Per Aspenberg

Summary

Country: Sweden

Publications

  1. pmc Mechanical load and BMP signaling during tendon repair: a role for follistatin?
    Pernilla Eliasson
    The Section for Orthopaedics and Sports Medicine, IKE, Faculty of Health Sciences, Linkoping University, SE 581 85, Linkoping, Sweden
    Clin Orthop Relat Res 466:1592-7. 2008
  2. pmc Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate
    Jörg Schilcher
    Department of Orthopedics, AIM IKE, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Acta Orthop 80:413-5. 2009
  3. ncbi request reprint Atypical femoral fractures, bisphosphonates, and mechanical stress
    Per Aspenberg
    Department of Clinical and Experimental Medicine, Orthopedics, Faculty of Health Science, Linkoping University, 581 85, Linkoping, Sweden
    Curr Osteoporos Rep 12:189-93. 2014
  4. pmc Bisphosphonate-coated external fixation pins appear similar to hydroxyapatite-coated pins in the tibial metaphysis and to uncoated pins in the shaft
    Soren Toksvig-Larsen
    Department of Orthopedics, Hassleholm Hospital, Hassleholm, and Department of Orthopedics, Clinical Sciences, Lund University, Lund, Sweden
    Acta Orthop 84:314-8. 2013
  5. pmc Dichotomous location of 160 atypical femoral fractures
    Veronika A Koeppen
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:561-4. 2013
  6. pmc Distal radial fractures heal by direct woven bone formation
    Per Aspenberg
    Department of Orthopedics, Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:297-300. 2013
  7. pmc Annotation: parathyroid hormone and fracture healing
    Per Aspenberg
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:4-6. 2013
  8. pmc Teriparatide improves early callus formation in distal radial fractures
    Per Aspenberg
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 81:234-6. 2010
  9. doi request reprint Targeting RANKL for reduction of bone loss around unstable implants: OPG-Fc compared to alendronate in a model for mechanically induced loosening
    Per Aspenberg
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences at Linköping University, SE 581 85 Linkoping, Sweden
    Bone 48:225-30. 2011
  10. doi request reprint Sol-gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
    Paula Linderbäck
    Department of Physics, Chemistry and Biology, Laboratory of Applied Physics, Linkoping University, SE 581 83 Linkoping, Sweden
    J Biomed Mater Res A 94:389-95. 2010

Detail Information

Publications83

  1. pmc Mechanical load and BMP signaling during tendon repair: a role for follistatin?
    Pernilla Eliasson
    The Section for Orthopaedics and Sports Medicine, IKE, Faculty of Health Sciences, Linkoping University, SE 581 85, Linkoping, Sweden
    Clin Orthop Relat Res 466:1592-7. 2008
    ..Loading strongly decreased the expression of follistatin, which could lead to increased signaling. The BMP system appears involved in tendon maintenance and healing, and may respond to mechanical loading...
  2. pmc Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate
    Jörg Schilcher
    Department of Orthopedics, AIM IKE, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Acta Orthop 80:413-5. 2009
    ..Recent case reports have identified an association between long-term bisphosphonate treatment and stress fractures of the femoral shaft. The risk of such fractures in bisphosphonate users has not been determined...
  3. ncbi request reprint Atypical femoral fractures, bisphosphonates, and mechanical stress
    Per Aspenberg
    Department of Clinical and Experimental Medicine, Orthopedics, Faculty of Health Science, Linkoping University, 581 85, Linkoping, Sweden
    Curr Osteoporos Rep 12:189-93. 2014
    ..Possibly, ongoing bisphosphonate use reduces the ability to resorb and replace areas of microdamage by targeted remodeling. This could lead to crack propagation beyond a point of no return, ending in macroscopic stress fracture. ..
  4. pmc Bisphosphonate-coated external fixation pins appear similar to hydroxyapatite-coated pins in the tibial metaphysis and to uncoated pins in the shaft
    Soren Toksvig-Larsen
    Department of Orthopedics, Hassleholm Hospital, Hassleholm, and Department of Orthopedics, Clinical Sciences, Lund University, Lund, Sweden
    Acta Orthop 84:314-8. 2013
    ..We now tested a bisphosphonate coating on steel pins for external fixation. The primary hypothesis was that coated pins would be better fixed in the diaphysis...
