S J Spechler

Summary

Publications

  1. doi request reprint Barrett's esophagus: Clinical issues
    Stuart Jon Spechler
    Department of Medicine, Veterans Affairs North Texas Healthcare System, Dallas, TX, USA
    Gastrointest Endosc Clin N Am 21:1-7. 2011
  2. doi request reprint Barrett's esophagus: the American perspective
    Stuart Jon Spechler
    Department of Medicine, VA North Texas Healthcare System, and The University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
    Dig Dis 31:10-6. 2013
  3. doi request reprint Barrett esophagus and risk of esophageal cancer: a clinical review
    Stuart Jon Spechler
    VA North Texas Healthcare System, Dallas, Texas, USA
    JAMA 310:627-36. 2013
  4. pmc Tissue remodeling in eosinophilic esophagitis
    Edaire Cheng
    Departments of Pediatrics, Children s Medical Center, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1175-87. 2012
  5. ncbi request reprint Clinical manifestations and esophageal complications of GERD
    Stuart Jon Spechler
    Division of Gastroenterology, Dallas Department of Veterans Affairs Medical Center, Texas 75216, USA
    Am J Med Sci 326:279-84. 2003
  6. ncbi request reprint The natural history of dysplasia and cancer in esophagitis and Barrett esophagus
    Stuart Jon Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    J Clin Gastroenterol 36:S2-5; discussion S26-8. 2003
  7. doi request reprint Clinical trial: intragastric acid control in patients who have Barrett's oesophagus--comparison of once- and twice-daily regimens of esomeprazole and lansoprazole
    S J Spechler
    VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Aliment Pharmacol Ther 30:138-45. 2009
  8. ncbi request reprint Screening and surveillance for Barrett's esophagus-an unresolved dilemma
    Stuart J Spechler
    Division of Gastroenterology at the Dallas VA Medical Center, Dallas, TX 75216, USA
    Nat Clin Pract Gastroenterol Hepatol 4:470-1. 2007
  9. pmc Are we underestimating acid reflux?
    S J Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Gut 53:162-3. 2004
  10. ncbi request reprint Review article: screening and surveillance of Barrett's oesophagus: what is a cost-effective framework?
    S J Spechler
    Department of Medicine, VA Medical Center, Dallas, Texas, USA
    Aliment Pharmacol Ther 19:49-53. 2004

Collaborators

Detail Information

Publications73

  1. doi request reprint Barrett's esophagus: Clinical issues
    Stuart Jon Spechler
    Department of Medicine, Veterans Affairs North Texas Healthcare System, Dallas, TX, USA
    Gastrointest Endosc Clin N Am 21:1-7. 2011
    ..This article considers some key clinical issues that impact the management of patients with Barrett's esophagus...
  2. doi request reprint Barrett's esophagus: the American perspective
    Stuart Jon Spechler
    Department of Medicine, VA North Texas Healthcare System, and The University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
    Dig Dis 31:10-6. 2013
    ..In the absence of definitive data, concerns about the frequency and importance of buried metaplastic glands and recurrent metaplasia should temper enthusiasm for treating nondysplastic Barrett's esophagus with RFA. ..
  3. doi request reprint Barrett esophagus and risk of esophageal cancer: a clinical review
    Stuart Jon Spechler
    VA North Texas Healthcare System, Dallas, Texas, USA
    JAMA 310:627-36. 2013
    ..Controversy exists regarding the issues of endoscopic screening and surveillance for Barrett esophagus, treatment for the underlying GERD, and the role of endoscopic eradication therapy...
  4. pmc Tissue remodeling in eosinophilic esophagitis
    Edaire Cheng
    Departments of Pediatrics, Children s Medical Center, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1175-87. 2012
    ..This report reviews the potential roles of fibroblasts, eosinophils, mast cells, and profibrotic cytokines in esophageal remodeling in EoE and identifies potential targets for future therapies that might prevent EoE complications...
  5. ncbi request reprint Clinical manifestations and esophageal complications of GERD
    Stuart Jon Spechler
    Division of Gastroenterology, Dallas Department of Veterans Affairs Medical Center, Texas 75216, USA
    Am J Med Sci 326:279-84. 2003
    ..The management of these conditions is discussed below...
