Paul W Sperduto

Summary

Publications

  1. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
  2. ncbi A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database
    Paul W Sperduto
    Minneapolis Radiation Oncology, Minneapolis, MN, USA
    Int J Radiat Oncol Biol Phys 70:510-4. 2008
  3. doi Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1-3 brain metastases; poststratified by the graded prognostic assessment (GPA)
    Paul W Sperduto
    Metro Minnesota CCOP and Minneapolis Radiation Oncology, Minneapolis, Minnesota Electronic address
    Int J Radiat Oncol Biol Phys 90:526-31. 2014
  4. doi The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer
    Paul W Sperduto
    Minneapolis Radiation Oncology, University of Minnesota Gamma Knife, Minneapolis, MN, USA
    J Neurooncol 112:467-72. 2013
  5. pmc A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320
    Paul W Sperduto
    Metro MN CCOP, Minneapolis, Minnesota, USA
    Int J Radiat Oncol Biol Phys 85:1312-8. 2013
  6. pmc Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases
    Paul W Sperduto
    University of Minnesota Gamma Knife, Minneapolis Radiation Oncology, Minneapolis, MN, USA
    Int J Radiat Oncol Biol Phys 82:2111-7. 2012
  7. pmc Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
    Paul W Sperduto
    University of Minnesota Gamma Knife, Minneapolis Radiation Oncology, MN, USA
    J Clin Oncol 30:419-25. 2012
  8. doi Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients
    Paul W Sperduto
    Gamma Knife Center, University of Minnesota, Minneapolis, MN 55387, USA
    Int J Radiat Oncol Biol Phys 77:655-61. 2010
  9. doi Twenty-year survival in glioblastoma: a case report and molecular profile
    Christina Maria Sperduto
    Minneapolis Radiation Oncology, Minneapolis, MN, USA
    Int J Radiat Oncol Biol Phys 75:1162-5. 2009
  10. ncbi A review of stereotactic radiosurgery in the management of brain metastases
    Paul W Sperduto
    Methodist Hospital, Minneapolis, Minnesota, USA
    Technol Cancer Res Treat 2:105-10. 2003

Detail Information

Publications11

  1. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG)...
  2. ncbi A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database
    Paul W Sperduto
    Minneapolis Radiation Oncology, Minneapolis, MN, USA
    Int J Radiat Oncol Biol Phys 70:510-4. 2008
    ..Treatment for brain metastases varies widely. A sound prognostic index is thus important to guide both clinical decision making and outcomes research...
  3. doi Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1-3 brain metastases; poststratified by the graded prognostic assessment (GPA)
    Paul W Sperduto
    Metro Minnesota CCOP and Minneapolis Radiation Oncology, Minneapolis, Minnesota Electronic address
    Int J Radiat Oncol Biol Phys 90:526-31. 2014
    ..An improved prognostic index, the graded prognostic assessment (GPA) has been developed. Our hypothesis was that if the data from RTOG 9508 were poststratified by the GPA, the conclusions may vary...
  4. doi The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer
    Paul W Sperduto
    Minneapolis Radiation Oncology, University of Minnesota Gamma Knife, Minneapolis, MN, USA
    J Neurooncol 112:467-72. 2013
    ..Patients with Basal and HER2 tumor subtypes have short TPDBM. Prospective studies are needed to determine if screening brain MRIs are indicated in patients with Basal or HER2 subtypes...
  5. pmc A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320
    Paul W Sperduto
    Metro MN CCOP, Minneapolis, Minnesota, USA
    Int J Radiat Oncol Biol Phys 85:1312-8. 2013
    ..Because temozolomide (TMZ) and erlotinib (ETN) cross the blood-brain barrier and have documented activity in NSCLC, a phase 3 study was designed to test whether these drugs would improve the OS associated with WBRT + SRS...
  6. pmc Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases
    Paul W Sperduto
    University of Minnesota Gamma Knife, Minneapolis Radiation Oncology, Minneapolis, MN, USA
    Int J Radiat Oncol Biol Phys 82:2111-7. 2012
    ..The diagnosis-specific Graded Prognostic Assessment (GPA) was published to clarify prognosis for patients with brain metastases. This study refines the existing Breast-GPA by analyzing a larger cohort and tumor subtype...
  7. pmc Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
    Paul W Sperduto
    University of Minnesota Gamma Knife, Minneapolis Radiation Oncology, MN, USA
    J Clin Oncol 30:419-25. 2012
    ..The purpose of this report is to present the updated diagnosis-specific GPA indices in a single, unified, user-friendly report to allow ease of access and use by treating physicians...
  8. doi Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients
    Paul W Sperduto
    Gamma Knife Center, University of Minnesota, Minneapolis, MN 55387, USA
    Int J Radiat Oncol Biol Phys 77:655-61. 2010
    ..The purpose of the present study was to identify significant diagnosis-specific prognostic factors and indexes (Diagnosis-Specific Graded Prognostic Assessment [DS-GPA])...
  9. doi Twenty-year survival in glioblastoma: a case report and molecular profile
    Christina Maria Sperduto
    Minneapolis Radiation Oncology, Minneapolis, MN, USA
    Int J Radiat Oncol Biol Phys 75:1162-5. 2009
    ..Historically, the median survival has been 6 to 9 months. Recent research has improved the outcome slightly. A computer search of the literature reveals few long-term survivors...
  10. ncbi A review of stereotactic radiosurgery in the management of brain metastases
    Paul W Sperduto
    Methodist Hospital, Minneapolis, Minnesota, USA
    Technol Cancer Res Treat 2:105-10. 2003
    ..If the patient refuses WBRT or needs salvage after WBRT, then SRS alone is appropriate. Clinicians should not be too dogmatic and should always apply the best clinical judgment...
  11. ncbi A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    Penny K Sneed
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 53:519-26. 2002
    ..Data collected from 10 institutions were reviewed to compare survival probabilities of patients with newly diagnosed brain metastases managed initially with radiosurgery (RS) alone vs. RS + whole brain radiotherapy (WBRT)...