  5. pmc Dichotomous location of 160 atypical femoral fractures
    Veronika A Koeppen
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:561-4. 2013
    ..We determined whether there is a dichotomy in this respect...
  6. pmc Distal radial fractures heal by direct woven bone formation
    Per Aspenberg
    Department of Orthopedics, Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:297-300. 2013
    ..In reality, most fractures occur in metaphyseal cancellous bone. Apart from a study of vertebral fractures, we have not found any histological description of cancellous bone healing in humans...
  7. pmc Annotation: parathyroid hormone and fracture healing
    Per Aspenberg
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:4-6. 2013
    ..Although both are encouraging and appear to show acceleration of normal fracture healing, they have methodological shortcomings that preclude definitive conclusions...
  8. pmc Teriparatide improves early callus formation in distal radial fractures
    Per Aspenberg
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 81:234-6. 2010
    ..As radiographic cortical continuity appears late in the healing process, perhaps too late for clinical relevance, we studied the qualitative appearance of the callus 5 weeks after fracture...
  9. doi request reprint Targeting RANKL for reduction of bone loss around unstable implants: OPG-Fc compared to alendronate in a model for mechanically induced loosening
    Per Aspenberg
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences at Linköping University, SE 581 85 Linkoping, Sweden
    Bone 48:225-30. 2011
    ..The results suggest the possibility of targeting osteoclast recruitment via the RANKL system in patients with impending prosthetic loosening...
  10. doi request reprint Sol-gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
    Paula Linderbäck
    Department of Physics, Chemistry and Biology, Laboratory of Applied Physics, Linkoping University, SE 581 83 Linkoping, Sweden
    J Biomed Mater Res A 94:389-95. 2010
    ..Also, locally delivered, that is, surface immobilized alendronate showed a better fixation than systemically delivered. Using sol-gel derived TiO(2) as a platform, it is possible to administer controllable amounts of a variety of BPs...
  11. doi request reprint Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants
    Therese Andersson
    Experimental Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, 58183 Linkoping, Sweden
    J Mater Sci Mater Med 21:3029-37. 2010
    ..No pronounced increase was seen around the pamidronate coated screws. Together, the results demonstrate the possibility of obtaining a significant local therapeutic effect with minute amounts of surface immobilized zoledronate...
  12. pmc Fluid pressure and flow as a cause of bone resorption
    Anna Fahlgren
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 81:508-16. 2010
    ..This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced by fluctuations in fluid pressure or flow, caused by implant instability...
  13. pmc Celecoxib does not appear to affect prosthesis fixation in total knee replacement: A randomized study using radiostereometry in 50 patients
    Andreas Meunier
    Division of Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 80:46-50. 2009
    ..This could tamper prosthesis fixation. We investigated whether celecoxib, a selective Cox-2 inhibitor, increases prosthesis migration in total knee replacement (TKR)...
  14. doi request reprint Early Achilles tendon healing in sheep
    Olena Virchenko
    Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Science, Linkoping, Sweden
    Arch Orthop Trauma Surg 128:1001-6. 2008
    ..This is the first description of early tendon healing in sheep Achilles tendons...
  15. pmc Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study
    Ulrik Hansson
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    Acta Orthop 80:41-5. 2009
    ..By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement...
  16. pmc Etanercept does not impair healing in rat models of tendon or metaphyseal bone injury
    Olof Sandberg
    Orthopedics Division, Department of Clinical and Experimental Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Acta Orthop 83:305-10. 2012
    ..We therefore investigated whether blocking of TNF-α with etanercept influences the healing process in established rat models of injury of tendons and metaphyseal bone...
  17. pmc Locally applied Simvastatin improves fracture healing in mice
    Bjorn Skoglund
    Division of Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    BMC Musculoskelet Disord 8:98. 2007
    ..In this study, simvastatin was administered either subcutaneously or directly to the fracture area, with the goal of stimulating fracture repair at acceptable doses...
