Hemalatha S, Sengodan S, Nadhan R, Dev J, Sushama R, Somasundaram V, et al
. Brcal Defective Breast Cancer Cells Induce in vitro Transformation of Cancer Associated Fibroblasts (CAFs) to Metastasis Associated Fibroblasts (MAF). Sci Rep. 2018;8:13903 pubmed publisher
..This highlights the intriguing possibilities of combination therapy using MAF inhibitors as anti-metastatic agents along with anticancer drugs, to control the metastatic spread from primary tumor site. ..
Nair R, Kuriakose M, Somasundaram V, Shenoi V, Kurup M, Srinivas P. The molecular response of vanadium complexes of nicotinoyl hydrazone in cervical cancers--a possible interference with HPV oncogenic markers. Life Sci. 2014;116:90-7 pubmed publisher
..This is the first study demonstrating that vanadium complexes could induce a p53 dependent apoptotic mechanism in high risk HPV16-positive cervical cancers. ..
Achyutuni S, Nadhan R, Sengodan S, Srinivas P. The prodigious network of chromosome 17 miRNAs regulating cancer genes that influence the hallmarks of cancer. Semin Oncol. 2017;44:254-264 pubmed publisher
Reshma R, Sreelatha K, Somasundaram V, Satheesh Kumar S, Nadhan R, Nair R, et al
. Plumbagin, a naphthaquinone derivative induces apoptosis in BRCA 1/2 defective castrate resistant prostate cancer cells as well as prostate cancer stem-like cells. Pharmacol Res. 2016;105:134-45 pubmed publisher
..Overall studies suggest that PB's antitumour mechanisms holds promise for novel therapeutic approaches against BRCA mutated cancers as well as CSCs. ..
Somasundaram V, Nadhan R, K Hemalatha S, Kumar Sengodan S, Srinivas P. Nitric oxide and reactive oxygen species: Clues to target oxidative damage repair defective breast cancers. Crit Rev Oncol Hematol. 2016;101:184-92 pubmed publisher
..Preliminary findings support the potential to employ various combinatorial regimes for anti-cancer therapies with regard to exploiting the chemo-sensitization property of NO donors. ..
Sengodan S, K H S, Nadhan R, Srinivas P. Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer. Crit Rev Oncol Hematol. 2018;123:74-82 pubmed publisher
Srinivas P, Patra C, Bhattacharya S, Mukhopadhyay D. Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles. Int J Nanomedicine. 2011;6:2113-22 pubmed publisher
..Therefore, it can be concluded that conjugation with gold nanoparticles can reduce the cytotoxicity of these compounds. ..
Somasundaram V, Hemalatha S, Pal K, Sinha S, Nair A, Mukhopadhyay D, et al
. Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells. BMC Cancer. 2016;16:336 pubmed publisher
..The best marker for identifying BCSCs in BRCA1 defective condition could be ALDH1 and that BRCA1 mutated BCSCs would be mostly 'stem like' than 'mesenchymal'. Also ROS inducers like PB could reduce BCSCs in BRCA1 defective cancers. ..
Nadhan R, Vaman J, C N, Kumar Sengodan S, Krishnakumar Hemalatha S, Rajan A, et al
. Insights into dovetailing GTD and Cancers. Crit Rev Oncol Hematol. 2017;114:77-90 pubmed publisher
..This review would render a wider eye towards a new paradigm of thoughts to connect GTD and breast cancer, which has not been into the picture till date. ..