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Genomes and Genes | S AnderssonSummaryCountry: Sweden Publications
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Publications
Adenocarcinoma of the uterine cervix: the presence of human papillomavirus and the method of detectionSonia Andersson
Institute for Clinical Science, Division of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
Acta Obstet Gynecol Scand 82:960-5. 2003..The aim of our study was to analyze cervical adenocarcinoma in greater detail: symptoms preceding the detection, the method of detection and the prevalence of human papillomavirus (HPV) with respect to age at diagnosis...
Choriocarcinoma presented as a vaginal tumorSonia Andersson
Institute for Clinical Science, Division of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden
Acta Obstet Gynecol Scand 83:776-7. 2004
Types of human papillomavirus revealed in cervical adenocarcinomas after DNA sequencingSonia Andersson
Institute for Clinical Science, Department of Obstetrics and Gynaecology, Huddinge University Hospital, Karolinska Institutet, 14186 Stockholm, Sweden
Oncol Rep 10:175-9. 2003..We have concluded that the oncogenic role of HPV in cervical squamous carcinomas and adenocarcinomas is, in some respects, discrepant...
Type distribution, viral load and integration status of high-risk human papillomaviruses in pre-stages of cervical cancer (CIN)S Andersson
Institute for Clinical Science, Division of Obstetrics and Gynaecology, Karolinska University Hospital, Huddinge, Karolinska Institute, 141 86 Stockholm, Sweden
Br J Cancer 92:2195-200. 2005..All samples were found to contain integrated forms of HPV 16, frequently mixed with an episomal form...
A comparison of the human papillomavirus test and Papanicolaou smear as a second screening method for women with minor cytological abnormalitiesSonia Andersson
Division of Obstetrics and Gynecology, Institute for Clinical Science, Karolinska University Hospital, Huddinge, Karolinska Institute, Stockholm, Sweden
Acta Obstet Gynecol Scand 84:996-1000. 2005....
The clinicopathologic significance of laminin-5 gamma2 chain expression in cervical squamous carcinoma and adenocarcinomaS Andersson
Institute for Clinical Science, Division of Obstetrics and Gynaecology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
Int J Gynecol Cancer 15:1065-72. 2005..Independent prognostic values for the survival of the patients were age and stage of the disease...
The carcinogenic role of oncogenic HPV and p53 gene mutation in cervical adenocarcinomasS Andersson
Department of Obstetrics and Gynecology, Institute for Clinical Science, Karolinska University Hospital, Huddinge, Karolinska Institute, 14186 Stockholm, Sweden
Med Oncol 23:113-9. 2006..However, p53 gene mutations were somewhat more prevalent in low differentiated tumors (p < 0.02). The results indicate that oncogenic HPV and p53 gene mutations have independent carcinogenic roles in cervical adenocarcinomas...
Expression of p16(INK4a) in relation to histopathology and viral load of 'high-risk' HPV types in cervical neoplastic lesionsSonia Andersson
Institute for Clinical Science, Division of Obstetrics and Gynaecology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden
Eur J Cancer 42:2815-20. 2006....
Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesionsS Andersson
Department of Obstetrics and Gynaecology, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
Br J Cancer 83:307-10. 2000..A single amino-acid shift in the HPV16 E6 gene appears to result in a different transforming potential in squamous and glandular cervical lesions...
Human papillomavirus 'reflex' testing as a screening method in cases of minor cytological abnormalitiesM Froberg
Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
Br J Cancer 99:563-8. 2008....
The role of human papillomavirus in cervical adenocarcinoma carcinogenesisS Andersson
Department of Obstetrics and Gynaecology, Huddinge University Hospital, Huddinge, Sweden
Eur J Cancer 37:246-50. 2001....
Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervixF Erlandsson
Cancer Center Karolinska, CCK R8 04, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm 17176, Sweden
Br J Cancer 94:1045-50. 2006....
Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic valueM I Lomnytska
Department of Obstetrics and Gynecology, Institute for Clinical Science and Technology, CLINTEC, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm SE 14186, Sweden
Br J Cancer 104:110-9. 2011..Cytology-based diagnostics of squamous cervical cancer (SCC) precursor lesions is subjective and can be improved by objective markers...
Age-specific prevalence of HPV genotypes in cervical cytology samples with equivocal or low-grade lesionsS Brismar-Wendel
Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynaecology, Karolinska University Hospital Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden
Br J Cancer 101:511-7. 2009..To define the spectrum of human papillomavirus (HPV) types and establish an age limit for triage HPV testing in atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL)...
Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses in HIV-2-infected and in HIV-2-exposed but uninfected individuals in Guinea-BissauS Andersson
Swedish Institute for Infectious Disease Control and the Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Clin Exp Immunol 139:483-9. 2005..These immune responses could be important for resistance to the infection and for the control of established infection and, thus, play a role in the lower transmission and progression of HIV-2 compared to HIV-1...
Intestinal parasites in HIV-2 associated AIDS cases with chronic diarrhoea in Guinea-BissauM Lebbad
Swedish Institute for Infectious Disease Control, Stockholm, Sweden
Acta Trop 80:45-9. 2001..Other stool parasites such as Blastocystis hominis, hookworm and Strongyloides stercoralis were observed both among HIV-positive and HIV-negative patients...
Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomasS Andersson
Department for Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm SE 141 86, Sweden
Br J Cancer 95:331-8. 2006..Therefore, application of our probe set may provide an objective genetic test for the assessment of glandular cells in Pap smears and hence for the diagnosis of cervical adenocarcinomas...
Impact of genomic stability on protein expression in endometrioid endometrial cancerM I Lomnytska
Department of Obstetrics and Gynaecology, Karolinska University Hospital, Solna, Karolinska Institute, SE 17176 Stockholm, Sweden
Br J Cancer 106:1297-305. 2012..Genomic stability is one of the crucial prognostic factors for patients with endometrioid endometrial cancer (EEC). The impact of genomic stability on the tumour tissue proteome of EEC is not yet well established...
Screening for human T cell leukaemia/lymphoma virus among blood donors in Sweden: cost effectiveness analysisE Tynell
Division of Infectious Diseases, Karolinska Institutet, Danderyd University Hospital, Danderyd, Sweden
BMJ 316:1417-22. 1998..To analyse the cost effectiveness of a national programme to screen blood donors for infection with the human T cell leukaemia/lymphoma virus...
Differential tissue-specific protein markers of vaginal carcinomaK Hellman
Department of Gynaecologic Oncology, Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden
Br J Cancer 100:1303-14. 2009..However, the expression level of some of these proteins markedly differs among the three tissue specimens indicating that they might be useful molecular markers...
Not 15 but 50% of smokers develop COPD?--Report from the Obstructive Lung Disease in Northern Sweden StudiesB Lundback
Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Respir Med 97:115-22. 2003..The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature...
Unexpected low prevalence of HIV among fertile women in Luanda, Angola. Does war prevent the spread of HIV?R T Strand
Division of International Health, Karolinska Institutet, Stockholm, Sweden
Int J STD AIDS 18:467-71. 2007..The challenge for preventive actions is urgent. This example may be relevant to other areas with a recent end-of-war situation...
The significance of p53 codon 72 polymorphism for the development of cervical adenocarcinomasS Andersson
Department of Obstetrics and Gynaecology, Huddinge University Hospital, affiliated with the Karolinska Institute, Huddinge, 14186, Sweden
Br J Cancer 85:1153-6. 2001..The results indicate that women homozygotic for arg/arg in codon 72 of the p53 gene are at an increased risk for the development of cervical adenocarcinomas. However, this genetic disposition seems to be unrelated to the HPV infection...
Antigen-specific beta-chemokine production and CD8 T-cell noncytotoxic antiviral activity in HIV-2-infected individualsR K S Ahmed
Tumorbiology Center, Karolinska Institute, Solna, Sweden
Scand J Immunol 61:63-71. 2005..Taken together, our results indicate that the production of CD8+ T-cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV-2-infected patients...
Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brainN Sugiyama
Department of Biosciences and Nutrition, Karolinska Institute, Novum, Huddinge, Sweden
Mol Psychiatry 14:223-32, 117. 2009..In addition, the importance of aromatase has to be reconsidered as the alternative estrogen, 3betaAdiol, is important in neuronal function in the postnatal brain...
Pooling of samples for seroepidemiological surveillance of human T-cell lymphotropic virus types I and IIS Andersson
Department of Immunology, Swedish Institute for Infectious Disease Control, SE 17182 Solna, Stockholm, Sweden
Virus Res 78:101-6. 2001..Using the best performing assays in this evaluation for pools of e.g. five samples would leave a reasonable safety margin...
p53 codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer developmentI Zehbe
Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Cancer Res 61:608-11. 2001..Moreover, the frequency of the arginine allele was similar in groups with different E6 genotypes. It is concluded that p53 arginine is a risk factor for cervical cancer but probably acts independently of E6 variants...
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductasesS Andersson
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
Proc Natl Acad Sci U S A 87:3640-4. 1990..However, synthetic 4-azasteroids demonstrated marked differences in their abilities to inhibit the human and rat steroid 5 alpha-reductases...