  18. doi request reprint Rat Achilles tendon healing: mechanical loading and gene expression
    Pernilla Eliasson
    Linkoping University, Orthopedics, AIM IKE, Faculty of Health Sciences, SE 581 83 Linkoping, Sweden
    J Appl Physiol (1985) 107:399-407. 2009
    ..In the late phase of healing, tendon-specific genes (scleraxis and tenomodulin) were upregulated with loading, and the healing tissue might to some extent represent a regenerate rather than a scar...
  19. pmc Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats
    Fredrik Agholme
    Orthopaedics Division, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Sweden
    Acta Orthop 82:628-32. 2011
    ..Sclerostin expression is upregulated in unloaded bone and is downregulated by loading. We wanted to determine whether an anti-sclerostin antibody would stimulate metaphyseal healing in unloaded bone in a rat model...
  20. doi request reprint Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats
    Per Aspenberg
    Section of Orthopedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 79:111-5. 2008
    ..Thus, we hypothesized that in contrast to the case in osteoporosis treatment, PTH and bisphosphonates have an additive effect in situations involving bone regeneration...
  21. ncbi request reprint How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation
    Olena Virchenko
    Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Linkoping University, Linkoping, SE 581 85, Sweden
    Acta Orthop 77:806-12. 2006
    ..In a rat Achilles tendon transection model, 1 postoperative injection resulted in increased strength after 4 weeks. Considering the short half-lives of factors released by platelets, this very late effect calls for an explanation...
  22. ncbi request reprint Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats
    Jörgen Astrand
    Department of Orthopedics, Lund University Hospital, Sweden
    Acta Orthop Scand 73:24-30. 2002
    ..Instability-induced bone resorption therefore seems to be reduced by bisphosphonates, but higher doses are needed to obtain this effect than to reduce bone resorption associated with normal remodeling of untraumatized bone...
  23. ncbi request reprint A combination of bisphosphonate and BMP additives in impacted bone allografts
    Charlotte Jeppsson
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    Acta Orthop Scand 74:483-9. 2003
    ..Although the problems associated with the use of OP-1 in impaction grafting may be solved by adding a bisphosphonate, some of the benefits of OP-1 can be lost...
  24. ncbi request reprint Doxycycline-coated sutures improve the suture-holding capacity of the rat Achilles tendon
    Björn Pasternak
    Orthopaedics Section, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 78:680-6. 2007
    ..We therefore hypothesized that treatment with the MMP inhibitor doxycycline would improve the sutureholding capacity of tendon...
  25. doi request reprint Low-level mechanical stimulation is sufficient to improve tendon healing in rats
    Therese Andersson
    Experimental Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    J Appl Physiol (1985) 113:1398-402. 2012
    ..This stimulation appears to affect mainly tissue quality, whereas stronger stimulation also increases callus size...
  26. ncbi request reprint Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks
    Karin Wermelin
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    J Biomed Mater Res A 86:220-7. 2008
    ..We conclude that the fixation of titanium implants in bone can be improved by fibrinogen matrix-bound bisphosphonates...
  27. doi request reprint Weak effect of strontium on early implant fixation in rat tibia
    Paula Linderbäck
    Laboratory of Applied Physics, Department of Physics, Chemistry and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Bone 50:350-6. 2012
    ..Strontium is known to improve bone density, but it appears that this effect is weak in conjunction with metaphyseal bone repair and early implant fixation...
  28. doi request reprint Tissue memory in healing tendons: short loading episodes stimulate healing
    Therese Andersson
    Orthopedics and Sports Medicine, AIR IKE, Faculty of Health Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    J Appl Physiol (1985) 107:417-21. 2009
    ..This suggests that patients might be allowed early short loading episodes following, e.g., an Achilles tendon rupture for a better outcome...
  29. doi request reprint The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions
    Fredrik Agholme
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Bone 48:988-96. 2011
    ..It also seems that Dkk1 is up-regulated both after metaphyseal trauma and after unloading, and that Dkk1 is involved in mechano-transduction...
