Kamani Tennekoon

Summary

Publications:
1: Jayanthiny P, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundera AP.
Di-Nucleotide Repeat Polymorphisms of the Insulin-Like Growth Factor-1 Gene and
Their Association with IGF-1, Insulin-Like Growth Factor-Binding Protein-1 and
Birth Size in a Sri-Lankan Cohort. Neonatology. 2010 Dec 30;100(1):37-43. [Epub
ahead of print] PubMed PMID: .


2: Gomes TS, Lindner U, Tennekoon KH, Karandagoda W, Gortner L, Obeid R.
Homocysteine in small-for-gestational age and appropriate-for-gestational age
preterm neonates from mothers receiving folic acid supplementation. Clin Chem Lab
Med. 2010 Aug;48(8):1157-61. PubMed PMID: .


3: Sugathadasa BH, Tennekoon KH, Karunanayake EH, Kumarasiri JM, Wijesundere AP.
Association of -2548 G/A polymorphism in the leptin gene with
preeclampsia/pregnancy-induced hypertension. Hypertens Pregnancy.
2010;29(4):366-74. PubMed PMID: .


4: Silva NY, Tennekoon KH, Senanayake L, Karunanayake EH. Cord blood leptin
levels in normal pregnancies, pregnancy induced hypertension and gestational
diabetes mellitus. Ceylon Med J. 2008 Sep;53(3):79-82. PubMed PMID: .


5: De Silva W, Karunanayake EH, Tennekoon KH, Allen M, Amarasinghe I, Angunawala
P, Ziard MH. Novel sequence variants and a high frequency of recurrent
polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk
individuals. BMC Cancer. 2008 Jul 29;8:214. PubMed PMID: ; PubMed Central
PMCID: PMC2519088.


6: Pathmaperuma AN, Tennekoon KH, Senanayake L, Karunanayake EH. Maternal and
cord blood levels of insulin-like growth factors--I and--II and insulin-like
growth factor binding protein-1: correlation with birth weight and maternal
anthropometric indices. Ceylon Med J. 2007 Jun;52(2):48-52. PubMed PMID:
.


7: Tennekoon KH, Pathmaperuma AN, Senanayake L, Karunanayake EH. Insulin-like
growth factors-I and -II and insulin-like growth factor binding protein-1 during
normal pregnancy: pattern of secretion and correlation with other placental
hormones. Ceylon Med J. 2007 Mar;52(1):8-13. PubMed PMID: .


8: Tennekoon KH, Eswaramohan T, Karunanayake EH. Effect of leptin on prolactin
and insulin-like growth factor-I secretion by cultured rat endometrial stromal
cells. Fertil Steril. 2007 Jul;88(1):193-9. Epub 2007 Feb 20. PubMed PMID:
.


9: Tennekoon KH, Wasalathanthri S, Jeevathayaparan S, Karunanayake EH. Serum
leptin and lactational amenorrhea in well-nourished and undernourished lactating
women. Fertil Steril. 2005 Apr;83(4):988-94. PubMed PMID: .


10: Wasalathanthri S, Tennekoon KH, Sufi S. Feasibility of using paper
impregnated with urine instead of liquid urine for assessing ovarian activity.
Ceylon Med J. 2003 Mar;48(1):4-6. PubMed PMID: .


11: Tennekoon KH. Leptin, the adipocyte hormone. Ceylon Med J. 2001
Dec;46(4):115-8. PubMed PMID: .


12: Tennekoon KH. Maternal prolactin concentrations and lactational behaviour in
the early postpartum period in women with lactational amenorrhoea. Ceylon Med J.
2001 Mar;46(1):6-10. PubMed PMID: .


13: Wasalathanthri S, Tennekoon KH. Lactational amenorrhea/anovulation and some
of their determinants: a comparison of well-nourished and undernourished women.
Fertil Steril. 2001 Aug;76(2):317-25. PubMed PMID: .


14: Tennekoon KH, Karunanayake EH, Seneviratne HR. Effect of skim milk
supplementation of the maternal diet on lactational amenorrhea, maternal
prolactin, and lactational behavior. Am J Clin Nutr. 1996 Sep;64(3):283-90.
PubMed PMID: 8780335.


15: Tennekoon KH. Immunocontraceptives. Ceylon Med J. 1994 Dec;39(4):157-60.
PubMed PMID: 7728911.


16: Tennekoon KH, Jeevathayaparan S, Angunawala P, Karunanayake EH, Jayasinghe
KS. Effect of Momordica charantia on key hepatic enzymes. J Ethnopharmacol. 1994
Oct;44(2):93-7. PubMed PMID: 7853870.


