Eugene Sverdlov

Summary

Affiliation: Institute of molecular genetics RAS
Location: Moscow, Russia
Summary:
Human molecular genetics, cancer gene therapy, transcription regulation

Publications

  1. ncbi request reprint Genetic surgery - a right strategy to attack cancer
    Eugene D Sverdlov
    Institute of Molecular Genetics, Shemyakin Ovchinnikov, Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Curr Gene Ther 11:501-31. 2011
  2. doi request reprint Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors
    Svetlana V Kalinichenko
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Lung Cancer 62:173-80. 2008
  3. doi request reprint Methylation of the prominin 1 TATA-less main promoters and tissue specificity of their transcript content
    Victor V Pleshkan
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow, Russia
    Biochim Biophys Acta 1779:599-605. 2008
  4. pmc Maps of cis-Regulatory Nodes in Megabase Long Genome Segments are an Inevitable Intermediate Step Toward Whole Genome Functional Mapping
    Lev G Nikolaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Curr Genomics 8:137-49. 2007
  5. ncbi request reprint Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010
  6. ncbi request reprint Fundamental taboos of biology
    E D Sverdlov
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia
    Biochemistry (Mosc) 74:939-44. 2009
  7. pmc Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity
    L G Nikolaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Curr Genomics 10:294-302. 2009
  8. pmc Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas
    E P Kopantzev
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia
    Br J Cancer 102:1533-40. 2010
  9. pmc Properties of PEI-based polyplex nanoparticles that correlate with their transfection efficacy
    Alexey V Ulasov
    Department of Molecular Genetics of Intracellular Transport, Institute of Gene Biology, RAS, Moscow, Russia
    Mol Ther 19:103-12. 2011
  10. ncbi request reprint Dam methylase accessibility as an instrument for analysis of mammalian chromatin structure
    Svetlana S Bulanenkova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Epigenetics 6:1078-84. 2011

Collaborators

  • Yuri B Lebedev
  • Ilgar Z Mamedov
  • Konstantin Khodosevich
  • J├╝rgen Bode
  • Sergey V Razin
  • Anton Buzdin
  • G T Sukhikh
  • M V Zinovyeva
  • S B Akopov
  • Lev G Nikolaev
  • Igor P Chernov
  • Eugene P Kopantzev
  • Dmitry A Didych
  • Elena S Kotova
  • Svetlana S Bulanenkova
  • Alexey V Ulasov
  • I V Laskova
  • E P Kopantzev
  • K K Mineev
  • L G Nikolaev
  • Svetlana V Kalinichenko
  • Tatyana V Vinogradova
  • Victor V Pleshkan
  • Anna S Vetchinova
  • Olga V Iarovaia
  • Eugene V Snezhkov
  • Andrey A Rosenkranz
  • Alexander S Sobolev
  • Tatyana L Azhikina
  • Alena A Kozlova
  • Georgiy A Trusov
  • Yuri V Khramtsov
  • E E Tret'yakova
  • M R Kopantseva
  • N A Vayshlya
  • V I Egorov
  • I B Zborovskaya
  • M Pikunov
  • T V Vinogradova
  • A M Petrov
  • T N Reznikova
  • D A Didych
  • A V Pozdnyakov
  • G V Kataeva
  • I D Stolyarov
  • A G Il'ves
  • L N Prakhova
  • Alexander G Tonevitsky
  • Andrey N Petrov
  • Maria V Bateva
  • Larisa E Zavalishina
  • Galina S Monastyrskaya
  • Elena V Korobko
  • Irina V Palgova
  • Igor V Korobko
  • Olga B Filyukova
  • Georgii A Frank
  • Marya B Kostina
  • Kira A Timchenko

