Kamani Tennekoon

Summary

Publications:
1: Jayanthiny P, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundera AP.
Di-Nucleotide Repeat Polymorphisms of the Insulin-Like Growth Factor-1 Gene and
Their Association with IGF-1, Insulin-Like Growth Factor-Binding Protein-1 and
Birth Size in a Sri-Lankan Cohort. Neonatology. 2010 Dec 30;100(1):37-43. [Epub
ahead of print] PubMed PMID: .


2: Gomes TS, Lindner U, Tennekoon KH, Karandagoda W, Gortner L, Obeid R.
Homocysteine in small-for-gestational age and appropriate-for-gestational age
preterm neonates from mothers receiving folic acid supplementation. Clin Chem Lab
Med. 2010 Aug;48(8):1157-61. PubMed PMID: .


3: Sugathadasa BH, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundere AP.
Association of -2548 G/A polymorphism in the leptin gene with
preeclampsia/pregnancy-induced hypertension. Hypertens Pregnancy.
2010;29(4):366-74. PubMed PMID: .


4: Silva NY, Tennekoon KH, Senanayake L, Karunanayake EH. Cord blood leptin
levels in normal pregnancies, pregnancy induced hypertension and gestational
diabetes mellitus. Ceylon Med J. 2008 Sep;53(3):79-82. PubMed PMID: .


5: De Silva W, Karunanayake EH, Tennekoon KH, Allen M, Amarasinghe I, Angunawala
P, Ziard MH. Novel sequence variants and a high frequency of recurrent
polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk
individuals. BMC Cancer. 2008 Jul 29;8:214. PubMed PMID: ; PubMed Central
PMCID: PMC2519088.


6: Pathmaperuma AN, Tennekoon KH, Senanayake L, Karunanayake EH. Maternal and
cord blood levels of insulin-like growth factors--I and--II and insulin-like
growth factor binding protein-1: correlation with birth weight and maternal
anthropometric indices. Ceylon Med J. 2007 Jun;52(2):48-52. PubMed PMID:
.


7: Tennekoon KH, Pathmaperuma AN, Senanayake L, Karunanayake EH. Insulin-like
growth factors-I and -II and insulin-like growth factor binding protein-1 during
normal pregnancy: pattern of secretion and correlation with other placental
hormones. Ceylon Med J. 2007 Mar;52(1):8-13. PubMed PMID: .


8: Tennekoon KH, Eswaramohan T, Karunanayake EH. Effect of leptin on prolactin
and insulin-like growth factor-I secretion by cultured rat endometrial stromal
cells. Fertil Steril. 2007 Jul;88(1):193-9. Epub 2007 Feb 20. PubMed PMID:
.


9: Tennekoon KH, Wasalathanthri S, Jeevathayaparan S, Karunanayake EH. Serum
leptin and lactational amenorrhea in well-nourished and undernourished lactating
women. Fertil Steril. 2005 Apr;83(4):988-94. PubMed PMID: .


10: Wasalathanthri S, Tennekoon KH, Sufi S. Feasibility of using paper
impregnated with urine instead of liquid urine for assessing ovarian activity.
Ceylon Med J. 2003 Mar;48(1):4-6. PubMed PMID: .


11: Tennekoon KH. Leptin, the adipocyte hormone. Ceylon Med J. 2001
Dec;46(4):115-8. PubMed PMID: .


12: Tennekoon KH. Maternal prolactin concentrations and lactational behaviour in
the early postpartum period in women with lactational amenorrhoea. Ceylon Med J.
2001 Mar;46(1):6-10. PubMed PMID: .


13: Wasalathanthri S, Tennekoon KH. Lactational amenorrhea/anovulation and some
of their determinants: a comparison of well-nourished and undernourished women.
Fertil Steril. 2001 Aug;76(2):317-25. PubMed PMID: .


14: Tennekoon KH, Karunanayake EH, Seneviratne HR. Effect of skim milk
supplementation of the maternal diet on lactational amenorrhea, maternal
prolactin, and lactational behavior. Am J Clin Nutr. 1996 Sep;64(3):283-90.
PubMed PMID: 8780335.


15: Tennekoon KH. Immunocontraceptives. Ceylon Med J. 1994 Dec;39(4):157-60.
PubMed PMID: 7728911.


16: Tennekoon KH, Jeevathayaparan S, Angunawala P, Karunanayake EH, Jayasinghe
KS. Effect of Momordica charantia on key hepatic enzymes. J Ethnopharmacol. 1994
Oct;44(2):93-7. PubMed PMID: 7853870.


