Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trialE C Strain
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
JAMA 281:1000-5. 1999
..However, despite recommendations regarding effective dosing of methadone, controlled clinical trials of higher-dose methadone have not been conducted...
- Relative bioavailability of different buprenorphine formulations under chronic dosing conditions
Eric C Strain
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 74:37-43. 2004
..This study compared the relative buprenorphine bioavailability of these different formulations...
- Single versus multiple drug focus in substance abuse clinical trials research: the devil is in the details
Eric C Strain
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:131-4. 2003
- Assessment and treatment of comorbid psychiatric disorders in opioid-dependent patients
Eric C Strain
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Clin J Pain 18:S14-27. 2002
..The presence of a pain condition can further complicate assessment and treatment, as either pain itself or treatments used for pain may produce symptoms that overlap with psychiatric disorders...
- Blockade of hydromorphone effects by buprenorphine/naloxone and buprenorphine
Eric C Strain
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 159:161-6. 2002
..Naloxone has been combined with buprenorphine to decrease the parenteral abuse potential of buprenorphine. This addition of naloxone may also confer further opioid blockade efficacy...
- Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers
E C Strain
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 148:374-83. 2000
..Non-parenteral abuse of opioids such as buprenorphine may be more likely in people who have less severe substance abuse disorders (e.g., are not physically dependent upon opioids)...
- HIV risk behaviors during pharmacologic treatment for opioid dependence: a comparison of levomethadyl acetate [corrected] buprenorphine, and methadone
David C Lott
Chemical Dependency Program, Linden Oaks Hospital at Edward, 825 S West St, Naperville, IL 60540, USA
J Subst Abuse Treat 31:187-94. 2006
..These results demonstrate that all three medications can be highly effective in decreasing HIV risk behaviors when the dose is optimized. Reductions in sexual behaviors for the METH group are consistent with known METH side effects...
- Assessment of agonist and antagonist effects of tramadol in opioid-dependent humans
C Patrick Carroll
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 14:109-20. 2006
..In contrast, tramadol's pattern of effects was more similar to that of hydromorphone and suggestive of mild opioid-agonist effects (withdrawal suppression), though not to a statistically significant degree...
- Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h period
Christopher J Correia
Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 189:297-306. 2006
..However, withdrawal did not differ as a function of B/N maintenance dose. CONCLUSIONS: These findings suggest that B/N doses greater than 8/2 mg provide minimal incremental value in terms of opioid blockade and withdrawal suppression...
- Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence
Lisa A Marsch
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Clin Psychopharmacol 13:293-302. 2005
..We did not find any factors that would strongly guide selection of one medication over others...
- Characteristics of older opioid maintenance patients
Michelle R Lofwall
Johns Hopkins University School of Medicine Behavioral Pharmacology Research Unit and Addiction Treatment Services, Baltimore, MD 21224, USA
J Subst Abuse Treat 28:265-72. 2005
..Low rates of positive urine opioid tests occurred for both older and younger patients without age-specific services...
Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadoneJames Rosado
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 90:261-9. 2007
..Acute doses of buprenorphine can precipitate withdrawal in opioid dependent persons. The likelihood of this withdrawal increases as a function of the level of physical dependence...
- A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers
Miriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 74:205-9. 2004
..Future studies incorporating larger sample sizes and non-drug controls, as well as directly comparing buprenorphine to methadone and LAAM are needed to further test the hypothesis of limited impairment with buprenorphine...
- Modest opioid withdrawal suppression efficacy of oral tramadol in humans
Michelle R Lofwall
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 194:381-93. 2007
..Tramadol is in an unscheduled atypical analgesic with low rates of diversion and abuse and mixed pharmacologic actions, including modest opioid agonist activity...
- Evaluation of the effects of lofexidine and clonidine on naloxone-precipitated withdrawal in opioid-dependent humans
Sharon L Walsh
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Addiction 98:427-39. 2003
..To examine the efficacy of lofexidine, an alpha2 adrenergic agonist, to suppress opioid withdrawal symptoms in opioid-dependent humans under in-patient laboratory conditions by using a naloxone challenge procedure...