  30. ncbi request reprint Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses
    Björn Pasternak
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Int J Colorectal Dis 23:271-6. 2008
    ..Several experimental studies show that MMP inhibitors administered systemically alleviate postoperative weakening of intestinal anastomoses. We hypothesised that local delivery of MMP inhibitors would achieve a similar effect...
  31. doi request reprint Autologous platelets have no effect on the healing of human achilles tendon ruptures: a randomized single-blind study
    Thorsten Schepull
    Department of Clinical and Experimental Medicine, IKE, Linkoping University, Sweden
    Am J Sports Med 39:38-47. 2011
    ..Animal studies have shown that local application of platelet-rich plasma (PRP) stimulates tendon repair. Preliminary results from a retrospective case series have shown faster return to sports...
  32. doi request reprint Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing
    Fredrik Agholme
    Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Orthop Res 32:471-6. 2014
    ....
  33. ncbi request reprint Parecoxib impairs early tendon repair but improves later remodeling
    Olena Virchenko
    Section for Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping, Sweden
    Am J Sports Med 32:1743-7. 2004
    ..Cyclooxygenase-2 inhibitors inhibit bone repair...
  34. doi request reprint Manipulating the anabolic and catabolic response in bone graft remodeling: synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate
    Anna Kajsa Harding
    Department of Orthopedics, Lund University Hospital, SE 221 85 Lund, Sweden
    J Orthop Res 26:1245-9. 2008
    ..This combination might be useful in various conditions in orthopedic reconstruction...
  35. ncbi request reprint Systemic zoledronate precoating of a bone graft reduces bone resorption during remodeling
    Magnus Tagil
    Department of Orthopedics, Lund University Hospital SE 221 85 Lund, Linkoping, Sweden
    Acta Orthop 77:23-6. 2006
    ..Bisphosphonates are used to reduce resorption of necrotic bone. We tested a systemic pretreatment before harvesting the graft in order to protect the bone and cartilage against collapse and secondary arthrosis...
  36. ncbi request reprint Improved healing of transected rabbit Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2
    Carina Forslund
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    Am J Sports Med 31:555-9. 2003
    ..Achilles tendon ruptures in humans might be treated more efficiently with the help of a growth factor. Cartilage-derived morphogenetic protein-2 has been shown to induce formation of tendon-like tissue...
  37. doi request reprint Primary gene response to mechanical loading in healing rat Achilles tendons
    Pernilla Eliasson
    Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    J Appl Physiol (1985) 114:1519-26. 2013
    ..The five regulated genes appear to constitute a general activation machinery. The further development of gene regulation might depend on the tissue context...
  38. doi request reprint Influence of a single loading episode on gene expression in healing rat Achilles tendons
    Pernilla Eliasson
    Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    J Appl Physiol (1985) 112:279-88. 2012
    ..In conclusion, the fact that there were hardly any regulated genes 24 h after loading suggests that optimal stimulation of healing requires a mechanical loading stimulus every day...
  39. ncbi request reprint Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit knee
    Anna Fahlgren
    Department of Neuroscience and Locomotion, Division of Orthopedics and Sports Medicine, Faculty of Health and Sciences, Linkoping University, Sweden
    Acta Orthop Scand 74:437-41. 2003
    ..Our findings suggest that the first bony response after meniscectomy occurs in the subchondral bone plate rather than in the trabecular bone...
  40. ncbi request reprint Unloaded rat Achilles tendons continue to grow, but lose viscoelasticity
    Pernilla Eliasson
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Appl Physiol 103:459-63. 2007
    ..No effect of doxycycline was observed. The results suggest that in growing animals, the tendons continue to grow regardless of mechanical loading history, whereas maintenance of damping properties requires mechanical stimulation...
  41. ncbi request reprint Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses: a randomized, double-blind radiostereometric study of 50 patients
    Maria Hilding
    Department of Orthopedics, Västerås Central Hospital, Vasteras, Sweden
    Acta Orthop 78:795-9. 2007
    ..We now report the results of local peroperative treatment with another bisphosphonate, ibandronate, with the same prosthesis...
