Fredrik J Swartling

Summary

Publications

  1. pmc What underlies the diversity of brain tumors?
    Fredrik J Swartling
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Cancer Metastasis Rev 32:5-24. 2013
  2. pmc Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    Fredrik J Swartling
    University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
    Cancer Cell 21:601-13. 2012
  3. pmc Myc proteins in brain tumor development and maintenance
    Fredrik J Swartling
    Uppsala University, Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Ups J Med Sci 117:122-31. 2012
  4. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
  5. pmc Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
  6. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012

Detail Information

Publications6

  1. pmc What underlies the diversity of brain tumors?
    Fredrik J Swartling
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Cancer Metastasis Rev 32:5-24. 2013
    ..This review describes numerous murine brain tumor models in the context of normal brain development and the potential for these animals to impact brain tumor research...
  2. pmc Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    Fredrik J Swartling
    University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
    Cancer Cell 21:601-13. 2012
    ..These differences were regulated in part by the transcription factor SOX9, activated in the SHH subclass of human medulloblastoma. Our results demonstrate context-dependent transformation of NSCs in response to a common oncogenic signal...
  3. pmc Myc proteins in brain tumor development and maintenance
    Fredrik J Swartling
    Uppsala University, Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Ups J Med Sci 117:122-31. 2012
    ..This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies...
  4. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
    ..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis...
  5. pmc Non-stem cell origin for oligodendroglioma
    Anders I Persson
    Department of Neurology, University of California, San Francisco, 94158, USA
    Cancer Cell 18:669-82. 2010
    ..Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor...
  6. pmc miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma
    Jelena Polajeva
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    BMC Cancer 12:378. 2012
    ..We decided to investigate the expression of the oncogenic miR-21 during normal mouse development and glioma, focusing on PDGF signaling as a potential regulator of miR-21...