W D Ratnasooriya

Summary

Affiliation: University of Colombo
Country: Sri Lanka

Publications

  1. ncbi request reprint Leaf extract of Crinum bulbispermum has antinociceptive activity in rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    J Ethnopharmacol 97:123-8. 2005
  2. ncbi request reprint Diuretic activity of Spilanthes acmella flowers in rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    J Ethnopharmacol 91:317-20. 2004
  3. ncbi request reprint Adverse pregnancy outcome in rats following exposure to a Salacia reticulata (Celastraceae) root extract
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo, Sri Lanka
    Braz J Med Biol Res 36:931-5. 2003
  4. ncbi request reprint Sodium nitroprusside impairs sexual competence of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 3, Sri Lanka
    Hum Exp Toxicol 23:187-92. 2004
  5. ncbi request reprint Antinociceptive action of aqueous extract of the leaves of Ixora coccinea
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Acta Biol Hung 56:21-34. 2005
  6. ncbi request reprint Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo
    M G Dharmasiri
    Department of Zoology, University of Colombo, 3, Colombo, Sri Lanka
    J Ethnopharmacol 87:199-206. 2003
  7. doi request reprint Alpinia calcarata Roscoe: a potent antiinflammatory agent
    L D A M Arawwawala
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, Sri Lanka
    J Ethnopharmacol 139:889-92. 2012
  8. ncbi request reprint Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats
    S A Deraniyagala
    Department of Chemistry, University of Colombo, P O Box 1490, Colombo, Sri Lanka
    J Ethnopharmacol 86:21-6. 2003
  9. ncbi request reprint Sedative activity of stem bark of the Sri Lankan endemic plant, Vateria copallifera
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 3, Sri Lanka
    Fitoterapia 77:331-2. 2006
  10. ncbi request reprint Antioxidant activity of water extract of Scoparia dulcis
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Fitoterapia 76:220-2. 2005

Collaborators

  • K R W Abeywickrama
  • L S R Arambewela
  • L D A M Arawwawala
  • E R H S S Ediriweera
  • J R A C Jayakody
  • A H Sathananthan
  • M G Dharmasiri
  • S A Deraniyagala
  • I Ilayperuma
  • G A Premakumara
  • P Randeniya
  • A de Silva
  • S S P Liyanage
  • C L Goonasekara
  • G Galhena
  • T R Weerasooriya
  • A S Amarasekare
  • L M Tillekeratne

