Kingman Strohl

Summary

Publications

  1. pmc Mechanical properties of the upper airway
    Kingman P Strohl
    Center for Sleep Disorders Research, Division of Pulmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Compr Physiol 2:1853-72. 2012
  2. ncbi request reprint Ventilatory behavior and metabolism in two strains of obese rats
    K P Strohl
    Department of Medicine, Case Western Reserve University, 111j w, Louis Stokes Cleveland DVA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Respir Physiol 124:85-93. 2001
  3. ncbi request reprint Preventative risk management for obstructive sleep apnea
    Kingman P Strohl
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Sleep Breath 7:197. 2003
  4. ncbi request reprint Graduate medical training, learning, relationships, and sleep loss
    Klara K Papp
    111j w, 10701 East Boulevard, Cleveland, OH 44122, USA
    Sleep Med Rev 10:339-45. 2006
  5. ncbi request reprint Periodic breathing and genetics
    Kingman P Strohl
    Center for Sleep Disorders Research, Louis Stokes VA Medical Center, 111j w VAMC, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 135:179-85. 2003
  6. ncbi request reprint Incorporating inheritance into models for understanding ventilatory behavior
    K P Strohl
    Department of Medicine, Louis Stokes VA Medical Center, and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Sleep Breath 5:47-51. 2001
  7. ncbi request reprint Invited commentary: to sleep, perchance to discover
    Kingman P Strohl
    Center for Sleep Disorders Research, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44122, USA
    Am J Epidemiol 155:394-5; discussion 396-7. 2002
  8. ncbi request reprint Lessons in hypoxic adaptation from high-altitude populations
    Kingman P Strohl
    Department of Medicine, Case Western Reserve University, Veterans Administration Medical Center, 111 J, 10701 East Boulevard, Cleveland, OH 44106, USA
    Sleep Breath 12:115-21. 2008
  9. ncbi request reprint Competency-based goals for sleep and chronobiology in undergraduate medical education
    Kingman P Strohl
    Case Western Reserve University, USA
    Sleep 26:333-6. 2003
  10. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007

Research Grants

  1. A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models
    Kingman Strohl; Fiscal Year: 2006
  2. SLEEP MEDICINE NEUROBIOLOGY AND EPIDEMIOLOGY
    Kingman Strohl; Fiscal Year: 2007
  3. Genetic Mechanisms for Central Apneas
    Kingman Strohl; Fiscal Year: 2007
  4. SLEEP AND ENTERTAIMENT OF SCN FUNCTION
    Kingman Strohl; Fiscal Year: 2002
  5. SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERS
    Kingman Strohl; Fiscal Year: 2002
  6. GENETIC DISSECTION OF VENTILATORY TRAITS
    Kingman Strohl; Fiscal Year: 2001

