Presenilin is required for activity and nuclear access of Notch in DrosophilaG Struhl
Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Nature 398:522-5. 1999
..Furthermore, we provide evidence that presenilin is required for the proteolytic release of the intracellular domain from the membrane following activation of Notch by ligand...
- Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos
S Greenwood
Howard Hughes Medical Institute, and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Development 124:4879-86. 1997
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- Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
C M Chen
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Development 126:5441-52. 1999
..These results extend prior evidence of a ligand-receptor relationship between Wnt and Frizzled proteins and suggest that Fz and Fz2 are the primary receptors for Wg in Drosophila...
- Nuclear access and action of notch in vivo
G Struhl
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cell 93:649-60. 1998
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- Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen
G Struhl
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Development 124:2155-65. 1997
..We conclude that, in the abdomen, cell type and cell polarity reflect distinct outputs of Hh signalling and propose that these outputs are controlled by separable gradient and signal relay mechanisms...
- Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway
S Greenwood
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Development 126:5795-808. 1999
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- Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
J Jiang
Howard Hughes Medical Institute, Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nature 391:493-6. 1998
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- Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen
G Struhl
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Development 124:2143-54. 1997
..Many of these results are unexpected and lead us to reassess the role of gradients and compartments in patterning insect segments...
- Dual roles for patched in sequestering and transducing Hedgehog
Y Chen
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cell 87:553-63. 1996
..Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement...
- Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
G Struhl
Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Mol Cell 6:625-36. 2000
..Hence, Notch, beta-APP, and perhaps other proteins may be targeted for Presenilin-mediated transmembrane cleavage by upstream processing events that sever the extracellular domain from the rest of the protein...
- Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor
A Tomlinson
Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Mol Cell 7:487-95. 2001
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- Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye
A Tomlinson
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Development 126:5725-38. 1999
..As a consequence of this reciprocal cell fate decision, the R4 cell moves asymmetrically relative to the R3 cell, initiating the appropriate chiral pattern of the remaining cells of the ommatidium...
- In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
Y Chen
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Development 125:4943-8. 1998
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- Organizing activity of wingless protein in Drosophila
G Struhl
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 72:527-40. 1993
..We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc...
- Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development
J Jiang
Howard Hughes Medical Institute Department of Genetics and Development Columbia University College of Physicians and Surgeons New York, New York 10032, USA
Cell 86:401-9. 1996
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- RNA recognition and translational regulation by a homeodomain protein
J Dubnau
Howard Hughes Medical Research Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Nature 379:694-9. 1996
..RNA binding by bcd seems to involve direct interactions between the bcd homeodomain and discrete target sequences within the 3' untranslated region of the cad messenger RNA and to block the initiation of cad translation...
- A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
J Briscoe
Department of Biochemistry and Molecular Biophysics, Howard Hughes Institute, Columbia University, 701 West 168th Street, 10032, New York, NY, USA
Mol Cell 7:1279-91. 2001
..mPtc1(Deltaloop2) expression also caused the abnormal spread of Shh to more dorsal cells, indicating that Shh in the neural tube, like Hh in Drosophila, induces a feedback mechanism that limits its range of action...
- Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade
E Ronchi
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Cell 74:347-55. 1993
..We propose that phosphorylation resulting from the activity of the tor signal transduction cascade down-regulates transcriptional activation by the bcd morphogen...
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in DrosophilaG Struhl
Department of Genetics and Development, and Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 98:229-34. 2001
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- The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila
J Casanova
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
Nature 362:152-5. 1993
..Ligand trapping by receptor may also localize spatial signals in other patterning systems, including specification of the dorsal-ventral axis in Drosophila and of vulval cell fates in Caenorhabditis elegans...
- Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos
G Struhl
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
Nature 338:741-4. 1989
..Within this hunchback-free domain the pattern of abdominal segments must be specified by other morphogens, possibly by shorter range gradients of the products of zygotic gap genes Kruppel, knirps and tailless...
- The gradient morphogen bicoid is a concentration-dependent transcriptional activator
G Struhl
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 57:1259-73. 1989
..They also suggest that the bcd gradient has the instructive capacity to activate other subordinate control genes by the same mechanism, each in a distinct spatial domain according to its affinity for bcd protein...
- RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
R P Wharton
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032
Cell 67:955-67. 1991
..Based on these and other results, we argue that nos acts as a morphogen, controlling hb expression (and hence abdominal pattern) as a function of its concentration-dependent interaction with the NREs...
- Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila
H M Chung
Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Nat Cell Biol 3:1129-32. 2001
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- Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
G Struhl
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 74:331-45. 1993
..Our results also suggest that equivalent truncated forms of lin-12/Notch family members in vertebrates, including known oncogenes, are similarly active...
- Protein kinase A and hedgehog signaling in Drosophila limb development
J Jiang
Howard Hughes Medical Institute, Department of Genetics and Development Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 80:563-72. 1995
..We propose that the basal activity of PKA imposes a block on the transcription of dpp and wg and that hh exerts its organizing influence by alleviating this block...
- Structure of the Drosophila BicaudalD protein and its role in localizing the the posterior determinant nanos
R P Wharton
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 59:881-92. 1989
..Taken together, these results suggest that BicD encodes a cytoskeleton-like protein involved in transporting or anchoring the nanos morphogen within the oocyte cytoplasm...
- Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila
J Casanova
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
Genes Dev 3:2025-38. 1989
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- cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos
P M Macdonald
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, N Y 10032
Nature 336:595-8. 1988
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- Decoding positional information: regulation of the pair-rule gene hairy
K R Howard
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032
Development 110:1223-31. 1990
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- Control of Drosophila body pattern by the hunchback morphogen gradient
G Struhl
Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
Cell 69:237-249. 1992
..Thus, hb protein functions as a classical morphogen, triggering several distinct responses as a function of its graded distribution...