  6. ncbi request reprint The natural history of dysplasia and cancer in esophagitis and Barrett esophagus
    Stuart Jon Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    J Clin Gastroenterol 36:S2-5; discussion S26-8. 2003
    ..Dysplasia in the metaplastic epithelium clearly is a worrisome finding, but the progression from dysplasia to cancer may take years and may not be inevitable...
  7. doi request reprint Clinical trial: intragastric acid control in patients who have Barrett's oesophagus--comparison of once- and twice-daily regimens of esomeprazole and lansoprazole
    S J Spechler
    VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Aliment Pharmacol Ther 30:138-45. 2009
    ..Substantial indirect evidence suggests that gastric acid control may have a chemopreventive role in Barrett's oesophagus...
  8. ncbi request reprint Screening and surveillance for Barrett's esophagus-an unresolved dilemma
    Stuart J Spechler
    Division of Gastroenterology at the Dallas VA Medical Center, Dallas, TX 75216, USA
    Nat Clin Pract Gastroenterol Hepatol 4:470-1. 2007
  9. pmc Are we underestimating acid reflux?
    S J Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Gut 53:162-3. 2004
  10. ncbi request reprint Review article: screening and surveillance of Barrett's oesophagus: what is a cost-effective framework?
    S J Spechler
    Department of Medicine, VA Medical Center, Dallas, Texas, USA
    Aliment Pharmacol Ther 19:49-53. 2004
    ..Endoscopic screening and surveillance for Barrett's oesophagus compares favourably with mammography for the detection of breast cancer and other accepted medical practices...
  11. ncbi request reprint Intestinal metaplasia at the gastroesophageal junction
    Stuart Jon Spechler
    Dallas Department ofVeterans Affairs Medical Center, and The University of Texas Southwestern Medical Center at Dallas, 75216, USA
    Gastroenterology 126:567-75. 2004
  12. ncbi request reprint Medical or invasive therapy for GERD: an acidulous analysis
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Clin Gastroenterol Hepatol 1:81-8. 2003
    ..There is not yet sufficient data available on the endoscopic antireflux procedures to make meaningful conclusions regarding their safety and efficacy...
  13. ncbi request reprint Esophageal complications of gastroesophageal reflux disease: presentation, diagnosis, management, and outcomes
    Stuart Jon Spechler
    Division of Gastroenterology, Dallas Veterans Affairs Medical Center, Texas 75216, USA
    Clin Cornerstone 5:41-8; discussion 49-50. 2003
    ..Because Barrett's esophagus predisposes individuals to esophageal adenocarcinoma, these patients are advised to have regular endoscopic surveillance to detect early, curable neoplasms...
  14. ncbi request reprint Barrett's esophagus: a molecular perspective
    Stuart Jon Spechler
    Division of Gastroenterology, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Curr Gastroenterol Rep 7:177-81. 2005
    ..Finally, this report discusses recent data regarding the role of the Cdx2 gene in the development of esophageal intestinal metaplasia...
  15. doi request reprint Endoscopic therapy in Barrett's esophagus: when and how?
    Stuart Jon Spechler
    Department of Medicine, Division of Gastroenterology, VA North Texas Healthcare System, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Surg Oncol Clin N Am 18:509-21. 2009
    ..In this article, we discuss the use of endoscopic therapies for Barrett's esophagus presenting with no neoplasia, low and high-grade dysplasia, and early adenocarcinoma...
  16. ncbi request reprint A 59-year-old woman with gastroesophageal reflux disease and Barrett esophagus
    Stuart Jon Spechler
    Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    JAMA 289:466-75. 2003
  17. ncbi request reprint Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial
    S J Spechler
    Division of Gastroenterology 111B1, Department of Veterans Affairs Medical Center, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    JAMA 285:2331-8. 2001
    ..Severe gastroesophageal reflux disease (GERD) is a lifelong problem that can be complicated by peptic esophageal stricture and adenocarcinoma of the esophagus...
