Vitamin D levels, lung function, and steroid response in adult asthmaE Rand Sutherland
Department of Medicine, University of Colorado, Denver, Colorado, USA
Am J Respir Crit Care Med 181:699-704. 2010
..Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma...
- Cluster analysis of obesity and asthma phenotypes
E Rand Sutherland
Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
PLoS ONE 7:e36631. 2012
..We utilized an hypothesis-free cluster analytical approach to define the contribution of obesity and related variables to asthma phenotype...
Nebulized formoterol effect on bronchodilation and satisfaction in COPD patients compared to QID ipratropium/albuterol MDIE Rand Sutherland
National Jewish Health, Denver, CO80206, USA
Curr Med Res Opin 25:653-61. 2009
..Pulmonary function and patient preference/satisfaction were compared before and after treatment with a short-acting ipratropium/albuterol combination and long-acting nebulized formoterol...
- Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
E Rand Sutherland
National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 123:1328-34.e1. 2009
..Although obesity has been hypothesized to worsen asthma, data from studies of subjects with well-characterized asthma are lacking...
- A trial of clarithromycin for the treatment of suboptimally controlled asthma
E Rand Sutherland
National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 126:747-53. 2010
..PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma...
Comparative effect of body mass index on response to asthma controller therapyE Rand Sutherland
Department of Medicine, National Jewish Health, Denver, Colorado, USA
Allergy Asthma Proc 31:20-5. 2010
..05). FP produced a significantly greater clinical response for normal, overweight, and obese subjects compared with montelukast. Irrespective of BMI, FP appears to be the more effective asthma controller therapy...
- Body mass and glucocorticoid response in asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
Am J Respir Crit Care Med 178:682-7. 2008
..Obesity may alter glucocorticoid response in asthma...
- Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts
Christina C Lewis
National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 123:356S. 2003
- Distal lung inflammation in asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
Ann Allergy Asthma Immunol 89:119-24; quiz 124-5, 211. 2002
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- Asthma and atypical bacterial infection
E Rand Sutherland
National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson St, J220, Denver, CO 80206, USA
Chest 132:1962-6. 2007
..Current studies will further define the role of macrolide antibiotics in the treatment of stable patients with asthma, ultimately determining whether these therapeutic agents have a place in asthma management...
- Obesity and asthma
E Rand Sutherland
National Jewish Medical and Research Center, Denver, CO 80206, USA
Immunol Allergy Clin North Am 28:589-602, ix. 2008
..We evaluate animal studies that provide biological underpinnings to an association between the two disorders and clinical and epidemiologic studies that suggest that the relationship between these two disorders is clinically important...
- Management of chronic obstructive pulmonary disease
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, Denver, USA
N Engl J Med 350:2689-97. 2004
- Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
Prescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Am J Respir Crit Care Med 181:438-45. 2010
..Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD)...
- Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies
David A Beuther
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
Am J Respir Crit Care Med 175:661-6. 2007
..Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence, particularly in men...
- Obesity and asthma
David A Beuther
National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
Am J Respir Crit Care Med 174:112-9. 2006
..Further research is warranted to synthesize these disparate observations into a cohesive understanding of the relationship between obesity and asthma...
- Nocturnal asthma
E Rand Sutherland
National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 116:1179-86; quiz 1187. 2005
..Treatment strategies in nocturnal asthma are similar to those used in persistent asthma, although dosing of medications to target optimum effect during periods of nocturnal worsening is beneficial...
- Obesity and pulmonary function testing
David A Beuther
National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 115:1100-1. 2005
- Immunomodulatory effects of melatonin in asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Am J Respir Crit Care Med 166:1055-61. 2002
..M., suggesting chronic overstimulation in vivo. These results suggest differential immunomodulatory effects of melatonin based on asthma clinical phenotype and may indicate an adverse effect of exogenous melatonin in asthma...
- Altered pituitary-adrenal interaction in nocturnal asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA
J Allergy Clin Immunol 112:52-7. 2003
..Conversely, adrenal response to corticotropin might be enhanced in nonnocturnal asthma, attenuating nocturnal worsening of airway inflammation...
- Elevated serum melatonin is associated with the nocturnal worsening of asthma
E Rand Sutherland
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 112:513-7. 2003
..CONCLUSIONS: Nocturnal asthma is associated with elevation and phase delay of peak serum melatonin levels. Elevated melatonin levels might contribute to the pathogenesis of nocturnal asthma...
- Safety of sputum induction in moderate-to-severe chronic obstructive pulmonary disease
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
Respir Med 96:482-6. 2002
..A protocol for sputum induction which restricts the use of hypertonic saline based on lung function is both safe and effective in subjects with moderate to severe COPD...
- Physiologic correlates of distal lung inflammation in asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 217, Denver, CO 80206, USA
J Allergy Clin Immunol 113:1046-50. 2004
..The distal lung is an important site of inflammation in asthma. Maximal midexpiratory flows and the ratio of maximal:partial flows are purported to reflect distal lung function...
- Atypical bacterial pneumonia and asthma risk
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Asthma 41:863-8. 2004
..Prospective studies are warranted to more fully evaluate the importance of atypical bacterial pneumonia as an asthma risk factor...
- Nocturnal asthma: underlying mechanisms and treatment
E Rand Sutherland
National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Room J 217, Denver, CO 80206, USA
Curr Allergy Asthma Rep 5:161-7. 2005
..Treatment strategies in nocturnal asthma are similar to those used in persistent asthma, although dosing of medications to target optimum delivery during periods of nocturnal worsening is beneficial...
- Airway fibroblasts exhibit a synthetic phenotype in severe asthma
Christina C Lewis
Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, Denver, Colo, USA
J Allergy Clin Immunol 115:534-40. 2005
..Platelet-derived growth factor (PDGF) may have a significant role in airway remodeling in asthma, because it is a powerful inductor of many airway fibroblast activities such as collagen synthesis...
- Outpatient treatment of chronic obstructive pulmonary disease: comparisons with asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 114:715-24; quiz 725. 2004
..Drug therapy consists of optimal bronchodilator therapy supplemented, when necessary, with either inhaled corticosteroids or theophylline. Nondrug therapies include pulmonary rehabilitation, supplemental oxygen, and surgery...
- Sham procedure versus usual care as the control in clinical trials of devices: which is better?
E Rand Sutherland
National Jewish Medical and Research Center and University of Colorado at Denver and Health Sciences Center, 1400 Jackson Street, J220 Denver, CO 80206, USA
Proc Am Thorac Soc 4:574-6. 2007
..This review addresses issues pertaining to the use of sham controls in clinical trials of devices and procedures and provides examples from the literature which demonstrate the importance of and controversy surrounding sham controls...
- Increased expression of platelet-derived growth factor receptor-beta in airway fibroblasts of severe asthmatics
Christina C Lewis
National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 123:428S-9S. 2003
- Hypothalamic-pituitary-adrenal axis dysfunction during sleep in nocturnal asthma
E Rand Sutherland
National Jewish Medical and Research Center, Denver, CO 80206, USA
Chest 123:405S. 2003
- Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma
E Rand Sutherland
Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colo, USA
J Allergy Clin Immunol 112:819-27; quiz 828. 2003
..The contrasting inflammatory phenotypes of asthma and COPD have important implications for clinical and physiologic manifestations of disease, as well as for therapy...
