Karsten Suhre

Summary

Publications

  1. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
  2. doi request reprint Human metabolic individuality in biomedical and pharmaceutical research
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Nature 477:54-60. 2011
  3. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
  4. doi request reprint Childhood obesity is associated with changes in the serum metabolite profile
    Simone Wahl
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Obes Facts 5:660-70. 2012
  5. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
  6. doi request reprint Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Eur J Epidemiol 26:145-56. 2011
  7. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
  8. pmc Discovery of sexual dimorphisms in metabolic and genetic biomarkers
    Kirstin Mittelstrass
    Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 7:e1002215. 2011
  9. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
  10. doi request reprint Bayesian independent component analysis recovers pathway signatures from blood metabolomics data
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Germany
    J Proteome Res 11:4120-31. 2012

Detail Information

Publications27

  1. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  2. doi request reprint Human metabolic individuality in biomedical and pharmaceutical research
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Nature 477:54-60. 2011
    ..The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research...
  3. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
    ..The use of metabolomics will increase our understanding of aging networks and may lead to discoveries that help enhance healthy aging...
  4. doi request reprint Childhood obesity is associated with changes in the serum metabolite profile
    Simone Wahl
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Obes Facts 5:660-70. 2012
    ..Therefore, investigation of serum metabolite concentrations in obese children might give new insights into biological mechanisms associated with childhood obesity...
  5. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
    ..Its flexible design enables both the use of prior knowledge and the generation of new knowledge on connection of multiple phenotypes. A software program for PSEA based on GWAS results is available upon request...
  6. doi request reprint Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Eur J Epidemiol 26:145-56. 2011
    ..Metabolomics may, thus, facilitate evaluating questionnaires and improving future questionnaire-based epidemiological studies on human health...
  7. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
    ..To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study...
  8. pmc Discovery of sexual dimorphisms in metabolic and genetic biomarkers
    Kirstin Mittelstrass
    Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 7:e1002215. 2011
    ..Our study provides new important insights into sex-specific differences of cell regulatory processes and underscores that studies should consider sex-specific effects in design and interpretation...
  9. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
    ..Our approach is generic in nature and can be directly transferred to metabolomics data from different experimental platforms...
  10. doi request reprint Bayesian independent component analysis recovers pathway signatures from blood metabolomics data
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Germany
    J Proteome Res 11:4120-31. 2012
    ..We conclude that the Bayesian ICA methodology has the power and flexibility to replace many of the nowadays common PCA and clustering-based analyses common in the research field...
  11. doi request reprint Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mol Nutr Food Res 53:1357-65. 2009
    ..In summary, we demonstrate strong positive associations between coffee consumption and two classes of sphingomyelins and a negative association between coffee consumption and long- and medium-chain acylcarnitines...
  12. pmc On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    BMC Bioinformatics 13:120. 2012
    ..So far, only a rule of thumb was applied to determine the significance of the p-gain...
  13. pmc Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 5:e13953. 2010
    ....
  14. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
    ..5 x 10(-179). These loci explained 5.6%-36.3% of the observed variance in metabolite concentrations. For several loci, associations with clinically relevant parameters have been reported previously...
  15. doi request reprint Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Psychoneuroendocrinology 38:1299-309. 2013
    ..The underlying biomechanisms that link this psychological affect to a pathological state are not well understood. This study applied a metabolomic approach to explore biochemical pathways that may contribute to the Type D personality...
  16. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
    ..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
  17. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  18. pmc Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, Neuherberg, 85764, Germany
    BMC Med 11:60. 2013
    ..Here, we extend our metabolomics study with a large prospective study including female smokers and quitters...
  19. doi request reprint Genetic variation in metabolic phenotypes: study designs and applications
    Karsten Suhre
    1 Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P O Box 24144, Doha, Qatar 2 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Nat Rev Genet 13:759-69. 2012
    ..We discuss such design considerations and applications in this Review...
  20. doi request reprint Genetic associations with lipoprotein subfractions provide information on their biological nature
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
    Hum Mol Genet 21:1433-43. 2012
    ..Future clinical studies are now needed to investigate their biomedical relevance...
  21. pmc Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Germany
    BMC Syst Biol 5:21. 2011
    ..Previous studies in this area mainly focused on Pearson correlation coefficients, which however are generally incapable of distinguishing between direct and indirect metabolic interactions...
  22. doi request reprint Metabolomics platforms for genome wide association studies-linking the genome to the metabolome
    Jerzy Adamski
    Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universitat Munchen, 85354 Freising Weihenstephan, Germany German Center for Diabetes Research, 85764 Neuherberg, Germany Electronic address
    Curr Opin Biotechnol 24:39-47. 2013
    ..At the example of recent GWAS with metabolic traits (mGWAS) we review the high-throughput screening approaches that are available to further advance the field...
  23. doi request reprint Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in preclinical drug testing
    Karsten Suhre
    1Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    J Biomol Screen 16:467-75. 2011
    ..In addition, this approach can be considered a proof-of-principle study that can be applied to other lipid-pathway targeting mechanisms...
  24. pmc MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data
    Brigitte Wägele
    Institute of Bioinformatics and Systems Biology, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e39860. 2012
    ..Both types can be overlaid on metabolic pathways to obtain biological information on the studied system. For the joint analysis of both data types the MassTRIX webserver was updated. MassTRIX is freely available at www.masstrix.org...
  25. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
    ..However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized...
  26. pmc Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
    Rui Wang-Sattler
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e3863. 2008
    ..Our findings provide new insight into the pathophysiology of smoking addiction. Activation of the enzyme alkyl-DHAP by small molecules may provide novel routes for therapy...
  27. doi request reprint Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, Neuherberg, Germany
    Endocrinology 149:3478-89. 2008
    ..The bioinformatics data analysis approach introduced here can be readily generalized to other drug testing scenarios and other medical disorders...