  18. pmc Classification of oesophageal motility abnormalities
    S J Spechler
    Department of Medicine Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Gut 49:145-51. 2001
    ..This should facilitate and improve comparisons among patients and studies. However, it is important to emphasise that fulfilment of the proposed criteria does not establish the clinical importance of the motility abnormalities...
  19. ncbi request reprint Review article: what I do now to manage adenocarcinoma risk, and what I may be doing in 10 years' time
    S J Spechler
    Division of Gastroenterology, Dallas VA Medical Center, Dallas, TX 75216, USA
    Aliment Pharmacol Ther 20:105-10. 2004
    ..Future studies on carcinogenesis in Barrett's oesophagus may well focus on the combined roles of nitric oxide and gastric acid...
  20. ncbi request reprint Columnar-lined esophagus. Definitions
    Stuart Jon Spechler
    Department of Veterans Affairs Medical Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Chest Surg Clin N Am 12:1-13, vii. 2002
    ..If biopsy specimens from the columnar-lined segment show specialized intestinal metaplasia, then the patient has Barrett's esophagus (BE), and the extent of the columnar lining determines if it is short- or long-segment BE...
  21. ncbi request reprint Racial differences in the frequency of symptoms and complications of gastro-oesophageal reflux disease
    S J Spechler
    Dallas VA Medical Center, TX 75216, USA
    Aliment Pharmacol Ther 16:1795-800. 2002
    ....
  22. pmc History, molecular mechanisms, and endoscopic treatment of Barrett's esophagus
    Stuart Jon Spechler
    VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Gastroenterology 138:854-69. 2010
    ..In this report, we review historical, molecular, and endoscopic therapeutic aspects of Barrett's esophagus that are of interest to clinicians and researchers...
  23. ncbi request reprint Screening and surveillance for complications related to gastroesophageal reflux disease
    S J Spechler
    Division of Gastroenterology, Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, 111 B1, Dallas, TX 75216, USA
    Am J Med 111:130S-136S. 2001
    ....
  24. doi request reprint The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology
    R M Genta
    Department of Gastrointestinal Pathology, Caris Research Institute, Irving, Texas, USA
    Dis Esophagus 24:10-7. 2011
    ....
  25. ncbi request reprint Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus
    R F Souza
    Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Aliment Pharmacol Ther 15:1087-100. 2001
    ..The goal of this review is to provide the clinician with a useful conceptual basis for evaluating studies on the molecular mechanisms underlying the progression from metaplasia to carcinoma in Barrett's oesophagus...
  26. ncbi request reprint Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells
    R F Souza
    Department of Medicine, Dallas VA Medical Center, Texas 75216, USA
    Cancer Res 60:5767-72. 2000
    ..These observations suggest a potential role for selective COX-2 inhibitors in the prevention and treatment of esophageal adenocarcinoma for patients with Barrett's esophagus...
  27. ncbi request reprint Concepts in the prevention of adenocarcinoma of the distal esophagus and proximal stomach
    Rhonda F Souza
    Division of Gastroenterology, Dallas VA Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    CA Cancer J Clin 55:334-51. 2005
    ..The similarities and differences in risk factors, molecular pathogenesis, and in preventive strategies for adenocarcinomas of the esophagus and gastric cardia are highlighted...
  28. ncbi request reprint NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells
    Jin Si
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Biol Chem 282:16244-55. 2007
    ..COX2-derived PGE2 production may contribute to NOX5-S-mediated cell proliferation in SEG1 cells...
  29. ncbi request reprint Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line
    Kshama Jaiswal
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Am J Physiol Gastrointest Liver Physiol 290:G335-42. 2006
    ..These findings suggest a potential mechanism whereby bile reflux may facilitate the neoplastic progression of BE...
  30. ncbi request reprint Mechanisms of oxidant production in esophageal squamous cell and Barrett's cell lines
    Linda A Feagins
    Department of Medicine, Dallas VA Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 294:G411-7. 2008
    ....
  31. ncbi request reprint Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells
    Rhonda F Souza
    Department of Medicine, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 287:G743-8. 2004
    ..These findings suggest potential mechanisms whereby acid reflux might promote carcinogenesis in Barrett's esophagus...