- Buprenorphine for postoperative pain following general surgery in a buprenorphine-maintained patient
Sarah W Book
Am J Psychiatry 164:979. 2007
- Comparison of demographic and clinical characteristics between opioid-dependent individuals admitted to a community-based treatment setting and those enrolled in a research-based treatment setting
C Patrick Carroll
Addiction Treatment Services, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Subst Abuse Treat 33:355-61. 2007
..Interestingly, many of these differences were strongest in women as compared with men...
- Simultaneous determination of buprenorphine, norbuprenorphine and the enantiomers of methadone and its metabolite (EDDP) in human plasma by liquid chromatography/mass spectrometry
Maria Esther Rodriguez-Rosas
Bioanalytical and Drug Discovery Unit, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224 6825, USA
J Chromatogr B Analyt Technol Biomed Life Sci 850:538-43. 2007
..5% and for accuracy was <4.0%. The method was validated and used to analyze plasma samples obtained from opioid dependent methadone-maintained adults enrolled in a research study...
- Treatment of patients with substance use disorders, second edition. American Psychiatric Association
Herbert D Kleber
Am J Psychiatry 164:5-123. 2007
- Treatment of patients with substance use disorders, second edition. American Psychiatic Association
Herbert D Kleber
Am J Psychiatry 163:5-82. 2006
- Impact of formulation on the abuse liability, safety and regulation of medications: the expert panel report
Charles Grudzinskas
NDA Partners LLC, 720 Riverview Terrace, Annapolis, MD 21401, USA
Drug Alcohol Depend 83:S77-82. 2006
..Finally, knowledge and experience are needed to translate scientific work into a predictable, transparent and reliable regulatory process...
- Decreased frontal white-matter volume in chronic substance abuse
Thomas E Schlaepfer
Department of Psychiatry, University Hospital, Bonn, Germany
Int J Neuropsychopharmacol 9:147-53. 2006
....
- Safety and efficacy of L-tryptophan and behavioral incentives for treatment of cocaine dependence: a randomized clinical trial
Hendree E Jones
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Addict 13:421-37. 2004
..This study also showed that contingent vouchers were effective in the novel experimental model of relapse prevention...
- [Brazilian guideline for the treatment of patients with opioids dependence syndrome]
Danilo Antonio Baltieri
, , Brazil
Rev Bras Psiquiatr 26:259-69. 2004
..Also, the essential historical, epidemiological and neurobiological aspects of opioid dependence are reviewed...
- A liquid chromatographic-electrospray ionization-tandem mass spectrometric method for determination of buprenorphine, its metabolite, norbuprenorphine, and a coformulant, naloxone, that is suitable for in vivo and in vitro metabolism studies
David E Moody
Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
Anal Biochem 306:31-9. 2002
..These results suggest this method is suitable for both in vivo and in vitro studies of buprenorphine metabolism to norbuprenorphine...
- Outpatient treatment entry and health care utilization after a combined medical/substance abuse intervention for hospitalized medical patients
THOMAS P O'TOOLE
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Gen Intern Med 17:334-40. 2002
..Drug-abusing patients utilize extensive amounts of health services resources, yet the acute medical hospitalization has typically not been used effectively to engage patients in substance abuse treatment...
- Voucher-based reinforcement of opiate abstinence during methadone detoxification
Elias Robles
Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Drug Alcohol Depend 65:179-89. 2002
..Voucher-based reinforcement procedures could be useful for successfully transitioning patients into opiate antagonist therapy, or drug-free treatments...
- Experimentally-induced spontaneous opiate withdrawal: relationship to cigarette craving and expired air carbon monoxide
Michelle R Lofwall
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 16:310-5. 2007
..Interestingly, craving was only reduced for items related to the positive reinforcing effects of smoking. These preliminary results suggest that OW may be a favorable context to initiate smoking cessation treatment interventions...