  42. pmc Stimulation of tendon repair: mechanical loading, GDFs and platelets. A mini-review
    Per Aspenberg
    Section for Orthopaedics, Inst for Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, 581 85, Linkoping, Sweden
    Int Orthop 31:783-9. 2007
    ..This suggests that the mechanical microenvironment might be favourable for the clinical use of growth factors or platelets for this indication. New methods to quantitate human Achilles tendon repair have been developed...
  43. ncbi request reprint No augmentation of morselized and impacted bone graft by OP-1 in a weight-bearing model
    Magnus Tagil
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    Acta Orthop Scand 74:742-8. 2003
    ..In this study, our aim was to determine whether it was possible to increase further the remodeling of impacted morselized bone allografts by combining load-bearing with a BMP...
  44. ncbi request reprint Surface-bound bisphosphonates enhance screw fixation in rats--increasing effect up to 8 weeks after insertion
    Karin Wermelin
    Orthopedics Section, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 78:385-92. 2007
    ..A bisphosphonate coating improves screw fixation 2 weeks after implantation in cancellous bone. This study on rats examined further development of fixation over time for screws inserted in cancellous and cortical bone...
  45. ncbi request reprint Independent and additive stimulation of tendon repair by thrombin and platelets
    Olena Virchenko
    Department of Neuroscience and Locomotion, Faculty of Health Science, Orthopaedics and Sports Medicine, Linkoping, Sweden
    Acta Orthop 77:960-6. 2006
    ..Upon tissue injury, platelets are activated by thrombin, which has many biological properties in common with growth factors. We wanted to differentiate the effect of platelets from that of thrombin...
  46. doi request reprint Sclerostin antibody treatment enhances metaphyseal bone healing in rats
    Fredrik Agholme
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    J Bone Miner Res 25:2412-8. 2010
    ..Thus, as measured by the amount of bone and its mechanical resistance, the sclerostin antibody increased bone formation during metaphyseal repair but also in untraumatized bone...
  47. doi request reprint Myostatin in tendon maintenance and repair
    Pernilla Eliasson
    Division of Orthopaedics, AIM IKE, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Growth Factors 27:247-54. 2009
    ..However, no effect on further development towards connective tissue formation was found...
  48. doi request reprint Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures
    Per Aspenberg
    Orthopaedics, Linkoping University, Linkoping, Sweden
    J Bone Miner Res 25:404-14. 2010
    ..The shortened time to healing for teriparatide 20 microg compared with placebo still may suggest that fracture repair can be accelerated by teriparatide, but this result should be interpreted with caution and warrants further study...
  49. doi request reprint Bisphosphonate use and atypical fractures of the femoral shaft
    Jörg Schilcher
    Department of Experimental and Clinical Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    N Engl J Med 364:1728-37. 2011
    ..Studies show conflicting results regarding the possible excess risk of atypical fractures of the femoral shaft associated with bisphosphonate use...
  50. ncbi request reprint Indomethacin and celecoxib improve tendon healing in rats
    Carina Forslund
    Orthopedic Department, Lund University Hospital, Lund, Sweden
    Acta Orthop Scand 74:465-9. 2003
    ..Because of the reduction in cross-sectional area without an effect on failure load, the use of Cox-inhibitors may be beneficial in clinical situations where thickening of a healing tendon is a problem--e.g., in the hand or shoulder...
  51. pmc Mechanical properties during healing of Achilles tendon ruptures to predict final outcome: a pilot Roentgen stereophotogrammetric analysis in 10 patients
    Thorsten Schepull
    Section for Orthopaedics and Sports Medicine, Department of Neurosciences and Locomotion, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    BMC Musculoskelet Disord 8:116. 2007
    ..We tested if Roentgen stereophotogrammetric analysis (RSA) can be used to follow the restoration of mechanical properties during healing of ruptured Achilles tendons, and if early measurements can predict clinical results...
  52. ncbi request reprint Improved healing of ligament to bone with point fixation in rabbits
    Shwan Khoschnau
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 77:967-72. 2006
    ..This healing can be achieved either by pressing the tissue against the bone (press fixation) or by suturing the soft tissue to the bone (point fixation)...
