Barrett's esophagus: Clinical issuesStuart Jon Spechler
Department of Medicine, Veterans Affairs North Texas Healthcare System, Dallas, TX, USA
Gastrointest Endosc Clin N Am 21:1-7. 2011
..This article considers some key clinical issues that impact the management of patients with Barrett's esophagus...
Tissue remodeling in eosinophilic esophagitisEdaire Cheng
Departments of Pediatrics, Children s Medical Center, USA
Am J Physiol Gastrointest Liver Physiol 303:G1175-87. 2012
..This report reviews the potential roles of fibroblasts, eosinophils, mast cells, and profibrotic cytokines in esophageal remodeling in EoE and identifies potential targets for future therapies that might prevent EoE complications...
Barrett's esophagus: a molecular perspectiveStuart Jon Spechler
Division of Gastroenterology, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Curr Gastroenterol Rep 7:177-81. 2005
..Finally, this report discusses recent data regarding the role of the Cdx2 gene in the development of esophageal intestinal metaplasia...
- The natural history of dysplasia and cancer in esophagitis and Barrett esophagus
Stuart Jon Spechler
Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
J Clin Gastroenterol 36:S2-5; discussion S26-8. 2003
..Dysplasia in the metaplastic epithelium clearly is a worrisome finding, but the progression from dysplasia to cancer may take years and may not be inevitable...
- Clinical trial: intragastric acid control in patients who have Barrett's oesophagus--comparison of once- and twice-daily regimens of esomeprazole and lansoprazole
S J Spechler
VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
Aliment Pharmacol Ther 30:138-45. 2009
..Substantial indirect evidence suggests that gastric acid control may have a chemopreventive role in Barrett's oesophagus...
- Clinical manifestations and esophageal complications of GERD
Stuart Jon Spechler
Division of Gastroenterology, Dallas Department of Veterans Affairs Medical Center, Texas 75216, USA
Am J Med Sci 326:279-84. 2003
..The management of these conditions is discussed below...
- Screening and surveillance for Barrett's esophagus-an unresolved dilemma
Stuart J Spechler
Division of Gastroenterology at the Dallas VA Medical Center, Dallas, TX 75216, USA
Nat Clin Pract Gastroenterol Hepatol 4:470-1. 2007
- Are we underestimating acid reflux?
S J Spechler
Division of Gastroenterology 111B1, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Gut 53:162-3. 2004
- Review article: screening and surveillance of Barrett's oesophagus: what is a cost-effective framework?
S J Spechler
Department of Medicine, VA Medical Center, Dallas, Texas, USA
Aliment Pharmacol Ther 19:49-53. 2004
..Endoscopic screening and surveillance for Barrett's oesophagus compares favourably with mammography for the detection of breast cancer and other accepted medical practices...
- Intestinal metaplasia at the gastroesophageal junction
Stuart Jon Spechler
Dallas Department ofVeterans Affairs Medical Center, and The University of Texas Southwestern Medical Center at Dallas, 75216, USA
Gastroenterology 126:567-75. 2004
- Medical or invasive therapy for GERD: an acidulous analysis
Stuart Jon Spechler
Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
Clin Gastroenterol Hepatol 1:81-8. 2003
..There is not yet sufficient data available on the endoscopic antireflux procedures to make meaningful conclusions regarding their safety and efficacy...
- Esophageal complications of gastroesophageal reflux disease: presentation, diagnosis, management, and outcomes
Stuart Jon Spechler
Division of Gastroenterology, Dallas Veterans Affairs Medical Center, Texas 75216, USA
Clin Cornerstone 5:41-8; discussion 49-50. 2003
..Because Barrett's esophagus predisposes individuals to esophageal adenocarcinoma, these patients are advised to have regular endoscopic surveillance to detect early, curable neoplasms...
