Malin Lindqvist Appell

Summary

Country: Sweden

Publications

  1. pmc Nomenclature for alleles of the thiopurine methyltransferase gene
    Malin L Appell
    Department of Medical and Health Sciences, Division of Drug Research, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pharmacogenet Genomics 23:242-8. 2013
  2. doi request reprint Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene
    Malin Lindqvist Appell
    Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pharmacogenet Genomics 20:700-7. 2010
  3. doi request reprint A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
    Malin Lindqvist Appell
    Division of Drug Research Clinical Pharmacology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    J Crohns Colitis 7:510-3. 2013
  4. ncbi request reprint Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5
    Patricia Wennerstrand
    Department of Physics, Chemistry, and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Biochemistry 51:5912-20. 2012
  5. doi request reprint Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia
    Patricia Wennerstrand
    Department of Physics, Chemistry and Biology, Linkoping University, Sweden
    Eur J Clin Pharmacol 69:1641-9. 2013

Collaborators

Detail Information

Publications5

  1. pmc Nomenclature for alleles of the thiopurine methyltransferase gene
    Malin L Appell
    Department of Medical and Health Sciences, Division of Drug Research, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pharmacogenet Genomics 23:242-8. 2013
    ..The committee has decided to renumber two alleles: nucleotide position 106 (G>A) from TPMT*24 to TPMT*30 and position 611 (T>C, rs79901429) from TPMT*28 to TPMT*31. Nomenclature for all other known alleles remains unchanged...
  2. doi request reprint Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene
    Malin Lindqvist Appell
    Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pharmacogenet Genomics 20:700-7. 2010
    ..A total of 29 sequence variants have been identified so far in the TPMT gene. However, most of these variants are rare and not fully characterized...
  3. doi request reprint A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
    Malin Lindqvist Appell
    Division of Drug Research Clinical Pharmacology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    J Crohns Colitis 7:510-3. 2013
    ..A skewed thiopurine metabolism is a phenomenon associated with both poor treatment response and toxicity. Our aim was to evaluate the frequency of this phenomenon and the relationship to thiopurine methyltransferase (TPMT) function...
  4. ncbi request reprint Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5
    Patricia Wennerstrand
    Department of Physics, Chemistry, and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Biochemistry 51:5912-20. 2012
    ..In conclusion, this in vitro study, conducted to probe structural changes during unfolding of TPMT*2 and TPMT*5, demonstrates that the various causes of the low enzyme activity in vivo could be explained on a molecular level...
  5. doi request reprint Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia
    Patricia Wennerstrand
    Department of Physics, Chemistry and Biology, Linkoping University, Sweden
    Eur J Clin Pharmacol 69:1641-9. 2013
    ..The aim of this study was to investigate the fluctuation in TPMT enzyme activity over time and the effect of high-dose MTX infusions on TPMT enzyme activity and 6-MP metabolites in paediatric ALL patients...