  32. ncbi request reprint Esophageal obstruction due to extensive intramural esophageal dissection: diagnosis and treatment using an endoscopic 'rendezvous' technique
    J H Shelton
    Department of Gastroenterology, Baylor University Medical Center, Dallas, TX 75246, USA
    Dis Esophagus 20:274-7. 2007
    ..The literature is reviewed for current knowledge of this condition. We also propose that 'intramural esophageal dissection' should be the preferred name for this condition, which at present is known by many names...
  33. ncbi request reprint Hallmarks of cancer progression in Barrett's oesophagus
    Carmela P Morales
    Department of Medicine, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas 75216, USA
    Lancet 360:1587-9. 2002
    ..The metaplastic cells of Barrett's oesophagus are predisposed to develop these cancer hallmarks...
  34. ncbi request reprint Acid increases MAPK-mediated proliferation in Barrett's esophageal adenocarcinoma cells via intracellular acidification through a Cl-/HCO3- exchanger
    George A Sarosi
    Dept of Surgery, Medical University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 289:G991-7. 2005
    ..The magnitude of these effects is pH dependent, and the effects can be inhibited by preventing intracellular acidification with DIDS...
  35. pmc Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Gut 59:170-80. 2010
    ..Bile acids may have an important role in this progression. This study aimed at examining the role of NADPH oxidase NOX5-S and a novel bile acid receptor TGR5 in taurodeoxycholic acid (TDCA)-induced increase in cell proliferation...
  36. pmc Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, 02903, USA
    Am J Physiol Gastrointest Liver Physiol 299:G697-706. 2010
    ....
  37. ncbi request reprint Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T)
    K R Jaiswal
    Department of Surgery, University of Texas Southwestern Medical Center at Dallas and the VA North Texas Healthcare System, Dallas, TX 75216, USA
    Dis Esophagus 20:256-64. 2007
    ..This cell line should be a useful model for the study of the early events in carcinogenesis in Barrett's esophagus...
  38. ncbi request reprint In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway
    Hui Ying Zhang
    Department of Medicine, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Cancer Res 67:8580-7. 2007
    ..Thus, we have elucidated a mechanism whereby acid can exert disparate effects on proliferation in neoplastic and non-neoplastic BAR-T cells...
  39. ncbi request reprint Barrett's esophagus: chemoprevention
    Rhonda F Souza
    Division of Gastroenterology, Dallas VA Medical Center, Dallas, TX 75216, USA
    Gastrointest Endosc Clin N Am 13:419-32. 2003
    ..Results of well-designed, prospective clinical studies, however, are still needed to establish the efficacy of potent acid suppression, COX-2 inhibitors, and DFMO in the prevention of this malignancy...
  40. pmc Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus
    Xiaofang Huo
    Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas, USA
    Gastroenterology 139:194-203.e1. 2010
    ..We hypothesized that differences among individuals in molecular pathways activated when esophageal squamous epithelium is exposed to reflux underlie the development of Barrett's metaplasia...
  41. pmc Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway
    Kathy Hormi-Carver
    Department of Medicine, VA North Texas Health Care System, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Cancer Res 69:672-7. 2009
    ..This capacity to avoid apoptosis despite genotoxic damage may underlie the persistence and malignant predisposition of Barrett's metaplasia...
  42. ncbi request reprint Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells
    Linda A Feagins
    Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Am J Gastroenterol 102:10-20. 2007
    ..We studied the effects of acid on proliferation and apoptosis in a nonneoplastic, telomerase-immortalized Barrett's epithelial cell line...
  43. ncbi request reprint All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells
    Kathy Hormi-Carver
    1Departments of Medicine, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Am J Physiol Gastrointest Liver Physiol 292:G18-27. 2007
    ..This study elucidates molecular pathways whereby retinoid treatment might prevent carcinogenesis in Barrett's metaplasia and suggests a potential role for the use of safer retinoids for chemoprevention in Barrett's esophagus...
  44. ncbi request reprint Gastric and esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial
    Stuart J Spechler
    Dallas Department of Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Am J Gastroenterol 101:1964-71. 2006
    ..It has been suggested that patients with Barrett's esophagus (BE) are unusually resistant to the antisecretory effects of proton pump inhibitors (PPIs)...