17: Tennekoon KH, Arulambalam PD, Karunanayake EH, Seneviratne HR. Prolactin
response to suckling in a group of fully breast feeding women during the early
postpartum period. Asia Oceania J Obstet Gynaecol. 1994 Sep;20(3):311-9. PubMed
PMID: 7811200.


18: Tennekoon KH, Karunanayake EH. Effect of age on serum prolactin concentration
in presumably fertile men in Sri Lanka. Ceylon Med J. 1994 Mar;39(1):11-3. PubMed
PMID: 8194139.


19: Tennekoon KH, Lenton EA. Synchronous secretion of LH and prolactin during the
normal menstrual cycle. Asia Oceania J Obstet Gynaecol. 1993 Mar;19(1):101-7.
PubMed PMID: 8489460.


20: Tennekoon KH, Karunanayake EH. Serum FSH, LH, and testosterone concentrations
in presumably fertile men: effect of age. Int J Fertil. 1993
Mar-Apr;38(2):108-12. PubMed PMID: 8097499.


21: Tennekoon KH. Biorhythms. Ceylon Med J. 1992 Sep;37(3):65-7. PubMed PMID:
1291135.


22: Tennekoon KH, Lenton EA. Time series analysis of biologically active
luteinizing hormone concentrations during different stages of the menstrual
cycle. Asia Oceania J Obstet Gynaecol. 1991 Jun;17(2):165-71. PubMed PMID:
1867586.


23: Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH.
Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J
Ethnopharmacol. 1991 Mar;31(3):283-9. PubMed PMID: 1676078.


24: Karunanayake EH, Jeevathayaparan S, Tennekoon KH. Effect of Momordica
charantia fruit juice on streptozotocin-induced diabetes in rats. J
Ethnopharmacol. 1990 Sep;30(2):199-204. PubMed PMID: 2255210.


25: Tennekoon KH, Lenton EA. A rise in the biologically active LH:
immunologically active LH (B/I) ratio during the normal luteal phase. Asia
Oceania J Obstet Gynaecol. 1989 Sep;15(3):299-305. Erratum in: Asia Oceania J
Obstet Gynaecol 1990 Jun;16(2):following ix. PubMed PMID: 2597094.


26: Tennekoon KH, Lenton EA. Prolactin concentrations during the normal menstrual
cycle: rhythms within rhythms. Ceylon Med J. 1989 Jun;34(2):65-71. PubMed PMID:
2620370.


27: Tennekoon KH, Lenton EA. Circatrigintan rhythm of prolactin. Ceylon Med J.
1988 Jun;33(2):57-61. PubMed PMID: 3240432.


28: Tennekoon KH, Lenton EA. Early evening prolactin rise in women with regular
cycles. J Reprod Fertil. 1985 Mar;73(2):523-7. PubMed PMID: 4039366.

Publications

  1. Tennekoon K, Eswaramohan T, Karunanayake E. Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells. Fertil Steril. 2007;88:193-9 pubmed
    ..Leptin did not significantly affect IGF-I secretion either in a dose- or a time-dependent manner. Biological effects of leptin on the rat endometrium include dose- and time-dependent stimulatory effects on stromal cell PRL secretion. ..
  2. Tennekoon K, Pathmaperuma A, Senanayake L, Karunanayake E. Insulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones. Ceylon Med J. 2007;52:8-13 pubmed
    ..Maternal IGF-I and IGFBP-1 but not IGF-II significantly increase as pregnancy advances. Components of the IGF system regulate or are affected by some of the placental hormones and the effects vary with the period of gestation. ..
  3. De Silva W, Karunanayake E, Tennekoon K, Allen M, Amarasinghe I, Angunawala P, et al. Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals. BMC Cancer. 2008;8:214 pubmed publisher
    ..3086delT and c.5404delG) in two families were identified and two more possibly pathogenic mutations (c.856T>G and IVS17-2A>T) in two families were identified. BRCA1--Gene Bank: Accession # U14680 Version # 14680.1. ..
  4. Wasalathanthri S, Tennekoon K. Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. Fertil Steril. 2001;76:317-25 pubmed
    ..Improved maternal nutritional status has no significant effect on fertility: ovulation is not advanced despite early resumption of regular menstruation. ..
  5. Tennekoon K, Jeevathayaparan S, Angunawala P, Karunanayake E, Jayasinghe K. Effect of Momordica charantia on key hepatic enzymes. J Ethnopharmacol. 1994;44:93-7 pubmed
    ..Thus, Momordica charantia may either contain hepatotoxins capable of causing cellular damage at the molecular level without causing significant histopathological changes or the plant may have an enzyme inducing effect. ..
  6. Tennekoon K, Karunanayake E. Effect of age on serum prolactin concentration in presumably fertile men in Sri Lanka. Ceylon Med J. 1994;39:11-3 pubmed
    ..05), but lower than between 61 to 70 (p < 0.05) and 75 to 85 (p < 0.01) years. Serum prolactin concentrations show age related variations in presumably fertile men. ..
  7. Wasalathanthri S, Tennekoon K, Sufi S. Feasibility of using paper impregnated with urine instead of liquid urine for assessing ovarian activity. Ceylon Med J. 2003;48:4-6 pubmed
  8. Tennekoon K. Maternal prolactin concentrations and lactational behaviour in the early postpartum period in women with lactational amenorrhoea. Ceylon Med J. 2001;46:6-10 pubmed
    ..This could be explained by a greater sensitivity of the pituitary lactotrophe to the suckling stimulus in women who have longer periods of lactational amenorrhoea. ..
  9. Tennekoon K, Karunanayake E, Seneviratne H. Effect of skim milk supplementation of the maternal diet on lactational amenorrhea, maternal prolactin, and lactational behavior. Am J Clin Nutr. 1996;64:283-90 pubmed
    ..Thus, maternal nutritional supplementation does not appear to affect the contraceptive benefit of lactation when the frequency of breast-feeding is not compromised but apparently lengthens the duration of nearly full breast-feeding. ..

