Travis H Stracker

Summary

Publications

  1. pmc The ATM signaling network in development and disease
    Travis H Stracker
    Oncology Programme, Institute for Research in Biomedicine IRB Barcelona Barcelona, Spain
    Front Genet 4:37. 2013
  2. pmc Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
    Travis H Stracker
    Molecular Biology, Sloan Kettering Institute, New York, NY, USA
    DNA Repair (Amst) 8:1047-54. 2009
  3. ncbi request reprint The MRE11 complex: starting from the ends
    Travis H Stracker
    Institute for Research in Biomedicine Barcelona, C Baldiri Reixac 10, 08028 Barcelona, Spain
    Nat Rev Mol Cell Biol 12:90-103. 2011
  4. pmc Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability
    Travis H Stracker
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10065, USA
    Mol Cell Biol 29:503-14. 2009
  5. pmc Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
    Travis H Stracker
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    Mol Cell 31:21-32. 2008
  6. pmc Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
    Ludovic Deriano
    Department of Pathology, The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute for Biomolecular Medicine and, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 34:13-25. 2009
  7. pmc The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
    Travis H Stracker
    Molecular Biology and Genetics, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 447:218-21. 2007
  8. pmc Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression
    Steven S Foster
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 109:9953-8. 2012
  9. ncbi request reprint The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together
    Travis H Stracker
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    DNA Repair (Amst) 3:845-54. 2004
  10. pmc Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression
    Travis H Stracker
    Molecular Biology, Sloan Kettering Institute, New York, New York 10021, USA
    Cell Cycle 7:3618-21. 2008

Collaborators

Detail Information

Publications11

  1. pmc The ATM signaling network in development and disease
    Travis H Stracker
    Oncology Programme, Institute for Research in Biomedicine IRB Barcelona Barcelona, Spain
    Front Genet 4:37. 2013
    ..This review will describe the general roles of ATM signaling and highlight some recent advances that have shed light on the diverse roles of ATM and related proteins in human disease...
  2. pmc Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
    Travis H Stracker
    Molecular Biology, Sloan Kettering Institute, New York, NY, USA
    DNA Repair (Amst) 8:1047-54. 2009
    ..This review will focus on recent advances in our understanding of the structure, regulation, and functions of the effector kinases in the DDR, as well as their potential roles in human disease...
  3. ncbi request reprint The MRE11 complex: starting from the ends
    Travis H Stracker
    Institute for Research in Biomedicine Barcelona, C Baldiri Reixac 10, 08028 Barcelona, Spain
    Nat Rev Mol Cell Biol 12:90-103. 2011
    ....
  4. pmc Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability
    Travis H Stracker
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10065, USA
    Mol Cell Biol 29:503-14. 2009
    ..Our results reveal a role for DNA-PKcs in the maintenance of S/G(2)-phase chromosome stability and in the induction of cell cycle checkpoint responses...
  5. pmc Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
    Travis H Stracker
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    Mol Cell 31:21-32. 2008
    ..These data suggest that Chk2 suppresses the oncogenic potential of DNA damage arising during S and G2 phases of the cell cycle...
  6. pmc Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates
    Ludovic Deriano
    Department of Pathology, The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute for Biomolecular Medicine and, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 34:13-25. 2009
    ..These data demonstrate that the MRE11 complex functions at two distinct levels, regulating repair pathway choice (likely through enhancing the stability of DNA end complexes) and participating in alternative NHEJ of coding ends...
  7. pmc The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
    Travis H Stracker
    Molecular Biology and Genetics, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 447:218-21. 2007
    ..Instead, the defects observed in Nbs1(DeltaC/DeltaC) result from impaired phosphorylation of ATM targets including SMC1 and the proapoptotic factor, BID...
  8. pmc Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression
    Steven S Foster
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 109:9953-8. 2012
    ....
  9. ncbi request reprint The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together
    Travis H Stracker
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    DNA Repair (Amst) 3:845-54. 2004
    ..Further genetic analysis of the Mre11 complex will be an invaluable tool for dissecting its function on an organismal level and determining its role in the prevention of malignancy...
  10. pmc Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression
    Travis H Stracker
    Molecular Biology, Sloan Kettering Institute, New York, New York 10021, USA
    Cell Cycle 7:3618-21. 2008
    ..2,3) We found that the checkpoint kinase Chk2 is crucial for the suppression of a diverse array of tumor types in Mre11 complex mutants and uncovered multiple roles for the Mre11 complex in apoptotic signaling in parallel to Chk2.(4,5)...
  11. ncbi request reprint The cellular response to DNA double-strand breaks: defining the sensors and mediators
    John H J Petrini
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    Trends Cell Biol 13:458-62. 2003
    ..We discuss the possible role of the Mre11 complex as a primary damage sensor and the complex relationship between DNA damage sensors, transducers and mediators...