Guangchao Sui

Summary

Publications

  1. pmc Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1
    Weiwei Huang
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nucleic Acids Res 40:1033-49. 2012
  2. pmc Dmp1α inhibits HER2/neu-induced mammary tumorigenesis
    Elizabeth A Fry
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, North Carolina, United States of America Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e77870. 2013
  3. pmc Noncoding RNA in oncogenesis: a new era of identifying key players
    Guorui Deng
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Mol Sci 14:18319-49. 2013
  4. pmc Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27
    Meimei Wan
    Comprehensive Cancer Center Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Pathol 180:2120-33. 2012
  5. pmc MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta
    Paul Cao
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer 9:108. 2010
  6. pmc The regulation of SOX7 and its tumor suppressive role in breast cancer
    Daniel B Stovall
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, North Carolina
    Am J Pathol 183:1645-53. 2013
  7. pmc Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer
    Sinan Zhu
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina Graduate Program in Molecular Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    Am J Pathol 183:1339-50. 2013
  8. pmc Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines
    Shuai Tang
    Molecular Pathology Graduate Program, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e35570. 2012
  9. pmc Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer
    Daniele Baiz
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston Salem, NC
    Neoplasia 15:1172-83. 2013
  10. pmc Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function
    Donna P Frazier
    Department of Pathology and Cancer Biology, and Graduate Program in Molecular Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 72:1740-50. 2012

Collaborators

Detail Information

Publications22

  1. pmc Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1
    Weiwei Huang
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nucleic Acids Res 40:1033-49. 2012
    ..In addition, the analysis of a gene array data consisting of the breast cancer samples of 258 patients also indicates a significant, positive correlation between G4R1 and YY1 expression...
  2. pmc Dmp1α inhibits HER2/neu-induced mammary tumorigenesis
    Elizabeth A Fry
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, North Carolina, United States of America Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e77870. 2013
    ..Our data demonstrate critical roles of Dmp1 in preventing mammary tumorigenesis and raise the possibility of treating breast cancer by restoring Dmp1α expression. ..
  3. pmc Noncoding RNA in oncogenesis: a new era of identifying key players
    Guorui Deng
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Mol Sci 14:18319-49. 2013
    ..At the end, we will also discuss recently unraveled activities of circular RNAs (circRNAs)...
  4. pmc Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27
    Meimei Wan
    Comprehensive Cancer Center Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Pathol 180:2120-33. 2012
    ..In addition, YY1 promoted p27 ubiquitination and physically interacted with p27. In conclusion, our data suggest that YY1 is an oncogene and identify p27 as a new target of YY1...
  5. pmc MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta
    Paul Cao
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer 9:108. 2010
    ..In addition, the expression of miR-101 alters upon androgen treatment and HIF-1alpha/HIF-1beta induction...
  6. pmc The regulation of SOX7 and its tumor suppressive role in breast cancer
    Daniel B Stovall
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, North Carolina
    Am J Pathol 183:1645-53. 2013
    ..Overall, our data suggest that SOX7 acts as a tumor suppressor in breast cancer. SOX7 expression is likely regulated by multiple mechanisms and potentially serves as a prognostic marker for breast cancer patients. ..
  7. pmc Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer
    Sinan Zhu
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina Graduate Program in Molecular Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    Am J Pathol 183:1339-50. 2013
    ..Overall, our study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer. ..
  8. pmc Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines
    Shuai Tang
    Molecular Pathology Graduate Program, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e35570. 2012
    ..Our results also suggest multiple roles for YY1 in prostate cancer which may contribute to disease progression by modulation of genes such as PSCA...
  9. pmc Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer
    Daniele Baiz
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston Salem, NC
    Neoplasia 15:1172-83. 2013
    ..These results suggest that the combination of a PI3K inhibitor and a PSMA-targeted protein synthesis inhibitor toxin represents a promising novel strategy for advanced prostate cancer therapy that should be further investigated. ..
  10. pmc Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function
    Donna P Frazier
    Department of Pathology and Cancer Biology, and Graduate Program in Molecular Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 72:1740-50. 2012
    ..Together, our findings identify a robust new mechanism of p53 activation mediated by direct physical interaction between Dmp1 and p53...
  11. pmc Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells
    Zhiyong Deng
    Department of Radiation Oncology and Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e36739. 2012
    ..Overall, our study reveals that the MEK-ERK1/2 signaling pathway, but not the JNK pathway, contributes to the c-Jun-dependent microglial inflammatory response following irradiation...
  12. pmc Suppression of Tak1 promotes prostate tumorigenesis
    Min Wu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 72:2833-43. 2012
    ..Together, our findings functionally validate the proposed tumor suppressor role of Tak1 in prostate cancer...
  13. pmc Yin Yang 1: a multifaceted protein beyond a transcription factor
    Zhiyong Deng
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Transcription 1:81-4. 2010
    ..Recent studies revealed that YY1 possesses functions independent of its DNA binding activity and its regulatory role in tumorigenesis has started to emerge...
  14. pmc Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer
    Shihua Wang
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Carcinogenesis 33:404-12. 2012
    ..Dietary omega-3 PUFA supplementation in conjunction with androgen ablation may significantly delay the development of castration-resistant prostate cancer in patients compared with androgen ablation alone...
  15. pmc BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells
    Dana Yancey
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e74561. 2013
    ..These results establish the mechanism for the synergistic induction of apoptosis by the combination of a PI3K inhibitor and of a protein synthesis inhibitor in PTEN-deficient prostate cancer cells. ..
  16. pmc PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway
    Caroline I Schnegg
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Free Radic Biol Med 52:1734-43. 2012
    ..These data support the hypothesis that PPARδ activation can modulate radiation-induced oxidative stress and inflammatory responses in microglia...
  17. pmc Interleukin-1α mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells
    Sophia L Maund
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Cancer Res 71:5276-86. 2011
    ..These studies establish a system to study the molecular profile of PrP/SC differentiation, proliferation, and senescence, and they point to an important new role for IL-1α in vitamin D(3) signaling in PrP/SCs...
  18. doi request reprint Ferritin H is a novel marker of early erythroid precursors and macrophages
    Wei Wang
    Department of Pathology, Wake Forest Baptist Health, Winston Salem, NC 27157, USA
    Histopathology 62:931-40. 2013
    ..In this study, we aimed to determine whether ferritin is highly expressed in macrophages and erythroid precursors, and whether it can be used as a marker for these two cell types...
  19. pmc The oncogenic role of Yin Yang 1
    Qiang Zhang
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Crit Rev Oncog 16:163-97. 2011
    ....
  20. ncbi request reprint SOX7: from a developmental regulator to an emerging tumor suppressor
    Daniel B Stovall
    Department of Cancer Biology and Comprehensive Cancer Center, and Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Histol Histopathol 29:439-45. 2014
    ..The research of SOX7 in cancers remains a fertile area to be explored. ..
  21. pmc Ferroportin and iron regulation in breast cancer progression and prognosis
    Zandra K Pinnix
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Sci Transl Med 2:43ra56. 2010
    ..Ferroportin is a pivotal protein in breast biology and a strong and independent predictor of prognosis in breast cancer...
  22. pmc 1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells
    Linara S Axanova
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 70:1658-71. 2010
    ..We hypothesized that inhibition of the PI3K/AKT pathway synergizes with the antiproliferative signaling of 1,25(OH)(2)D(3)...