Grzegorz Sulkowski

Summary

Publications

  1. pmc Modulation of neurological deficits and expression of glutamate receptors during experimental autoimmune encephalomyelitis after treatment with selected antagonists of glutamate receptors
    Grzegorz Sulkowski
    Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Biomed Res Int 2013:186068. 2013
  2. doi request reprint Effects of antagonists of glutamate receptors on pro-inflammatory cytokines in the brain cortex of rats subjected to experimental autoimmune encephalomyelitis
    Grzegorz Sulkowski
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    J Neuroimmunol 261:67-76. 2013
  3. ncbi request reprint Alterations in glutamate transport and group I metabotropic glutamate receptors in the rat brain during acute phase of experimental autoimmune encephalomyelitis
    Grzegorz Sulkowski
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Folia Neuropathol 47:329-37. 2009
  4. doi request reprint Aroclor 1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat
    Lidia Struzynska
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Toxicology 300:12-8. 2012
  5. ncbi request reprint Inflammation-like glial response in lead-exposed immature rat brain
    Lidia Struzynska
    Department of Neurochemistry, Medical Research Centre, Laboratory of Pathoneurochemistry, Polish Academy of Sciences, 02 106 Warsaw, Poland
    Toxicol Sci 95:156-62. 2007
  6. ncbi request reprint Changes in expression of neuronal and glial glutamate transporters in lead-exposed adult rat brain
    Lidia Struzynska
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Neurochem Int 47:326-33. 2005
  7. doi request reprint Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis
    Tomasz Grygorowicz
    Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Neurochem Int 57:823-9. 2010
  8. ncbi request reprint Changes of cytoskeletal proteins in ischaemic brain under cardiac arrest and reperfusion conditions
    Grzegorz Sulkowski
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Folia Neuropathol 44:133-9. 2006
  9. ncbi request reprint The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity
    Lidia Struzynska
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Toxicology 212:185-94. 2005
  10. ncbi request reprint CNPase activity in myelin from adult rat brains after prolonged lead exposure in vivo
    Beata Dabrowska-Bouta
    Laboratory of Pathobiochemistry of the Central Nervous System, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St, 02 106 Warsaw, Poland
    Chem Biol Interact 150:171-8. 2004

Collaborators

Detail Information

Publications10

  1. pmc Modulation of neurological deficits and expression of glutamate receptors during experimental autoimmune encephalomyelitis after treatment with selected antagonists of glutamate receptors
    Grzegorz Sulkowski
    Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Biomed Res Int 2013:186068. 2013
    ..During the late disease phase (20-25 d.p.i.), the mRNA expression levels reached 300% of control values. In contrast, treatment with individual receptor antagonists resulted in a reduction of mRNA levels relative to untreated animals. ..
  2. doi request reprint Effects of antagonists of glutamate receptors on pro-inflammatory cytokines in the brain cortex of rats subjected to experimental autoimmune encephalomyelitis
    Grzegorz Sulkowski
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    J Neuroimmunol 261:67-76. 2013
    ..Conversely, antagonists of group I metabotropic glutamate receptors, mGluRs (LY 367385 and MPEP), do not affect the inflammatory process and the neurological condition of EAE rats. ..
  3. ncbi request reprint Alterations in glutamate transport and group I metabotropic glutamate receptors in the rat brain during acute phase of experimental autoimmune encephalomyelitis
    Grzegorz Sulkowski
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Folia Neuropathol 47:329-37. 2009
    ..The results suggest that during the inflammatory conditions in the acute phase of EAE, disturbances in glutamate transport take place that may lead to the excitotoxicity...
  4. doi request reprint Aroclor 1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat
    Lidia Struzynska
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Toxicology 300:12-8. 2012
    ..Conversely, we observed enhanced glutamate uptake into nerve-endings fractions paralleled by increased EAAC1 protein expression. This may reflect the induction of protective mechanisms...
  5. ncbi request reprint Inflammation-like glial response in lead-exposed immature rat brain
    Lidia Struzynska
    Department of Neurochemistry, Medical Research Centre, Laboratory of Pathoneurochemistry, Polish Academy of Sciences, 02 106 Warsaw, Poland
    Toxicol Sci 95:156-62. 2007
    ..Obtained results indicate chronic glial activation with coexisting inflammatory and neurodegenerative features as a new mechanism of Pb neurotoxicity in immature rat brain...
  6. ncbi request reprint Changes in expression of neuronal and glial glutamate transporters in lead-exposed adult rat brain
    Lidia Struzynska
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Neurochem Int 47:326-33. 2005
    ..This observation suggests that under conditions of Pb toxicity in adult rat brain, the hippocampus is most vulnerable to the excitotoxic cell damage arising from impaired clearance of the released glutamate...
  7. doi request reprint Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis
    Tomasz Grygorowicz
    Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Neurochem Int 57:823-9. 2010
    ..This suggests the early involvement of this kind of receptor into pathological mechanisms leading for symptoms characteristic for EAE...
  8. ncbi request reprint Changes of cytoskeletal proteins in ischaemic brain under cardiac arrest and reperfusion conditions
    Grzegorz Sulkowski
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Folia Neuropathol 44:133-9. 2006
    ..In these conditions calpain-mediated degradation of cytoskeleton may be involved in the disturbances in synaptic vesicles transport and hence to the changes in neurotransmission...
  9. ncbi request reprint The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity
    Lidia Struzynska
    Laboratory of Pathoneurochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Str, 02 106 Warsaw, Poland
    Toxicology 212:185-94. 2005
    ....
  10. ncbi request reprint CNPase activity in myelin from adult rat brains after prolonged lead exposure in vivo
    Beata Dabrowska-Bouta
    Laboratory of Pathobiochemistry of the Central Nervous System, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St, 02 106 Warsaw, Poland
    Chem Biol Interact 150:171-8. 2004
    ..Observed disturbances in enzyme activity may be one of the potential reasons of the ultrastructural changes. It is thus tempting to speculate that Pb may be considered as a one of the factors contributing to demyelinating diseases...