Ventilatory behavior and metabolism in two strains of obese ratsK P Strohl
Department of Medicine, Case Western Reserve University, 111j w, Louis Stokes Cleveland DVA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
Respir Physiol 124:85-93. 2001
..We conclude that that factors other than fat accumulation contribute to the expression of respiratory control and ventilation in obesity in the rat...
- Lessons in hypoxic adaptation from high-altitude populations
Kingman P Strohl
Department of Medicine, Case Western Reserve University, Veterans Administration Medical Center, 111 J, 10701 East Boulevard, Cleveland, OH 44106, USA
Sleep Breath 12:115-21. 2008
..Future studies will require the ability to identify combinations of genetic variants with outcomes including expression levels, appropriate phenotypes, and functional responses...
- Periodic breathing and genetics
Kingman P Strohl
Center for Sleep Disorders Research, Louis Stokes VA Medical Center, 111j w VAMC, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA
Respir Physiol Neurobiol 135:179-85. 2003
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- Graduate medical training, learning, relationships, and sleep loss
Klara K Papp
111j w, 10701 East Boulevard, Cleveland, OH 44122, USA
Sleep Med Rev 10:339-45. 2006
..The multi-dimensional approach might include not only resident physicians, but also residency program directors and attending physicians at their institutions...
- Incorporating inheritance into models for understanding ventilatory behavior
K P Strohl
Department of Medicine, Louis Stokes VA Medical Center, and Case Western Reserve University, Cleveland, Ohio 44106, USA
Sleep Breath 5:47-51. 2001
..Conscious integration of genetic principles into existing explanatory models may increase the likelihood of detecting traits that correlate with protein systems responsible for the structures and the functional components of respiration...
- Invited commentary: to sleep, perchance to discover
Kingman P Strohl
Center for Sleep Disorders Research, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44122, USA
Am J Epidemiol 155:394-5; discussion 396-7. 2002
- Preventative risk management for obstructive sleep apnea
Kingman P Strohl
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
Sleep Breath 7:197. 2003
- Competency-based goals for sleep and chronobiology in undergraduate medical education
Kingman P Strohl
Case Western Reserve University, USA
Sleep 26:333-6. 2003
..Sleep and circadian rhythms are biologic processes operative in health and disease, but as yet there is no articulated curriculum for undergraduate medical education...
- The scoring of respiratory events in sleep: reliability and validity
Susan Redline
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
J Clin Sleep Med 3:169-200. 2007
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- Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders
Brian D Hoit
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106 5038, USA
J Appl Physiol 99:1796-801. 2005
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- The effects of sleep loss and fatigue on resident-physicians: a multi-institutional, mixed-method study
Klara K Papp
Case Western Reserve University School of Medicine, and Department of Medicine, University Hospitals of Cleveland and the Cleveland VA Medical Center, Ohio 44106, USA
Acad Med 79:394-406. 2004
..To identify and model the effects of sleep loss and fatigue on resident-physicians' professional lives and personal well-being...
- An Ethiopian pattern of human adaptation to high-altitude hypoxia
Cynthia M Beall
Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 99:17215-8. 2002
..Thus, Ethiopian highlanders maintain venous hemoglobin concentrations and arterial oxygen saturation within the ranges of sea level populations, despite the unavoidable, universal decrease in the ambient oxygen tension at high altitude...
- Periodic breathing in the mouse
Fang Han
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Appl Physiol 92:1133-40. 2002
..We conclude that differences in expression of PB between these strains indicate that genetic influences strongly affect the stability of ventilation in the mouse...
- Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains
Motoo Yamauchi
Department of Medicine, Case Western Reserve University, VA Medical Center, Research Service K216, 10701 East Blvd, Cleveland, OH 44106, USA
J Appl Physiol 105:518-26. 2008
..We conclude that buspirone improves posthypoxic ventilatory irregularities in the B6 mouse through its agonist effects on the 5-HT1A receptor...
- Acetazolamide protects against posthypoxic unstable breathing in the C57BL/6J mouse
Motoo Yamauchi
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
J Appl Physiol 103:1263-8. 2007
..We conclude that Acz improves unstable breathing in the B6 model, without altering hypoxic response or producing short-term potentiation, but with some blunting of hypercapnic responsiveness...
- Breathing and sleep: measurement methods, genetic influences, and developmental impacts
David M Baekey
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 5067, USA
ILAR J 50:248-61. 2009
..In this article we focus on methods of investigating respiratory control and applicable rodent models...
- Strain differences in murine ventilatory behavior persist after urethane anesthesia
Iahn Gonsenhauser
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4941, USA
J Appl Physiol 97:888-94. 2004
..The neural substrate for these differences, at least partially, exists within subcortical structures generating the breathing pattern...
- Post-hypoxic unstable breathing in the C57BL/6J mouse: effects of acetazolamide
Motoo Yamauchi
Department of Medicine, Case Western Reserve University, Cleveland VA Medical Center, USA
Adv Exp Med Biol 605:75-9. 2008
..ACZ improves unstable breathing in the B6 model of periodic breathing, despite producing post-hypoxic frequency decline. Our speculation is that periodic breathing occurs through pathways independent of the A5 pontine area...
