EVERETT SUTHERLAND

Summary

Publications

  1. pmc Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
  2. doi request reprint Designing clinical trials to address the needs of childhood and adult asthma: the National Heart, Lung, and Blood Institute's AsthmaNet
    E Rand Sutherland
    Department of Medicine, National Jewish Health, The University of Colorado School of Medicine, Denver, Colo Electronic address
    J Allergy Clin Immunol 133:34-8.e1. 2014
  3. pmc Cluster analysis of obesity and asthma phenotypes
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e36631. 2012
  4. ncbi request reprint Nebulized formoterol effect on bronchodilation and satisfaction in COPD patients compared to QID ipratropium/albuterol MDI
    E Rand Sutherland
    National Jewish Health, Denver, CO80206, USA
    Curr Med Res Opin 25:653-61. 2009
  5. pmc Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:1328-34.e1. 2009
  6. pmc A trial of clarithromycin for the treatment of suboptimally controlled asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:747-53. 2010
  7. doi request reprint Comparative effect of body mass index on response to asthma controller therapy
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 31:20-5. 2010
  8. pmc Body mass and glucocorticoid response in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:682-7. 2008
  9. ncbi request reprint Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts
    Christina C Lewis
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:356S. 2003
  10. ncbi request reprint Distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
    Ann Allergy Asthma Immunol 89:119-24; quiz 124-5, 211. 2002

