Research Topics
Genomes and Genes | Eike StaubSummaryAffiliation: Merck KGaA Publications
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Publications
An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor typesEike Staub
Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
J Mol Med (Berl) 87:633-44. 2009....- Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumorsEike Staub
Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
Mol Cancer 6:79. 2007.... - A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancerEike Staub
Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Berlin, Germany
Mol Cancer 5:37. 2006..Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression... - An inventory of yeast proteins associated with nucleolar and ribosomal componentsEike Staub
Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
Genome Biol 7:R98. 2006..Phylogenetic profiling and gene expression analysis were carried out to shed light on evolutionary and regulatory aspects of nucleoli and ribosome assembly... 
Predicting the site of origin of tumors by a gene expression signature derived from normal tissuesE Staub
Merck KGaA, Merck Serono, Drug Discovery Informatics, Darmstadt, Germany
Oncogene 29:4485-92. 2010..We conclude that gene expression patterns of normal tissues harbor phenotypic information that is retained in tumors and can be sufficient to recover the type of primary tumor from expression patterns alone...
Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypesJuliane C Dohm
Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, AG Protein Families and Cellular Evolution, Ihnestrasse 63-73, 14195, Berlin, Germany
J Mol Evol 63:437-47. 2006..We argue that the traditional division of life into Prokaryota (non-chimeric) and Eukaryota (chimeric) is favorable compared to Woese's trichotomy into Archaea/Bacteria/Eukaryota...- Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12J Grone
Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Hindenburgdamm 30, 12200, Berlin, Germany
Int J Colorectal Dis 22:651-9. 2007..We performed an expression analysis of genes encoding tight junction proteins to display differential gene expression on RNA and protein level and to identify and validate potential targets for colorectal cancer (CRC) therapy... - The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosomeYan Qin
Max Planck Institut fur Molekulare Genetik, D 14195 Berlin, Germany
Cell 127:721-33. 2006..We suggest renaming LepA as elongation factor 4 (EF4)... - About the interrelation of evolutionary rate and protein ageHannes Luz
Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
Genome Inform 17:240-50. 2006..We estimate time points of duplication events that gave rise to novel protein functions and show that younger proteins were duplicated more recently than older ones... - Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overloadDaniela Fliegner
Institute of Gender in Medicine, Charité Medical University Berlin, Germany
Am J Physiol Regul Integr Comp Physiol 298:R1597-606. 2010..Female sex offers protection against ventricular chamber dilation in the TAC model. Both female sex and ERbeta attenuate the development of fibrosis and apoptosis, thus slowing the progression to heart failure... - Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and IIIJoern Groene
Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Berlin, Germany
Int J Cancer 119:1829-36. 2006.... - Genetic analysis of the LGI/Epitempin gene family in sporadic and familial lateral temporal lobe epilepsyA Ayerdi-Izquierdo
Unitat de Genetica Molecular, Dept de Genòmica i Proteòmica, Institut de Biomedicina de València CSIC, Jaume Roig, 11 E46010 València, Spain
Epilepsy Res 70:118-26. 2006..No analyzed polymorphisms modified susceptibility in either the familial or sporadic forms of this partial epilepsy... - Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungiTorsten Schwecke
Institute of Chemistry, Technical University Berlin, Franklinstrasse 29, 10587 Berlin, Germany
Chembiochem 7:612-22. 2006..A phylogenetic analysis of both NRPSs and associated L-N5-ornithine monooxygenases revealed that ferrichrome-type siderophore biosynthesis has coevolved in fungi with varying in trans interactions of NRPS domains... - Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteomeEike Staub
metaGen Pharmaceuticals GmbH, Oudenarderstr 16, 13347, Berlin, Germany
Cell Signal 16:435-56. 2004..We hypothesise that ITIM signalling is not restricted to immune cells, but also functions in diverse solid organs of mouse and man... - ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancerMarina Himmelfarb
metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
Cancer Lett 204:69-77. 2004..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development... - Insights into the evolution of the nucleolus by an analysis of its protein domain repertoireEike Staub
metaGen Pharmaceuticals GmbH, Berlin, Germany
Bioessays 26:567-81. 2004..Supplementary material for this article can be found on the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html... - The SYSTERS Protein Family Database in 2005Thomas Meinel
Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany
Nucleic Acids Res 33:D226-9. 2005..A new access point, PhyloMatrix, allows the retrieval of phylogenetic profiles of SYSTERS families across organisms with completely sequenced genomes... - The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progressionGrit Kasper
metaGen Pharmaceuticals GmbH i L, Oudenarderstr 16, 13347 Berlin, Germany
Cancer Lett 224:93-103. 2005.... - Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancerIngo Alldinger
Department of Visceral, Thoracic- and Vascular Surgery, University Hospital, Dresden, Germany
Pancreatology 5:370-9. 2005..CONCLUSION: Using gene expression profiling of pancreatic cell lines we were able to identify genes differentially expressed in pancreatic adenocarcinoma, which might contribute to pancreatic cancer development... - Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2Petra Seemann
Institut fur Medizinische Genetik, Charite, Universitatsmedizin Berlin, Berlin, Germany
J Clin Invest 115:2373-81. 2005..The presented experiments have identified some of the main determinants of GDF5 receptor-binding specificity in vivo and open new prospects for generating antagonists and superagonists of GDF5... - Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreasRobert Grutzmann
Department of Visceral, Thoracic and Vascular Surgery, University Clinic Carl Gustav Carus, Technical University Dresden, Dresden, Germany
Pancreatology 3:169-78. 2003..Identification of these genes is essential for understanding the molecular events in the development of PaCa... - Gene expression profiles of microdissected pancreatic ductal adenocarcinomaRobert Grutzmann
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Germany
Virchows Arch 443:508-17. 2003..In conclusion, using microarray technology we were able to identify a set of genes whose aberrant expression was associated with PDAC and may be used to target the disease... - Different structural organization of the encephalopsin gene in man and mouseGrit Kasper
metaGen Pharmaceuticals, Oudenarderstrasse 16, 13347 Berlin, Germany
Gene 295:27-32. 2002..e. the number of genes within a certain cluster may differ between man and mouse. OPN3 provides an exception to this rule, since it is positionally uncoupled from other genes of the opsin family...