M Srinivasan

Summary

Publications

  1. ncbi request reprint Influence of ferulic acid on gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Toxicology 228:249-58. 2006
  2. ncbi request reprint Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro
    M Srinivasan
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Biochim Biophys Acta 1770:659-65. 2007
  3. doi request reprint Lycopene: An antioxidant and radioprotector against gamma-radiation-induced cellular damages in cultured human lymphocytes
    M Srinivasan
    Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India
    Toxicology 262:43-9. 2009
  4. doi request reprint Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes
    K B Kalpana
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Mutat Res 676:54-61. 2009
  5. doi request reprint Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Chem Biol Interact 176:1-8. 2008
  6. ncbi request reprint Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Mutat Res 611:96-103. 2006
  7. doi request reprint Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane
    K B Kalpana
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India
    Mol Cell Biochem 323:21-9. 2009
  8. ncbi request reprint Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study
    N Devipriya
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Singapore Med J 48:311-8. 2007
  9. ncbi request reprint Protective effect of ferulic acid on gamma-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes
    N Rajendra Prasad
    Department of Biochemistry, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Mutat Res 603:129-34. 2006
  10. doi request reprint Antioxidant potential of aminothiazole derivative and its protective effect on H(2)O(2)-induced oxidative damage on pBR322 DNA and RBC cellular membrane
    K B Kalpana
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    Mol Cell Biochem 314:95-103. 2008

Collaborators

  • Venugopal P Menon
  • K B Kalpana
  • Ponnian Stanely Mainzen Prince
  • N Rajendra Prasad
  • R Rajaram
  • I Sathyamurthy
  • David C Gritz
  • P Vijayalakshmi
  • K Kathiresan
  • N Devipriya
  • A Vinodhkumaradithyaa
  • S S Iyengar
  • G Athappan
  • S Bragadeeswaran
  • R Ramakrishnan
  • Jayahar M Bharathi
  • M Jayahar Bharathi
  • R Meenakshi
  • S Padmavathy
  • Steven L Mansberger
  • John F Warren
  • S Rathinam
  • U Jadhav
  • V K Katiyal
  • Kamaldeep Chawla
  • J S Hiremath
  • P K Sahoo
  • R K Jain
  • D Kumbla
  • Tiny Nair
  • I Ananthalakshmi
  • L Jeyaseelan
  • P Thirumalaikolundusubramanian
  • R V Jeba Rajasekhar
  • David Pradeep Kumar
  • T Ponniah
  • Tennyson Daniel
  • U Kanaga Rajan
  • C Shivakumar
  • A R Sudheer
  • Prajna N Lalitha
  • M Rajasegar
  • A Ram Sudheer
  • Usha Kim
  • V Balamurugan
  • John H Wilkins
  • Chris A Johnson
  • Dongseok Choi
  • Scott D Smith
  • George A Cioffi
  • S R Krishnadas
  • Eugene J Thonar
  • Anthony J Aldave
  • John P Whitcher
  • Abha B Kumar
  • Vicky Cevallos
  • Todd P Margolis
  • R W Read
  • N A Rao
  • R Gautom
  • T R Fritsche
  • P Namperumalsamy

