On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studiesAnn Kristin Petersen
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
BMC Bioinformatics 13:120. 2012
..abstract:..
Human metabolic individuality in biomedical and pharmaceutical researchKarsten Suhre
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
Nature 477:54-60. 2011
..The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research...
- A genome-wide association study of metabolic traits in human urine
Karsten Suhre
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
Nat Genet 43:565-9. 2011
..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
- Human serum metabolic profiles are age dependent
Zhonghao Yu
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
Aging Cell 11:960-7. 2012
..The use of metabolomics will increase our understanding of aging networks and may lead to discoveries that help enhance healthy aging...
- Childhood obesity is associated with changes in the serum metabolite profile
Simone Wahl
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
Obes Facts 5:660-70. 2012
..Therefore, investigation of serum metabolite concentrations in obese children might give new insights into biological mechanisms associated with childhood obesity...
- PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
Janina S Ried
Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
Genet Epidemiol 36:244-52. 2012
..Its flexible design enables both the use of prior knowledge and the generation of new knowledge on connection of multiple phenotypes. A software program for PSEA based on GWAS results is available upon request...
- Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics
Elisabeth Altmaier
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
Eur J Epidemiol 26:145-56. 2011
..Metabolomics may, thus, facilitate evaluating questionnaires and improving future questionnaire-based epidemiological studies on human health...
- Body fat free mass is associated with the serum metabolite profile in a population-based study
Carolin Jourdan
Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 7:e40009. 2012
..To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study...
- Discovery of sexual dimorphisms in metabolic and genetic biomarkers
Kirstin Mittelstrass
Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
PLoS Genet 7:e1002215. 2011
..Our study provides new important insights into sex-specific differences of cell regulatory processes and underscores that studies should consider sex-specific effects in design and interpretation...
- Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
Jan Krumsiek
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
PLoS Genet 8:e1003005. 2012
..Our approach is generic in nature and can be directly transferred to metabolomics data from different experimental platforms...
- Bayesian independent component analysis recovers pathway signatures from blood metabolomics data
Jan Krumsiek
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Germany
J Proteome Res 11:4120-31. 2012
..We conclude that the Bayesian ICA methodology has the power and flexibility to replace many of the nowadays common PCA and clustering-based analyses common in the research field...
- Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics
Elisabeth Altmaier
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
Mol Nutr Food Res 53:1357-65. 2009
..In summary, we demonstrate strong positive associations between coffee consumption and two classes of sphingomyelins and a negative association between coffee consumption and long- and medium-chain acylcarnitines...
- Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
Karsten Suhre
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 5:e13953. 2010
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- A genome-wide perspective of genetic variation in human metabolism
Thomas Illig
Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
Nat Genet 42:137-41. 2010
..5 x 10(-179). These loci explained 5.6%-36.3% of the observed variance in metabolite concentrations. For several loci, associations with clinically relevant parameters have been reported previously...
- Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
Christian Gieger
Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
PLoS Genet 4:e1000282. 2008
..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
- Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
Jan Krumsiek
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Germany
BMC Syst Biol 5:21. 2011
..Previous studies in this area mainly focused on Pearson correlation coefficients, which however are generally incapable of distinguishing between direct and indirect metabolic interactions...
- Novel biomarkers for pre-diabetes identified by metabolomics
Rui Wang-Sattler
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
Mol Syst Biol 8:615. 2012
..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
- Genetic variation in metabolic phenotypes: study designs and applications
Karsten Suhre
1 Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P O Box 24144, Doha, Qatar 2 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
Nat Rev Genet 13:759-69. 2012
..We discuss such design considerations and applications in this Review...
- Genetic associations with lipoprotein subfractions provide information on their biological nature
Ann Kristin Petersen
Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
Hum Mol Genet 21:1433-43. 2012
..Future clinical studies are now needed to investigate their biomedical relevance...
- Metabolomics platforms for genome wide association studies-linking the genome to the metabolome
Jerzy Adamski
Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universitat Munchen, 85354 Freising Weihenstephan, Germany German Center for Diabetes Research, 85764 Neuherberg, Germany Electronic address
Curr Opin Biotechnol 24:39-47. 2013
..At the example of recent GWAS with metabolic traits (mGWAS) we review the high-throughput screening approaches that are available to further advance the field...
- Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in preclinical drug testing
Karsten Suhre
1Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
J Biomol Screen 16:467-75. 2011
..In addition, this approach can be considered a proof-of-principle study that can be applied to other lipid-pathway targeting mechanisms...
- Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
Rui Wang-Sattler
Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 3:e3863. 2008
..Our findings provide new insight into the pathophysiology of smoking addiction. Activation of the enzyme alkyl-DHAP by small molecules may provide novel routes for therapy...
- MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data
Brigitte Wägele
Institute of Bioinformatics and Systems Biology, German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 7:e39860. 2012
..Both types can be overlaid on metabolic pathways to obtain biological information on the studied system. For the joint analysis of both data types the MassTRIX webserver was updated. MassTRIX is freely available at www.masstrix.org...
- Differences between human plasma and serum metabolite profiles
Zhonghao Yu
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
PLoS ONE 6:e21230. 2011
..However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized...
- Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication
Elisabeth Altmaier
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, Neuherberg, Germany
Endocrinology 149:3478-89. 2008
..The bioinformatics data analysis approach introduced here can be readily generalized to other drug testing scenarios and other medical disorders...