- Are sleep symptoms predictors of resistant hypertension in a population-based sample? Findings from the National Health and Nutritional Examination Survey
Harneet Walia
Department of Pulmonary, Critical Care and Sleep Medicine, University Hospitals, Case Medical Center, Cleveland, OH, USA
J Clin Hypertens (Greenwich) 14:530-6. 2012
..The association between poorly controlled diabetes and RHTN warrants further emphasis on strict control of diabetes in these individuals...
- An exploration of differences in sleep characteristics between Mexico-born US immigrants and other Americans to address the Hispanic Paradox
Sinziana Seicean
Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA
Sleep 34:1021-31. 2011
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- The fa leptin receptor mutation and the heritability of respiratory frequency in a Brown Norway and Zucker intercross
Sudha K Iyengar
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Appl Physiol 97:811-20. 2004
..We conclude that, unlike its major effect on weight, the effect of the fa allele is not a major gene involved in the regulation of breathing frequency...
- Post-sigh breathing behavior and spontaneous pauses in the C57BL/6J (B6) mouse
Motoo Yamauchi
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, USA
Respir Physiol Neurobiol 162:117-25. 2008
..A greater irregularity and the lower complexity of post-sigh breathing in B6 are reversed by elements on A/J chromosome 1 and by increased 5-HT1A serotonergic tone...
- L-NAME differentially alters ventilatory behavior in Sprague-Dawley and Brown Norway rats
Shyam Subramanian
Department of Medicine, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Appl Physiol 93:984-9. 2002
..3 vs. 134.4 beats/min at baseline; VE: 66.3 vs. 88.8 ml/min at baseline; P < 0.05). Thus NOS blockade results in a strain-specific alteration in resting ventilation and uncovers the Dejours phenomenon in the SD strain...
- Erectile dysfunction and sleep related disorders
Jason T Jankowski
Department of Urology and Division of Pulmonary, Critical Care and Sleep Medicine, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Urol 179:837-41. 2008
..We reviewed the physiology of penile erection during sleep and the possible links between the pathophysiology of erectile dysfunction and the most commonly diagnosed sleep disorders...
- Assessment and policy for commercial driver license referrals
Christopher M Miller
Louis Stokes DVA Medical Center, Division of Pulmonary and Critical Care Medicine, Department ofFamily Medicine, Case Western Reserve University, Cleveland, OH 44107, USA
J Clin Sleep Med 3:417-23. 2007
..An educational component was an important feature of this response. We suspect that this approach may be appropriate for managed care systems in general...
- Erectile dysfunction and symptoms of sleep disorders
Allen D Seftel
Department of Urology, Cleveland VA Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
Sleep 25:643-7. 2002
..CONCLUSIONS: Urology patients will report a variety of sleep problems, but neither persistent snoring nor suspected OSAHS is correlated uniquely to ED...
- Sleep-related epilepsy in the A/J mouse
Kingman P Strohl
Department of Medicine, Case Western Reserve University, Cleveland OH, USA
Sleep 30:169-76. 2007
..A previous observation of spontaneous spike-and-wave activity during sleep in several A/J mice (A/J JAX) from Jackson Laboratory (Bar Harbor, ME) prompted this description of the inheritance of epileptic activity...
- Domperidone and ventilatory behavior: Sprague-Dawley versus Brown Norway rats
Shyamsunder Subramanian
Department of Medicine, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, OH 44106, USA
Respir Physiol Neurobiol 155:22-8. 2007
..We speculate that hypoxic ventilatory responses may be differently configured even among strains of the same species...
- 7-nitroindazole and posthypoxic ventilatory behavior in the A/J and C57BL/6J mouse strains
Edwin R Price
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
J Appl Physiol 95:1097-104. 2003
..Furthermore, neuronal nitric oxide may be an organizing feature in the presence, length, and/or cycle length of apnea in the susceptible strain...
- Inspired oxygen concentrations during positive pressure therapy
Elizabeth A Yoder
Louis Stokes Cleveland DVA Medical Center, Medical Service, Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, Ohio, USA
Sleep Breath 8:1-5. 2004
..This study examined the effects of various factors that might influence the fraction of oxygen in inspired air (FiO (2)) in a human and in a model system during nasal positive pressure treatments...
- Incidence of serious adverse events during nocturnal polysomnography
Reena Mehra
Center for Sleep Disorders Research, Louis Stokes DVA Medical Center, Case Western Reserve University Cleveland, OH, USA
Sleep 27:1379-83. 2004
..The purpose of the study was to verify whether minimal concern is warranted in regard to serious adverse effects in the sleep laboratory...
- Prevalence of symptoms and risk of sleep apnea in primary care
Nikolaus C Netzer
The Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, OH, USA
Chest 124:1406-14. 2003
..9% vs 17.2%, respectively; p < 0.01). CONCLUSIONS: Primary care physicians in the United States and Europe will encounter a high demand for services to confirm or manage sleep apnea, sleepiness, and obesity...