Collaborators

Detail Information

Publications50

  1. pmc Mechanical properties of the upper airway
    Kingman P Strohl
    Center for Sleep Disorders Research, Division of Pulmonary, Critical Care, and Sleep Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Compr Physiol 2:1853-72. 2012
    ....
  2. ncbi request reprint Ventilatory behavior and metabolism in two strains of obese rats
    K P Strohl
    Department of Medicine, Case Western Reserve University, 111j w, Louis Stokes Cleveland DVA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Respir Physiol 124:85-93. 2001
    ..We conclude that that factors other than fat accumulation contribute to the expression of respiratory control and ventilation in obesity in the rat...
  3. ncbi request reprint Preventative risk management for obstructive sleep apnea
    Kingman P Strohl
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Sleep Breath 7:197. 2003
  4. ncbi request reprint Graduate medical training, learning, relationships, and sleep loss
    Klara K Papp
    111j w, 10701 East Boulevard, Cleveland, OH 44122, USA
    Sleep Med Rev 10:339-45. 2006
    ..The multi-dimensional approach might include not only resident physicians, but also residency program directors and attending physicians at their institutions...
  5. ncbi request reprint Periodic breathing and genetics
    Kingman P Strohl
    Center for Sleep Disorders Research, Louis Stokes VA Medical Center, 111j w VAMC, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 135:179-85. 2003
    ....
  6. ncbi request reprint Incorporating inheritance into models for understanding ventilatory behavior
    K P Strohl
    Department of Medicine, Louis Stokes VA Medical Center, and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Sleep Breath 5:47-51. 2001
    ..Conscious integration of genetic principles into existing explanatory models may increase the likelihood of detecting traits that correlate with protein systems responsible for the structures and the functional components of respiration...
  7. ncbi request reprint Invited commentary: to sleep, perchance to discover
    Kingman P Strohl
    Center for Sleep Disorders Research, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44122, USA
    Am J Epidemiol 155:394-5; discussion 396-7. 2002
  8. ncbi request reprint Lessons in hypoxic adaptation from high-altitude populations
    Kingman P Strohl
    Department of Medicine, Case Western Reserve University, Veterans Administration Medical Center, 111 J, 10701 East Boulevard, Cleveland, OH 44106, USA
    Sleep Breath 12:115-21. 2008
    ..Future studies will require the ability to identify combinations of genetic variants with outcomes including expression levels, appropriate phenotypes, and functional responses...
  9. ncbi request reprint Competency-based goals for sleep and chronobiology in undergraduate medical education
    Kingman P Strohl
    Case Western Reserve University, USA
    Sleep 26:333-6. 2003
    ..Sleep and circadian rhythms are biologic processes operative in health and disease, but as yet there is no articulated curriculum for undergraduate medical education...
  10. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....
  11. ncbi request reprint Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
    Brian D Hoit
    Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
    J Appl Physiol 99:1796-801. 2005
    ....
  12. ncbi request reprint The effects of sleep loss and fatigue on resident-physicians: a multi-institutional, mixed-method study
    Klara K Papp
    Case Western Reserve University School of Medicine, and Department of Medicine, University Hospitals of Cleveland and the Cleveland VA Medical Center, Ohio 44106, USA
    Acad Med 79:394-406. 2004
    ..To identify and model the effects of sleep loss and fatigue on resident-physicians' professional lives and personal well-being...
  13. ncbi request reprint Periodic breathing in the mouse
    Fang Han
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol 92:1133-40. 2002
    ..We conclude that differences in expression of PB between these strains indicate that genetic influences strongly affect the stability of ventilation in the mouse...
  14. pmc An Ethiopian pattern of human adaptation to high-altitude hypoxia
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 99:17215-8. 2002
    ..Thus, Ethiopian highlanders maintain venous hemoglobin concentrations and arterial oxygen saturation within the ranges of sea level populations, despite the unavoidable, universal decrease in the ambient oxygen tension at high altitude...
  15. pmc Are sleep symptoms predictors of resistant hypertension in a population-based sample? Findings from the National Health and Nutritional Examination Survey
    Harneet Walia
    Department of Pulmonary, Critical Care and Sleep Medicine, University Hospitals, Case Medical Center, Cleveland, OH, USA
    J Clin Hypertens (Greenwich) 14:530-6. 2012
    ..The association between poorly controlled diabetes and RHTN warrants further emphasis on strict control of diabetes in these individuals...
  16. pmc Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains
    Motoo Yamauchi
    Department of Medicine, Case Western Reserve University, VA Medical Center, Research Service K216, 10701 East Blvd, Cleveland, OH 44106, USA
    J Appl Physiol 105:518-26. 2008
    ..We conclude that buspirone improves posthypoxic ventilatory irregularities in the B6 mouse through its agonist effects on the 5-HT1A receptor...
  17. ncbi request reprint Breathing and sleep: measurement methods, genetic influences, and developmental impacts
    David M Baekey
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5067, USA
    ILAR J 50:248-61. 2009
    ..In this article we focus on methods of investigating respiratory control and applicable rodent models...
  18. ncbi request reprint Strain differences in murine ventilatory behavior persist after urethane anesthesia
    Iahn Gonsenhauser
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4941, USA
