Sameera R Samarakoon
Affiliation: University of Colombo
Country: Sri Lanka
Senathilake K, Karunanayake E, Samarakoon S, Tennekoon K, de Silva E. Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro. Exp Parasitol. 2016;167:50-60 pubmed publisher
Ediriweera M, Tennekoon K, Adhikari A, Samarakoon S, Thabrew I, de Silva E. New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. J Ethnopharmacol. 2016;189:165-74 pubmed publisher
Ediriweera M, Tennekoon K, Samarakoon S, Adhikari A, Thabrew I, Dilip DE Silva E. Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential. Biomed Pharmacother. 2017;89:194-200 pubmed publisher
..Furthermore, it also led to an increase in ROS and GST levels while depleting GSH levels. Results of this study suggest that isolated new resorcinolic lipid can induce apoptosis in MCF-7 cells, possibly via oxidative stress mechanism. ..
Ediriweera M, Tennekoon K, Samarakoon S, Thabrew I, de Silva E. Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines (Basel). 2017;4: pubmed publisher
..Considering the high prevalence of obesity, this observation provides a rationale for use of curcumin, quercetin and EGCG as antagonists of leptin in the treatment of obese breast cancer patients. ..
Samarakoon S, Thabrew I, Galhena P, Tennekoon K. Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects. BMC Complement Altern Med. 2012;12:25 pubmed publisher
..The main aim of the present study was to determine whether apoptosis is also a major mechanism by which the decoction mediates its anti-hepatocarcinogenic action...