Petra E Spies

Summary

Publications

  1. doi request reprint A prediction model to calculate probability of Alzheimer's disease using cerebrospinal fluid biomarkers
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 9:262-8. 2013
  2. ncbi request reprint Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Front Biosci (Landmark Ed) 17:2024-34. 2012
  3. doi request reprint CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, and Alzheimer Centre, Nijmegen, The Netherlands
    Neurosci Lett 504:336-8. 2011
  4. doi request reprint Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers
    Diane Slats
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurobiol Aging 33:831.e1-9. 2012
  5. ncbi request reprint Addition of MHPG to Alzheimer's disease biomarkers improves differentiation of dementia with Lewy bodies from Alzheimer's disease but not other dementias
    Megan K Herbert
    Department of Neurology, Radboud University Medical Centre, and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands Radboud Alzheimer Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 10:448-455.e2. 2014
  6. doi request reprint Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, Nijmegen, The Netherlands
    J Alzheimers Dis 16:363-9. 2009

Collaborators

Detail Information

Publications6

  1. doi request reprint A prediction model to calculate probability of Alzheimer's disease using cerebrospinal fluid biomarkers
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 9:262-8. 2013
    ..We aimed to develop a prediction model based on cerebrospinal fluid (CSF) biomarkers, that would yield a single estimate representing the probability that dementia in a memory clinic patient is due to Alzheimer's disease (AD)...
  2. ncbi request reprint Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Front Biosci (Landmark Ed) 17:2024-34. 2012
    ..Evidence for other possibilities such as a decreased production of Abeta42, an increased proteolytic breakdown or microglial uptake of Abeta42, or an increased clearance of Abeta42 to the blood, is - at best - scarce or even absent...
  3. doi request reprint CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, and Alzheimer Centre, Nijmegen, The Netherlands
    Neurosci Lett 504:336-8. 2011
    ..Furthermore, we did not find evidence for an interaction between amyloid β and α-synuclein concentrations in CSF...
  4. doi request reprint Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers
    Diane Slats
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurobiol Aging 33:831.e1-9. 2012
    ..Furthermore, continuous sampling of CSF proved to be a useful and robust method, which may also be used to investigate AD pathogenesis and to evaluate pharmacotherapeutic interventions...
  5. ncbi request reprint Addition of MHPG to Alzheimer's disease biomarkers improves differentiation of dementia with Lewy bodies from Alzheimer's disease but not other dementias
    Megan K Herbert
    Department of Neurology, Radboud University Medical Centre, and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands Radboud Alzheimer Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 10:448-455.e2. 2014
    ....
  6. doi request reprint Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, Nijmegen, The Netherlands
    J Alzheimers Dis 16:363-9. 2009
    ..We conclude that in clinically diagnosed patients, alpha-synuclein does not appear to be a useful biomarker for the differentiation between DLB and other types of dementia...