Niklas Arnberg

Summary

Country: Sweden

Publications

  1. ncbi request reprint Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction
    Niklas Arnberg
    Department of Virology, University of Umea, S 90185, Umea, Sweden
    Virology 302:33-43. 2002
  2. pmc CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7
    Marko Marttila
    Department of Virology, Umea University, SE 901 85 Umea, Sweden
    J Virol 79:14429-36. 2005
  3. pmc Adenovirus type 37 uses sialic acid as a cellular receptor on Chang C cells
    Niklas Arnberg
    Department of Virology, University of Umea, SE 901 85 Umea, Sweden
    J Virol 76:8834-41. 2002
  4. pmc Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells
    Cecilia Johansson
    Department of Virology, Umea University, Umea, Sweden
    J Virol 81:954-63. 2007
  5. pmc Adenovirus type 11 uses CD46 as a cellular receptor
    Anna Segerman
    Department of Virology, Umea University, SE 90185 Umeå, Sweden
    J Virol 77:9183-91. 2003
  6. doi request reprint Adenovirus receptors: implications for targeting of viral vectors
    Niklas Arnberg
    Division of Virology, Department of Clinical Microbiology, Umea University, Umea, Sweden
    Trends Pharmacol Sci 33:442-8. 2012
  7. doi request reprint The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis
    Emma C Nilsson
    Department of Clinical Microbiology, Division of Virology, Umea University, Umea, Sweden
    Nat Med 17:105-9. 2011
  8. pmc There are two different species B adenovirus receptors: sBAR, common to species B1 and B2 adenoviruses, and sB2AR, exclusively used by species B2 adenoviruses
    Anna Segerman
    Department of Virology, Umea University, Sweden
    J Virol 77:1157-62. 2003
  9. doi request reprint Adenovirus receptors: implications for tropism, treatment and targeting
    Niklas Arnberg
    Division of Virology, Department of Clinical Microbiology, Umea University, Umea, SE 901 85, Sweden
    Rev Med Virol 19:165-78. 2009
  10. doi request reprint Sialic acid tissue distribution and influenza virus tropism
    Urban Kumlin
    Department of Clinical Microbiology, Division of Virology, Umea University, Umea, Sweden
    Influenza Other Respi Viruses 2:147-54. 2008

Collaborators

  • Jonas Nilsson
  • Thilo Stehle
  • Sigvard Olofsson
  • Johan Skog
  • A Segerman
  • S Cusack
  • Ya Fang Mei
  • M S Oberste
  • Susanne M C Johansson
  • Emma C Nilsson
  • Marko Marttila
  • Goran Wadell
  • Lars Frängsmyr
  • Urban Kumlin
  • B David Persson
  • Cecilia Johansson
  • Mikael Elofsson
  • David Persson
  • Jan Kihlberg
  • Wim P Burmeister
  • Jürgen H Blusch
  • Mattias Hedenström
  • Jonas Angstrom
  • Rickard J Storm
  • Aivar Lookene
  • Johannes Bauer
  • Fatima Pedrosa Domellöf
  • Simon Rinaldi
  • Therese L Eriksson
  • Hugh J Willison
  • Fariba Jamshidi
  • Ken Dimock
  • Xiao Long Fan
  • Jose M Casasnovas
  • Mari Jonsson
  • Nina Ahlskog
  • Dirk M Reiter
  • M Kathryn Liszewski
  • John P Atkinson
  • Dan Gustafsson
  • Delphine Guilligay
  • Zsolt Ruzsics
  • François Deryckère
  • Thomas Adrian
  • Mark Windheim
  • Hans Gerhard Burgert