Respiratory infection recurrence and passive smoking in early atherosclerosis in children and adolescents with type 1 diabetesM Odermarsky
Paediatric Cardiology, Lund University Hospital, Lund, Sweden
Eur J Clin Invest 38:381-8. 2008..We investigated whether recurrent episodes of acute respiratory infections and exposure to tobacco smoke could influence vascular phenotypes for early atherosclerosis in children and adolescents with type 1 diabetes...
Childhood growth and cardiovascular reactivity to psychological stressors in late adulthoodK Feldt
Departments of Psychology, University of Helsinki, Helsinki, Finland
J Intern Med 264:72-82. 2008..We studied whether CV reactivity, a predictor of CV disease risk, is associated with childhood growth trajectories...
Evolution of the dec-1 eggshell locus in Drosophila. II. Intraspecific DNA sequence analysis reveals length mutations in a repetitive region in D. melanogasterS Andersson
Department of Genetics, University of Umea, Sweden
J Mol Evol 36:536-44. 1993..The possibility that the most common allele, FC1, has a selective advantage over the other alleles is discussed...
Food sources of plant sterols in the EPIC Norfolk populationS Klingberg
Department of Clinical Nutrition, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Eur J Clin Nutr 62:695-703. 2008..To investigate the intake of plant sterols and identify major dietary sources of plant sterols in the British diet...
Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid dehydrogenase 3 gene (HSD17B3)N Moghrabi
Cecil H and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9051, USA
J Clin Endocrinol Metab 83:2855-60. 1998..The current findings boost to 16 the number of mutations in the HSD17B3 gene that impair testosterone synthesis and cause male pseudohermaphroditism, and add 1 apparently silent polymorphism to this tally...
Relevance of a combined HIV antigen/antibody assay to detect early HIV infections in a low prevalence population: case reportsS Andersson
University Hospital Orebro, Sweden
Clin Lab 50:409-13. 2004..The impact of HIV combo assays on screening and diagnosis in a low prevalence population is discussed...
The aphasic person's views of the encounter with other people: a grounded theory analysisS Andersson
Department of Geriatrics and Rehabilitation, County Hospital, Halmstad, Sweden
J Psychiatr Ment Health Nurs 9:285-92. 2002..This then will give the possibility for the patient to turn the interaction process from an obstructed into a secure one...
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductaseE P Jenkins
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
J Clin Invest 89:293-300. 1992..The results provide genetic, biochemical, and pharmacological support for the existence of at least two steroid 5 alpha-reductase isozymes in man...
High mortality and severe immunosuppression in hospitalized patients with pulmonary tuberculosis and HIV-2 infection in Guinea-BissauH Norrgren
National Public Health Laboratory, Bissau, Guinea-Bissau
Scand J Infect Dis 33:450-6. 2001....
Prevention of dislocation of the hip in children with cerebral palsy. The first ten years of a population-based prevention programmeG Hagglund
Department of Orthopaedics, University Hospital of Lund, Sweden
J Bone Joint Surg Br 87:95-101. 2005..001). Dislocation of the hip in cerebral palsy remains a serious problem, and prevention is important. Our screening programme and early intervention when lateral displacement of the femoral head was detected appear to be successful...
Leptin during assisted reproductive cycles: the effect of ovarian stimulation and of very early pregnancyL Unkila-Kallio
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Haartmaninkatu 2, FIN-00290 Helsinki, Finland
Hum Reprod 16:657-62. 2001..0001). We concluded that leptin concentrations are influenced by ovarian function and that the relationship between leptin and oestrogen (but not a single leptin concentration), may be an important factor for the outcome of IVF...
Mitochondrial myopathy with exercise intolerance and retinal dystrophy in a sporadic patient with a G583A mutation in the mt tRNA(phe) geneN Darin
Department of Pediatrics, Sahlgrenska University Hospital, Goteborg, Sweden
Neuromuscul Disord 16:504-6. 2006..Analysis of single muscle fibers revealed a significantly higher level of mutated mtDNA in COX-negative fibers. Our study indicates that the 583G>A mutation is pathogenic and expands the clinical spectrum of this mutation...
Correlations between ultraviolet coloration, overwinter survival and offspring sex ratio in the blue titS C Griffith
Edward Grey Institute, Department of Zoology, University of Oxford, UK
J Evol Biol 16:1045-54. 2003..However, careful experimental work is required to provide tests of the assumptions of these models, and should be a priority for future work...
Cardiovascular reactivity to psychological stressors in late adulthood is predicted by gestational age at birthK Feldt
Department of Psychology, University of Helsinki, Helsinki, Finland
J Hum Hypertens 21:401-10. 2007....
