Rotation thromboelastography for the detection and characterization of lipoteichoid acid-induced activation of haemostasis in an in vitro sepsis modelC Sucker
Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
Perfusion 28:146-51. 2013
..In gram-positive sepsis, lipoteichoic acid (LTA) can induce alterations of haemostasis, potentially leading to disseminated intravascular coagulation...
- [Spontaneous hematoma and hip pain in a 65-year old patient]
C Sucker
LaboMed Gerinnungszentrum Berlin, Tauentzienstr 7b c, 10789, Berlin, Deutschland
Internist (Berl) 53:1234-9. 2012
..Impairment of plasmatic hemostasis leads to a severe bleeding tendency in individuals without a preexisting coagulation defect with considerable mortality. Pathophysiology, diagnostic work-up, and treatment are summarized and discussed...
- Rotation thromboelastography (ROTEM) parameters are influenced by age, gender, and oral contraception
C Sucker
LaboMed Coagulation Centre, Tauentzienstrasse 7, Berlin, Germany
Perfusion 26:334-40. 2011
..Thus, adjustment for age, gender, and oral contraception is required when ROTEM is used to screen for distinct abnormalities of haemostasis...
- Exercise-induced hemostatic alterations are detectable by rotation thrombelastography (ROTEM): A marathon study
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center Dusseldorf, Dusseldorf, Germany
Clin Appl Thromb Hemost 16:543-8. 2010
..This might help to explain interindividual differences in exercise-induced alterations of hemostasis...
- Causes, etiology and diagnosis of acquired von Willebrand disease: a prospective diagnostic workup to establish the most effective therapeutic strategies
Christoph Sucker
LaboMed Coagulation Center Berlin, Tauentzienstrasse 7 b c, Berlin, Germany
Acta Haematol 121:177-82. 2009
..Since the optimal treatment strategy has not yet been defined for aVWD of different etiology, controlled multicenter trials aiming at the development of standardized treatment protocols are urgently needed...
- The TT genotype of the C677T polymorphism in the methylentetrahydrofolate reductase as a risk factor in thrombotic microangiopathies: results from a pilot study
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
Clin Appl Thromb Hemost 15:283-8. 2009
..The 677 TT genotype of this polymorphism appears to be a risk factor for manifestation of these rare thrombotic disorders, possibly explained by endothelial activation and increased oxidative stress...
- The G1691A mutation of the factor V gene (factor V Leiden) and the G20210A mutation of the prothrombin gene as risk factors in thrombotic microangiopathies
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
Clin Appl Thromb Hemost 15:360-3. 2009
..Thus, screening for these mutations does not allow the identification of individuals at increased risk for these rare thrombotic disorders...
- Are prothrombotic variants of platelet glycoprotein receptor polymorphisms involved in the pathogenesis of thrombotic microangiopathies?
Christoph Sucker
Departments of Hemostasis and Transfusion Medicine Heinrich Heine University Medical Center, Moorenstrasse 5, Dusseldorf, Germany
Clin Appl Thromb Hemost 15:402-7. 2009
..Along with this observation, screening for respective platelet-receptor polymorphisms does not appear to contribute to risk stratification of affected patients...
The homozygous leu variant of the factor XIII Val34Leu polymorphism as a risk factor for the manifestation of thrombotic microangiopathiesChristoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
Clin Appl Thromb Hemost 15:197-200. 2009
..Decreased fibrinolysis in the presence of this genetic variant provides a plausible explanation for this association...
- Use of recombinant factor VIIa in inherited and acquired von Willebrand disease
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
Clin Appl Thromb Hemost 15:27-31. 2009
..Controlled clinical studies are necessary to define the use of rFVIIa in this clinical setting...
- Determination of von Willebrand factor activity: evaluation of the HaemosIL assay in comparison with established procedures
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Duesseldorf, Germany
Clin Appl Thromb Hemost 12:305-10. 2006
..Since the assay does not predict the absence of high-molecular-weight multimers, multimeric analysis remains the procedure of choice for the differentiation of functional defects...
- Citrate plasma levels in patients under regional anticoagulation in continuous venovenous hemofiltration
Gerd R Hetzel
Department of Nephrology, Heinrich Heine University Medical Center, Duesseldorf, Germany
Am J Kidney Dis 48:806-11. 2006
..However, none of these parameters has been correlated with plasma citrate levels in critically ill patients...
- Association of genotypes of thrombin-activatable fibrinolysis inhibitors with thrombotic microangiopathies--a pilot study
Christoph Sucker
Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Moorenstrasse 5, 40221 Duesseldorf, Germany
Nephrol Dial Transplant 22:1347-50. 2007
..Although recent research has elucidated the pathogenesis of these rare thrombotic disorders to some extent, the determinants contributing to the manifestation remain rather unclear in the majority of affected patients...
- Fatal bleeding due to a heparin-like anticoagulant in a 37-year-old woman suffering from systemic mastocytosis
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Germany
Clin Appl Thromb Hemost 14:360-4. 2008
..The case illustrates the clinical presentation and diagnosis of heparin-like anticoagulants. Etiology, pathophysiology, and therapeutic options are discussed...
- Recombinant factor VIIa for the prophylaxis of perioperative hemorrhage in a patient with congenital factor XI deficiency undergoing brain tumor neurosurgery
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Moorenstrasse 5, Dusseldorf, Germany
Clin Appl Thromb Hemost 14:472-5. 2008
..In this setting, off-label use of recombinant activated factor VII appears to be a promising alternative for patients suffering from this rare hemostatic defect with hitherto limited therapeutic options...
- Monitoring oral anticoagulation may require determination of single coagulation factor activities in patients with antiphospholipid syndrome
Christoph Sucker
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Duesseldorf, Germany
J Rheumatol 33:1881-2. 2006
..The case illustrates that monitoring of oral anticoagulation may require determination of single coagulation factor activities in selected patients with APS...
- No evidence for increased intraoperative bleeding in aortic-valve stenosis: a comparative analysis of haemotherapy in 136 patients undergoing aortic-valve replacement
Christoph Sucker
LaboMed Coagulation Centre, Berlin, Germany
Acta Cardiol 65:675-9. 2010
..Consequently, highest-molecular weight multimers of the von Willebrand factor are degraded through a von Willebrand factor specific protease leading to impaired platelet-related haemostasis...
- Amyloidosis and bleeding: pathophysiology, diagnosis, and therapy
Christoph Sucker
Department of Hemostasis, Heinrich Heine University Medical Center, Duesseldorf, Germany
Am J Kidney Dis 47:947-55. 2006
..In this review, we focus on bleeding risks in patients with amyloid diseases. Current concepts with regard to pathophysiology, diagnosis, and treatment are summarized and discussed...
Indicators of acute and persistent renal damage in adult thrombotic microangiopathyFiruseh Dierkes
Department of Nephrology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
PLoS ONE 7:e30886. 2012
..Clinical presentation is highly variable and prognostic factors for clinical course and outcome are not well established...