Detail Information

Publications28

  1. ncbi request reprint Influence of ferulic acid on gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Toxicology 228:249-58. 2006
    ..Thus, pretreatment with FA helps in protecting the hepatocytes against gamma-radiation induced cellular damage and can be developed as a effective radioprotector during radiotherapy...
  2. ncbi request reprint Lycopene as a natural protector against gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes in vitro
    M Srinivasan
    Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Biochim Biophys Acta 1770:659-65. 2007
    ..31 muM of lycopene pretreatment. Thus, our results show that pretreatment with lycopene offers protection against gamma-radiation induced cellular damage and can be developed as an effective radioprotector during radiotherapy...
  3. doi request reprint Lycopene: An antioxidant and radioprotector against gamma-radiation-induced cellular damages in cultured human lymphocytes
    M Srinivasan
    Department of Biochemistry and Biotechnology, Annamalai University, Tamil Nadu, India
    Toxicology 262:43-9. 2009
    ..The dose of 5microg/ml of lycopene was found to be more effective than the other two doses. Thus, our result shows that pretreatment with lycopene offers protection to normal lymphocytes against gamma-radiation-induced cellular damage...
  4. doi request reprint Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes
    K B Kalpana
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Mutat Res 676:54-61. 2009
    ..Thus the current study shows HN to be an effective radioprotector against gamma-radiation induced in-vitro cellular damage in lymphocytes...
  5. doi request reprint Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Chem Biol Interact 176:1-8. 2008
    ..The maximum protection of hepatocytes was observed at 6.91 microM of curcumin analog pretreatment. Thus, our result shows that pretreatment with curcumin analog protects the hepatocytes against gamma-radiation-induced cellular damage...
  6. ncbi request reprint Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Mutat Res 611:96-103. 2006
    ..Thus, pretreatment with curcumin gives protection to lymphocytes against gamma-radiation induced cellular damage...
  7. doi request reprint Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane
    K B Kalpana
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India
    Mol Cell Biochem 323:21-9. 2009
    ..Thus, our result proves hesperidin to be a valuable antioxidant that protects pBR322 DNA and RBC cellular membrane from free radical induced oxidative damage...
  8. ncbi request reprint Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study
    N Devipriya
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Singapore Med J 48:311-8. 2007
    ..Our aim was to investigate, in vivo, the antioxidant potential of ellagic acid against oxidative stress induced by alcohol intoxication...
  9. ncbi request reprint Protective effect of ferulic acid on gamma-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes
    N Rajendra Prasad
    Department of Biochemistry, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Mutat Res 603:129-34. 2006
    ..Pretreatment with 10 microg/ml of FA significantly (p<0.05) prevented the decreases in the radiation-induced GSH, SOD, CAT and GPx activities. These findings suggest potential use and benefit of FA as a radioprotector...
  10. doi request reprint Antioxidant potential of aminothiazole derivative and its protective effect on H(2)O(2)-induced oxidative damage on pBR322 DNA and RBC cellular membrane
    K B Kalpana
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    Mol Cell Biochem 314:95-103. 2008
    ....
  11. ncbi request reprint Ferulic acid, a natural protector against carbon tetrachloride-induced toxicity
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Fundam Clin Pharmacol 19:491-6. 2005
    ..Administration of FA to normal rats did not produce any harmful effects. Thus our results show that FA is an effective antioxidant without any side-effects and may be a great gain in the current search for natural therapy...
  12. ncbi request reprint Modulatory effects of curcumin on γ-radiation-induced cellular damage in primary culture of isolated rat hepatocytes
    M Srinivasan
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Environ Toxicol Pharmacol 24:98-105. 2007
    ..Thus, pretreatment with curcumin helps in protecting the hepatocytes against γ-radiation-induced cellular damage and can be developed as an effective radioprotector during radiotherapy in near future...
  13. ncbi request reprint Efficacy and safety of tenecteplase in ST elevation myocardial infarction patients from the Elaxim Indian Registry
    S S Iyengar
    Department of Cardiology, St John s Medical College and Hospital, Bangalore, Karnataka, India
    Indian Heart J 61:480-1. 2009
    ..to study the efficacy and safety of indigenously developed tenecteplase injection in the management of Indian STEMI patients in clinical practice...
  14. ncbi request reprint Noise levels in a tertiary care hospital
    A Vinodhkumaradithyaa
    Department of Medicine, Madurai Medical College, Madurai 20, India
    Noise Health 10:11-3. 2008
    ..The morning hours showed higher levels of noise in most of the places probably due to overcrowding and higher vehicular movement. This study highlights the need for noise monitoring and control measures inside hospital areas...
  15. ncbi request reprint Meta-analysis of 5-year outcomes of CABG vs PCI with stenting in patients with multivessel disease
    G Athappan
    Caritas St Elizabeth Medical Center, Tufts School of Medicine, Boston, MA 02135, USA