Detail Information

Publications28

  1. ncbi request reprint Genetic surgery - a right strategy to attack cancer
    Eugene D Sverdlov
    Institute of Molecular Genetics, Shemyakin Ovchinnikov, Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Curr Gene Ther 11:501-31. 2011
    ....
  2. doi request reprint Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors
    Svetlana V Kalinichenko
    Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Lung Cancer 62:173-80. 2008
    ....
  3. doi request reprint Methylation of the prominin 1 TATA-less main promoters and tissue specificity of their transcript content
    Victor V Pleshkan
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow, Russia
    Biochim Biophys Acta 1779:599-605. 2008
    ..Therefore, we report an unusual instance of different mechanisms of transcription activity regulation for two closely located promoters of the same gene...
  4. pmc Maps of cis-Regulatory Nodes in Megabase Long Genome Segments are an Inevitable Intermediate Step Toward Whole Genome Functional Mapping
    Lev G Nikolaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Curr Genomics 8:137-49. 2007
    ....
  5. ncbi request reprint Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010
    ..This tumor 'embryonization' supports the idea that stem or progenitor cells are implicated in esophageal cancer emergence...
  6. ncbi request reprint Fundamental taboos of biology
    E D Sverdlov
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia
    Biochemistry (Mosc) 74:939-44. 2009
    ....
  7. pmc Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity
    L G Nikolaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Curr Genomics 10:294-302. 2009
    ....
  8. pmc Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas
    E P Kopantzev
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia
    Br J Cancer 102:1533-40. 2010
    ..Stromal cells are a functionally important component of human carcinomas. The aim of this study was to obtain and characterise primary cultures of stromal cells from human carcinomas and the corresponding surrounding normal tissue...
  9. pmc Properties of PEI-based polyplex nanoparticles that correlate with their transfection efficacy
    Alexey V Ulasov
    Department of Molecular Genetics of Intracellular Transport, Institute of Gene Biology, RAS, Moscow, Russia
    Mol Ther 19:103-12. 2011
    ....
  10. ncbi request reprint Dam methylase accessibility as an instrument for analysis of mammalian chromatin structure
    Svetlana S Bulanenkova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Epigenetics 6:1078-84. 2011
    ..Some highly Dam methylase accessible regions are present in the intergenic regions of the locus suggesting that the latter contain either unidentified non-coding transcripts or extended regulatory elements like locus control regions...
  11. doi request reprint Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma
    Eugene P Kopantzev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Lung Cancer 62:23-34. 2008
    ..In surgical samples of NSCLC, these genes were down-regulated as compared to surrounding normal tissues and normal lungs, thus demonstrating opposite expression profiles for the genes up-regulated during fetal lung development...
  12. ncbi request reprint Identification of tissue-specific DNA-protein binding sites by means of two-dimensional electrophoretic mobility shift assay display
    Igor P Chernov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia
    Anal Biochem 364:60-6. 2007
    ..Most often, PTS-protein complexes were formed in all cases, but they were different for different nuclear extracts used...
  13. ncbi request reprint Most recent AluY insertions in human gene introns reduce the content of the primary transcripts in a cell type specific manner
    Yuri B Lebedev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Gene 390:122-9. 2007
    ..We demonstrated that some AluY insertions correlated with decreased content of the corresponding hnRNAs. The effect observed does not depend on sequences of Alu elements and their orientation but is likely to be cell type specific...
  14. ncbi request reprint Perpetually mobile footprints of ancient infections in human genome
    E D Sverdlov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    FEBS Lett 428:1-6. 1998
    ..This review describes the integration specificity and distribution of the HERVs and LTRs in the human genome and discusses possible functional consequences of their integration in the vicinity of genes...
  15. ncbi request reprint Retroviruses and primate evolution
    E D Sverdlov
    Institute of Molecular Genetics RAS, Kurchatov Sq, 123182 Moscow, Russia
    Bioessays 22:161-71. 2000
    ..BioEssays 22:161-171, 2000...
  16. pmc Genome-wide comparison of differences in the integration sites of interspersed repeats between closely related genomes
    Ilgar Mamedov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya Street, 117997 Moscow, Russia
    Nucleic Acids Res 30:e71. 2002
    ....
  17. pmc Large-scale determination of the methylation status of retrotransposons in different tissues using a methylation tags approach
    Konstantin Khodosevich
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16 10 Miklukho Maklaya St, 117997 Moscow, Russia
    Nucleic Acids Res 32:e31. 2004
    ..The described technique can be readily adapted to the use of DNA microarray technology...
  18. pmc Whole-genome experimental identification of insertion/deletion polymorphisms of interspersed repeats by a new general approach
    Ilgar Z Mamedov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences 16 10 Miklukho Maklaya Street, 117997 Moscow, Russia
    Nucleic Acids Res 33:e16. 2005
    ..The proposed method does not depend on preliminary knowledge of evolutionary history of retroelements and can be applied for identification of insertion/deletion polymorphic markers in genomes of different species...
  19. pmc Induction of transcription within chromosomal DNA loops flanked by MAR elements causes an association of loop DNA with the nuclear matrix
    Olga V Iarovaia
    Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology RAS, Vavilov Street 34 5, 117984 Moscow, Russia
    Nucleic Acids Res 33:4157-63. 2005
    ....
  20. ncbi request reprint Two-dimensional electrophoretic mobility shift assay: identification and mapping of transcription factor CTCF target sequences within an FXYD5-COX7A1 region of human chromosome 19
    Anna S Vetchinova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia
    Anal Biochem 354:85-93. 2006
    ..In vivo binding of CTCF to these sites was verified by chromatin immunoprecipitation assay. CTCF binding sites were mapped within gene introns and intergenic regions, and some of them contained Alu-like repeated elements...
  21. ncbi request reprint Identification, genome mapping, and CTCF binding of potential insulators within the FXYD5-COX7A1 locus of human chromosome 19q13.12
    Sergey B Akopov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117977, Moscow, Russia
    Mamm Genome 17:1042-9. 2006
    ..We believe that the proposed approach could be a useful instrument for functional analysis of genomes...
  22. doi request reprint Characteristics of neurological status and the electroencephalogram in nuclear power station control operators
    I V Laskova
    Department of Neurology and Neurosurgery, Kursk State Medical University, Russian Ministry of Health, Kursk, Russia
    Neurosci Behav Physiol 40:457-60. 2010
    ....
  23. doi request reprint Characteristics of neurological and cognitive status in patients with multiple sclerosis in relation to the location and volumes of demyelination foci and the severity of brain atrophy
    K K Mineev
    Institute of the Human Brain, Russian Academy of Sciences, St Petersburg, Russia
    Neurosci Behav Physiol 39:35-8. 2009
    ..Cognitive disorders were identified in 89% of patients, and the severity of these was associated with the level of atrophy and the volume of foci on T2 images in the dominant hemisphere...
  24. pmc DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity
    Dmitry A Didych
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    BMC Res Notes 5:178. 2012
    ..Here the positive-negative selection technique was used to check the ability of CTCF-binding human genomic fragments to block enhancer-promoter interaction when inserted into the genome...
  25. doi request reprint Mutation rate in stem cells: an underestimated barrier on the way to therapy
    Eugene D Sverdlov
    Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq, Moscow, 123182, Russia
    Trends Mol Med 19:273-80. 2013
    ..Selection of SCs with low mutation rate could reduce the risk of negative side effects during treatment...