William B Stallcup

Summary

Publications

  1. pmc Cell proliferation along vascular islands during microvascular network growth
    Molly R Kelly-Goss
    Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA
    BMC Physiol 12:7. 2012
  2. doi request reprint Bidirectional myoblast-pericyte plasticity
    William B Stallcup
    Tumor Microenvironment Program, Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Cell 24:563-4. 2013
  3. pmc Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
    Krissa Gibby
    Cancer Center, Tumor Microenvironment Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA
    Breast Cancer Res 14:R67. 2012
  4. pmc Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration
    Irwan T Makagiansar
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:155-65. 2007
  5. pmc Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse
    Feng Ju Huang
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA
    Dev Biol 344:1035-46. 2010
  6. ncbi request reprint Molecular basis of interaction between NG2 proteoglycan and galectin-3
    Yunfei Wen
    Burnham Institute, Developmental Neurobiology Program, La Jolla, California 92037, USA
    J Cell Biochem 98:115-27. 2006
  7. pmc NG2 proteoglycan expression in mouse skin: altered postnatal skin development in the NG2 null mouse
    Kuniko Kadoya
    Burnham Institute for Medical Research, La Jolla, California, USA
    J Histochem Cytochem 56:295-303. 2008
  8. doi request reprint FGF2-dependent neovascularization of subcutaneous Matrigel plugs is initiated by bone marrow-derived pericytes and macrophages
    Ulrich Tigges
    Burnham Institute for Medical Research, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 135:523-32. 2008
  9. ncbi request reprint Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility
    Irwan T Makagiansar
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:55262-70. 2004
  10. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004