- Women with sleep apnea have lower levels of sex hormones
Nikolaus C Netzer
Department of Medicine, Center for Sleep Disorders Research, Case Western Reserve University, Cleveland, Ohio, USA
Sleep Breath 7:25-9. 2003
..Low levels of sex hormones, especially progesterone, are suspected as a risk factor for sleep-disordered breathing (SDB)...
- Variations in physician interpretation of overnight pulse oximetry monitoring
Rory Ramsey
Department of Medicine, Case School of Medicine, University Hospitals, 11100 Euclid Ave, Cleveland, OH 44106 6003, USA
Chest 132:852-9. 2007
..The aim of this study was to describe physician interpretation, use, and opinions regarding overnight pulse oximetry...
- Alpha-melanocyte stimulating hormone and adrenocorticotropic hormone: an alternative approach when thinking about restless legs syndrome?
Brian B Koo
Department of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Mov Disord 23:1234-42. 2008
..These melanocortin hormones may play a role in the pathogenesis of RLS...
- Brain orexins and wake regulation in rats exposed to maternal deprivation
Pingfu Feng
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, and Cleveland Louis Stokes VA Medical Center, Cleveland, OH 44106, USA
Brain Res 1154:163-72. 2007
..We concluded that neonatal MD produces adult hyperarousal in sleep physiology and neurobiology, and that the adult MD rat could be a model of insomnia with an orexinergic mechanism...
- Underdiagnosis of sleep apnea syndrome in U.S. communities
Vishesh Kapur
Department of Medicine, University of Washington, Seattle, USA
Sleep Breath 6:49-54. 2002
..We conclude that disparities (especially in women and in those with lower BMI) exist between current recognition rates for OSAHS and the estimated prevalence by symptom report across the United States...
- Improvement of respiratory compromise through abductor reinnervation and pacing in a patient with bilateral vocal fold impairment
Michael Broniatowski
Department of Otolaryngology Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Laryngoscope 120:76-83. 2010
..To determine whether respiratory compromise from bilateral vocal fold impairment (paralysis) can be objectively alleviated by reinnervation and pacing...
- Knowledge and attitudes of primary care physicians toward sleep and sleep disorders
Klara K Papp
Case Western Reserve University, School of Medicine, Department of Medicine, University Hospitals of Cleveland, and Geriatric Research Education and Clinical Center, Louis B Stokes Cleveland VA Medical Center, OH 44106, USA
Sleep Breath 6:103-9. 2002
..To assess primary care physician (PCP) sleep knowledge and attitudes...
- Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains
Lee Friedman
The MIND Institute, Albuquerque, New Mexico 87106, USA
J Appl Physiol 97:1787-95. 2004
..035) and B6 (P < 0.0001). We conclude that genetic background affects features of breathing during NREM and REM sleep, despite broad changes in state, metabolism, and heart rate...
- Patient follow-up: a call for organized "research"
Kingman P Strohl
Sleep Breath 9:4-6. 2005
- Management of shift work sleep disorder: Alice in Wonderland redux?
Bruce W Sherman
J Occup Environ Med 46:1010-2. 2004
- Sleep networks and the anatomic and physiologic connections with respiratory control
Musa A Haxhiu
Specialized Neuroscience Research Program, Department of Physiology and Biophysics, Howard University College of Medicine, 520 W St N W, Washington, DC 20059, USA
Front Biosci 8:d946-62. 2003
..Pharmacological corrections of alterations of these transmitter specific converging systems might be an avenue for treatment of sleep related airway disorders such as sleep apnea and worsening of asthma...
- [New understanding of diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome]
Kingman P Strohl
Zhonghua Yi Xue Za Zhi 87:2163-6. 2007
- Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
Daniel E Brown
Department of Anthropology, University of Hawaii at Hilo, Hilo, HI 96720
Am J Hum Biol 18:196-202. 2006
..There was no significant association between the level of NO exhaled and the number of self-reported symptoms of AMS during this brief exposure...
- Respiration in neonate sea turtles
Edwin R Price
Department of Biology, Indiana Purdue University at Fort Wayne, Fort Wayne, IN 46805, USA
Comp Biochem Physiol A Mol Integr Physiol 146:422-8. 2007
..At the time of nest emergence, sea turtles have achieved a respiratory pattern that is similar to that of actively diving adults...
- Medical therapy for obstructive sleep apnea: a review by the Medical Therapy for Obstructive Sleep Apnea Task Force of the Standards of Practice Committee of the American Academy of Sleep Medicine
Sigrid C Veasey
Center for Sleep Respiratory Neurobiology, University of Pennsylvania, 972 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
Sleep 29:1036-44. 2006
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- Sleep apnea in acute coronary syndrome: high prevalence but low impact on 6-month outcome
Reena Mehra
Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH
Sleep Med 7:521-8. 2006
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- Con: sleep apnea is not an anatomic disorder
Kingman P Strohl
Am J Respir Crit Care Med 168:271-2; discussion 272-3. 2003