More Information

Publications33

  1. Silva N, Tennekoon K, Senanayake L, Karunanayake E. Cord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus. Ceylon Med J. 2008;53:79-82 pubmed
    ..506, p<0.05) and with birth weight in PIH (r=0.5463, p<0.05). In GDM cord blood leptin levels are significantly higher, and a source other than fetal adipocytes appears to contribute to this. ..
  2. Tennekoon K. Immunocontraceptives. Ceylon Med J. 1994;39:157-60 pubmed
  3. Tennekoon K, Lenton E. Circatrigintan rhythm of prolactin. Ceylon Med J. 1988;33:57-61 pubmed
  4. Tennekoon K, Lenton E. Synchronous secretion of LH and prolactin during the normal menstrual cycle. Asia Oceania J Obstet Gynaecol. 1993;19:101-7 pubmed
    ..Consistent significant correlations were not evident between prolactin and oestradiol, prolactin and progesterone, LH and oestradiol or LH and progesterone during any other stage of the cycle. ..
  5. Tennekoon K, Arulambalam P, Karunanayake E, Seneviratne H. Prolactin response to suckling in a group of fully breast feeding women during the early postpartum period. Asia Oceania J Obstet Gynaecol. 1994;20:311-9 pubmed
  6. Gomes T, Lindner U, Tennekoon K, Karandagoda W, Gortner L, Obeid R. Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation. Clin Chem Lab Med. 2010;48:1157-61 pubmed publisher
    ..Concentrations of tHcy did not differ between SGA and AGA preterm neonates born to mothers supplemented with folic acid. This finding argues against a causal role for folate deficiency or increased tHcy in growth restriction. ..
  7. Karunanayake E, Jeevathayaparan S, Tennekoon K. Effect of Momordica charantia fruit juice on streptozotocin-induced diabetes in rats. J Ethnopharmacol. 1990;30:199-204 pubmed
    ..Viable beta-cells capable of secreting insulin upon stimulation appear to be required for M. charantia to exert its oral hypoglycaemic activity. ..
  8. Sugathadasa B, Tennekoon K, Karunanayake E, Kumarasiri J, Wijesundere A. Association of -2548 G/A polymorphism in the leptin gene with preeclampsia/pregnancy-induced hypertension. Hypertens Pregnancy. 2010;29:366-74 pubmed publisher
    ..Preeclampsia/pregnancy induced hypertension appears to be associated with higher circulating leptin and lower SLR levels, and with the AA genotype of ?2548 G/A polymorphism of the leptin gene. ..
  9. Jayanthiny P, Tennekoon K, Karunanayake E, Kumarasiri J, Wijesundera A. Di-nucleotide repeat polymorphisms of the insulin-like growth factor-1 gene and their association with IGF-1, insulin-like growth factor-binding protein-1 and birth size in a Sri-Lankan cohort. Neonatology. 2011;100:37-43 pubmed publisher
    ..Almost all these effects were limited to primiparous pregnancies. In Sri Lankans intron 2 CT repeat polymorphism of the IGF-1 gene appears to be a significant contributor to IGF-1 levels and birth size in primiparous pregnancies. ..
  10. Tennekoon K, Wasalathanthri S, Jeevathayaparan S, Karunanayake E. Serum leptin and lactational amenorrhea in well-nourished and undernourished lactating women. Fertil Steril. 2005;83:988-94 pubmed
    ..53), but not leptin, was significantly and negatively correlated with the duration of lactational amenorrhea. Leptin is unlikely to be a major determinant of early resumption of regular menstruation in well-nourished women. ..
  11. Tennekoon K, Karunanayake E. Serum FSH, LH, and testosterone concentrations in presumably fertile men: effect of age. Int J Fertil. 1993;38:108-12 pubmed
    ..FSH significantly higher from 6th decade, LH from 7th decade; testosterone lower from 6th decade. Apparently, a rise in FSH and reduction in testosterone precede a rise in LH concentration. ..
  12. Tennekoon K, Lenton E. Early evening prolactin rise in women with regular cycles. J Reprod Fertil. 1985;73:523-7 pubmed
    ..It is therefore suggested that there may be an intrinsic rhythm in prolactin secretion apart from the sleep-induced rise. ..
