Eike Staub

Summary

Affiliation: Merck KGaA

Publications

  1. pmc An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Mol Med (Berl) 87:633-44. 2009
  2. pmc Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 6:79. 2007
  3. pmc A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 5:37. 2006
  4. pmc An inventory of yeast proteins associated with nucleolar and ribosomal components
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Genome Biol 7:R98. 2006
  5. doi Predicting the site of origin of tumors by a gene expression signature derived from normal tissues
    E Staub
    Merck KGaA, Merck Serono, Drug Discovery Informatics, Darmstadt, Germany
    Oncogene 29:4485-92. 2010
  6. ncbi Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypes
    Juliane C Dohm
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, AG Protein Families and Cellular Evolution, Ihnestrasse 63 73, 14195, Berlin, Germany
    J Mol Evol 63:437-47. 2006
  7. ncbi Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12
    J Grone
    Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Hindenburgdamm 30, 12200, Berlin, Germany
    Int J Colorectal Dis 22:651-9. 2007
  8. ncbi The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome
    Yan Qin
    Max Planck Institut fur Molekulare Genetik, D 14195 Berlin, Germany
    Cell 127:721-33. 2006
  9. ncbi About the interrelation of evolutionary rate and protein age
    Hannes Luz
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    Genome Inform 17:240-50. 2006
  10. doi Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload
    Daniela Fliegner
    Institute of Gender in Medicine, Charité Medical University Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 298:R1597-606. 2010