Detail Information

Publications27

  1. ncbi request reprint Leaf extract of Crinum bulbispermum has antinociceptive activity in rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    J Ethnopharmacol 97:123-8. 2005
    ..Additionally, the ALE had antihyperalgesic activity. The antinociception of the ALE appear to results from opioid mechanisms, sedation and antioxidant activities. Unfortunately, ALE is mild to moderately toxic...
  2. ncbi request reprint Diuretic activity of Spilanthes acmella flowers in rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    J Ethnopharmacol 91:317-20. 2004
    ..It may also inhibit ADH release and/or action. It is concluded that the Spilanthes acmella CWE has strong diuretic action as is claimed...
  3. ncbi request reprint Adverse pregnancy outcome in rats following exposure to a Salacia reticulata (Celastraceae) root extract
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo, Sri Lanka
    Braz J Med Biol Res 36:931-5. 2003
    ..9 2.6 vs 57.1 16.1%). However, the root extract was non-teratogenic. We conclude that the S. reticulata root extract can be hazardous to successful pregnancy in women and should not be used in pregnancy complicated by diabetes...
  4. ncbi request reprint Sodium nitroprusside impairs sexual competence of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 3, Sri Lanka
    Hum Exp Toxicol 23:187-92. 2004
    ..It is concluded that SNP impairs male sexual competence, at least, in rats although it promotes penile erection...
  5. ncbi request reprint Antinociceptive action of aqueous extract of the leaves of Ixora coccinea
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Acta Biol Hung 56:21-34. 2005
    ..Dopaminergic and antioxidative activities of ALE could arise, respectively, from its quaternary base alkaloid and flavonoid constituents...
  6. ncbi request reprint Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo
    M G Dharmasiri
    Department of Zoology, University of Colombo, 3, Colombo, Sri Lanka
    J Ethnopharmacol 87:199-206. 2003
    ..The antihistamine activity can produce the anti-itching effect claimed in Ayurveda medicine...
  7. doi request reprint Alpinia calcarata Roscoe: a potent antiinflammatory agent
    L D A M Arawwawala
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, Sri Lanka
    J Ethnopharmacol 139:889-92. 2012
    ..Therefore, the aim of this study was to investigate the antiinflammatory potential of Alpinia calcarata rhizomes using hot water extract (AWE) and hot ethanolic extract (AEE)...
  8. ncbi request reprint Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats
    S A Deraniyagala
    Department of Chemistry, University of Colombo, P O Box 1490, Colombo, Sri Lanka
    J Ethnopharmacol 86:21-6. 2003
    ..The antinociceptive effect was mediated mainly via opioid mechanisms. Such inhibition of pain could arise from phenolic and steroidal constituents as was shown to be present in the extract...
  9. ncbi request reprint Sedative activity of stem bark of the Sri Lankan endemic plant, Vateria copallifera
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 3, Sri Lanka
    Fitoterapia 77:331-2. 2006
    ..An aqueous bark extract of Vateria copallifera showed marked sedative activity, which supports the therapeutic effects claimed by Sri Lankan traditional physicians...
  10. ncbi request reprint Antioxidant activity of water extract of Scoparia dulcis
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Fitoterapia 76:220-2. 2005
    ..An aqueous extract of Scoparia dulcis showed marked antioxidative activity in vitro, which supports the therapeutic effects claimed by traditional practitioners...
  11. ncbi request reprint Effects of aqueous extract of Alpinia calcarata rhizomes on reproductive competence of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Acta Biol Hung 57:23-35. 2006
    ..Further, the HWE was nontoxic. It is concluded that A. calcarata rhizomes possess a strong and safe oral aphrodisiac activity...
  12. ncbi request reprint Effects of the prostanoid receptor antagonist, di-4-phloretin phosphate, upon human sperm motility
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Sri Lanka
    Contraception 45:239-48. 1992
    ..25 mM) of DPP, and the mechanism precipitating the antimotility effect may involve mobilization of stored calcium ions and modulation of cyclic AMP levels...
  13. ncbi request reprint Antidiuretic activity of aqueous bark extract of Sri Lankan Ficus racemosa in rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Acta Biol Hung 54:357-63. 2003
    ..The results provide scientific support for its claimed antidiuretic action and deserve intensive scrutiny...
  14. ncbi request reprint Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 3, Sri Lanka
    Asian J Androl 2:247-55. 2000
    ..To evaluate the antireproductive effect of paracetamol in male rats...
  15. doi request reprint Effect of black tea brew of Camellia sinensis on sexual competence of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    J Ethnopharmacol 118:373-7. 2008