    J Appl Physiol 97:888-94. 2004
    ..The neural substrate for these differences, at least partially, exists within subcortical structures generating the breathing pattern...
  19. ncbi request reprint Post-hypoxic unstable breathing in the C57BL/6J mouse: effects of acetazolamide
    Motoo Yamauchi
    Department of Medicine, Case Western Reserve University, Cleveland VA Medical Center, USA
    Adv Exp Med Biol 605:75-9. 2008
    ..ACZ improves unstable breathing in the B6 model of periodic breathing, despite producing post-hypoxic frequency decline. Our speculation is that periodic breathing occurs through pathways independent of the A5 pontine area...
  20. ncbi request reprint Acetazolamide protects against posthypoxic unstable breathing in the C57BL/6J mouse
    Motoo Yamauchi
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol 103:1263-8. 2007
    ..We conclude that Acz improves unstable breathing in the B6 model, without altering hypoxic response or producing short-term potentiation, but with some blunting of hypercapnic responsiveness...
  21. pmc An exploration of differences in sleep characteristics between Mexico-born US immigrants and other Americans to address the Hispanic Paradox
    Sinziana Seicean
    Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
    Sleep 34:1021-31. 2011
    ....
  22. ncbi request reprint Sleep-related epilepsy in the A/J mouse
    Kingman P Strohl
    Department of Medicine, Case Western Reserve University, Cleveland OH, USA
    Sleep 30:169-76. 2007
    ..A previous observation of spontaneous spike-and-wave activity during sleep in several A/J mice (A/J JAX) from Jackson Laboratory (Bar Harbor, ME) prompted this description of the inheritance of epileptic activity...
  23. ncbi request reprint L-NAME differentially alters ventilatory behavior in Sprague-Dawley and Brown Norway rats
    Shyam Subramanian
    Department of Medicine, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Appl Physiol 93:984-9. 2002
    ..3 vs. 134.4 beats/min at baseline; VE: 66.3 vs. 88.8 ml/min at baseline; P < 0.05). Thus NOS blockade results in a strain-specific alteration in resting ventilation and uncovers the Dejours phenomenon in the SD strain...
  24. ncbi request reprint Erectile dysfunction and symptoms of sleep disorders
    Allen D Seftel
    Department of Urology, Cleveland VA Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Sleep 25:643-7. 2002
    ..Sleep apnea often is associated with impotence and/or erectile dysfunction (ED). The purpose of this study was to test whether a presentation for ED confers a pretest probability for obstructive sleep apnea hypopnea syndrome (OSAHS)...
  25. doi request reprint Erectile dysfunction and sleep related disorders
    Jason T Jankowski
    Department of Urology and Division of Pulmonary, Critical Care and Sleep Medicine, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Urol 179:837-41. 2008
    ..We reviewed the physiology of penile erection during sleep and the possible links between the pathophysiology of erectile dysfunction and the most commonly diagnosed sleep disorders...
  26. pmc Post-sigh breathing behavior and spontaneous pauses in the C57BL/6J (B6) mouse
    Motoo Yamauchi
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, USA
    Respir Physiol Neurobiol 162:117-25. 2008
    ..A greater irregularity and the lower complexity of post-sigh breathing in B6 are reversed by elements on A/J chromosome 1 and by increased 5-HT1A serotonergic tone...
  27. pmc Assessment and policy for commercial driver license referrals
    Christopher M Miller
    Louis Stokes DVA Medical Center, Division of Pulmonary and Critical Care Medicine, Department ofFamily Medicine, Case Western Reserve University, Cleveland, OH 44107, USA
    J Clin Sleep Med 3:417-23. 2007
    ..An educational component was an important feature of this response. We suspect that this approach may be appropriate for managed care systems in general...
  28. ncbi request reprint Domperidone and ventilatory behavior: Sprague-Dawley versus Brown Norway rats
    Shyamsunder Subramanian
    Department of Medicine, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, OH 44106, USA
    Respir Physiol Neurobiol 155:22-8. 2007
    ..We speculate that hypoxic ventilatory responses may be differently configured even among strains of the same species...
  29. ncbi request reprint The fa leptin receptor mutation and the heritability of respiratory frequency in a Brown Norway and Zucker intercross
    Sudha K Iyengar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Appl Physiol 97:811-20. 2004
    ..We conclude that, unlike its major effect on weight, the effect of the fa allele is not a major gene involved in the regulation of breathing frequency...
  30. pmc Incidence of serious adverse events during nocturnal polysomnography
    Reena Mehra
    Center for Sleep Disorders Research, Louis Stokes DVA Medical Center, Case Western Reserve University Cleveland, OH, USA
    Sleep 27:1379-83. 2004
    ..The purpose of the study was to verify whether minimal concern is warranted in regard to serious adverse effects in the sleep laboratory...
  31. ncbi request reprint Inspired oxygen concentrations during positive pressure therapy
    Elizabeth A Yoder
    Louis Stokes Cleveland DVA Medical Center, Medical Service, Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, Ohio, USA
    Sleep Breath 8:1-5. 2004
    ..This study examined the effects of various factors that might influence the fraction of oxygen in inspired air (FiO (2)) in a human and in a model system during nasal positive pressure treatments...
  32. ncbi request reprint 7-nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains
    Edwin R Price
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Appl Physiol 95:1097-104. 2003
    ..Furthermore, neuronal nitric oxide may be an organizing feature in the presence, length, and/or cycle length of apnea in the susceptible strain...
  33. ncbi request reprint Prevalence of symptoms and risk of sleep apnea in primary care