Collaborators

Detail Information

Publications23

  1. pmc An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Mol Med (Berl) 87:633-44. 2009
    ....
  2. pmc Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 6:79. 2007
    ....
  3. pmc A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer
    Eike Staub
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
    Mol Cancer 5:37. 2006
    ..Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression...
  4. pmc An inventory of yeast proteins associated with nucleolar and ribosomal components
    Eike Staub
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Genome Biol 7:R98. 2006
    ..Phylogenetic profiling and gene expression analysis were carried out to shed light on evolutionary and regulatory aspects of nucleoli and ribosome assembly...
  5. doi Predicting the site of origin of tumors by a gene expression signature derived from normal tissues
    E Staub
    Merck KGaA, Merck Serono, Drug Discovery Informatics, Darmstadt, Germany
    Oncogene 29:4485-92. 2010
    ..We conclude that gene expression patterns of normal tissues harbor phenotypic information that is retained in tumors and can be sufficient to recover the type of primary tumor from expression patterns alone...
  6. ncbi Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypes
    Juliane C Dohm
    Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, AG Protein Families and Cellular Evolution, Ihnestrasse 63 73, 14195, Berlin, Germany
    J Mol Evol 63:437-47. 2006
    ..We argue that the traditional division of life into Prokaryota (non-chimeric) and Eukaryota (chimeric) is favorable compared to Woese's trichotomy into Archaea/Bacteria/Eukaryota...
  7. ncbi Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12
    J Grone
    Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Hindenburgdamm 30, 12200, Berlin, Germany
    Int J Colorectal Dis 22:651-9. 2007
    ..We performed an expression analysis of genes encoding tight junction proteins to display differential gene expression on RNA and protein level and to identify and validate potential targets for colorectal cancer (CRC) therapy...
  8. ncbi The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome
    Yan Qin
    Max Planck Institut fur Molekulare Genetik, D 14195 Berlin, Germany
    Cell 127:721-33. 2006
    ..We suggest renaming LepA as elongation factor 4 (EF4)...
  9. ncbi About the interrelation of evolutionary rate and protein age
    Hannes Luz
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
    Genome Inform 17:240-50. 2006
    ..We estimate time points of duplication events that gave rise to novel protein functions and show that younger proteins were duplicated more recently than older ones...
  10. doi Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload
    Daniela Fliegner
    Institute of Gender in Medicine, Charité Medical University Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 298:R1597-606. 2010
    ..Female sex offers protection against ventricular chamber dilation in the TAC model. Both female sex and ERbeta attenuate the development of fibrosis and apoptosis, thus slowing the progression to heart failure...
  11. ncbi Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III
    Joern Groene
    Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Berlin, Germany
    Int J Cancer 119:1829-36. 2006
    ....
  12. ncbi Genetic analysis of the LGI/Epitempin gene family in sporadic and familial lateral temporal lobe epilepsy
    A Ayerdi-Izquierdo
    Unitat de Genetica Molecular, Dept de Genòmica i Proteòmica, Institut de Biomedicina de València CSIC, Jaume Roig, 11 E46010 València, Spain
    Epilepsy Res 70:118-26. 2006
    ..No analyzed polymorphisms modified susceptibility in either the familial or sporadic forms of this partial epilepsy...
  13. ncbi Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungi
    Torsten Schwecke
    Institute of Chemistry, Technical University Berlin, Franklinstrasse 29, 10587 Berlin, Germany
    Chembiochem 7:612-22. 2006
    ..A phylogenetic analysis of both NRPSs and associated L-N5-ornithine monooxygenases revealed that ferrichrome-type siderophore biosynthesis has coevolved in fungi with varying in trans interactions of NRPS domains...
  14. ncbi Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome
    Eike Staub
    metaGen Pharmaceuticals GmbH, Oudenarderstr 16, 13347, Berlin, Germany
    Cell Signal 16:435-56. 2004
    ..We hypothesise that ITIM signalling is not restricted to immune cells, but also functions in diverse solid organs of mouse and man...
  15. ncbi ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer
    Marina Himmelfarb
    metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
    Cancer Lett 204:69-77. 2004
    ..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development...
  16. ncbi Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire
    Eike Staub
    metaGen Pharmaceuticals GmbH, Berlin, Germany
    Bioessays 26:567-81. 2004
    ..Supplementary material for this article can be found on the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
  17. pmc The SYSTERS Protein Family Database in 2005
    Thomas Meinel
    Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, 14195 Berlin, Germany
    Nucleic Acids Res 33:D226-9. 2005
    ..A new access point, PhyloMatrix, allows the retrieval of phylogenetic profiles of SYSTERS families across organisms with completely sequenced genomes...
  18. ncbi The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression
    Grit Kasper
    metaGen Pharmaceuticals GmbH i L, Oudenarderstr 16, 13347 Berlin, Germany
    Cancer Lett 224:93-103. 2005
    ....
  19. ncbi Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer
    Ingo Alldinger
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital, Dresden, Germany
    Pancreatology 5:370-9. 2005
    ..Using DNA gene expression analysis based on a custom made Affymetrix cancer array, we investigated the expression pattern of both primary and established pancreatic carcinoma cell lines...
  20. pmc Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2
    Petra Seemann
    Institut fur Medizinische Genetik, Charite, Universitatsmedizin Berlin, Berlin, Germany
    J Clin Invest 115:2373-81. 2005
    ..The presented experiments have identified some of the main determinants of GDF5 receptor-binding specificity in vivo and open new prospects for generating antagonists and superagonists of GDF5...
  21. ncbi Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Clinic Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Pancreatology 3:169-78. 2003
    ..Identification of these genes is essential for understanding the molecular events in the development of PaCa...
  22. ncbi Gene expression profiles of microdissected pancreatic ductal adenocarcinoma
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Germany
    Virchows Arch 443:508-17. 2003
    ..In conclusion, using microarray technology we were able to identify a set of genes whose aberrant expression was associated with PDAC and may be used to target the disease...
  23. ncbi Different structural organization of the encephalopsin gene in man and mouse
    Grit Kasper
    metaGen Pharmaceuticals, Oudenarderstrasse 16, 13347 Berlin, Germany
    Gene 295:27-32. 2002
    ..e. the number of genes within a certain cluster may differ between man and mouse. OPN3 provides an exception to this rule, since it is positionally uncoupled from other genes of the opsin family...