Xicheng Sun

Summary

Publications

  1. doi request reprint Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 22:2338-42. 2012
  2. doi request reprint Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement
    Xicheng Sun
    N30 Pharmaceuticals LLC, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:3671-5. 2011
  3. doi request reprint Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Suite 200, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:5849-53. 2011
  4. doi request reprint Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase
    Louis S Green
    N30 Pharmaceuticals, LLC, Boulder, Colorado 80301, United States
    Biochemistry 51:2157-68. 2012

Collaborators

  • Sarah C Mutka
  • Louis S Green
  • Gary J Rosenthal
  • Jane P Richards
  • Aaron K Patton
  • Lawrence E Chun

Detail Information

Publications4

  1. doi request reprint Structure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: carboxamide modification
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 22:2338-42. 2012
    ..We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice...
  2. doi request reprint Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement
    Xicheng Sun
    N30 Pharmaceuticals LLC, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:3671-5. 2011
    ..We identified equally potent and novel GSNOR inhibitors having pyrrole regioisomers as scaffolds using a structure based approach...
  3. doi request reprint Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities
    Xicheng Sun
    N30 Pharmaceuticals LLC, 3122 Sterling Circle, Suite 200, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:5849-53. 2011
    ..We identified potent and novel GSNOR inhibitors having reduced CYP inhibition activities and demonstrated efficacy in a mouse ovalbumin (OVA) model of asthma...
  4. doi request reprint Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase
    Louis S Green
    N30 Pharmaceuticals, LLC, Boulder, Colorado 80301, United States
    Biochemistry 51:2157-68. 2012
    ..N6022 is uncompetitive with cofactors NAD(+) and NADH. The potency, specificity, and MOI of related GSNOR inhibitor compounds are also reported...