17: Tennekoon KH, Arulambalam PD, Karunanayake EH, Seneviratne HR. Prolactin
response to suckling in a group of fully breast feeding women during the early
postpartum period. Asia Oceania J Obstet Gynaecol. 1994 Sep;20(3):311-9. PubMed
PMID: 7811200.


18: Tennekoon KH, Karunanayake EH. Effect of age on serum prolactin concentration
in presumably fertile men in Sri Lanka. Ceylon Med J. 1994 Mar;39(1):11-3. PubMed
PMID: 8194139.


19: Tennekoon KH, Lenton EA. Synchronous secretion of LH and prolactin during the
normal menstrual cycle. Asia Oceania J Obstet Gynaecol. 1993 Mar;19(1):101-7.
PubMed PMID: 8489460.


20: Tennekoon KH, Karunanayake EH. Serum FSH, LH, and testosterone concentrations
in presumably fertile men: effect of age. Int J Fertil. 1993
Mar-Apr;38(2):108-12. PubMed PMID: 8097499.


21: Tennekoon KH. Biorhythms. Ceylon Med J. 1992 Sep;37(3):65-7. PubMed PMID:
1291135.


22: Tennekoon KH, Lenton EA. Time series analysis of biologically active
luteinizing hormone concentrations during different stages of the menstrual
cycle. Asia Oceania J Obstet Gynaecol. 1991 Jun;17(2):165-71. PubMed PMID:
1867586.


23: Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH.
Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J
Ethnopharmacol. 1991 Mar;31(3):283-9. PubMed PMID: 1676078.


24: Karunanayake EH, Jeevathayaparan S, Tennekoon KH. Effect of Momordica
charantia fruit juice on streptozotocin-induced diabetes in rats. J
Ethnopharmacol. 1990 Sep;30(2):199-204. PubMed PMID: 2255210.


25: Tennekoon KH, Lenton EA. A rise in the biologically active LH:
immunologically active LH (B/I) ratio during the normal luteal phase. Asia
Oceania J Obstet Gynaecol. 1989 Sep;15(3):299-305. Erratum in: Asia Oceania J
Obstet Gynaecol 1990 Jun;16(2):following ix. PubMed PMID: 2597094.


26: Tennekoon KH, Lenton EA. Prolactin concentrations during the normal menstrual
cycle: rhythms within rhythms. Ceylon Med J. 1989 Jun;34(2):65-71. PubMed PMID:
2620370.


27: Tennekoon KH, Lenton EA. Circatrigintan rhythm of prolactin. Ceylon Med J.
1988 Jun;33(2):57-61. PubMed PMID: 3240432.


28: Tennekoon KH, Lenton EA. Early evening prolactin rise in women with regular
cycles. J Reprod Fertil. 1985 Mar;73(2):523-7. PubMed PMID: 4039366.

Publications

  1. ncbi request reprint Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
    J Ethnopharmacol 31:283-9. 1991
  2. ncbi request reprint Leptin, the adipocyte hormone
    K H Tennekoon
    Faculty of Medicine, University of Colombo
    Ceylon Med J 46:115-8. 2001
  3. ncbi request reprint Feasibility of using paper impregnated with urine instead of liquid urine for assessing ovarian activity
    Sudharshani Wasalathanthri
    Department of Physiology, Faculty of Medicine, University of Colombo
    Ceylon Med J 48:4-6. 2003
  4. ncbi request reprint Serum leptin and lactational amenorrhea in well-nourished and undernourished lactating women
    Kamani H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 8, Sri Lanka
    Fertil Steril 83:988-94. 2005
  5. ncbi request reprint Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells
    Kamani H Tennekoon
    Department of Physiology, University of Colombo, Colombo, Sri Lanka
    Fertil Steril 88:193-9. 2007
  6. ncbi request reprint Insulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo
    Ceylon Med J 52:8-13. 2007
  7. pmc Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals
    Wasanthi De Silva
    Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka
    BMC Cancer 8:214. 2008
  8. ncbi request reprint Cord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus
    N Y Silva
    Institute of Biochemistry, Molecular Biology and Biotechnology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Ceylon Med J 53:79-82. 2008
  9. doi request reprint Association of -2548 G/A polymorphism in the leptin gene with preeclampsia/pregnancy-induced hypertension
    B H K R Sugathadasa
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka
    Hypertens Pregnancy 29:366-74. 2010
  10. doi request reprint Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation
    Thushari S Gomes
    Department of General Pediatrics and Neonatology, University Children s Hospital, Faculty of Medicine, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 48:1157-61. 2010

