Alexis M Stranahan

Summary

Publications

  1. doi Reelin signaling in development, maintenance, and plasticity of neural networks
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Ageing Res Rev 12:815-22. 2013
  2. doi Metabolic reserve as a determinant of cognitive aging
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia, GA 30912, USA
    J Alzheimers Dis 30:S5-13. 2012
  3. pmc Similarities and differences in spatial learning and object recognition between young male C57Bl/6J mice and Sprague-Dawley rats
    Alexis M Stranahan
    Georgia Health Sciences University, Augusta, GA 30912, USA
    Behav Neurosci 125:791-5. 2011
  4. pmc Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
    J Neurochem 118:611-5. 2011
  5. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
  6. pmc Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    Alexis M Stranahan
    Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Hippocampus 18:1085-8. 2008
  7. pmc Bidirectional metabolic regulation of neurocognitive function
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:507-16. 2011
  8. pmc Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:150-5. 2011
  9. ncbi Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
    Curr Alzheimer Res 9:86-92. 2012
  10. pmc Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Neurobiol Learn Mem 90:479-83. 2008

Collaborators

Detail Information

Publications23

  1. doi Reelin signaling in development, maintenance, and plasticity of neural networks
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Ageing Res Rev 12:815-22. 2013
    ....
  2. doi Metabolic reserve as a determinant of cognitive aging
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia, GA 30912, USA
    J Alzheimers Dis 30:S5-13. 2012
    ..Identification of biomarkers for metabolic reserve could assist in generating a predictive model for the likelihood of cognitive decline with aging...
  3. pmc Similarities and differences in spatial learning and object recognition between young male C57Bl/6J mice and Sprague-Dawley rats
    Alexis M Stranahan
    Georgia Health Sciences University, Augusta, GA 30912, USA
    Behav Neurosci 125:791-5. 2011
    ..These observations suggest that while species differences in spatial memory retention are present, they do not correlate with differences in object recognition memory...
  4. pmc Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
    J Neurochem 118:611-5. 2011
    ..Taken together, these observations support the existence of a potentially pathogenic relationship between dietary fat intake, peripheral cholesterol and triglyceride levels, brain cell sphingolipid metabolism, and oxidative stress...
  5. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
    ..These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning...
  6. pmc Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    Alexis M Stranahan
    Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Hippocampus 18:1085-8. 2008
    ..We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines...
  7. pmc Bidirectional metabolic regulation of neurocognitive function
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:507-16. 2011
    ..Understanding the mechanisms for this continuum may yield novel therapeutic targets for the prevention and treatment of cognitive decline following aging, disease, or injury...
  8. pmc Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:150-5. 2011
    ..These observations support a role for entorhinal reelin signaling in spatial learning, and suggest that an intact reelin signaling pathway is essential for synaptic integrity in the adult entorhinal cortex...
  9. ncbi Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
    Curr Alzheimer Res 9:86-92. 2012
    ..In this respect, physical activity may promote neuronal resilience by reducing inflammation...
  10. pmc Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Neurobiol Learn Mem 90:479-83. 2008
    ..The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features...
  11. pmc Cortical gene transcription response patterns to water maze training in aged mice
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    BMC Neurosci 12:63. 2011
    ..We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training...
  12. doi Opposing effects of positive and negative stress on hippocampal plasticity over the lifespan
    Marlena Wosiski-Kuhn
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Ageing Res Rev 11:399-403. 2012
    ..These data suggest that exercise-induced neuroprotection and neuronal endangerment following adversity may both be transferable across generations, in a manner that has the potential to impact neuroplasticity over the lifespan...
  13. pmc Impact of energy intake and expenditure on neuronal plasticity
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Balitmore, MD, USA
    Neuromolecular Med 10:209-18. 2008
    ..The specific principles upheld by these findings are suggestive of a continuum, with global metabolic alterations fluctuating in concert with neuroplasticity in the hippocampus...
  14. doi Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Comp Neurol 520:1318-26. 2012
    ..These observations indicate that the dorsal PFC is susceptible to neuron loss with aging in rodent brain and suggest some common basis for vulnerability in cortical circuits across species...
  15. doi Recruiting adaptive cellular stress responses for successful brain ageing
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Nat Rev Neurosci 13:209-16. 2012
    ..We also describe the mechanisms underlying the neuroprotective actions of exercise and nutritional interventions, with the goal of recruiting these molecular targets for the treatment and prevention of neurodegenerative disease...
  16. pmc Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroendocrinology 93:58-64. 2011
    ....
  17. pmc Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's disease
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Neural Plast 2010:108190. 2010
    ..Taken together, the existing data point to a regional cascade in which entorhinal cortical alterations directly contribute to downstream changes in its primary afferent region, the hippocampus...
  18. pmc Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Cereb Cortex 21:392-400. 2011
    ..Taken together, these findings suggest that reduced reelin expression, emanating from layer II entorhinal neurons, may contribute to network dysfunction that occurs during memory loss in aging...
  19. ncbi Chronobiological approaches to Alzheimer's disease
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Curr Alzheimer Res 9:93-8. 2012
    ....
  20. pmc Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility
    Alexis M Stranahan
    Laboratory of Neurosciences, Cellular and Molecular Neurosciences Section, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Ageing Res Rev 7:164-76. 2008
    ..We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain...
  21. doi Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation
    Marlena Wosiski-Kuhn
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia, USA
    Synapse 66:661-4. 2012
    ..These results indicate that spine formation is a transient event that is required for dentate gyrus LTP...
  22. pmc Putting age-associated changes in neurogenesis in their place
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Aging 31:2179-80. 2010
    ....
  23. pmc Central mechanisms of HPA axis regulation by voluntary exercise
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neuroscience, National Institute of Aging Intramural Research Program, Gerontology Research Center, Nathan Shock Dr, Baltimore 5600, USA
    Neuromolecular Med 10:118-27. 2008
    ..While running indeed activates a number of systems related to the stress response, other mechanisms exist to reduce the reactivity to this stressor, with possible crosstalk between running and other forms of stress...