    Minerva Cardioangiol 56:453-60. 2008
    ....
  16. ncbi request reprint Effect of Ellagic Acid, a Plant Polyphenol, on Fibrotic Markers (MMPs and TIMPs) during Alcohol-Induced Hepatotoxicity
    N Devipriya
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India
    Toxicol Mech Methods 17:349-56. 2007
    ..These results suggest that EA at the dosage of 60 mg/kg body weight effectively decreased the expression pattern of fibrotic markers during alcohol-induced toxicity. Hence, it can be developed as an antifibrotic compound in near future...
  17. ncbi request reprint Effect of aqueous Enicostemma littorale Blume extract on key carbohydrate metabolic enzymes, lipid peroxides and antioxidants in alloxan-induced diabetic rats
    M Srinivasan
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India 608002
    J Pharm Pharmacol 57:497-503. 2005
    ..Insulin (6 units kg(-1)) normalized all the parameters in diabetic rats. Our study has provided evidence for the antidiabetic activity of E. littorale aqueous extract. This study can also be extrapolated to clinical studies in future...
  18. ncbi request reprint Sediment texture and nutrients of Arasalar estuary, Karaikkal, south-east coast of India
    S Bragadeeswaran
    Centre of Advanced Study in Marine Biology, Annamalai University, Parangipettai 608 502, India
    J Environ Biol 28:237-40. 2007
    ..Whereas, at station 3, clay was observed in summer and premonsoon and then it shifted to sandy loam type soil during monsoon. Sediment nutrients were lower than that of values of various ecosystem of India...
  19. ncbi request reprint Seasonal distribution of physico- chemical parameters in effluent discharge area of Uppanar estuary, Cuddalore, south-east coast of India
    R Rajaram
    Center of Advanced Study in Marine Biology, Annamalai University, Parangipettai 608 502, India
    J Environ Biol 26:291-7. 2005
    ..In the present study, the physico-chemical characteristic of Uppanar estuary carried out and variations are discussed...
  20. ncbi request reprint Fungal keratitis
    M Srinivasan
    Aravind Eye Care System, Tamil Nadu, India
    Curr Opin Ophthalmol 15:321-7. 2004
    ..Throughout the world, fungal keratitis is a leading cause of ocular morbidity. The purpose of this review is to discuss the recently published literature in relation to the epidemiology, etiology, diagnosis, and therapy of fungal keratitis...
  21. pmc Corneal ulceration in south-east Asia III: prevention of fungal keratitis at the village level in south India using topical antibiotics
    M Srinivasan
    Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
    Br J Ophthalmol 90:1472-5. 2006
    ..To determine whether topical antifungal prophylaxis distributed by paid village health workers (VHWs) in south India is necessary after corneal abrasion to prevent fungal keratitis in a population where half of the ulcers are fungal...
  22. pmc The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India
    D C Gritz
    Francis I Proctor Foundation for Research in Opthalmology and the Department of Opthalmology, University of California San Francisco, San Francisco, CA, USA
    Br J Ophthalmol 90:847-51. 2006
    ..To determine if antioxidant supplements (beta carotene and vitamins C and E) can decrease the progression of cataract in rural South India...
  23. ncbi request reprint Microbial keratitis in South India: influence of risk factors, climate, and geographical variation
    M Jayahar Bharathi
    Department of Microbiology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, South India
    Ophthalmic Epidemiol 14:61-9. 2007
    ..To determine the influence of risk factors, climate, and geographical variation on the microbial keratitis in South India...
  24. ncbi request reprint A study of the spectrum of Acanthamoeba keratitis: a three-year study at a tertiary eye care referral center in South India
    Jayahar M Bharathi
    Microbiology Research Centre, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu 627 001, India
    Indian J Ophthalmol 55:37-42. 2007
    ..To determine the epidemiological and clinical characteristics of Acanthamoeba keratitis and also to determine the sensitivity and specificity of smears in the detection of Acanthamoeba...
  25. ncbi request reprint Infective keratitis: a challenge to Indian ophthalmologists
    M Srinivasan
    Indian J Ophthalmol 55:5-6. 2007
  26. ncbi request reprint Predictive value of frequency doubling technology perimetry for detecting glaucoma in a developing country
    Steven L Mansberger
    Devers Eye Institute Discoveries In Sight, Portland, Oregon 97210, USA
    J Glaucoma 14:128-34. 2005
    ..To determine the feasibility and diagnostic precision of Frequency Doubling Technology (FDT) perimetry as a method to detect glaucoma in rural villages of a developing country...
  27. ncbi request reprint Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India
    John F Warren
    Francis I Proctor Foundation and the Department of Ophthalmology, University of California San Francisco, 94143 0944, USA
    Arch Ophthalmol 121:1608-12. 2003
    ..To further characterize the role of the carbohydrate sulfotransferase (CHST6) gene in macular corneal dystrophy (MCD) through identification of causative mutations in a cohort of affected patients from southern India...
  28. ncbi request reprint An outbreak of trematode-induced granulomas of the conjunctiva
    S Rathinam
    Aravind Eye Hospital, Madurai, India. Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Ophthalmology 108:1223-9. 2001
    ..Sporadic cases from other parts of the state with similar histories of exposure to their local pond or river water suggest a widespread distribution of the etiologic agent...