Collaborators

  • Ludwig Gortner
  • Rima Obeid
  • Thushari S Gomes
  • Wasanthi De Silva
  • E H Karunanayake
  • Sumadee De Silva
  • Sameera R Samarakoon
  • P Jayanthiny
  • J M Kumarasiri
  • B H K R Sugathadasa
  • N Y Silva
  • Sudharshani Wasalathanthri
  • Indrani Amarasinghe
  • Preethika Angunawela
  • Eric Hamilton Karunanayake
  • Prasanna B Galhena
  • Ira Thabrew
  • S Wasalathanthri
  • A P D S Wijesundera
  • A P D S Wijesundere
  • L Senanayake
  • S Sufi
  • S Jeevathayaparan

Detail Information

Publications27

  1. ncbi request reprint Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
    J Ethnopharmacol 31:283-9. 1991
    ..Degenerative changes in hepatocytes were seen following administration of D. volubilis while consistent significant histopathological changes were not evident following administration of N. sativa...
  2. ncbi request reprint Leptin, the adipocyte hormone
    K H Tennekoon
    Faculty of Medicine, University of Colombo
    Ceylon Med J 46:115-8. 2001
  3. ncbi request reprint Feasibility of using paper impregnated with urine instead of liquid urine for assessing ovarian activity
    Sudharshani Wasalathanthri
    Department of Physiology, Faculty of Medicine, University of Colombo
    Ceylon Med J 48:4-6. 2003
    ....
  4. ncbi request reprint Serum leptin and lactational amenorrhea in well-nourished and undernourished lactating women
    Kamani H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 8, Sri Lanka
    Fertil Steril 83:988-94. 2005
    ..To ascertain the possible role of leptin in the resumption of postpartum menstruation in lactating women with differing nutritional statuses...
  5. ncbi request reprint Effect of leptin on prolactin and insulin-like growth factor-I secretion by cultured rat endometrial stromal cells
    Kamani H Tennekoon
    Department of Physiology, University of Colombo, Colombo, Sri Lanka
    Fertil Steril 88:193-9. 2007
    ..To study the possible effect of leptin on PRL and insulin-like growth factor (IGF)-I secretion from rat endometrial stromal cells...
  6. ncbi request reprint Insulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo
    Ceylon Med J 52:8-13. 2007
    ..To describe pattern of secretion of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-1 and their correlation with each other and major placental hormones during normal pregnancy...
  7. pmc Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals
    Wasanthi De Silva
    Institute of Biochemistry Molecular Biology and Biotechnology, University of Colombo, 90, Cumaratunga Munidasa Mawatha, Colombo 03, Sri Lanka
    BMC Cancer 8:214. 2008
    ..There have been only a few reports from Asia on mutations in BRCA1/2 genes and none from Sri Lanka...
  8. ncbi request reprint Cord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus
    N Y Silva
    Institute of Biochemistry, Molecular Biology and Biotechnology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Ceylon Med J 53:79-82. 2008
    ..To compare cord blood leptin concentrations between normal pregnancy, pregnancy induced hypertension (PIH), and gestational diabetes mellitus (GDM)...
  9. doi request reprint Association of -2548 G/A polymorphism in the leptin gene with preeclampsia/pregnancy-induced hypertension
    B H K R Sugathadasa
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka
    Hypertens Pregnancy 29:366-74. 2010
    ..To investigate −2548 G/A polymorphism of LEP gene, plasma leptin and soluble leptin receptor in preeclampsia/pregnancy induced hypertension...
  10. doi request reprint Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation
    Thushari S Gomes
    Department of General Pediatrics and Neonatology, University Children s Hospital, Faculty of Medicine, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 48:1157-61. 2010
    ..We studied a total of 133 preterm neonates from normotensive mothers; SGA (n=96) and appropriate-for-gestational age (AGA, n=37)...
  11. doi request reprint Di-nucleotide repeat polymorphisms of the insulin-like growth factor-1 gene and their association with IGF-1, insulin-like growth factor-binding protein-1 and birth size in a Sri-Lankan cohort
    P Jayanthiny
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka
    Neonatology 100:37-43. 2011
    ..Ethnic variations of IGF-1 have also been suggested. Di-nucleotide repeat polymorphisms of the IGF-1 gene or their association with IGF-1 levels and birth size have not been studied in Sri Lankans...
  12. ncbi request reprint Maternal prolactin concentrations and lactational behaviour in the early postpartum period in women with lactational amenorrhoea
    K H Tennekoon
    Faculty of Medicine, University of Colombo
    Ceylon Med J 46:6-10. 2001
    ..This could be explained by a greater sensitivity of the pituitary lactotrophe to the suckling stimulus in women who have longer periods of lactational amenorrhoea...
  13. ncbi request reprint Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women
    S Wasalathanthri
