Research Topics
Genomes and Genes | Benoit StijlemansSummaryAffiliation: Vrije Universiteit brussel (VUB) Location: Brussels, Belgium Publications
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Publications
Detection of clinically relevant antibodies pretransplant and posttransplant with PRA-STAT. The Anti-CD45 Study GroupJ Neylan
Emory University Hospital, Atlanta, Georgia, USA
Transplant Proc 29:330-2. 1997- African trypanosomosis: from immune escape and immunopathology to immune interventionBenoit Stijlemans
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
Vet Parasitol 148:3-13. 2007..Finally, the possibility to interfere with such activation states hereby providing new therapeutical modalities in the treatment of this infectious disease will be illustrated... - A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis-associated immunopathologyBenoit Stijlemans
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussels, Pleinlaan 2, Brussels, Belgium
J Immunol 179:4003-14. 2007.... - Parallel selection of multiple anti-infectome Nanobodies without access to purified antigensDirk Saerens
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussels, Pleinlaan 2, B 1050 Brussels, Belgium
J Immunol Methods 329:138-50. 2008..Due to the omnipresence of these targets on different parasite species and forms, these antibody fragments are a valuable source for validation of novel, not yet identified targets to design new diagnostics and therapeutics... 
Role of iron homeostasis in trypanosomiasis-associated anemiaBenoit Stijlemans
Laboratory of Cellular and Molecular Immunology, VIB Department of Molecular and Cellular Interactions, Vrije Universiteit Brussel VUB, Building E, Level 8, Pleinlaan 2, B 1050 Brussels, Belgium
Immunobiology 213:823-35. 2008....- Camelid immunoglobulins and nanobody technologyS Muyldermans
Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, VIB, Vrije Universiteit Brussel, Brussels, Belgium
Vet Immunol Immunopathol 128:178-83. 2009..We have successfully developed recombinant Nbs for research purposes, as probe in biosensors, to diagnose infections, and to treat diseases like cancer or trypanosomosis... 
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in miceHannelie Korf
Laboratory of Mycobacterial Immunology, Scientific Institute of Public Health, Brussels, Belgium
J Clin Invest 119:1626-37. 2009..The dependence of LXR signaling on the neutrophil IL-17 axis represents what we believe to be a novel function for these nuclear receptors in resistance to M. tuberculosis infection and may provide a new target for therapeutics...- Inhibition of Staphylococcus epidermidis biofilm formation by rabbit polyclonal antibodies against the SesC proteinMohammad Shahrooei
Department of Medical Diagnostic Sciences, Laboratory of Medical Microbiology, KU Leuven, UZ Gasthuisberg, B 3000 Leuven, Belgium
Infect Immun 77:3670-8. 2009..epidermidis biofilms because it affects both the primary attachment and biofilm accumulation phases. The precise role of SesC in biofilm formation remains to be identified... - Understanding the role of monocytic cells in liver inflammation using parasite infection as a modelTom Bosschaerts
Department of Molecular and Cellular Interactions, VIB, Brussel, Belgium
Immunobiology 214:737-47. 2009.... - Identification of a parasitic immunomodulatory protein triggering the development of suppressive M1 macrophages during African trypanosomiasisJulio Gomez-Rodriguez
Department of Molecular and Cellular Interactions, Vlaams Institute voor Biotechnologie VIB, Vrije Universiteit Brussel, 1050 Brussels, Belgium
J Infect Dis 200:1849-60. 2009..TSIF knock-down trypanosomes died within 2 days, indicating that TSIF may be essential for parasite biology... - The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approachesBenoit Stijlemans
Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
Endocr Metab Immune Disord Drug Targets 10:71-82. 2010.... - Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasisBenoit Stijlemans
Department of Molecular and Cellular Interactions, VIB, 1050 Brussel, Belgium
Microbes Infect 12:389-99. 2010..Collectively, our results demonstrate that reprogramming macrophages towards an anti-inflammatory state alleviates anemia of inflammation by normalizing iron homeostasis and restoring erythropoiesis... - Current status of vaccination against African trypanosomiasisStefan Magez
Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
Parasitology 137:2017-27. 2010..This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology... - Lack of galectin-3 alleviates trypanosomiasis-associated anemia of inflammationAnn Vankrunkelsven
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
Immunobiology 215:833-41. 2010..Our data indicate that Gal-3 is involved in the development of inflammation-associated anemia during African trypanosomiasis, possibly due to a disturbed iron metabolism that in turn may also lead to liver malfunction... - [Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor]Toya Nath Baral
, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Bruxelles, Belgique
Med Sci (Paris) 22:914-6. 2006 - Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory responseGuy Caljon