    Nikolaus C Netzer
    The Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, OH, USA
    Chest 124:1406-14. 2003
    ..To obtain prevalence estimates for key symptoms and features that can indicate the presence of obstructive sleep apnea (OSA) in a broad range of primary care settings...
  34. ncbi request reprint Women with sleep apnea have lower levels of sex hormones
    Nikolaus C Netzer
    Department of Medicine, Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, Ohio, USA
    Sleep Breath 7:25-9. 2003
    ..Low levels of sex hormones, especially progesterone, are suspected as a risk factor for sleep-disordered breathing (SDB)...
  35. ncbi request reprint Brain orexins and wake regulation in rats exposed to maternal deprivation
    Pingfu Feng
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, and Cleveland Louis Stokes VA Medical Center, Cleveland, OH 44106, USA
    Brain Res 1154:163-72. 2007
    ..We concluded that neonatal MD produces adult hyperarousal in sleep physiology and neurobiology, and that the adult MD rat could be a model of insomnia with an orexinergic mechanism...
  36. doi request reprint Improvement of respiratory compromise through abductor reinnervation and pacing in a patient with bilateral vocal fold impairment
    Michael Broniatowski
    Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Laryngoscope 120:76-83. 2010
    ..To determine whether respiratory compromise from bilateral vocal fold impairment (paralysis) can be objectively alleviated by reinnervation and pacing...
  37. pmc Variations in physician interpretation of overnight pulse oximetry monitoring
    Rory Ramsey
    Department of Medicine, Case School of Medicine, University Hospitals, 11100 Euclid Ave, Cleveland, OH 44106 6003, USA
    Chest 132:852-9. 2007
    ..The aim of this study was to describe physician interpretation, use, and opinions regarding overnight pulse oximetry...
  38. ncbi request reprint Underdiagnosis of sleep apnea syndrome in U.S. communities
    Vishesh Kapur
    Department of Medicine, University of Washington, Seattle, USA
    Sleep Breath 6:49-54. 2002
    ..We conclude that disparities (especially in women and in those with lower BMI) exist between current recognition rates for OSAHS and the estimated prevalence by symptom report across the United States...
  39. doi request reprint Alpha-melanocyte stimulating hormone and adrenocorticotropic hormone: an alternative approach when thinking about restless legs syndrome?
    Brian B Koo
    Department of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Mov Disord 23:1234-42. 2008
    ..These melanocortin hormones may play a role in the pathogenesis of RLS...
  40. ncbi request reprint Knowledge and attitudes of primary care physicians toward sleep and sleep disorders
    Klara K Papp
    Case Western Reserve University, School of Medicine, Department of Medicine, University Hospitals of Cleveland, and Geriatric Research Education and Clinical Center, Louis B Stokes Cleveland VA Medical Center, OH 44106, USA
    Sleep Breath 6:103-9. 2002
    ..To assess primary care physician (PCP) sleep knowledge and attitudes...
  41. ncbi request reprint Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains
    Lee Friedman
    The MIND Institute, Albuquerque, New Mexico 87106, USA
    J Appl Physiol 97:1787-95. 2004
    ..035) and B6 (P < 0.0001). We conclude that genetic background affects features of breathing during NREM and REM sleep, despite broad changes in state, metabolism, and heart rate...
  42. ncbi request reprint Sleep networks and the anatomic and physiologic connections with respiratory control
    Musa A Haxhiu
    Specialized Neuroscience Research Program, Department of Physiology and Biophysics, Howard University College of Medicine, 520 W St N W, Washington, DC 20059, USA
    Front Biosci 8:d946-62. 2003
    ..Pharmacological corrections of alterations of these transmitter specific converging systems might be an avenue for treatment of sleep related airway disorders such as sleep apnea and worsening of asthma...
  43. ncbi request reprint Con: sleep apnea is not an anatomic disorder
    Kingman P Strohl
    Am J Respir Crit Care Med 168:271-2; discussion 272-3. 2003
  44. ncbi request reprint Sleep apnea in acute coronary syndrome: high prevalence but low impact on 6-month outcome
    Reena Mehra
    Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH
    Sleep Med 7:521-8. 2006
    ....
  45. ncbi request reprint Medical therapy for obstructive sleep apnea: a review by the Medical Therapy for Obstructive Sleep Apnea Task Force of the Standards of Practice Committee of the American Academy of Sleep Medicine
    Sigrid C Veasey
    Center for Sleep Respiratory Neurobiology, University of Pennsylvania, 972 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Sleep 29:1036-44. 2006
    ....
  46. ncbi request reprint Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
    Daniel E Brown
    Department of Anthropology, University of Hawaii at Hilo, Hilo, HI 96720
    Am J Hum Biol 18:196-202. 2006
    ..There was no significant association between the level of NO exhaled and the number of self-reported symptoms of AMS during this brief exposure...
  47. ncbi request reprint Patient follow-up: a call for organized "research"
    Kingman P Strohl
    Sleep Breath 9:4-6. 2005
  48. ncbi request reprint Management of shift work sleep disorder: Alice in Wonderland redux?
    Bruce W Sherman
    J Occup Environ Med 46:1010-2. 2004
  49. ncbi request reprint [New understanding of diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome]
    Kingman P Strohl
    Zhonghua Yi Xue Za Zhi 87:2163-6. 2007
  50. pmc Respiration in neonate sea turtles
    Edwin R Price
    Department of Biology, Indiana Purdue University at Fort Wayne, Fort Wayne, IN 46805, USA
    Comp Biochem Physiol A Mol Integr Physiol 146:422-8. 2007
    ..At the time of nest emergence, sea turtles have achieved a respiratory pattern that is similar to that of actively diving adults...