  53. ncbi request reprint Synovial fluid depletion: successful arthrodesis without operative cartilage removal
    Henrik Lauge-Pedersen
    Department of Orthopaedics, Lund University Hospital, S 22185, Lund, Sweden
    J Orthop Sci 8:591-5. 2003
    ..A combination with perforation of the bone-cartilage junction appears to lead to reasonably quick removal of the cartilage matrix...
  54. ncbi request reprint Direct ex vivo measurement of the fluid permeability of loose scar tissue
    Anna Fahlgren
    Department of Clinical and Experimental Medicine, Sweden
    Acta Bioeng Biomech 14:47-51. 2012
    ..We measured the tissue permeability in fibrous soft tissue, using a novel technique to obtain specimens by allowing soft tissue to grow into coralline hydroxyapatite scaffoldings implanted between the abdominal muscle layers of rats...
  55. ncbi request reprint Systemic and local ibandronate enhance screw fixation
    Bjorn Skoglund
    Division of Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University Hospital, Linkoping SE 581 85, Sweden
    J Orthop Res 22:1108-13. 2004
    ..02). These results demonstrate that early remodeling events plays an important role in screw fixation, and that systemic or local bisphosphonate treatment could be an effective pharmacological path to improve early implant fixation...
  56. ncbi request reprint Drugs and fracture repair
    Per Aspenberg
    Department of Neuroscience and Locomotion, Faculty of Health Science, Orthopaedics and Sports Medicine, Linkoping, SE 581 85, Sweden
    Acta Orthop 76:741-8. 2005
  57. doi request reprint Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone
    Brandon R Macias
    Orthopedics, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185, Linkoping, Sweden
    Bone 53:515-9. 2013
    ..This proposes a more complex expression pattern for Sost in response to unloading. Therapeutics that target Sclerostin during altered loading conditions may result in local bone mass changes that are difficult to predict...
  58. ncbi request reprint PMMA particles and pressure--a study of the osteolytic properties of two agents proposed to cause prosthetic loosening
    Bjorn Skoglund
    Department of Neuroscience and Locomotion Division of Orthopaedics and Sports Medicine, INR, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    J Orthop Res 21:196-201. 2003
    ..These results suggest that, whereas particles can be shown to elicit an osteolytic response, the much less studied osteolytic effects of pressure could be far more important...
  59. ncbi request reprint Platelet concentrate injection improves Achilles tendon repair in rats
    Per Aspenberg
    Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Science, SE 581 85 Linkoping, Sweden
    Acta Orthop Scand 75:93-9. 2004
    ..Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair...
  60. pmc Wnt signaling and orthopedics, an overview
    Fredrik Agholme
    Department of Clinical and Experimental Medicine, IKE, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 82:125-30. 2011
    ..Animal studies have also suggested that these drugs can accelerate fracture healing and implant fixation. This brief overview focuses on currently available information on the effects of manipulations of Wnt signaling on bone healing...
  61. doi request reprint Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone
    Jahan Abtahi
    Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    J Oral Pathol Med 41:494-9. 2012
    ..We tested the hypothesis that primary osteocyte death is not necessary for the development of jaw osteonecrosis...
  62. doi request reprint Achilles tendon healing in rats is improved by intermittent mechanical loading during the inflammatory phase
    Pernilla Eliasson
    Experimental Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, 58185 Sweden
    J Orthop Res 30:274-9. 2012
    ..Our results indicate that a short episodes of early loading may improve the outcome of tendon healing. This could be of interest to clinical practice...
  63. ncbi request reprint Postoperative clodronate decreases prosthetic migration: 4-year follow-up of a randomized radiostereometric study of 50 total knee patients
    Maria Hilding
    Department of Orthopedics, Central Hospital of Västerås, Linkoping, Sweden
    Acta Orthop 77:912-6. 2006
    ..We now report the 4-year results...
  64. pmc Tourniquet use in total knee replacement does not improve fixation, but appears to reduce final range of motion
    Håkan Ledin
    Department of Orthopedics, Aleris Specialist Care, Motala, Sweden
    Acta Orthop 83:499-503. 2012
    ..We investigated whether the use of a tourniquet influences prosthesis fixation measured with RSA. This has not been investigated previously to our knowledge...
