Alagarsamy Srinivasan

Summary

Publications

  1. pmc Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells
    Debjani Guha
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    J Neuroinflammation 9:138. 2012
  2. pmc A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes
    Alagarsamy Srinivasan
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 5:99. 2008
  3. ncbi request reprint The role of Vpr in the regulation of HIV-1 gene expression
    Jianqi Cui
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cell Cycle 5:2626-38. 2006
  4. ncbi request reprint Role of HIV-1 Vpr in AIDS pathogenesis: relevance and implications of intravirion, intracellular and free Vpr
    Parithosh K Tungaturthi
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, JAH Rm 461, Philadelphia, PA 19107, USA
    Biomed Pharmacother 57:20-4. 2003
  5. ncbi request reprint HIV-1 Vpr: genetic diversity and functional features from the perspective of structure
    Parithosh K Tungaturthi
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 23:207-22. 2004
  6. ncbi request reprint Mutational analysis reveals an essential role for the LXXLL motif in the transformation function of the human herpesvirus-8 oncoprotein, kaposin
    Brian Tomkowicz
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 24:10-20. 2005
  7. pmc Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis
    Edward A Acheampong
    The Dorrance H, Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, PA 19107, USA
    Virol J 6:183. 2009
  8. pmc Effect of the V3 loop deletion of envelope glycoprotein on cellular responses and protection against challenge with recombinant vaccinia virus expressing gp160 of primary human immunodeficiency virus type 1 isolates
    Irena Kiszka
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Virol 76:4222-32. 2002
  9. ncbi request reprint Human herpesvirus-8 encoded Kaposin: subcellular localization using immunofluorescence and biochemical approaches
    Brian Tomkowicz
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 21:151-62. 2002

Collaborators

Detail Information

Publications9

  1. pmc Neuronal apoptosis by HIV-1 Vpr: contribution of proinflammatory molecular networks from infected target cells
    Debjani Guha
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    J Neuroinflammation 9:138. 2012
    ..The objective of this study was to assess the effect of Vpr in the context of infectious virus particles on neuronal death through proinflammatory cytokines released from macrophages...
  2. pmc A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes
    Alagarsamy Srinivasan
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virol J 5:99. 2008
    ..The available data on naturally occurring polymorphisms will be useful to assess their potential effect on the structural and functional constraints of Vpr and also on the fitness of HIV-1 for replication...
  3. ncbi request reprint The role of Vpr in the regulation of HIV-1 gene expression
    Jianqi Cui
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cell Cycle 5:2626-38. 2006
    ..These observations reveal a new cellular partner for Vpr, and provide a new therapeutic avenue for controlling HIV-1 expression...
  4. ncbi request reprint Role of HIV-1 Vpr in AIDS pathogenesis: relevance and implications of intravirion, intracellular and free Vpr
    Parithosh K Tungaturthi
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, JAH Rm 461, Philadelphia, PA 19107, USA
    Biomed Pharmacother 57:20-4. 2003
    ..These results led us to propose a model for the role of Vpr in AIDS pathogenesis...
  5. ncbi request reprint HIV-1 Vpr: genetic diversity and functional features from the perspective of structure
    Parithosh K Tungaturthi
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 23:207-22. 2004
    ..This is an area which, we hope, will attract investigators for further studies, and may provide information for understanding the molecular basis of Vpr functions...
  6. ncbi request reprint Mutational analysis reveals an essential role for the LXXLL motif in the transformation function of the human herpesvirus-8 oncoprotein, kaposin
    Brian Tomkowicz
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 24:10-20. 2005
    ..Ironically, both Kap-FL and Kap-AXXAAFL were able to activate the AP-1 promoter. These results support an important role for the LXXLL motif in the ability of Kaposin to induce transformation...
  7. pmc Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis
    Edward A Acheampong
    The Dorrance H, Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, PA 19107, USA
    Virol J 6:183. 2009
    ..Taken together, the data suggests that HIV-1 infected individuals with hyperglycemia could potentially be at a higher risk of developing CNS related complications...
  8. pmc Effect of the V3 loop deletion of envelope glycoprotein on cellular responses and protection against challenge with recombinant vaccinia virus expressing gp160 of primary human immunodeficiency virus type 1 isolates
    Irena Kiszka
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Virol 76:4222-32. 2002
    ..The results from our studies provide insights into approaches for boosting the breadth of envelope-specific CTL responses...
  9. ncbi request reprint Human herpesvirus-8 encoded Kaposin: subcellular localization using immunofluorescence and biochemical approaches
    Brian Tomkowicz
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    DNA Cell Biol 21:151-62. 2002
    ..Taken together, these results suggest that Kaposin exhibits multicompartmental localization in cells...