The treatment of hyponatremiaRichard H Sterns
Department of Medicine, Rochester General Hospital, Rochester, NY 14534, USA
Semin Nephrol 29:282-99. 2009
..Frequent monitoring of the serum sodium concentration and urine output are mandatory. Administration of desmopressin to terminate an unwanted water diuresis is an effective strategy to avoid or reverse overcorrection...
- Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective?
Richard H Sterns
Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Am Soc Nephrol 21:733-5. 2010
..There is growing concern, however, that suspensions of SPS in sorbitol can be harmful. It would be wise to exhaust other alternatives for managing hyperkalemia before turning to these largely unproven and potentially harmful therapies...
- Treatment of hyponatremia
Richard H Sterns
Nephrology Division, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Curr Opin Nephrol Hypertens 19:493-8. 2010
..Recently approved vasopressin antagonists now make it possible to normalize the serum sodium concentration on a chronic basis, but practical considerations have limited their use...
- Treating profound hyponatremia: a strategy for controlled correction
Richard H Sterns
Rochester General Hospital, Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Am J Kidney Dis 56:774-9. 2010
..This case illustrates the value of controlled correction of profound hyponatremia...
Brain volume regulation in response to hypo-osmolality and its correctionRichard H Sterns
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
Am J Med 119:S12-6. 2006
..In an experimental model of chronic hyponatremia, exogenous administration of myoinositol speeds the brain's reuptake of the osmolyte and reduces osmotic demyelination and mortality caused by rapid correction...
Mortality and serum sodium: do patients die from or with hyponatremia?Arun Chawla
Division of Nephrology and Hypertension, Hofstra North Shore LIJ School of Medicine, Great Neck, New York, USA
Clin J Am Soc Nephrol 6:960-5. 2011
..Severe hyponatremia (<120 mEq/L) in hospitalized patients has a high mortality rate. We hypothesized that underlying diseases causing hyponatremia attribute to mortality rather than hyponatremia itself...
- Diuretic-associated hyponatremia
John K Hix
Nephrology Division, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
Semin Nephrol 31:553-66. 2011
..Hypokalemia, which often is present, increases the susceptibility to osmotic demyelination syndrome and replacement of potassium deficits contributes to the increase in serum sodium concentration...
- Cerebral salt wasting versus SIADH: what difference?
Richard H Sterns
Rochester General Hospital, Rochester, New York, USA
J Am Soc Nephrol 19:194-6. 2008
..Furthermore, the distinction does not make a difference; regardless of volume status, hyponatremia complicating intracranial disease should be treated with hypertonic saline...
- Hypertonic saline for hyponatremia: risk of inadvertent overcorrection
Hashim K Mohmand
Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
Clin J Am Soc Nephrol 2:1110-7. 2007
....
- Current perspectives in the management of hyponatremia: prevention of CPM
Richard H Sterns
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine, Rochester, NY, USA
Expert Rev Neurother 7:1791-7. 2007
....
- Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia
Lonika Sood
Rochester General Hospital, Rochester, NY, USA
Am J Kidney Dis 61:571-8. 2013
..However, inadvertent overcorrection is common, usually caused by the unexpected emergence of a water diuresis...
- DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia
Anjana Perianayagam
Rochester General Hospital, Department of Medicine, 1425 Portland Avenue, Rochester NY 14621, USA
Clin J Am Soc Nephrol 3:331-6. 2008
....
- Hyponatremia treatment guidelines 2007: expert panel recommendations
Joseph G Verbalis
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
Am J Med 120:S1-21. 2007
..This review presents their conclusions, including identification of appropriate treatment populations and possible future indications for aquaretic AVPR antagonists...
- Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats
Stephen M Silver
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine, Rochester, New York, NY 14621, USA
J Neuropathol Exp Neurol 65:37-44. 2006
..25 +/- 1.1 versus 6.42 +/- 1.4 lesions/brain, p < 0.03). We conclude that myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats...
- Calciphylaxis from nonuremic causes: a systematic review
Sagar U Nigwekar
Departments of Internal Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
Clin J Am Soc Nephrol 3:1139-43. 2008
..This systematic review was designed to characterize etiologies, clinical features, laboratory abnormalities, and prognosis of nonuremic calciphylaxis...
- Transient diabetes insipidus after discontinuation of therapeutic vasopressin
Judith L Kristeller
Department of Pharmacy, Rochester General Hospital, Rochester, New York, USA
Pharmacotherapy 24:541-5. 2004
..The drug may have diminished vasoconstrictive effects in this patient population. Careful monitoring of water and sodium balance is warranted in all patients treated with vasopressin for septic shock...
- Brain uptake of myoinositol after exogenous administration
Stephen M Silver
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine, Rochester, New York 14621, USA
J Am Soc Nephrol 13:1255-60. 2002
..In conclusion, systemic infusion of myoinositol can rapidly increase brain myoinositol content, but only when plasma tonicity is concomitantly increased...