  65. doi request reprint Atypical femoral fractures are a separate entity, characterized by highly specific radiographic features. A comparison of 59 cases and 218 controls
    Jörg Schilcher
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Sweden
    Bone 52:389-92. 2013
    ..A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use...
  66. doi request reprint Fluid-induced osteolysis: modelling and experiments
    Lars Johansson
    Department of Management and Engineering, Linkoping University, Linkoping, Sweden
    Comput Methods Biomech Biomed Engin 14:305-18. 2011
    ....
  67. ncbi request reprint Cartilage injuries in distal radial fractures
    Tommy Lindau
    Department of Orthopedics, Angelholm Hospital, Sweden
    Acta Orthop Scand 74:327-31. 2003
    ..06). In conclusion, subchondral hematomas in distal radial fractures can lead to early onset of mild OA and worse outcome after 1 year...
  68. ncbi request reprint The radioulnar joint in distal radial fractures
    Tommy Lindau
    Department of Orthopedics, Hospital of Angelholm, Sweden
    Acta Orthop Scand 73:579-88. 2002
    ..Randomized studies should be done before advocating surgical treatment of these unforeseen injuries...
  69. pmc Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
    Hanna C Björnsson Hallgren
    Institution for Clinical and Experimental Medicine and Sports Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 83:523-8. 2012
    ..We measured the plasma levels of MMPs and their tissue inhibitors (TIMPs) in patients with rotator cuff tears and related changes in the pattern of MMP and TIMP levels to the extent of the rotator cuff tear...
  70. ncbi request reprint Parecoxib impairs early metaphyseal bone healing in rats
    Andreas Meunier
    Division of Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, SE, 581 85 Linkoping, Sweden
    Arch Orthop Trauma Surg 126:433-6. 2006
    ..Cox2 inhibitors decrease prostaglandin production and therefore influence bone healing especially in unstable long bone models. It is unclear to what extent implant fixation in stable metaphyseal bone is impaired...
  71. pmc Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics
    Björn Pasternak
    Orthopaedics and Sports Medicine, IKE, Linkoping University, Linkoping, Sweden
    Acta Orthop 80:693-703. 2009
    ..This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice...
  72. doi request reprint Bone resorption induced by fluid flow
    Lars Johansson
    Department of Management and Engineering, Linkoping University, Linkoping, Sweden
    J Biomech Eng 131:094505. 2009
    ....
  73. doi request reprint Fixed or loose? Dichotomy in RSA data for cemented cups
    Per Aspenberg
    Department of Orthopaedics, IKE, Faculty of Health Sciences, Linkoping, Sweden
    Acta Orthop 79:467-73. 2008
    ..We present an exploratory evaluation of such a dichotomy using a mixture distribution algorithm...
  74. ncbi request reprint Doxycycline impairs tendon repair in rats
    Björn Pasternak
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop Belg 72:756-60. 2006
    ..0) microg/ml. In conclusion, tendon healing can be affected by doxycycline at clinically relevant serum concentrations. This observation might be of relevance to further studies exploring effects of MMP-inhibitors on tendon tissue...
  75. ncbi request reprint Simvastatin improves fracture healing in mice
    Bjorn Skoglund
    Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping, Sweden
    J Bone Miner Res 17:2004-8. 2002
    ..These results point to a new possibility in the treatment of fractures...
  76. pmc The total costs of a displaced femoral neck fracture: comparison of internal fixation and total hip replacement. A randomised study of 146 hips
    Torsten Johansson
    Department of Neuroscience and Locomotion, Division of Orthopaedics and Sports Medicine, University Hospital, Linkoping, Sweden
    Int Orthop 30:1-6. 2006
    ..No difference was found between the treatment groups. The Harris hip scores were higher in the THR group, and pain was more common in the internal fixation group. In lucid patients, THR gives a better clinical result at the same cost...
  77. ncbi request reprint Bone allografts pretreated with a bisphosphonate are not resorbed
    Per Aspenberg
    Department of Orthopedics, Linkoping University Hospital, Sweden
    Acta Orthop Scand 73:20-3. 2002
    ..Local graft treatment with a bisphosphonate before insertion seems to be risk-free, and may prevent mechanical graft failure due to resorption in patients...