    ..O. Kuntze (Theaceae) is claimed to have male sexual stimulant activity. As this claim is not scientifically tested and proven, this study was undertaken to evaluate the effects of BTB on male sexual competence...
  16. ncbi request reprint Effects of Terminalia catappa seeds on sexual behaviour and fertility of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Sri Lanka
    Asian J Androl 2:213-9. 2000
    ..To evaluate the aphrodisiac potential of Tenminalia catappa Linn. seeds using a suspension of its kernel (SS) in 1% methyl cellulose in rats...
  17. ncbi request reprint L-arginine, the substrate of nitric oxide synthase, inhibits fertility of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Sri Lanka
    Asian J Androl 3:97-103. 2001
    ..To examine the effect of L-arginine, the substrate of nitric oxide (NO) synthase, on reproductive function of male rats...
  18. pmc Pro blood clotting activity of Scoparia dulcis in rats
    E R H S S Ediriweera
    Department of Nidana Cikithsa, Institute of Indigenous Medicine, University of Colombo, Rajagiriya, Sri Lanka
    Ayu 32:271-4. 2011
    ..It is concluded that S. dulcis has proclotting activity (rakthasthambhana property) and this was faster than vitamin K...
  19. ncbi request reprint Effects of Icon, a pyrethroid insecticide on early pregnancy of rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 3, Sri Lanka
    Hum Exp Toxicol 22:523-33. 2003
    ..Further progesterone had a protective effect against Icon induced anti-reproductive actions. Overall, the results suggest that exposure to Icon during early gestation may result in a threat to pregnancy...
  20. ncbi request reprint Human sperm motility stimulating activity of a sulfono glycolipid isolated from Sri Lankan marine red alga Gelidiella acerosa
    G A Premakumara
    Natural Products Development Group, Industrial Technology Institute (CISIR, Colombo, Sri Lanka
    Asian J Androl 3:27-31. 2001
    ..CONCLUSION: S-ACT-1 of Gelidiella acerosa is a Sulfono glycolipid. S-ACT-1 has a potent sperm motility stimulating activity in vitro and has the potential to be developed into a sperm stimulant...
  21. doi request reprint Oral hypoglycaemic, antihyperglycaemic and antidiabetic activities of Sri Lankan Broken Orange Pekoe Fannings (BOPF) grade black tea (Camellia sinensis L.) in rats
    K R W Abeywickrama
    Analytical Laboratory, Sri Lanka Tea Board, Colombo, Sri Lanka
    J Ethnopharmacol 135:278-86. 2011
    ..plant for regulation of glycaemia. However, they do not specify the grade of tea and their origin (i.e., agroclimatic elevation) and as such many prediabetics and milddiabetics use BOPF grade tea...
  22. ncbi request reprint Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Colombo 03, Sri Lanka
    Indian J Exp Biol 40:304-8. 2002
    ..In a mating study, SS failed to alter ejaculating competence and fertility. These results suggest that A. heterophyllous seeds do not have aphrodisiac action, at least, in rats...
  23. ncbi request reprint Effects of pyrethroid insecticide ICON (lambda cyhalothrin) on reproductive competence of male rats
    W D Ratnasooriya
    Department of Zoology, University of Colombo, Sri Lanka
    Asian J Androl 4:35-41. 2002
    ..To assess the effect of ICON (trade name of lambda-cyhalothrin) on sexual competence and fertility of male rats...
  24. ncbi request reprint Antidiabetic activities of aqueous and ethanolic extracts of Piper betle leaves in rats
    L S R Arambewela
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo 7, Sri Lanka
    J Ethnopharmacol 102:239-45. 2005
    ..However, the weight of the spleen had increased in treated groups possibly indicating lymphoproliferative activity. It is concluded that HWE and CEE of Piper betle leaves possess safe and strong antidiabetic activity...
  25. ncbi request reprint Effect of Withania somnifera root extract on the sexual behaviour of male rats
    I Ilayperuma
    Department of Anatomy, Faculty of Medicine, University of Ruhuna, Sri Lanka
    Asian J Androl 4:295-8. 2002
    ..To determine the effect of a methanolic extract of Withania somnifera (L.) Dunal roots on sexual competence of male rats...
  26. ncbi request reprint Antinociceptive activities of aqueous and ethanolic extracts of Alpinia calcarata rhizomes in rats
    L S R Arambewela
    Industrial Technology Institute, Bauddhaloka Mawatha, Colombo 7, Sri Lanka
    J Ethnopharmacol 95:311-6. 2004
    ..The antinociceptive effect was slightly higher in HEE than that of HWE. The antinociceptive effect was mediated via opioid mechanisms...
  27. ncbi request reprint Rediscovering Boveri's centrosome in Ascaris (1888): its impact on human fertility and development
    A H Sathananthan
    Centre for Early Human Development and Monash Immunology and Stem Cell Laboratories, Monash University, Melbourne, Australia
    Reprod Biomed Online 12:254-70. 2006
    ..We now know the origins of the centrosome in human somatic cells--predominantly from the sperm cell. The impact of Boveri's work on human development is highlighted in this age of assisted reproductive technology...