivated a comparative study where the two continuous combined regimens most commonly used in Sweden during the 1990s have been studied regarding effects on lipid profile...
  37. doi request reprint Chronic allopregnanolone treatment accelerates Alzheimer's disease development in AβPP(Swe)PSEN1(ΔE9) mice
    Sara K Bengtsson
    Department of Clinical Science, Obstetrics and Gynaecology, Umeå Neurosteroid Research Centre, Umea University, Umea, Sweden
    J Alzheimers Dis 31:71-84. 2012
    ..However, further studies are required in order to determine the underlying mechanism...
  38. doi request reprint Increased neurosteroid sensitivity--an explanation to symptoms associated with chronic work related stress in women?
    Torbjorn Backstrom
    Umeå Neurosteroid Research Centre, Department of Clinical Science, Umea University, Umea, Sweden
    Psychoneuroendocrinology 38:1078-89. 2013
    ..Flumazenil does not block the effect of allopregnanolone...
  39. ncbi request reprint Altered sensitivity to alcohol in the late luteal phase among patients with premenstrual dysphoric disorder
    Sigrid Nyberg
    Department of Clinical Science, Obstetrics and Gynecology, Umea University Hospital, S 901 85 Umea, Sweden
    Psychoneuroendocrinology 29:767-77. 2004
    ..Although the majority of prior studies have indicated that alcohol sensitivity does not differ between menstrual cycle phases, patients with PMDD have thus far not been studied...
  40. ncbi request reprint Allopregnanolone inhibits learning in the Morris water maze
    Inga Maj Johansson
    Department of Clinical Science, Obstetrics and Gynecology, UKBF 3B, 2nd Floor, Umea University Hospital, S E 901 85, Umea, Sweden
    Brain Res 934:125-31. 2002
    ..The learning impairment might be due to a combination of changed swimming behavior and difficulties in navigation...
  41. ncbi request reprint Psychophysically determined thresholds for thermal perception and pain perception in healthy women across the menstrual cycle
    Karin Söderberg
    Department of Pharmacology and Clinical Neurosciences, Clinical Neurophysiology, Umea University, SE 901 87 Umea, Sweden
    Clin J Pain 22:610-6. 2006
    ..The aim was to quantify temperature and temperature pain thresholds at biochemically defined stages of the menstrual cycle...
  42. ncbi request reprint No difference in responsiveness to a low dose of alcohol between healthy women and men
    Sigrid Nyberg
    Department of Clinical Science, Obstetrics and Gynecology, University Hospital of Umea, Umea, S 901 85 Sweden
    Pharmacol Biochem Behav 78:603-10. 2004
    ..According to the findings of the present study, no gender differences in the responsiveness to a low-dose alcohol infusion were found...
  43. doi request reprint Evaluation of gonadotropin-releasing hormone agonist treatment for prevention of menstrual-related attacks in acute porphyria
    Eva Innala
    Department of Clinical Science, Obstetrics and Gynecology, Umea University, Umea, Sweden
    Acta Obstet Gynecol Scand 89:95-100. 2010
    ..To describe concomitant add-back therapies with estradiol and progesterone and describe their benefits and adverse effects...
  44. ncbi request reprint Estrogen and progesterone receptors in ovarian epithelial tumors
    Peter R Lindgren
    Department of Obstetrics and Gynecology, Umea University Hospital, S 901 85 Umea, Sweden
    Mol Cell Endocrinol 221:97-104. 2004
    ..These novel findings may provide a rationale for the development of new diagnostic and possibly therapeutic strategies...
  45. doi request reprint Allopregnanolone promotes success in food competition in subordinate male rats
    Magnus Löfgren
    Division of Obstetrics and Gynecology, Department of Clinical Sciences, Umea Neurosteroid Research Center, Umea University Hospital, Umea, Sweden
    Neuropsychobiology 68:15-23. 2013
    ..Therefore, it is of particular interest to determine if there is a relationship between an anxiolytic effect and aggressive behavior following AlloP administration...
  46. ncbi request reprint Steroid receptor expression in vaginal epithelium of healthy fertile women and influences of hormonal contraceptive usage
    Anna Ildgruben
    Department of Clinical Science, Obstetrics and Gynecology, Umea University, S 90185 Umea, Sweden
    Contraception 72:383-92. 2005
    ..The objective of this study was to evaluate whether long-term usage of hormonal contraceptives modifies the steroid receptor expression in the human vaginal epithelium of healthy young women...
  47. ncbi request reprint Allopregnanolone and pregnanolone are produced by the human corpus luteum
    Ulrika Ottander
    Department of Clinical Science, Obstetrics and Gynecology, Umea University Hospital, Umea, Sweden
    Mol Cell Endocrinol 239:37-44. 2005
    ..In conclusion, the neurosteroids allopregnanolone and pregnanolone are produced in the human corpus luteum and their release is stimulated by trophic hormone...