Peter Munch Andersen

Summary

Country: Sweden

Publications

  1. doi request reprint Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
    Peter M Andersen
    Institute of Pharmacology and Clinical Neuroscience, Section for Neurology, Umea University, SE 901 85 Umea, Sweden
    Nat Rev Neurol 7:603-15. 2011
  2. doi request reprint EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task force
    Peter M Andersen
    Umea University, Umea, Sweden
    Eur J Neurol 19:360-75. 2012
  3. ncbi request reprint EFNS task force on management of amyotrophic lateral sclerosis: guidelines for diagnosing and clinical care of patients and relatives
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Eur J Neurol 12:921-38. 2005
  4. ncbi request reprint Good practice in the management of amyotrophic lateral sclerosis: clinical guidelines. An evidence-based review with good practice points. EALSC Working Group
    Peter Munch Andersen
    Department of Neurology, Umea University Hospital, Umea, Sweden
    Amyotroph Lateral Scler 8:195-213. 2007
  5. ncbi request reprint Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene
    Peter M Andersen
    Department of Neurology, Umea University Hospital, SE 901 85, Umea, Sweden
    Curr Neurol Neurosci Rep 6:37-46. 2006
  6. ncbi request reprint The genetics of amyotrophic lateral sclerosis (ALS)
    Peter Munch Andersen
    Department of Clinical Neuroscience, Umea University Hospital, S 901 85 Umea, Sweden
    Suppl Clin Neurophysiol 57:211-27. 2004
  7. ncbi request reprint Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes
    Peter M Andersen
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital East and Harvard Medical School, Charlestown, MA, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:62-73. 2003
  8. ncbi request reprint External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis
    P M Andersen
    Department of Clinical Neuroscience, Umea University, Umea, Sweden
    J Neurol Sci 191:111-4. 2001
  9. ncbi request reprint The geographical and ethnic distribution of the D90A CuZn-SOD mutation in the Russian Federation
    P M Andersen
    Department of Pharmacology and Clinical Neuroscience, Russian Academy of Medical Sciences, Moscow
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:63-9. 2001
  10. ncbi request reprint Genetics of sporadic ALS
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:S37-41. 2001

