Research Topics
Genomes and Genes | S G AnderssonSummaryCountry: Sweden Publications
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Publications
Genome degradation is an ongoing process in RickettsiaJ O Andersson
Department of Molecular Evolution, Uppsala University, Sweden
Mol Biol Evol 16:1178-91. 1999..This may explain the low genomic G + C content (29%), the small genome size (1.1 Mb), and the high noncoding content (24%), as well as the presence of several pseudogenes in the Rickettsia prowazekii genome...- Origins of mitochondria and hydrogenosomesS G Andersson
Department of Molecular Evolution Box 590 Biomedical Center 751 24, Uppsala, Sweden
Curr Opin Microbiol 2:535-41. 1999..In contrast, the hydrogen and the syntrophy hypotheses for the origin of mitochondria do not receive support from the available data. It remains to be seen how the evolution of hydrogenosomes is related to that of mitochondria... - Bioenergetics of the obligate intracellular parasite Rickettsia prowazekiiS G Andersson
Department of Molecular Biology, Uppsala University, Uppsala, Sweden
Biochim Biophys Acta 1365:105-11. 1998..prowazekii and to discuss the results of phylogenetic reconstructions based on a variety of bioenergetic molecules which shed light on the origin and evolution of the mitochondrial genomes... - Reductive evolution of resident genomesS G Andersson
Dept of Molecular Biology, Uppsala University, Sweden
Trends Microbiol 6:263-8. 1998..Here, we discuss the influence of such reductive processes on the evolution of genomes that replicate within the domain of a host genome... - Molecular phylogeny and rearrangement of rRNA genes in Rickettsia speciesS G Andersson
Department of Molecular Evolution, University of Uppsala, Sweden
Mol Biol Evol 16:987-95. 1999..The unique organization of the 23S rRNA genes provides a simple diagnostic tool for identification of Rickettsia species... - Pseudogenes, junk DNA, and the dynamics of Rickettsia genomesJ O Andersson
Department of Molecular Evolution, University of Uppsala, Uppsala, Sweden
Mol Biol Evol 18:829-39. 2001.... - Evolutionary rates for tuf genes in endosymbionts of aphidsE U Brynnel
Department of Molecular Biology, Uppsala University, Sweden
Mol Biol Evol 15:574-82. 1998..We relate the observed differences in substitution frequencies to the absence of selective codon preferences in Buchnera and to the influence of Muller's ratchet on small asexual populations... - Insights into the evolutionary process of genome degradationJ O Andersson
Department of Molecular Evolution, Uppsala University, Biomedical Center, Box 590, Uppsala, 751 24, Sweden
Curr Opin Genet Dev 9:664-71. 1999..The basic principles of gene degradation and elimination that are being explored in Rickettsia are likely to be of major importance for our understanding of how microbial genomes evolve... - A phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes supports an origin of mitochondria from within the RickettsiaceaeT Sicheritz-Ponten
Department of Molecular Biology, Uppsala University, Sweden
Biochim Biophys Acta 1365:545-51. 1998..We have estimated that the common ancestor of mitochondria and Rickettsiaceae dates back to more than 1500 million years ago... - Mutualists and parasites: how to paint yourself into a (metabolic) cornerI Tamas
Department of Molecular Evolution, University of Uppsala, , S-752 36, Uppsala, Sweden
FEBS Lett 498:135-9. 2001..The presence of pseudogenes in both genomes provides examples of recent gene inactivation events and offers clues to the process of genome deterioration and host-cell adaptation... 
A phylogenomic approach to microbial evolutionT Sicheritz-Ponten
Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, 752 36 Uppsala, Sweden
Nucleic Acids Res 29:545-52. 2001..The results have revealed a rich web of phylogenetic connections. However, the separation of Bacteria and Archaea into two separate domains remains robust...- A chimeric disposition of the elongation factor genes in Rickettsia prowazekiiA C Syvanen
Department of Molecular Biology, Biomedical Center, Uppsala University, Sweden
J Bacteriol 178:6192-9. 1996..coli. This atypical disposition of genes suggests that intrachromosomal recombination between duplicated tuf genes has contributed to the evolution of the unique genomic architecture of R. prowazekii... - Origin and evolution of the mitochondrial proteomeC G Kurland
Department of Molecular Evolution, Evolutionary Biology Centre, University of Uppsala, Uppsala SE 752 36, Lund University, Lund SE 223 62, Sweden
Microbiol Mol Biol Rev 64:786-820. 2000..There are no indications of a specific alpha-proteobacterial origin to genes for glycolysis. In the absence of data to the contrary, it is assumed that the ancestral host cell was a heterotroph... - Determinative value of a portion of the nifH sequence for the genera Nostoc and Anabaena (cyanobacteria)I Tamas
Department of Molecular Evolution, EBC, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
Curr Microbiol 41:197-200. 2000..The data suggest that the currently recognized genera Nostoc and Anabaena may in fact belong within a single, broadly defined genus... - Codon usage and base composition in Rickettsia prowazekiiS G Andersson
Department of Molecular Biology, Uppsala University, Sweden
J Mol Evol 42:525-36. 1996..5% and 21.4%, respectively. Extrapolation from these values suggests that R. prowazekii has around 800 genes and that 60-70% of the genome may be coding... - Unusual organization of the rRNA genes in Rickettsia prowazekiiS G Andersson
Department of Molecular Biology, Uppsala University, Sweden
J Bacteriol 177:4171-5. 1995..In this organism, the 23S and the 5S rRNA genes are tightly linked to each other, whereas the 16S rRNA gene is separated from this cluster. The 23S-5S unit is preceded by the methionyl-tRNAfMet formyltransferase gene... - Rickettsia prowazekii and Bartonella henselae: differences in the intracellular life styles revisitedS G Andersson
Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Sweden
Int J Med Microbiol 290:135-41. 2000..prowazekii is more specialised to growth in an intracellular environment. Functional genomics will provide the potential to further resolve the genetic basis for successful human infections by these important parasites... - Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhiJ M Troyer
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
Antimicrob Agents Chemother 42:1845-6. 1998..typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance...