G B Stefano

Summary

Publications

  1. ncbi The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide
    G B Stefano
    The Mind Body Medical Institute, CareGroup, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115, Boston, MA, USA
    Brain Res Brain Res Rev 35:1-19. 2001
  2. ncbi The biochemical substrate of nitric oxide signaling is present in primitive non-cognitive organisms
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 924:82-9. 2002
  3. ncbi Vascular pulsations stimulating nitric oxide release during cyclic exercise may benefit health: a molecular approach (review)
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:119-29. 2001
  4. ncbi Cell surface estrogen receptors coupled to cNOS mediate immune and vascular tissue regulation: therapeutic implications
    G B Stefano
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 7:1066-74. 2001
  5. ncbi Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 793:341-5. 1998
  6. ncbi Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury 11568, USA
    J Immunol 163:3758-63. 1999
  7. ncbi Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Int J Cardiol 64:S3-13. 1998
  8. ncbi Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Brain Res 763:63-8. 1997
  9. ncbi Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Brain Res 753:219-24. 1997
  10. ncbi 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Pharmacol Res 42:317-22. 2000

Collaborators

  • T V Bilfinger
  • W Zhu
  • M Salzet
  • G L Fricchione
  • V Prevot
  • G Baggerman
  • D G Deutsch
  • C Breton
  • I Welters
  • M Pope
  • Enzo Ottaviani
  • B S Weeks
  • Tobias Esch
  • Elisa Peruzzi
  • Stephen C Pryor
  • Federico M Casares
  • D Sonetti
  • Aaron Deykin
  • Kirk J Mantione
  • Patrick Cadet
  • Richard M Kream
  • Elliott Salamon
  • P Cadet
  • Kirk Mantione
  • R M Kream
  • John J Cho
  • K Mantione
  • Melinda Sheehan
  • Jeanette Cheng
  • Jeffery A Dusek
  • Y Goumon
  • Theodore Pak
  • Suraj Rambhia
  • C M Rialas
  • Mads Rasmussen
  • Massimo Guarna
  • Peter Olsen
  • Dolisha A Jones
  • Anna Członkowska
  • R Ptacek
  • F E Nieto-Fernandez
  • Yannick Goumon
  • C Fimiani
  • Nai Ljiang Liu
  • Chen Zhang
  • Ji Sheng Han
  • John J Witmeyer
  • Pamela L Esposito
  • Thomas R Esposito
  • Maojuan Zhuang
  • Patricia L Hibberd
  • Celline Kim
  • Sara Lazar
  • Jamil Zaki
  • Herbert Benson
  • Ann L Wohlhueter
  • Bei Hung Chang
  • Enrica Bianchi
  • Laura Noli
  • Else K Tønnesen
  • Carla Neri
  • Alessandro Bartolini
  • Carla Ghelardini
  • Else Tonnesen
  • Nicoletta Galeotti
  • Maxime Simon
  • Richard Im
  • Minsun Kim
  • Jeong Ho Nam
  • Raymond Hong
  • John Beaulieu
  • A L Franklin
  • Andrzej Członkowski
  • Iwona Kurkowska-Jastrzebska
  • J Tonnesen
  • C Rialas
  • Doris Peter
  • K J Mantione
  • E Arcuri
  • D Peter
  • B Salzet
  • D Mattocks
  • A Santoni
  • F Cavani

Detail Information

Publications82

  1. ncbi The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide
    G B Stefano
    The Mind Body Medical Institute, CareGroup, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115, Boston, MA, USA
    Brain Res Brain Res Rev 35:1-19. 2001
    ..In closing, we conclude that enough scientific information exists to support these phenomena as actual physical processes that can be harnessed to provide better patient care...
  2. ncbi The biochemical substrate of nitric oxide signaling is present in primitive non-cognitive organisms
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 924:82-9. 2002
    ..We conclude that basal nitric oxide functioning was established in these organisms and that this molecule was later employed in man, including its involvement in cognitive neural processes...
  3. ncbi Vascular pulsations stimulating nitric oxide release during cyclic exercise may benefit health: a molecular approach (review)
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:119-29. 2001
    ..We conclude that mild exercise represents an alternate and economical therapy to preserve health and/or diminish the rate of decline of the normal physiological processes that may even be associated with aging...
  4. ncbi Cell surface estrogen receptors coupled to cNOS mediate immune and vascular tissue regulation: therapeutic implications
    G B Stefano
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 7:1066-74. 2001
    ....
  5. ncbi Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 793:341-5. 1998
    ..2+/-1.3 nM to 8.6+/-2.1 nM. Taken together, the results indirectly demonstrate the presence of anandamide amidase in these tissues, suggesting that the enzyme may serve as an endogenous regulator of anandamide action...
  6. ncbi Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury 11568, USA
    J Immunol 163:3758-63. 1999
    ..Taken together, a physiological dose of estrogen acutely stimulates NO release from human monocytes via the activation of an estrogen surface receptor that is coupled to increases in intracellular calcium...
  7. ncbi Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Int J Cardiol 64:S3-13. 1998
    ..Thus. the chemokinetic inducing activities of these agents may be the basis for excitotoxin liberation in neural tissues and/or a higher viral load in various organ systems since cellular adherence and random migration are stimulated...
  8. ncbi Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Brain Res 763:63-8. 1997
    ..We postulate that cannabinoids and their endogenous effectors play a prominent role in the regulation of catecholamine release in invertebrates via NO release as is the case for opiate alkaloids...
  9. ncbi Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Brain Res 753:219-24. 1997
    ..The presence of a cannabinoid receptor in these organisms indicates that this signaling system has been conserved during evolution...
  10. ncbi 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Pharmacol Res 42:317-22. 2000
    ..Taken together these results indicate that 2-AG exerts immune and vascular actions similar to those observed with anandamide...
  11. ncbi Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural mu 3 opiate receptor
    C M Rialas
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Acta Pharmacol Sin 21:516-20. 2000
    ..To determine if endomorphin-1, -2 and nociceptin (orphanin FQ) bind to the mu 3 opiate receptor subtype or release nitric oxide as mu 3 selective ligands do...
  12. ncbi Morphine coupling to invertebrate immunocyte nitric oxide release is dependent on intracellular calcium transients
    F E Nieto-Fernandez
    Neuroscience Research Institute, State University of New York at Old Westbury 11568 0210, USA
    Comp Biochem Physiol B Biochem Mol Biol 123:295-9. 1999
    ..The opiate stimulation of [Ca2+]i- was attenuated in cells leached of calcium. strongly suggesting that intracellular calcium levels regulate cNOS activity in invertebrate immunocytes...
  13. ncbi Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the micro(3) opiate receptor subtype: a hormonal role for endogenous morphine
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    J Physiol Pharmacol 55:279-88. 2004
    ..Taken together, we surmise morphine acts as a hormone to limit gut activity via micro(3) coupled to NO release since micro opiate receptors are found in the gut and endogenous morphine is not but is found in blood...
  14. ncbi Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:419-22. 2001
    ..14 da) yields morphine (286.14 Da) obtained from the heart tissues and with the authentic material, further demonstrating the presence of endogenous morphine. Thus, vascular tissues appear to contain endogenous opiate alkaloids...
  15. ncbi Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Blood 95:3951-8. 2000
    ..Blood. 2000;95:3951-3958)..
  16. ncbi Presence of morphine and morphine-6-glucuronide in the marine mollusk Mytilus edulis ganglia determined by GC/MS and Q-TOF-MS. Starvation increases opiate alkaloid levels
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 88:155-60. 2001
    ..These new method of opiate alkaloid detection, conclusively proves that morphine and morphine-6-glucuronide are present in animal tissues...
  17. ncbi Cell behavior and signal molecule involvement in a case study of malignant histiocytosis: a negative model of morphine as an immunoregulator
    G L Fricchione
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hematol 56:197-205. 1997
    ..Additionally, the data indicate that MCSF deregulation may be involved as an initiating factor for this disorder...
  18. ncbi The presence of morphine in ganglionic tissues of Modiolus deminissus: a highly sensitive method of quantitation for morphine and its derivatives
    Y Goumon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 86:184-8. 2001
    ..Furthermore, both morphine and morphine-6-glucuronide were identified in this mollusk's pedal ganglia by mass spectrometry analysis...
  19. ncbi Endogenous morphine: up-to-date review 2011
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Folia Biol (Praha) 58:49-56. 2012
    ..The implications of endogenous morphine coupling to nitric oxide regulation of mitochondrial function, with special reference to the cardiovascular system, are now formulated after many years of neglect...
  20. ncbi Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Westbury NY, 11568, USA
    Pharmacol Res 43:199-203. 2001
    ....
  21. ncbi Psychiatric implications of endogenous morphine: up-to-date review
    R M Kream
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568, USA
    Folia Biol (Praha) 56:231-41. 2010
    ....
  22. ncbi Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells
    P Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568-0210, USA
    Med Sci Monit 7:1123-8. 2001
    ..CONCLUSIONS: This study confirms that human mononuclear cells express the mu opiate receptor transcript and demonstrates that nitric oxide is involved in regulation of its expression...
  23. ncbi Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568 0210, USA
    Prog Neurobiol 60:513-30. 2000
    ..Taken together, cNOS derived NO enhances basal NO actions, i.e., cellular activation state, and these actions are further enhanced by iNOS derived NO...
  24. ncbi Dracunculus medinensis and Schistosoma mansoni contain opiate alkaloids
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Ann Trop Med Parasitol 96:309-16. 2002
    ....
  25. ncbi Cholinergic regulation of morphine release from human white blood cells: evidence for a novel nicotinic receptor via pharmacological and microarray analysis
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Immunopathol Pharmacol 20:229-37. 2007
    ..The number of variants suggests that indeed a novel nicotinic receptor may be mediating this effect, while simultaneously demonstrating the significance of the cholinergic receptor expression in these immune cells...
  26. ncbi HIV gp120 and morphine alter mu opiate receptor expression in human vascular endothelium
    P Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 8:165-9. 2001
    ..Therefore, the immune down-regulating action of morphine may prevent viral replication because this process requires immune activation that can, in part, be provided for by gp120 proinflammatory actions...
  27. ncbi Ischemic preconditioning - an opiate constitutive nitric oxide molecular hypothesis
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Med Sci Monit 7:1357-75. 2001
    ..In conclusion, it appears as though endogenous nitric oxide stimulators offer their selective preconditioning protection by joining an already existing process that limits activation following normal physical exertion...
  28. ncbi Morphine 6 glucuronide stimulates nitric oxide release in mussel neural tissues: evidence for a morphine 6 glucuronide opiate receptor subtype
    K Mantione
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Cell Mol Life Sci 59:570-4. 2002
    ..However, morphine exhibited a twofold higher affinity, again suggesting that a novel mu opiate receptor may be present...
  29. ncbi The stress response and autoimmunoregulation
    G L Fricchione
    Division of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Adv Neuroimmunol 4:13-27. 1994
    ..The study of immunocyte behavior in certain clinical conditions associated with a variant stress response may help illuminate the functioning of the neuroendocrine-neuroimmune stress response system...
  30. ncbi Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release
    C Fimiani
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Cancer Lett 146:45-51. 1999
    ..Our findings identify a unique role for the mu3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression...
  31. ncbi The presence of the mu3 opiate receptor in invertebrate neural tissues
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury 11568, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 113:369-73. 1996
    ..This view is supported by additional data, in particular the demonstration of endogenous morphine in nervous tissue and its localization within distinct neurons...
  32. ncbi Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide
    Anna Członkowska
    2nd Department of Neurology, Institute of Psychiatry and Neurology, Department of Clinical and Experimental Pharmacology, Medical University, Warsaw, Poland
    Med Sci Monit 8:RA165-77. 2002
    ..These observations suggest that treatment with anti-inflammatory drugs may act to slow progression of PD...
  33. ncbi Homeopathic ethanol
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 14:SC11-3. 2008
    ..Perturbation of this subtle regulatory relationship by exogenous intake of ethanol may shed light on the biochemical and molecular bases of reward and addictive states...
  34. ncbi Association between oxygen consumption and nitric oxide production during the relaxation response
    Jeffery A Dusek
    Mind Body Medical Institute, 824 Boylston Street, Chestnut Hill, MA 02467, USA
    Med Sci Monit 12:CR1-10. 2006
    ..We evaluated whether depth of RR elicitation was correlated with changes in NO, as measured by percentage changes in fractional exhaled nitric oxide (F(E)NO)...
  35. ncbi Morphine modulation of the ubiquitin-proteasome complex is neuroprotective
    Suraj Rambhia
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 11:BR386-96. 2005
    ....
  36. ncbi Morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for Alzheimer's disease
    Theodore Pak
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 11:BR357-66. 2005
    ..However, the exact role of the Abeta peptide in causing AD's symptoms is unclear...
  37. ncbi Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review)
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 16:621-30. 2005
    ..We conclude that constitutive nitric oxide may crucially contribute to potentially beneficial outcomes and effects in diverse pathologies, exerting a global healing effect...
  38. ncbi Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries
    Gregory Fricchione
    Department of Psychiatry, Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, 02114, USA
    Med Sci Monit 11:MS54-65. 2005
    ..In addition, mesolimbic/mesocortical control of the stress response systems may provide a way for the placebo response to benefit other medical conditions...
  39. ncbi Pain, immunity, opiate and opioid compounds and health
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Med Sci Monit 11:MS47-53. 2005
    ..Thus, morphine down regulates immune processes in addiction, an action/function that it appears to normally perform when the situation calls for this action and by so doing in this natural setting, sustains life...
  40. ncbi Endogenous morphine and ACTH association in neural tissues
    Dario Sonetti
    Department of Animal Biology, University of Modena and Reggio Emilia, Italy
    Med Sci Monit 11:MS22-30. 2005
    ..Their presence and function in "simple" animals, demonstrates their involvement in mechanisms underlying the stress response, preceding the mammalian neuroendocrine axis...
  41. ncbi Advances in endogenous morphine
    George B Stefano
    Med Sci Monit 11:ED1-1. 2005
  42. ncbi Morphine regulates gill ciliary activity via coupling to nitric oxide release in a bivalve mollusk: opiate receptor expression in gill tissues
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR195-200. 2006
    ..We hypothesized that morphinergic signaling may also take place in Mytilus edulis gill since they are innervated, in part, with dopamine nerves...
  43. ncbi Nitric oxide and anandamide in OMT research
    George B Stefano
    J Am Osteopath Assoc 106:588-9; author reply 589. 2006
  44. ncbi Nitric oxide's pulsatile release in lobster heart and its regulation by opiate signaling: pesticide interference
    Federico M Casares
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR373-378. 2006
    ....
  45. ncbi Anticipatory stress response: a significant commonality in stress, relaxation, pleasure and love responses
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 14:RA17-21. 2008
    ..Therefore, love and relaxation responses may be considered as intrinsic health promoting physiological capabilities...
  46. ncbi Endogenous morphine: opening new doors for the treatment of pain and addiction
    Stephen C Pryor
    State University of New York College at Old Westbury, Neuroscience Research Institute, Old Westbury, NY 11568, USA
    Expert Opin Biol Ther 5:893-906. 2005
    ..Taken together, a select morphinergic signalling system utilising NO opens the gate for the development of novel pharmaceuticals and/or the use of old pharmaceuticals in new ways...
  47. pmc Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology
    George B Stefano
    Neuroscience Research Institute, State University of New York SUNY College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Semin Cancer Biol 18:199-210. 2008
    ..Thus, it would appear that morphinergic signaling has inserted itself in many processes taking a long time to evolve, including those regulating the proliferation of cells across diverse phyla...
  48. doi Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Semin Cancer Biol 18:190-8. 2008
    ..Finally, structural similarities between the intracellular domains of mu3 opiate receptors and chemokine receptors CCR2 and CCR5 provide an additional chemical basis for these contentions...
  49. ncbi Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review)
    George B Stefano
    Neuroscience Research Institute, SUNY College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 20:837-41. 2007
    ....
  50. ncbi A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells
    Patrick Cadet
    Neuroscience Research Institute, State University of New York College, Old Westbury, NY 11568, USA
    J Immunol 179:5839-44. 2007
    ..Our data provide compelling evidence in support of both the evolutionary primacy and primordial regulatory role of mu(3)-like opiate receptor/NO signaling in embryogenesis...
  51. ncbi TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues
    Jeanette Cheng
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 13:BR163-7. 2007
    ..An extremely promising method for treatment of low to moderate levels of chronic pain in humans is transcutaneous electrical nerve stimulation (TENS)...
  52. ncbi Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Addict Biol 13:118-23. 2008
    ..Taken together, it appears that morphine has the ability to modulate its own synthesis via autocrine and paracrine signaling...
  53. ncbi Detection of nitric oxide in exhaled human breath: exercise and resting determinations
    Kirk J Mantione
    Kiernan Wellness Center, Rockaway Park, NY 11694, USA
    Med Sci Monit 13:MT1-5. 2007
    ..Nitric oxide has become a vital indicator of health since many cells produce it constitutively. It is present in exhaled breath and can be measured...
  54. ncbi Synthesis and pharmacological analysis of a morphine/substance P chimeric molecule with full analgesic potency in morphine-tolerant rats
    Richard M Kream
    Department of Biochemistry, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Med Sci Monit 13:BR25-31. 2007
    ....
  55. ncbi The American lobster, Homarus americanus, contains morphine that is coupled to nitric oxide release in its nervous and immune tissues: Evidence for neurotransmitter and hormonal signaling
    Federico M Casares
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 26:89-97. 2005
    ..In this regard, it was also important to determine if lobster immune and neural tissues express the mu opiate receptor subtype, which was coupled to constitutive nitric oxide synthase derived nitric oxide release...
  56. ncbi Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release
    Elliott Salamon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Acta Pharmacol Sin 26:389-95. 2005
    ..We begin with a brief anatomical and functional review of amygdalar function, and then proceed to demonstrate its relationship with NO...
  57. ncbi [Morphine affects the proliferation of tumour cells]
    Peter Olsen
    Anaestesiologisk lntensiv Afdeling N, Arhus Universitetshospital, Arhus Sygehus
    Ugeskr Laeger 166:4347-50. 2004
  58. ncbi Effects of cold stress on morphine-induced nitric oxide production and mu-opiate receptor gene expression in Mytilus edulis pedal ganglia
    Kirk Mantione
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Neuro Endocrinol Lett 24:68-72. 2003
    ..edulis ganglionic mu receptors exposed to morphine was coupled to the immediate release nitric oxide (NO). In this study, we measured morphine-induced NO release in M. edulis subjected to acute cold stress...
  59. ncbi Endocannabinoids as autoregulatory signaling molecules: coupling to nitric oxide and a possible association with the relaxation response
    George B Stefano
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Med Sci Monit 9:RA63-75. 2003
    ..e, norepinephrine. Here, a possible association of NO and endocannabinoid signaling with the relaxation response, a physiological counterpart of the stress response, may exist...
  60. ncbi The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men
    John J Cho
    Neuroscience Research Institute State University of New York Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 9:RA63-8. 2003
    ..Therapeutic strategies to preserve basal nitric oxide levels through the maintenance of normal physiological estradiol levels may confer cardiovascular benefits to aging males...
  61. ncbi Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Endocrinology 144:1234-40. 2003
    ..In summary, our results suggest that a physiological dose of estrogen acutely stimulates NO release within pedal ganglia via an estrogen cell surface receptor...
  62. ncbi Invertebrate opiate immune and neural signaling
    George B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury, USA
    Adv Exp Med Biol 521:126-47. 2003
  63. ncbi The therapeutic use of the relaxation response in stress-related diseases
    Tobias Esch
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Med Sci Monit 9:RA23-34. 2003
    ..Further studies are necessary to elucidate the complex physiology underlying the RR and its impact upon stress-related disease states...
  64. ncbi Stress-related diseases -- a potential role for nitric oxide
    Tobias Esch
    The Mind Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Med Sci Monit 8:RA103-18. 2002
    ..A failure to terminate or shift originally protective mechanisms may lead to a vicious cycle of disease-supporting pathophysiological pathways...
  65. ncbi Cyclic nitric oxide release by human granulocytes, and invertebrate ganglia and immunocytes: nano-technological enhancement of amperometric nitric oxide determination
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568 0210, USA
    Med Sci Monit 8:BR199-204. 2002
    ..Various tissues from vertebrates and invertebrates respond to external signal molecules by rapid release of nitric oxide (NO) mediated by constitutive nitric oxide synthase...
  66. ncbi Morphine down regulates human vascular tissue estrogen receptor expression determined by real-time RT-PCR
    Patrick Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 23:95-100. 2002
    ..Human vascular endothelial cells express the estrogen receptor-beta (ER-beta), which can be modulated by the opiate alkaloid morphine...
  67. ncbi The blueprint for stress can be found in invertebrates
    George B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 23:85-93. 2002
    ..Thus, it would appear that these responses evolved first in simpler organisms and were then maintained and enhanced during evolution...
  68. ncbi Cold stress alters Mytilus edulis pedal ganglia expression of mu opiate receptor transcripts determined by real-time RT-PCR and morphine levels
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res Mol Brain Res 99:26-33. 2002
    ..This study provides further evidence that mu-type opiate receptors and morphine are expressed in mollusk ganglia and appear to be involved in physiological processes responding to thermal stress...
  69. ncbi Sound therapy induced relaxation: down regulating stress processes and pathologies
    Elliott Salamon
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568, USA
    Med Sci Monit 9:RA96-RA101. 2003
    ..Furthermore we explore the interrelationship between the varying emotion centers within the central nervous system and explain how the introduction of music can mediate its effects via NO coupled to these complex pathways...
  70. ncbi Risk factors for breast cancer and the prognosis of African American women: estrogen's role
    Dolisha A Jones
    Neuroscience Research Institute, State University of New York College at Old Westbury, U S A
    Med Sci Monit 9:RA111-9. 2003
    ..By determining the relative concentration of estrogen and related proteins within black and white populations we hope to better understand the above mentioned disparity...
  71. ncbi Reticuline exposure to invertebrate ganglia increases endogenous morphine levels
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 25:323-30. 2004
    ....
  72. ncbi Presence of morphine in rat amygdala: evidence for the mu3 opiate receptor subtype via nitric oxide release in limbic structures
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 10:BR433-9. 2004
    ..We, and others, have also demonstrated the presence of opiate alkaloids as endogenous substances in various nerve tissues taken from mammals, man and invertebrates...
  73. ncbi Endogenous morphinergic signaling and tumor growth
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Front Biosci 9:3176-86. 2004
    ..This review will focus on the influence of opiate alkaloids, e.g., morphine, on tumor growth, with emphasis on immuno-regulatory and antiproliferative mechanisms...
  74. ncbi Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice
    Massimo Guarna
    Department of Anatomical and Biomedical Sciences, University of Siena, Italy
    Int J Neuropsychopharmacol 7:311-9. 2004
    ..These findings support a role for endogenous morphine in weakening memory processes under stress conditions...
  75. ncbi Nitric oxide as a possible mechanism for understanding the therapeutic effects of osteopathic manipulative medicine (Review)
    Elliott Salamon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 14:443-9. 2004
    ..These findings combined with the overwhelming amount of research into the beneficial effects of constitutive NO provide a dynamic theoretical framework to explain the therapeutic effects of OMM...
  76. ncbi Music alters constitutively expressed opiate and cytokine processes in listeners
    George B Stefano
    Long Island Conservatory, Albertson, NY, U S A
    Med Sci Monit 10:MS18-27. 2004
    ..Although these effects are robust, little research has been conducted into exploring the underlying neurochemical changes, which must occur to provide an individual with these objective sensations...
  77. ncbi Immunocytes modulate ganglionic nitric oxide release which later affects their activity level
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Neuro Endocrinol Lett 25:57-61. 2004
    ....
  78. ncbi Opiate alkaloids and nitric oxide production in the nematode Ascaris suum
    Wei Zhu
    State University of New York, Old Westbury Neuroscience Research Institute, P O Box 210, Old Westbury, New York 11568, USA
    J Parasitol 90:15-22. 2004
    ..This suggests that a novel mu opiate receptor was possibly present and selective toward M6G...
  79. ncbi A sub-nanomolar real-time nitric oxide probe: in vivo nitric oxide release in heart
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 10:MT47-9. 2004
    ..However, in the past, many probes suffered from a lack of sensitivity, durability and reliability, causing investigators to design numerous controls to support their data...
  80. ncbi Nitric oxide modulates microglial activation
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, U S A
    Med Sci Monit 10:BR17-22. 2004
    ..Little is known about the processes in neural tissues, which stabilize microglia. This study attempts to answer this question by demonstrating a role for basal NO in maintaining microglia juxtaposed to neurons...
  81. ncbi 17-beta estradiol down regulates ganglionic microglial cells via nitric oxide release: presence of an estrogen receptor beta transcript
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 24:130-6. 2003
    ..We also demonstrated the presence of estrogen signaling in Mytilus edulis ganglia. In the present report, we sought to determine a function for these ganglionic estrogen receptors, transcending a reproductive role for estrogen...
  82. ncbi Direct assessment and diminished production of morphine stimulated NO by diabetic endothelium from saphenous vein
    Thomas V Bilfinger
    Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19 080, Stony Brook, New York 11794 8191, USA
    Acta Pharmacol Sin 23:97-102. 2002
    ..To directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the mu opiate receptor, which has been linked with NO release...