  13. Tennekoon K, Lenton E. A rise in the biologically active LH: immunologically active LH (B/I) ratio during the normal luteal phase. Asia Oceania J Obstet Gynaecol. 1989;15:299-305 pubmed
    ..Mean B/I ratio over the 24 h study periods as well as over the 2 h study periods were significantly higher during the luteal phase than during either the follicular phase (p less than 0.002) or the mid cycle (p less than 0.02). ..
  14. Tennekoon K, Jeevathayaparan S, Kurukulasooriya A, Karunanayake E. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol. 1991;31:283-9 pubmed
    ..Degenerative changes in hepatocytes were seen following administration of D. volubilis while consistent significant histopathological changes were not evident following administration of N. sativa. ..
  15. Tennekoon K. Leptin, the adipocyte hormone. Ceylon Med J. 2001;46:115-8 pubmed
  16. Sundralingam T, Tennekoon K, de Silva S, De Silva S, Hewage S, Ranasinghe R. Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency. Growth Horm IGF Res. 2018;42-43:94-101 pubmed publisher
    ..HGVS nomenclature of the deletion is c.-3166_58-2057del. This novel structural variant was identified to be the cause of IGHD of the affected proband. ..
  17. Ranasinghe R, Tennekoon K, Karunanayake E, Lembring M, Allen M. A study of genetic polymorphisms in mitochondrial DNA hypervariable regions I and II of the five major ethnic groups and Vedda population in Sri Lanka. Leg Med (Tokyo). 2015;17:539-46 pubmed publisher
    ..Thus this study provides useful information for forensic analysis and anthropological studies of Sri Lankans. ..
  18. Senathilake K, Karunanayake E, Samarakoon S, Tennekoon K, de Silva E. Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro. Exp Parasitol. 2016;167:50-60 pubmed publisher
  19. Ediriweera M, Tennekoon K, Adhikari A, Samarakoon S, Thabrew I, de Silva E. New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. J Ethnopharmacol. 2016;189:165-74 pubmed publisher
  20. Samarakoon S, Thabrew I, Galhena P, Tennekoon K. Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects. BMC Complement Altern Med. 2012;12:25 pubmed publisher
    ..The main aim of the present study was to determine whether apoptosis is also a major mechanism by which the decoction mediates its anti-hepatocarcinogenic action...
  21. Ediriweera M, Tennekoon K, Samarakoon S, Adhikari A, Thabrew I, Dilip DE Silva E. Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential. Biomed Pharmacother. 2017;89:194-200 pubmed publisher
    ..Furthermore, it also led to an increase in ROS and GST levels while depleting GSH levels. Results of this study suggest that isolated new resorcinolic lipid can induce apoptosis in MCF-7 cells, possibly via oxidative stress mechanism. ..
  22. Mendis A, Thabrew I, Samarakoon S, Tennekoon K. Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes. BMC Complement Altern Med. 2015;15:404 pubmed publisher
    ..Overall findings suggest that the decoction has the potential to be exploited further for effective treatment of breast cancer. ..
  23. Sundralingam T, Tennekoon K, de Silva S, De Silva S, Hewage A. Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka. Growth Horm IGF Res. 2017;36:22-29 pubmed publisher
    ..The large novel deletion is likely to be pathogenic as it included exon 1 of GHRHR gene. Analysis of other genes will be needed to ascertain the genetic cause of IGHD in the remaining children. ..
  24. Ediriweera M, Tennekoon K, Samarakoon S, Thabrew I, de Silva E. Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines (Basel). 2017;4: pubmed publisher
    ..Considering the high prevalence of obesity, this observation provides a rationale for use of curcumin, quercetin and EGCG as antagonists of leptin in the treatment of obese breast cancer patients. ..