Olga Svarcova

Summary

Publications

  1. ncbi request reprint Nucleolar development and allocation of key nucleolar proteins require de novo transcription in bovine embryos
    Olga Svarcova
    Department of Basic Animal and Veterinary Sciences, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Mol Reprod Dev 74:1428-35. 2007
  2. ncbi request reprint Nuclear and nucleolar reprogramming during the first cell cycle in bovine nuclear transfer embryos
    Olga Østrup
    Constantin the Philosopher University, Nitra, Slovak Republic
    Cloning Stem Cells 11:367-75. 2009
  3. ncbi request reprint Analysis of nucleolar morphology and protein localization as an indicator of nuclear reprogramming
    Olga Østrup
    Department of Tumor Biology, Oslo University Hospital RH, Oslo, Norway
    Methods Mol Biol 1222:161-74. 2015
  4. ncbi request reprint The specific alteration of histone methylation profiles by DZNep during early zebrafish development
    Olga Ostrup
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway Stem Cell Epigenetics Laboratory, Institute of Basic Medical Sciences and Norwegian Center for Stem Cell Research, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, Oslo, Norway Electronic address
    Biochim Biophys Acta 1839:1307-15. 2014
  5. pmc RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions
    Olga Østrup
    Institute for Basic Medical Sciences, Faculty of Medicine, University of Oslo and Norwegian Center for Stem Cell Research, Oslo, Norway
    PLoS ONE 8:e61547. 2013
  6. ncbi request reprint Remodeling of ribosomal genes in somatic cells by Xenopus egg extract
    Olga Østrup
    Institute of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Biochem Biophys Res Commun 412:487-93. 2011
  7. ncbi request reprint Role of ooplasm in nuclear and nucleolar remodeling of intergeneric somatic cell nuclear transfer embryos during the first cell cycle
    Olga Østrup
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, Frederiksberg C, Denmark
    Cell Reprogram 13:145-55. 2011
  8. ncbi request reprint Nucleolar re-activation is delayed in mouse embryos cloned from two different cell lines
    O Svarcova
    IBHV, University of Copenhagen, Frederiksberg C, Denmark
    Mol Reprod Dev 76:132-41. 2009
  9. ncbi request reprint The role of RNA polymerase I transcription and embryonic genome activation in nucleolar development in bovine preimplantation embryos
    O Svarcova
    IBHV, University of Copenhagen, Frederiksberg C, Denmark
    Mol Reprod Dev 75:1095-103. 2008
  10. ncbi request reprint Ribosomal RNA and nucleolar proteins from the oocyte are to some degree used for embryonic nucleolar formation in cattle and pig
    P Maddox-Hyttel
    Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, DK 1870 Frederiksberg C, Denmark
    Theriogenology 68:S63-70. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Nucleolar development and allocation of key nucleolar proteins require de novo transcription in bovine embryos
    Olga Svarcova
    Department of Basic Animal and Veterinary Sciences, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Mol Reprod Dev 74:1428-35. 2007
    ..However, localization of these two proteins to the nucleolar compartments was negatively affected by the alpha-amanitin treatment. Consequently, functional nucleoli were not established...
  2. ncbi request reprint Nuclear and nucleolar reprogramming during the first cell cycle in bovine nuclear transfer embryos
    Olga Østrup
    Constantin the Philosopher University, Nitra, Slovak Republic
    Cloning Stem Cells 11:367-75. 2009
    ..At 1-3 hpa, chromatin gradually decondensed toward the nucleus periphery and nuclear envelope reformed. From 4 hpa, the somatic cell nucleus gained a PN-like appearance and displayed NPBs suggesting ooplasmic control of development...
  3. ncbi request reprint Analysis of nucleolar morphology and protein localization as an indicator of nuclear reprogramming
    Olga Østrup
    Department of Tumor Biology, Oslo University Hospital RH, Oslo, Norway
    Methods Mol Biol 1222:161-74. 2015
    ..Moreover, detailed protocols for monitoring the nucleolar changes by transmission electron microscopy and immunocytochemistry are presented. ..
  4. ncbi request reprint The specific alteration of histone methylation profiles by DZNep during early zebrafish development
    Olga Ostrup
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway Stem Cell Epigenetics Laboratory, Institute of Basic Medical Sciences and Norwegian Center for Stem Cell Research, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern, Oslo, Norway Electronic address
    Biochim Biophys Acta 1839:1307-15. 2014
    ..Altered H3K9me3 profiles were associated with severe neuronal and cranial phenotypes at day 4-5 post-fertilization. Thus, DZNep was shown to affect enrichment patterns of H3K27me3 and H3K9me3 at promoters in a gene-specific manner. ..
  5. pmc RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions
    Olga Østrup
    Institute for Basic Medical Sciences, Faculty of Medicine, University of Oslo and Norwegian Center for Stem Cell Research, Oslo, Norway
    PLoS ONE 8:e61547. 2013
    ..Moreover, comparison with mouse and human embryos showed striking overlap in functional annotation of transcripts during the EGA, suggesting conserved basic mechanisms regulating establishment of totipotency in mammalian development...
  6. ncbi request reprint Remodeling of ribosomal genes in somatic cells by Xenopus egg extract
    Olga Østrup
    Institute of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Biochem Biophys Res Commun 412:487-93. 2011
    ..Condition-specific and rapid silencing of ribosomal genes may serve as a sensitive marker for evaluation of various reprogramming methods...
  7. ncbi request reprint Role of ooplasm in nuclear and nucleolar remodeling of intergeneric somatic cell nuclear transfer embryos during the first cell cycle
    Olga Østrup
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, Frederiksberg C, Denmark
    Cell Reprogram 13:145-55. 2011
    ..In conclusion, the results demonstrate a possible reason why the intergeneric SCNT embryos never reached the full term...
  8. ncbi request reprint Nucleolar re-activation is delayed in mouse embryos cloned from two different cell lines
    O Svarcova
    IBHV, University of Copenhagen, Frederiksberg C, Denmark
    Mol Reprod Dev 76:132-41. 2009
    ..NT-MEF embryos displayed normal targeting but delayed activation of nucleolar proteins. Contrary, in NT-HM1 embryos, both of these processes were delayed...
  9. ncbi request reprint The role of RNA polymerase I transcription and embryonic genome activation in nucleolar development in bovine preimplantation embryos
    O Svarcova
    IBHV, University of Copenhagen, Frederiksberg C, Denmark
    Mol Reprod Dev 75:1095-103. 2008
    ....
  10. ncbi request reprint Ribosomal RNA and nucleolar proteins from the oocyte are to some degree used for embryonic nucleolar formation in cattle and pig
    P Maddox-Hyttel
    Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, DK 1870 Frederiksberg C, Denmark
    Theriogenology 68:S63-70. 2007
    ..In conclusion, the nucleolus is important for the development of oocytes and embryos and may serve as a marker for the completion of oocyte growth and the normality of activation of the embryonic genome...