Collaborators

Detail Information

Publications29

  1. pmc Cell proliferation along vascular islands during microvascular network growth
    Molly R Kelly-Goss
    Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA
    BMC Physiol 12:7. 2012
    ..The objective of this study was to determine if vascular islands are involved in angiogenesis during microvascular network growth...
  2. doi request reprint Bidirectional myoblast-pericyte plasticity
    William B Stallcup
    Tumor Microenvironment Program, Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Cell 24:563-4. 2013
    ..Cappellari et al. (2013) report in this issue of Developmental Cell that myoblasts can return the favor by generating pericytes via the action of Dll4 Notch ligand and PDGF-BB...
  3. pmc Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
    Krissa Gibby
    Cancer Center, Tumor Microenvironment Program, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA
    Breast Cancer Res 14:R67. 2012
    ....
  4. pmc Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migration
    Irwan T Makagiansar
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:155-65. 2007
    ..Thus, phosphorylation and the resulting site of NG2-integrin localization may determine the specific downstream effects of integrin signaling...
  5. pmc Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse
    Feng Ju Huang
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA
    Dev Biol 344:1035-46. 2010
    ..These findings demonstrate the importance of NG2-dependent pericyte/endothelial cell interaction in the development and maturation of tumor blood vessels, identifying NG2 as a potential target for anti-angiogenic cancer therapy...
  6. ncbi request reprint Molecular basis of interaction between NG2 proteoglycan and galectin-3
    Yunfei Wen
    Burnham Institute, Developmental Neurobiology Program, La Jolla, California 92037, USA
    J Cell Biochem 98:115-27. 2006
    ..These studies establish a foundation for attempts to reduce the aggressive properties of tumor cells by disrupting the NG2/galectin-3 interaction...
  7. pmc NG2 proteoglycan expression in mouse skin: altered postnatal skin development in the NG2 null mouse
    Kuniko Kadoya
    Burnham Institute for Medical Research, La Jolla, California, USA
    J Histochem Cytochem 56:295-303. 2008
    ..Thickening of the subcutis is also delayed in NG2 null skin due to deficiencies in the adipocyte population...
  8. doi request reprint FGF2-dependent neovascularization of subcutaneous Matrigel plugs is initiated by bone marrow-derived pericytes and macrophages
    Ulrich Tigges
    Burnham Institute for Medical Research, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 135:523-32. 2008
    ....
  9. ncbi request reprint Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility
    Irwan T Makagiansar
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:55262-70. 2004
    ..PKC-alpha-mediated NG2 phosphorylation at Thr(2256) is therefore a key step for initiating cell polarization and motility...
  10. pmc NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:3580-90. 2004
    ....
  11. pmc Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, La Jolla, California, USA
    Angiogenesis 7:269-76. 2004
    ..These experiments therefore demonstrate both the functional importance of NG2 in pericyte development and the feasibility of using pericytes as anti-angiogenic targets...
  12. ncbi request reprint Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis
    Michaela Thallmair
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Neurol 202:167-78. 2006
    ..These results suggest that the null mutation for NG2 does not influence adult hippocampal neurogenesis or hippocampal-dependent behavioral tasks...
  13. pmc Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord
    Karolina Kucharova
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Neuroinflammation 8:158. 2011
    ..The NG2 proteoglycan is expressed by OPCs, pericytes, and macrophages/microglia. In this report we investigate the effects of NG2 on these cell types during spinal cord demyelination/remyelination...
  14. pmc Early contribution of pericytes to angiogenic sprouting and tube formation
    Ugur Ozerdem
    La Jolla Institute for Molecular Medicine, Vascular Biology Division, 4570 Executive Drive, Suite 100, La Jolla, CA 92121, USA
    Angiogenesis 6:241-9. 2003
    ..The ability to study these precocious contributions of pericytes to neovascularization depends heavily on the use of NG2 and PDGF beta -receptor as reliable early markers for activated pericytes...
  15. pmc Collagen VI ablation retards brain tumor progression due to deficits in assembly of the vascular basal lamina
    Weon Kyoo You
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, California 92037, USA
    Am J Pathol 180:1145-58. 2012
    ..Overall, these vascular deficits produced a twofold decrease in tumor volume in collagen VI-null mice, confirming that collagen VI-dependent basal lamina assembly is a critical aspect of vessel development...
  16. pmc A role for the NG2 proteoglycan in glioma progression
    William B Stallcup
    Burnham Institute for Medical Research, Cancer Research Center, La Jolla, California 92037, USA
    Cell Adh Migr 2:192-201. 2008
    ..These molecular interactions allow the proteoglycan to contribute to critical processes such as cell proliferation, cell motility and cell survival...
  17. ncbi request reprint Differential responses of spinal axons to transection: influence of the NG2 proteoglycan
    Romulo de Castro
    Developmental Neurobiology Program, The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Neurol 192:299-309. 2005
    ..This work therefore emphasizes the importance of including in vivo models in evaluating the responses of specific types of neurons to spinal cord injury...
  18. pmc Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity
    Yunchao Chang
    Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e30637. 2012
    ..As a consequence, obesity in NG2 null mice may occur due to disruptions in brown fat-dependent energy homeostasis, with resulting effects on lipid storage in white adipocytes...
  19. pmc Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects
    Yoshihiro Matsumoto
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:19227-34. 2010
    ..Together, our results show that HS is essential for patterning of limb skeletal elements and that BMP signaling is one of the major targets for the regulatory role of HS in this developmental context...
  20. ncbi request reprint Expression of NG2 proteoglycan during endochondral and intramembranous ossification
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 228:143-8. 2003
    ..Our results indicate that NG2 expression is up-regulated during both endochondral and intramembranous ossification, but is down-regulated as ossification is completed...
  21. pmc Adventitial pericyte progenitor/mesenchymal stem cells participate in the restenotic response to arterial injury
    Ulrich Tigges
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA utigges gmail com
    J Vasc Res 50:134-44. 2013
    ..These cells are different from myofibroblasts, smooth muscle cells, and other progenitor populations that have been shown to participate in the restenotic process...
  22. pmc An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and
    Marcia I Dawson
    Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 50:2622-39. 2007
    ..3-Cl-AHPC at 1.0 microM induced human microvascular endothelial cell apoptosis but did not inhibit cell migration or tube formation...
  23. ncbi request reprint The NG2 proteoglycan: past insights and future prospects
    William B Stallcup
    The Burnham Institute, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurocytol 31:423-35. 2002
    ..This research suggests that interaction of NG2 with extracellular and intracellular ligands regulates signaling events that are important for both cell proliferation and cell migration...
  24. ncbi request reprint Plastic casting of embryonic, placental, and tumor vasculature in the mouse
    Ugur Ozerdem
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Microvasc Res 64:486-90. 2002
  25. ncbi request reprint Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
    Mei Liu
    Program in Signal Transduction Research, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 65:5325-36. 2005
    ....
  26. ncbi request reprint NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors
    Leonard L Jones
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 22:2792-803. 2002
    ..Thus, NG2 is a major component of this putatively inhibitory class of ECM molecules expressed at sites of SCI and may restrict axonal regeneration...
  27. doi request reprint A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  28. ncbi request reprint Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas
    Mousumi Majumdar
    The Burnham Institute, Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 15:79-84. 2003
    ..Formation of lamellipodia on the N143-coated surfaces is also inhibited by transfection of the dominant negative CasdeltaSD construct. This result implicates p130cas as an additional functional player in NG2-mediated cell spreading...
  29. ncbi request reprint NG2 proteoglycan expression by pericytes in pathological microvasculature
    Ugur Ozerdem
    Cancer Research Center, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Microvasc Res 63:129-34. 2002