    University of Colombo, Sri Lanka
    Fertil Steril 76:317-25. 2001
    ..CONCLUSION(S): Improved maternal nutritional status has no significant effect on fertility: ovulation is not advanced despite early resumption of regular menstruation...
  14. ncbi request reprint Effect of skim milk supplementation of the maternal diet on lactational amenorrhea, maternal prolactin, and lactational behavior
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
    Am J Clin Nutr 64:283-90. 1996
    ..Thus, maternal nutritional supplementation does not appear to affect the contraceptive benefit of lactation when the frequency of breast-feeding is not compromised but apparently lengthens the duration of nearly full breast-feeding...
  15. ncbi request reprint Effect of Momordica charantia fruit juice on streptozotocin-induced diabetes in rats
    E H Karunanayake
    Department of Biochemistry, Faculty of Medicine, University of Colombo, Sri Lanka
    J Ethnopharmacol 30:199-204. 1990
    ..Viable beta-cells capable of secreting insulin upon stimulation appear to be required for M. charantia to exert its oral hypoglycaemic activity...
  16. ncbi request reprint A rise in the biologically active LH: immunologically active LH (B/I) ratio during the normal luteal phase
    K H Tennekoon
    Asia Oceania J Obstet Gynaecol 15:299-305. 1989
    ..Mean B/I ratio over the 24 h study periods as well as over the 2 h study periods were significantly higher during the luteal phase than during either the follicular phase (p less than 0.002) or the mid cycle (p less than 0.02)...
  17. ncbi request reprint Circatrigintan rhythm of prolactin
    K H Tennekoon
    Ceylon Med J 33:57-61. 1988
  18. ncbi request reprint Early evening prolactin rise in women with regular cycles
    K H Tennekoon
    J Reprod Fertil 73:523-7. 1985
    ..It is therefore suggested that there may be an intrinsic rhythm in prolactin secretion apart from the sleep-induced rise...
  19. ncbi request reprint Immunocontraceptives
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo
    Ceylon Med J 39:157-60. 1994
  20. ncbi request reprint Prolactin response to suckling in a group of fully breast feeding women during the early postpartum period
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo Sri Lanka
    Asia Oceania J Obstet Gynaecol 20:311-9. 1994
    ....
  21. ncbi request reprint Effect of Momordica charantia on key hepatic enzymes
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
    J Ethnopharmacol 44:93-7. 1994
    ..Thus, Momordica charantia may either contain hepatotoxins capable of causing cellular damage at the molecular level without causing significant histopathological changes or the plant may have an enzyme inducing effect...
  22. ncbi request reprint Serum FSH, LH, and testosterone concentrations in presumably fertile men: effect of age
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
    Int J Fertil 38:108-12. 1993
    ..Delineation of change in male hormone and gonadotropin levels from age 21 to 85...
  23. ncbi request reprint Effect of age on serum prolactin concentration in presumably fertile men in Sri Lanka
    K H Tennekoon
    Faculty of Medicine, University of Colombo
    Ceylon Med J 39:11-3. 1994
    ..To examine possible age related variation in serum prolactin in men...
  24. ncbi request reprint Synchronous secretion of LH and prolactin during the normal menstrual cycle
    K H Tennekoon
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka
    Asia Oceania J Obstet Gynaecol 19:101-7. 1993
    ..Consistent significant correlations were not evident between prolactin and oestradiol, prolactin and progesterone, LH and oestradiol or LH and progesterone during any other stage of the cycle...
  25. pmc Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects
    Sameera R Samarakoon
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, 90, Cumarathunga Munidasa Mawatha, Colombo 3, Sri Lanka
    BMC Complement Altern Med 12:25. 2012
    ..The main aim of the present study was to determine whether apoptosis is also a major mechanism by which the decoction mediates its anti-hepatocarcinogenic action...
  26. ncbi request reprint Analysis of BRCA1and BRCA2 large genomic rearrangements in Sri Lankan familial breast cancer patients and at risk individuals
    Sumadee De Silva
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka
    BMC Res Notes 7:344. 2014
    ..Large genomic rearrangements have been characterized in BRCA1 and BRCA2 genes in several populations but these have not been characterized in Sri Lankan breast cancer patients...
  27. pmc LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study
    Kamani Hemamala Tennekoon
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka
    BMC Res Notes 5:308. 2012
    ..Leptin is known to be elevated in pre-eclampsia/ pregnancy induced hypertension (PE/PIH). However the reports on the association of leptin receptor (LEPR) c.668A>G polymorphism with PE/PIH are inconsistent...