Collaborators

Detail Information

Publications19

  1. doi request reprint Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
    Peter M Andersen
    Institute of Pharmacology and Clinical Neuroscience, Section for Neurology, Umea University, SE 901 85 Umea, Sweden
    Nat Rev Neurol 7:603-15. 2011
    ..Genetic counseling and risk assessment in relatives depend on establishing the specific gene defect and the disease penetrance in the particular family...
  2. doi request reprint EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task force
    Peter M Andersen
    Umea University, Umea, Sweden
    Eur J Neurol 19:360-75. 2012
    ..The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak...
  3. ncbi request reprint EFNS task force on management of amyotrophic lateral sclerosis: guidelines for diagnosing and clinical care of patients and relatives
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Eur J Neurol 12:921-38. 2005
    ..Advance directives for palliative end of life care are important and should be fully discussed early with the patient and relatives respecting the patients social and cultural background...
  4. ncbi request reprint Good practice in the management of amyotrophic lateral sclerosis: clinical guidelines. An evidence-based review with good practice points. EALSC Working Group
    Peter Munch Andersen
    Department of Neurology, Umea University Hospital, Umea, Sweden
    Amyotroph Lateral Scler 8:195-213. 2007
    ..During the course of the disease, every effort should be made to maintain patient autonomy. Advance directives for palliative end of life care are important and should be discussed early with the patient and relatives if they so wish...
  5. ncbi request reprint Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene
    Peter M Andersen
    Department of Neurology, Umea University Hospital, SE 901 85, Umea, Sweden
    Curr Neurol Neurosci Rep 6:37-46. 2006
    ....
  6. ncbi request reprint The genetics of amyotrophic lateral sclerosis (ALS)
    Peter Munch Andersen
    Department of Clinical Neuroscience, Umea University Hospital, S 901 85 Umea, Sweden
    Suppl Clin Neurophysiol 57:211-27. 2004
  7. ncbi request reprint Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes
    Peter M Andersen
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital East and Harvard Medical School, Charlestown, MA, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:62-73. 2003
    ..We searched for novel SOD1 mutations and for clinical characteristics of patients with these mutations...
  8. ncbi request reprint External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis
    P M Andersen
    Department of Clinical Neuroscience, Umea University, Umea, Sweden
    J Neurol Sci 191:111-4. 2001
    ..The procedure was well tolerated with few side effects. Low dosage external radiotherapy of the salivary glands is effective in reducing drooling satisfactorily in ALS patients, especially in well-hydrated patients...
  9. ncbi request reprint The geographical and ethnic distribution of the D90A CuZn-SOD mutation in the Russian Federation
    P M Andersen
    Department of Pharmacology and Clinical Neuroscience, Russian Academy of Medical Sciences, Moscow
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:63-9. 2001
    ..The exception is the D90A mutation which in Finland, northern Norway and northern Sweden exists with an allele frequency of 1-2.5% and is in these regions associated with ALS inherited as a recessive trait...
  10. ncbi request reprint Genetics of sporadic ALS
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:S37-41. 2001
    ..Statistical and genealogical evidence suggest that quite a number of diagnosed sporadic cases may in fact be familial cases in pedigrees with very low disease penetrance...
  11. ncbi request reprint Genetic factors in the early diagnosis of ALS
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:S31-42. 2000
    ..It is not warranted in cases with no proven family history for three generations, unless the patient shows the characteristic phenotype associated with recessive inheritance of the D90A CuZn-SOD mutation...
  12. ncbi request reprint SOD1A4V-mediated ALS: absence of a closely linked modifier gene and origination in Asia
    W J Broom
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, 114 16th Street, Navy Yard, Charlestown, MA 02129, USA
    Neurosci Lett 430:241-5. 2008
    ..The conserved minimal haplotype is statistically more similar to Asian than European population DNA sets, suggesting that the A4V mutation arose in native Asian-Americans who reached the Americas through the Bering Strait...
  13. ncbi request reprint Clinicopathological phenotype of ALS with a novel G72C SOD1 gene mutation mimicking a myopathy
    H G Stewart
    Department of Clinical Neurosciences, Umea University, SE 90785 Umeå, Sweden
    Muscle Nerve 33:701-6. 2006
    ..This case expands the phenotypic spectrum of ALS associated with SOD1 mutations to include presenting features that mimic a myopathy...
  14. pmc A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS
    A M Wills
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurology 73:16-24. 2009
    ..However, several other large studies, including five genome-wide association studies, have not duplicated this finding...
  15. ncbi request reprint Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Nat Genet 10:61-6. 1995
    ..Our findings suggest that this CuZn-SOD mutation causes ALS by a gain of function rather than by loss, and that the Asp90Ala mutation is less detrimental than previously reported mutations...
  16. ncbi request reprint CuZn-superoxide dismutase, extracellular superoxide dismutase, and glutathione peroxidase in blood from individuals homozygous for Asp90Ala CuZu-superoxide dismutase mutation
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    J Neurochem 70:715-20. 1998
    ..The absence of response of the blood antioxidant enzymes to the Asp90Ala CuZn-superoxide dismutase mutation does not support the theory that the ALS-linked CuZn-superoxide dismutase mutations cause disease by increased oxidant stress...
  17. pmc Disease-related changes in the cerebrospinal fluid metabolome in amyotrophic lateral sclerosis detected by GC/TOFMS
    Anna Wuolikainen
    Institute of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden
    PLoS ONE 6:e17947. 2011
    ..The metabolomic methodology is suitable for screening large cohorts of samples. Global metabolomics can be used for detecting changes of metabolite concentrations in samples of fluids such as CSF...
  18. doi request reprint A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts
    Caroline Ingre
    Institute of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden
    Neurobiol Aging 34:1708.e1-6. 2013
    ..Moreover, this new mutation suggests that fine-tuning of actin polymerization by phosphorylation of profilin 1 might be necessary for motor neuron survival...
  19. ncbi request reprint Superoxide dismutase in CSF from amyotrophic lateral sclerosis patients with and without CuZn-superoxide dismutase mutations
    J Jacobsson
    Department of Pharmacology and Clinical Neurosciences and Department of Medical Biosciences, Clinical Chemistry, , , Sweden
    Brain 124:1461-6. 2001
    ..There was no difference in the amount of extracellular SOD between any of the groups...