Research Grants

  1. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010

Detail Information

Publications31

  1. pmc Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
    ..Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma...
  2. doi request reprint Designing clinical trials to address the needs of childhood and adult asthma: the National Heart, Lung, and Blood Institute's AsthmaNet
    E Rand Sutherland
    Department of Medicine, National Jewish Health, The University of Colorado School of Medicine, Denver, Colo Electronic address
    J Allergy Clin Immunol 133:34-8.e1. 2014
    ....
  3. pmc Cluster analysis of obesity and asthma phenotypes
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e36631. 2012
    ..We utilized an hypothesis-free cluster analytical approach to define the contribution of obesity and related variables to asthma phenotype...
  4. ncbi request reprint Nebulized formoterol effect on bronchodilation and satisfaction in COPD patients compared to QID ipratropium/albuterol MDI
    E Rand Sutherland
    National Jewish Health, Denver, CO80206, USA
    Curr Med Res Opin 25:653-61. 2009
    ..Pulmonary function and patient preference/satisfaction were compared before and after treatment with a short-acting ipratropium/albuterol combination and long-acting nebulized formoterol...
  5. pmc Body mass index and phenotype in subjects with mild-to-moderate persistent asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:1328-34.e1. 2009
    ..Although obesity has been hypothesized to worsen asthma, data from studies of subjects with well-characterized asthma are lacking...
  6. pmc A trial of clarithromycin for the treatment of suboptimally controlled asthma
    E Rand Sutherland
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:747-53. 2010
    ..PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma...
  7. doi request reprint Comparative effect of body mass index on response to asthma controller therapy
    E Rand Sutherland
    Department of Medicine, National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 31:20-5. 2010
    ..05). FP produced a significantly greater clinical response for normal, overweight, and obese subjects compared with montelukast. Irrespective of BMI, FP appears to be the more effective asthma controller therapy...
  8. pmc Body mass and glucocorticoid response in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 220 Denver, CO 80206, USA
    Am J Respir Crit Care Med 178:682-7. 2008
    ..Obesity may alter glucocorticoid response in asthma...
  9. ncbi request reprint Interleukin-4 and interleukin-13 augment the proliferative effect of dexamethasone on distal lung fibroblasts
    Christina C Lewis
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:356S. 2003
  10. ncbi request reprint Distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
    Ann Allergy Asthma Immunol 89:119-24; quiz 124-5, 211. 2002
    ..To review the role of distal lung inflammation in asthma...
  11. ncbi request reprint Asthma and atypical bacterial infection
    E Rand Sutherland
    National Jewish Medical and Research Center, Department of Medicine, 1400 Jackson St, J220, Denver, CO 80206, USA
    Chest 132:1962-6. 2007
    ..Current studies will further define the role of macrolide antibiotics in the treatment of stable patients with asthma, ultimately determining whether these therapeutic agents have a place in asthma management...
  12. pmc Obesity and asthma
    E Rand Sutherland
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 28:589-602, ix. 2008
    ..We evaluate animal studies that provide biological underpinnings to an association between the two disorders and clinical and epidemiologic studies that suggest that the relationship between these two disorders is clinically important...
  13. ncbi request reprint Management of chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, USA
    N Engl J Med 350:2689-97. 2004
  14. doi request reprint Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Respir Crit Care Med 181:438-45. 2010
    ..Epidermal growth factor receptor (EGFR) activation is implicated in mucin hypersecretion in chronic obstructive pulmonary disease (COPD)...
  15. pmc Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies
    David A Beuther
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
    Am J Respir Crit Care Med 175:661-6. 2007
    ..Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence, particularly in men...
  16. pmc Obesity and asthma
    David A Beuther
    National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
    Am J Respir Crit Care Med 174:112-9. 2006
    ..Further research is warranted to synthesize these disparate observations into a cohesive understanding of the relationship between obesity and asthma...
  17. ncbi request reprint Nocturnal asthma
    E Rand Sutherland
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 116:1179-86; quiz 1187. 2005
    ..Treatment strategies in nocturnal asthma are similar to those used in persistent asthma, although dosing of medications to target optimum effect during periods of nocturnal worsening is beneficial...
  18. ncbi request reprint Obesity and pulmonary function testing
    David A Beuther
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:1100-1. 2005
  19. ncbi request reprint Immunomodulatory effects of melatonin in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Am J Respir Crit Care Med 166:1055-61. 2002
    ..M., suggesting chronic overstimulation in vivo. These results suggest differential immunomodulatory effects of melatonin based on asthma clinical phenotype and may indicate an adverse effect of exogenous melatonin in asthma...
  20. ncbi request reprint Altered pituitary-adrenal interaction in nocturnal asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA
    J Allergy Clin Immunol 112:52-7. 2003
    ..Increased airway inflammation at night contributes to the nocturnal worsening of asthma, but the mechanisms regulating circadian variations in airway inflammation are unknown...
  21. ncbi request reprint Elevated serum melatonin is associated with the nocturnal worsening of asthma
    E Rand Sutherland
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:513-7. 2003
    ..In vitro studies have shown exogenous melatonin to be pro-inflammatory in asthma, but it is unknown whether endogenous melatonin levels are a controller of airway inflammation in nocturnal asthma...
  22. ncbi request reprint Safety of sputum induction in moderate-to-severe chronic obstructive pulmonary disease
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Respir Med 96:482-6. 2002
    ..A protocol for sputum induction which restricts the use of hypertonic saline based on lung function is both safe and effective in subjects with moderate to severe COPD...
  23. ncbi request reprint Physiologic correlates of distal lung inflammation in asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J 217, Denver, CO 80206, USA
    J Allergy Clin Immunol 113:1046-50. 2004
    ..The distal lung is an important site of inflammation in asthma. Maximal midexpiratory flows and the ratio of maximal:partial flows are purported to reflect distal lung function...
  24. ncbi request reprint Atypical bacterial pneumonia and asthma risk
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Asthma 41:863-8. 2004
    ..Prospective studies are warranted to more fully evaluate the importance of atypical bacterial pneumonia as an asthma risk factor...
  25. ncbi request reprint Nocturnal asthma: underlying mechanisms and treatment
    E Rand Sutherland
    National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Room J 217, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 5:161-7. 2005
    ..Treatment strategies in nocturnal asthma are similar to those used in persistent asthma, although dosing of medications to target optimum delivery during periods of nocturnal worsening is beneficial...
  26. ncbi request reprint Airway fibroblasts exhibit a synthetic phenotype in severe asthma
    Christina C Lewis
    Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Medical and Research Center, Denver, Colo, USA
    J Allergy Clin Immunol 115:534-40. 2005
    ..Platelet-derived growth factor (PDGF) may have a significant role in airway remodeling in asthma, because it is a powerful inductor of many airway fibroblast activities such as collagen synthesis...
  27. ncbi request reprint Outpatient treatment of chronic obstructive pulmonary disease: comparisons with asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:715-24; quiz 725. 2004
    ..Drug therapy consists of optimal bronchodilator therapy supplemented, when necessary, with either inhaled corticosteroids or theophylline. Nondrug therapies include pulmonary rehabilitation, supplemental oxygen, and surgery...
  28. ncbi request reprint Sham procedure versus usual care as the control in clinical trials of devices: which is better?
    E Rand Sutherland
    National Jewish Medical and Research Center and University of Colorado at Denver and Health Sciences Center, 1400 Jackson Street, J220 Denver, CO 80206, USA
    Proc Am Thorac Soc 4:574-6. 2007
    ..This review addresses issues pertaining to the use of sham controls in clinical trials of devices and procedures and provides examples from the literature which demonstrate the importance of and controversy surrounding sham controls...
  29. ncbi request reprint Increased expression of platelet-derived growth factor receptor-beta in airway fibroblasts of severe asthmatics
    Christina C Lewis
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:428S-9S. 2003
  30. ncbi request reprint Hypothalamic-pituitary-adrenal axis dysfunction during sleep in nocturnal asthma
    E Rand Sutherland
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Chest 123:405S. 2003
  31. ncbi request reprint Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma
    E Rand Sutherland
    Department of Medicine, National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colo, USA
    J Allergy Clin Immunol 112:819-27; quiz 828. 2003
    ..The contrasting inflammatory phenotypes of asthma and COPD have important implications for clinical and physiologic manifestations of disease, as well as for therapy...

Research Grants2

  1. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..