Detail Information

Publications16

  1. ncbi request reprint Adenovirus type 37 binds to cell surface sialic acid through a charge-dependent interaction
    Niklas Arnberg
    Department of Virology, University of Umea, S 90185, Umea, Sweden
    Virology 302:33-43. 2002
    ..Taken together, the results presented provide strong evidence for a charge mechanism during the interaction between the Ad37 fiber knob and sialic acid...
  2. pmc CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7
    Marko Marttila
    Department of Virology, Umea University, SE 901 85 Umea, Sweden
    J Virol 79:14429-36. 2005
    ..From the results obtained, we conclude that CD46 is a major cellular receptor on A549 cells for all species B adenoviruses except types 3 and 7...
  3. pmc Adenovirus type 37 uses sialic acid as a cellular receptor on Chang C cells
    Niklas Arnberg
    Department of Virology, University of Umea, SE 901 85 Umea, Sweden
    J Virol 76:8834-41. 2002
    ..From these results, we conclude that Ad37 uses sialic acid as a major receptor in cell lines derived from both genital and corneal tissues...
  4. pmc Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells
    Cecilia Johansson
    Department of Virology, Umea University, Umea, Sweden
    J Virol 81:954-63. 2007
    ..Thus, we have identified a novel binding mechanism whereby adenovirus hijacks HLf, a component of the innate immune system, and uses it as a bridge for attachment to host cells...
  5. pmc Adenovirus type 11 uses CD46 as a cellular receptor
    Anna Segerman
    Department of Virology, Umea University, SE 90185 Umeå, Sweden
    J Virol 77:9183-91. 2003
    ..From these results we conclude that CD46 is a cellular receptor for Ad11...
  6. doi request reprint Adenovirus receptors: implications for targeting of viral vectors
    Niklas Arnberg
    Division of Virology, Department of Clinical Microbiology, Umea University, Umea, Sweden
    Trends Pharmacol Sci 33:442-8. 2012
    ..This review provides an update of new and previously known molecules that mediate cellular attachment of human adenoviruses and discusses how these may influence the targeting of adenovirus-based vectors...
  7. doi request reprint The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis
    Emma C Nilsson
    Department of Clinical Microbiology, Division of Virology, Umea University, Umea, Sweden
    Nat Med 17:105-9. 2011
    ..Surface plasmon resonance analysis shows that the knob-GD1a glycan interaction has high affinity. Our findings therefore form a basis for the design and development of sialic acid-containing antiviral drugs for topical treatment of EKC...
  8. pmc There are two different species B adenovirus receptors: sBAR, common to species B1 and B2 adenoviruses, and sB2AR, exclusively used by species B2 adenoviruses
    Anna Segerman
    Department of Virology, Umea University, Sweden
    J Virol 77:1157-62. 2003
    ..Furthermore, binding of the species B serotypes to sBAR was abolished with EDTA and restored with Ca(2+), whereas the binding of Ad11p and Ad35 to SB2AR was independent of divalent cations...
  9. doi request reprint Adenovirus receptors: implications for tropism, treatment and targeting
    Niklas Arnberg
    Division of Virology, Department of Clinical Microbiology, Umea University, Umea, SE 901 85, Sweden
    Rev Med Virol 19:165-78. 2009
    ....
  10. doi request reprint Sialic acid tissue distribution and influenza virus tropism
    Urban Kumlin
    Department of Clinical Microbiology, Division of Virology, Umea University, Umea, Sweden
    Influenza Other Respi Viruses 2:147-54. 2008
    ..Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for alpha2,3-linked sialic acid...
  11. pmc Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites
    Wim P Burmeister
    Laboratoire de Virologie Moleculaire et Structurale, Universite Joseph Fourier, Faculte de Medecine de Grenoble, F 38042 Grenoble Cedex 9, France
    J Virol 78:7727-36. 2004
    ..Our results show that the altered viral tropism and cell binding of Ad19p relative to those of Ad37 are not explained by a different binding ability toward sialyl-lactose...
  12. ncbi request reprint Adenovirus type 11 binding alters the conformation of its receptor CD46
    B David Persson
    Interfaculty Institute for Biochemistry, University of Tubingen, D 72076 Tubingen, Germany
    Nat Struct Mol Biol 14:164-6. 2007
    ..This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules...
  13. pmc Sialic acid is a cellular receptor for coxsackievirus A24 variant, an emerging virus with pandemic potential
    Emma C Nilsson
    Department of Clinical Microbiology, Division of Virology, Umea University, Umeå SE 901 85, Sweden
    J Virol 82:3061-8. 2008
    ..Since several unrelated viruses with tropism for the eye use this receptor, sialic acid-based antiviral drugs that prevent virus entry may be useful for topical treatment of such infections...
  14. ncbi request reprint Multivalent sialic acid conjugates inhibit adenovirus type 37 from binding to and infecting human corneal epithelial cells
    Susanne M C Johansson
    Organic Chemistry, Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    Antiviral Res 73:92-100. 2007
    ..We conclude that multivalent sialic acid may be a potential new antiviral drug, for use in the treatment of epidemic keratoconjunctivitis caused by the adenoviruses that use sialic acid as cellular receptor...
  15. ncbi request reprint Multivalent HSA conjugates of 3'-sialyllactose are potent inhibitors of adenoviral cell attachment and infection
    Susanne M C Johansson
    Organic Chemistry, Department of Chemistry, Umea Universitet, 901 87 Umea, Sweden
    Chembiochem 6:358-64. 2005
    ..The results revealed that these compounds effectively prevent Ad37 from binding to and infecting human corneal epithelial (HCE) cells. Moreover, the inhibition is significantly increased with higher orders of multivalency...
  16. ncbi request reprint The novel early region 3 protein E3/49K is specifically expressed by adenoviruses of subgenus D: implications for epidemic keratoconjunctivitis and adenovirus evolution
    Jürgen H Blusch
    Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
    Virology 296:94-106. 2002
    ..The implications of these findings in light of the temporal appearance of the EKC-causing Ad strains are discussed...