Research Grants14

  1. A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models
    Kingman Strohl; Fiscal Year: 2006
    ..The proposed research will facilitate animal studies that may lead to a better understanding of sleep disorders and potentially new interventions. ..
  2. SLEEP MEDICINE NEUROBIOLOGY AND EPIDEMIOLOGY
    Kingman Strohl; Fiscal Year: 2007
    ..There are weekly seminars, and an annual retreat that includes outside advisors, consultants, and faculty. (END OF ABSTRACT) ..
  3. Genetic Mechanisms for Central Apneas
    Kingman Strohl; Fiscal Year: 2007
    ....
  4. SLEEP AND ENTERTAIMENT OF SCN FUNCTION
    Kingman Strohl; Fiscal Year: 2002
    ..abstract_text> ..
  5. SLEEP ACADEMIC AWARD--RECOGNITION OF SLEEP DISORDERS
    Kingman Strohl; Fiscal Year: 2002
    ..We will disseminate of educational assessments, patient-oriented material, and clinical pathways through local and national consultants in both the public and private sector, as well as through interaction with other awardees. ..
  6. GENETIC DISSECTION OF VENTILATORY TRAITS
    Kingman Strohl; Fiscal Year: 2001
    ..Results will be relevant to illnesses known to result from, or be exacerbated by, poor or excessive ventilatory responses to environmental and pathophysiologic stresses. ..