Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injuryXiao Su
Center for Lung and Vascular Biology and Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
J Immunol 184:401-10. 2010
..coli-induced ALI by reducing chemokine production and transalveolar neutrophil migration, suggesting that activation of alpha7 nAChR may be a promising strategy for treatment of sepsis-induced ALI...
- Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice
Xiao Su
Cardiovascular Research Institute, University of California, San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Inflamm Res 60:619-32. 2011
..In this study, we investigated whether a lack of functional CFTR in neutrophils would promote lipopolysaccharide (LPS)-induced lung inflammation and injury...
- Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
Xiao Su
Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009
..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies...
- Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis
Xiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Anat Rec (Hoboken) 292:580-6. 2009
..Thus, PAR2 does not appear to play a critical role in the pathogeneses of experimental acid-induced acute lung injury, E. coli pneumonia, and bleomycin-induced acute lung injury and pulmonary fibrosis in mice...
- Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
Xiao Su
Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Am J Respir Cell Mol Biol 37:186-92. 2007
..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...
Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in miceNaveen Gupta
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 179:1855-63. 2007
..In conclusion, treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice...
- CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
Xiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 180:6947-53. 2008
..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury...
- Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice
Xiao Su
Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 290:L769-L776. 2006
..coli pneumonia in mice by two mechanisms: 1) reducing lung vascular injury and 2) upregulating the resolution of alveolar edema...
- Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice
Viktor Brovkovych
Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott, Chicago, Illinois 60612, USA
Am J Physiol Lung Cell Mol Physiol 295:L96-103. 2008
..Thus augmented iNOS expression and NO production in MPO(-/-) mice compensate for the lack of HOCl-mediated bacterial killing, and the absence of MPO-derived oxidants mitigates E. coli sepsis-induced lung inflammation and injury...
- Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms
Xiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 175:2598-605. 2005
..These effects were either partly or completely neuropeptide dependent, suggesting that PAR2 can cause lung inflammation by a neurogenic mechanism...
- Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
Anna Krasnodembskaya
Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis...
- Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
R Gisli Jenkins
Lung Biology Center, UCSF, San Francisco, California 94158, USA
J Clin Invest 116:1606-14. 2006
....
- Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury
Mark R Looney
Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 116:1615-23. 2006
..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors...
- Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
Jan Hirsch
Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
Crit Care Med 36:1846-54. 2008
..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
- Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome
Xiao Su
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, United States of America
Mol Med 18:1481-90. 2012
..Rats with the metabolic syndrome have ineffective inflammation-resolving mechanisms that represent plausible reasons for the exaggerated and persistent PCD...
- Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury
Joyce S Lee
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
Anat Rec (Hoboken) 294:165-72. 2011
..This model should be useful to investigators studying ALI who want to simulate the clinical setting in which more than one insult often leads to greater clinical lung injury...
- Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice
Xiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0130, USA
Exp Lung Res 30:479-93. 2004
..This method should be valuable for experimental lung studies in mice...