  45. ncbi request reprint Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus
    Rhonda F Souza
    Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Am J Gastroenterol 100:551-9. 2005
    ....
  46. ncbi request reprint Fundoplication and the risk of esophageal cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study
    Thomas Tran
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Am J Gastroenterol 100:1002-8. 2005
    ..It has been proposed that fundoplication can reduce the risk of esophageal cancer in patients with gastroesophageal reflux disease (GERD). In this cohort study, we assessed the effect of fundoplication on the incidence of esophageal cancer...
  47. pmc Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
    Hui Ying Zhang
    Department of Medcine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, MC 111B1, Dallas VA Medical Ctr, 4500 South Lancaster Rd, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 295:G470-8. 2008
    ..We speculate that these differences might underlie the development of Barrett's metaplasia...
  48. pmc In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks
    Hui Ying Zhang
    Department of Medicine, VA North Texas Health Care System, Dallas, Texas 75216, USA
    Cancer Res 69:9083-9. 2009
    ..Acid exposure causes DSBs in Barrett's epithelial cells through ROS produced as a consequence of intracellular acidification. These findings suggest that acid can be considered a carcinogen in Barrett's esophagus...
  49. ncbi request reprint Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus
    Linda A Feagins
    Dept of Gastrointestinology, MC 111B1, Dallas Veterans Affairs Medical Center, 4500 S Lancaster Road, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 290:G871-5. 2006
    ..We conclude that in patients with Barrett's esophagus, GOAGE for IGF-II is found frequently in the metaplastic esophageal epithelium as well as in normal gastric and duodenal epithelia...
  50. ncbi request reprint Clinical practice. Barrett's Esophagus
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas 75216, USA
    N Engl J Med 346:836-42. 2002
  51. ncbi request reprint Biomarkers and photodynamic therapy for Barrett's esophagus: time to FISH or cut bait?
    Stuart Jon Spechler
    Gastroenterology 135:354-7. 2008
  52. ncbi request reprint Should patients with GERD be screened once at least for Barrett's epithelium? A balancing view: To screen or not to screen: scoping out the issues
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs, Texas, USA
    Am J Gastroenterol 99:2295-6. 2004
  53. pmc Managing Barrett's oesophagus
    Stuart Jon Spechler
    BMJ 326:892-4. 2003
  54. ncbi request reprint Therapeutic approaches to reflux disease: newer approaches and strategies to columnar-lined esophagus
    Stuart Jon Spechler
    Division of Gastroenterology 111B1, Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    J Gastroenterol 38:20-4. 2003
  55. ncbi request reprint Carcinogenesis at the gastroesophageal junction: free radicals at the frontier
    Stuart Jon Spechler
    Gastroenterology 122:1518-20. 2002
  56. ncbi request reprint Barrett's esophagus and esophageal adenocarcinoma: pathogenesis, diagnosis, and therapy
    Stuart Jon Spechler
    Division of Gastroenterology, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Med Clin North Am 86:1423-45, vii. 2002
    ..This article examines such issues as the treatment, endoscopic surveillance, and chemoprevention of Barrett's esophagus. Also included are published guidelines and recommendations...
  57. ncbi request reprint Screening for Barrett's esophagus
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Rev Gastroenterol Disord 2:S25-9. 2002
    ..It is important for physicians to recognize that such models do not provide a single, definitive answer...
  58. ncbi request reprint Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus
    Rhonda F Souza
    Department of Medicine, Dallas VA Medical Center and University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Gastroenterology 122:299-307. 2002
    ....
  59. ncbi request reprint Stem cells in Barrett's esophagus: HALOs or horns?
    Stuart Jon Spechler
    Gastrointest Endosc 68:41-3. 2008
  60. ncbi request reprint Re-examination of the cost-effectiveness of surgical versus medical therapy in patients with gastroesophageal reflux disease: the value of long-term data collection
    Miguel R Arguedas
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Gastroenterol 99:1023-8. 2004
    ..We have incorporated these new data into a revised Markov model to examine the cost-effectiveness of surgical versus medical therapy in patients with severe reflux esophagitis...
