- Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia
Sección de Neurofarmacología y Neurociencias, Instituto de Investigaciones Clinicas Dr Americo Negrette, Facultad de Medicina, Universidad del Zulia, Apartado Postal 23, Maracaibo 4001 A, Venezuela Electronic address
Brain Res Bull 100:61-9. 2014
..These results suggest that the development of forced swim-induced thermal hyperalgesia requires the simultaneous presence of increased spinal IL-1β, microglial activation, and relatively decreased serum corticosterone. ..
- Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia
Section of Pharmacology, Instituto de Investigaciones Clinicas, Facultad de Medicina, University of Zulia, Apartado Postal 1151, Maracaibo 4001 A, Venezuela
Behav Brain Res 167:205-11. 2006
..Thus, swim stress-induced hyperalgesia might be initiated by the repeated stimulation of mu-opioid and NMDA receptors but maintained only by the activity of NMDA receptors...
- Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran
Instituto de Investigaciones Clinicas, Section of Neuropharmacology, University of Zulia, Apartado 23, Maracaibo, 4001 A, Venezuela
Physiol Behav 88:82-7. 2006
..Thus, repeated stress produces muscle hyperalgesia that can be pharmacologically dissociated from cutaneous hyperalgesia, suggesting that different mechanisms may underlie these two phenomena...
- Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress
Section of Neuropharmacology and Neuroscience, Instituto de Investigaciones Clinicas, Facultad de Medicina, University of Zulia, Apartado Postal 23, Maracaibo 4001 A, Venezuela
Behav Brain Res 189:159-69. 2008
..In conclusion, stress-induced reduction in GABA-A receptor activation is involved in the development of FS stress-induced hyperalgesia...
- Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord
Section of Neuropharmacology and Neuroscience, Instituto de Investigaciones Clinicas, Facultad de Medicina, University of Zulia, Maracaibo, Venezuela
Pain 152:1909-22. 2011
..Thus, stress-induced hyperalgesia is initiated by a decreased and delayed GABA release and GABA-A receptor activation, whereas it is maintained by increased glutamate release and NMDA glutamate receptor activation at the spinal level...
- Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord
Section of Pharmacology, Institute of Clinical Investigation, School of Medicine, University of Zulia, Apartado Postal 1151, Maracaibo 4001 A, Venezuela
Brain Res 965:259-68. 2003
..These findings suggest that repeated inescapable and uncontrollable stress could induce a sensitization and activation of sensory neurons at the spinal level...
- Enhanced central thermal nociception in mildly depressed nonpatients and transiently sad healthy subjects
IVIC Zulia, Maracaibo, Venezuela
J Pain 12:360-9. 2011
..Thus, there is a central thermal hyperalgesia in subjects with minor depression and sadness...
- Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals
Natural Products Laboratory, Faculty of Sciences, University of Zulia, Maracaibo, Venezuela
Invest Clin 45:317-22. 2004
..The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans...
- [The Zung's autoscale for depression as predictor of sensorial and autonomic alterations to pain]
Centro de Investigaciones Biomédicas IVIC Zulia, Fundación para el Desarrollo de la Ciencia y la Teenología en la Región Zuliana, Venezuela
Invest Clin 48:469-83. 2007
..This suggests that the affective category predicts cutaneous-muscular sensorial alterations with greater effectiveness than the Zung's total index...
- [Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism]
Departamento de Biologia, Facultad Experimental de Ciencias, Universidad del Zulia, Maracaibo, Venezuela
Invest Clin 50:315-26. 2009
..This suggests that autoimmunity against encephalic structures elicited by HSV infections could be involved in autism...