Unit of Cellular and Molecular Immunology, Flanders Interuniversity Institute for Biotechnology VIB, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
Infect Immun 74:6324-30. 2006..We propose that tsetse fly saliva accelerates the onset of trypanosome infection by inhibiting local and systemic inflammatory responses involved in parasite control... - Evidence for proteins involved in prophenoloxidase cascade Eisenia fetida earthwormsPetra Procházková
Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague 4, Czech Republic
J Comp Physiol B 176:581-7. 2006..Moreover, the level of phenoloxidase activity is lower and the activation slower as compared to other invertebrates... - The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factorsS Magez
Laboratory of Cellular Immunology, Flanders Interuniversity Institute for Biotechnology, Free University of Brussels, Belgium
J Immunol 160:1949-56. 1998.... - Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma bruceiM Radwanska
Laboratory of Molecular Parasitology, IBMM, Free University of Brussels ULB, 6041 Gosselies, Belgium
Infect Immun 68:848-60. 2000.... - Attenuation of Trypanosoma brucei is associated with reduced immunosuppression and concomitant production of Th2 lymphokinesB Namangala
Department of Immunology, Parasitology, and Ultrastructure, Flemish Interuniversity Institute for Biotechnology, St Genesius Rode, Belgium
J Infect Dis 181:1110-20. 2000..b. brucei correlates with the absence of cells suppressing ConA-induced T cell proliferation in the lymph nodes, with increased production of Th2 cytokines and a stronger IgG1 antibody response to trypanosome antigens... - A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding moleculeS Magez
Department of Immunology, Parasitology and Ultrastructure, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Paardenstraat 65, B 1640 Sint Genesius Rode, Belgium
J Biol Chem 276:33458-64. 2001.... - Distinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteriaM Bilej
Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
J Biol Chem 276:45840-7. 2001..These data provide evidence for the presence of spatially distinct carbohydrate recognition domains within this invertebrate defense molecule... - Bacterial lipoprotein-based vaccines induce tumor necrosis factor-dependent type 1 protective immunity against Leishmania majorJavier Cote-Sierra
Department of Immunology, Parasitology and Ultrastructure, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel, Sint Genesius Rode, Belgium
Infect Immun 70:240-8. 2002..These data indicate that bacterial lipoproteins constitute appropriate adjuvants to include in vaccines against diseases in which type 1 immune responses are important for protection... - Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-alpha inductionS Magez
Department of Immunology, Parasitology and Ultrastructure, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Paardenstraat 65, B 1640 Sint Genesius Rode, Belgium
Infect Immun 70:1342-51. 2002.... - VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathologyStefan Magez
Laboratory of Cellular Immunology, Free University of Brussels Flemish Interuniversity, Institute for Biotechnology, Paardenstraat 65, Sint Genesius Rode, Belgium
Microbes Infect 4:999-1006. 2002..Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology... - Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigmBenoit Stijlemans
Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium
J Biol Chem 279:1256-61. 2004..This was illustrated by the specific trypanolysis induced by an antibody::beta-lactamase fusion activating a prodrug... - P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasisStefan Magez
Laboratory of Cellular and Molecular Immunology, Department of Cellular and Molecular Recognition, Flanders Interuniversity Institute for Biotechnology, Free University of Brussels VUB, Brussels, Belgium
J Infect Dis 189:527-39. 2004.... - Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VHKatja Conrath
Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
J Mol Biol 350:112-25. 2005.... - The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependentMichael B Drennan
Immunology of Infectious Disease Medical Research Council University of Cape Town Unit, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa
J Immunol 175:2501-9. 2005..brucei infections. These results implicate the mammalian TLR family and MyD88 signaling in the innate immune recognition of T. brucei... - Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factorToya Nath Baral
Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
Nat Med 12:580-4. 2006..Treatment with this engineered conjugate resulted in clear curative and alleviating effects on acute and chronic infections of mice with both NHS-resistant and NHS-sensitive trypanosomes... - Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signalingTom Bosschaerts
Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
PLoS Pathog 6:e1001045. 2010..Therefore, investigating the contribution of recruited monocytes to African trypanosome induced liver injury could potentially identify new targets to treat hepatic inflammation in general, and during parasite infection in particular...