  61. ncbi request reprint High-frequency probe ultrasonography has limited accuracy for detecting invasive adenocarcinoma in patients with Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma: a case series
    Irving Waxman
    University Chicago Section of Endoscopy and Therapeutics and the Cancer Research Center, Chicago, Illinois 60637, USA
    Am J Gastroenterol 101:1773-9. 2006
    ....
  62. ncbi request reprint GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus
    Rhonda F Souza
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, and the Veterans Affairs North Texas Health Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 293:G19-24. 2007
    ..Telomeres in the squamous epithelium of the distal esophagus of patients who have GERD, with and without Barrett's esophagus, are significantly shorter than those of patients without GERD despite similar levels of telomerase activity...
  63. ncbi request reprint Banding without resection (endoscopic mucosal ligation) as a novel approach for the ablation of short-segment Barrett's epithelium: results of a pilot study
    Edgardo Diaz-Cervantes
    Saint Joseph s Hospital, Gastroenterology, Endoscopy and Motility Unit, Zacatecas, Mexico
    Am J Gastroenterol 102:1640-5. 2007
    ..During an endoscopic variceal ligation, we banded a varix with an overlying tongue of Barrett's epithelium (BE). One month later, the tongue was no longer visible, suggesting that banding could be used to eradicate BE...
  64. ncbi request reprint Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis
    Stuart Jon Spechler
    Department of Medicine, Dallas Department of Veterans Affairs Medical Center, and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Am J Gastroenterol 102:1301-6. 2007
    ..Furthermore, we suggest that a favorable response to PPI therapy does not preclude a diagnosis of eosinophilic esophagitis...
  65. ncbi request reprint The management of patients who have "failed" antireflux surgery
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Am J Gastroenterol 99:552-61. 2004
    ....
  66. ncbi request reprint Integrated approach to treatment of children and adults with eosinophilic esophagitis
    Seema S Aceves
    Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
    Gastrointest Endosc Clin N Am 18:195-217; xi. 2008
    ..In this article, three authors from diverse backgrounds combine their resources to propose treatment paths with justification based on their clinical experience and interpretation of the literature...
  67. ncbi request reprint Intestinal metaplasia at the gastroesophageal junction: Barrett's, bacteria, and biomarkers
    Carmela P Morales
    Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA
    Am J Gastroenterol 98:759-62. 2003
    ....
  68. doi request reprint Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus
    G Sarosi
    Dallas VA Medical Center, Dallas, Texas 75216, USA
    Dis Esophagus 21:43-50. 2008
    ..These observations suggest that multi-potential progenitor cells of bone marrow origin contribute to esophageal regeneration and metaplasia in this rat model of Barrett's esophagus...
  69. doi request reprint Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008
    ..The role of stem cells in the development of metaplasia and in carcinogenesis and the potential for therapies directed at those stem cells also is addressed...
  70. ncbi request reprint Dysplasia in Barrett's esophagus: limitations of current management strategies
    Stuart Jon Spechler
    Dallas Department of Veterans Affairs Medical Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Am J Gastroenterol 100:927-35. 2005
    ..Specific recommendations for management based on these considerations are proposed at the end of this report...
  71. ncbi request reprint Upper gastrointestinal bleeding in a patient with AIDS
    Valeska Balderas
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Clin Pract Gastroenterol Hepatol 3:349-53; quiz following 353. 2006
    ..The patient was not taking highly active antiretroviral therapy because of poor compliance and he denied use of NSAIDs...
  72. ncbi request reprint Laryngopharyngeal reflux: a cause of faulty phonation or a faulted, phony diagnosis?
    Stuart Jon Spechler
    Clin Gastroenterol Hepatol 4:431-2. 2006
  73. ncbi request reprint Irreversible ototoxicity associated with difluoromethylornithine
    Christopher D Lao
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, 48109, USA
    Cancer Epidemiol Biomarkers Prev 13:1250-2. 2004
    ..This is the first case reported of irreversible ototoxicity in a clinical trial participant receiving DFMO and, thus, trial participants should be made aware of this small but important risk...