- Review article: what I do now to manage adenocarcinoma risk, and what I may be doing in 10 years' time
S J Spechler
Division of Gastroenterology, Dallas VA Medical Center, Dallas, TX 75216, USA
Aliment Pharmacol Ther 20:105-10. 2004
..Future studies on carcinogenesis in Barrett's oesophagus may well focus on the combined roles of nitric oxide and gastric acid...
- A 59-year-old woman with gastroesophageal reflux disease and Barrett esophagus
Stuart Jon Spechler
Division of Gastroenterology (111B1, Dallas VA Medical Center, 4500 S Lancaster Rd, Dallas, TX 75216, USA
JAMA 289:466-75. 2003
- History, molecular mechanisms, and endoscopic treatment of Barrett's esophagus
Stuart Jon Spechler
VA North Texas Healthcare System and the University of Texas Southwestern Medical Center, Dallas, Texas, USA
Gastroenterology 138:854-69. 2010
..In this report, we review historical, molecular, and endoscopic therapeutic aspects of Barrett's esophagus that are of interest to clinicians and researchers...
- Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial
S J Spechler
Division of Gastroenterology 111B1, Department of Veterans Affairs Medical Center, 4500 S Lancaster Rd, Dallas, TX 75216, USA
JAMA 285:2331-8. 2001
..Severe gastroesophageal reflux disease (GERD) is a lifelong problem that can be complicated by peptic esophageal stricture and adenocarcinoma of the esophagus...
- Classification of oesophageal motility abnormalities
S J Spechler
Department of Medicine Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, Texas, USA
Gut 49:145-51. 2001
..This should facilitate and improve comparisons among patients and studies. However, it is important to emphasise that fulfilment of the proposed criteria does not establish the clinical importance of the motility abnormalities...
- Racial differences in the frequency of symptoms and complications of gastro-oesophageal reflux disease
S J Spechler
Dallas VA Medical Center, TX 75216, USA
Aliment Pharmacol Ther 16:1795-800. 2002
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- Endoscopic therapy in Barrett's esophagus: when and how?
Stuart Jon Spechler
Department of Medicine, Division of Gastroenterology, VA North Texas Healthcare System, 4500 South Lancaster Road, Dallas, TX 75216, USA
Surg Oncol Clin N Am 18:509-21. 2009
..In this article, we discuss the use of endoscopic therapies for Barrett's esophagus presenting with no neoplasia, low and high-grade dysplasia, and early adenocarcinoma...
- Columnar-lined esophagus. Definitions
Stuart Jon Spechler
Department of Veterans Affairs Medical Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Chest Surg Clin N Am 12:1-13, vii. 2002
..If biopsy specimens from the columnar-lined segment show specialized intestinal metaplasia, then the patient has Barrett's esophagus (BE), and the extent of the columnar lining determines if it is short- or long-segment BE...
- Screening and surveillance for complications related to gastroesophageal reflux disease
S J Spechler
Division of Gastroenterology, Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, 111 B1, Dallas, TX 75216, USA
Am J Med 111:130S-136S. 2001
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- Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus
R F Souza
Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Texas, USA
Aliment Pharmacol Ther 15:1087-100. 2001
..The goal of this review is to provide the clinician with a useful conceptual basis for evaluating studies on the molecular mechanisms underlying the progression from metaplasia to carcinoma in Barrett's oesophagus...
- Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells
R F Souza
Department of Medicine, Dallas VA Medical Center, Texas 75216, USA
Cancer Res 60:5767-72. 2000
..These observations suggest a potential role for selective COX-2 inhibitors in the prevention and treatment of esophageal adenocarcinoma for patients with Barrett's esophagus...
- The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology
R M Genta
Department of Gastrointestinal Pathology, Caris Research Institute, Irving, Texas, USA
Dis Esophagus 24:10-7. 2011
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- Concepts in the prevention of adenocarcinoma of the distal esophagus and proximal stomach
Rhonda F Souza
Division of Gastroenterology, Dallas VA Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
CA Cancer J Clin 55:334-51. 2005
..The similarities and differences in risk factors, molecular pathogenesis, and in preventive strategies for adenocarcinomas of the esophagus and gastric cardia are highlighted...
- Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line
Kshama Jaiswal
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
Am J Physiol Gastrointest Liver Physiol 290:G335-42. 2006
..These findings suggest a potential mechanism whereby bile reflux may facilitate the neoplastic progression of BE...
- Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells
Rhonda F Souza
Department of Medicine, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
Am J Physiol Gastrointest Liver Physiol 287:G743-8. 2004
..These findings suggest potential mechanisms whereby acid reflux might promote carcinogenesis in Barrett's esophagus...
- NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells
Jin Si
Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
J Biol Chem 282:16244-55. 2007
..COX2-derived PGE2 production may contribute to NOX5-S-mediated cell proliferation in SEG1 cells...
- Mechanisms of oxidant production in esophageal squamous cell and Barrett's cell lines
Linda A Feagins
Department of Medicine, Dallas VA Medical Center, Dallas, TX 75216, USA
Am J Physiol Gastrointest Liver Physiol 294:G411-7. 2008
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- Esophageal obstruction due to extensive intramural esophageal dissection: diagnosis and treatment using an endoscopic 'rendezvous' technique
J H Shelton
Department of Gastroenterology, Baylor University Medical Center, Dallas, TX 75246, USA
Dis Esophagus 20:274-7. 2007
..The literature is reviewed for current knowledge of this condition. We also propose that 'intramural esophageal dissection' should be the preferred name for this condition, which at present is known by many names...
- Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S
Jie Hong
Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, 02903, USA
Am J Physiol Gastrointest Liver Physiol 299:G697-706. 2010
....
- Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
Jie Hong
Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
Gut 59:170-80. 2010
..Bile acids may have an important role in this progression. This study aimed at examining the role of NADPH oxidase NOX5-S and a novel bile acid receptor TGR5 in taurodeoxycholic acid (TDCA)-induced increase in cell proliferation...
- Acid increases MAPK-mediated proliferation in Barrett's esophageal adenocarcinoma cells via intracellular acidification through a Cl-/HCO3- exchanger
George A Sarosi
Dept. of Surgery, Medical University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
Am J Physiol Gastrointest Liver Physiol 289:G991-7. 2005
..The magnitude of these effects is pH dependent, and the effects can be inhibited by preventing intracellular acidification with DIDS...
- Hallmarks of cancer progression in Barrett's oesophagus
Carmela P Morales
Department of Medicine, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas 75216, USA
Lancet 360:1587-9. 2002
..WHERE NEXT? The cancer hallmarks of Barrett's oesophagus provide a framework to categorise the genetic abnormalities described and to further understanding of the genetic events that underlie oesophageal carcinogenesis...
- Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T)
K R Jaiswal
Department of Surgery, University of Texas Southwestern Medical Center at Dallas and the VA North Texas Healthcare System, Dallas, TX 75216, USA
Dis Esophagus 20:256-64. 2007
..This cell line should be a useful model for the study of the early events in carcinogenesis in Barrett's esophagus...
- Fundoplication and the risk of esophageal cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study
Thomas Tran
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 100:1002-8. 2005
..The adjusted hazard ratio of esophageal cancer with fundoplication was 1.88 (95% CI: 0.70-5.03). CONCLUSIONS: GERD is a risk factor for esophageal cancer, but there is insufficient evidence that fundoplication reduces that risk...
- Barrett's esophagus: chemoprevention
Rhonda F Souza
Division of Gastroenterology, Dallas VA Medical Center, Dallas, TX 75216, USA
Gastrointest Endosc Clin N Am 13:419-32. 2003
..Results of well-designed, prospective clinical studies, however, are still needed to establish the efficacy of potent acid suppression, COX-2 inhibitors, and DFMO in the prevention of this malignancy...
- In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway
Hui Ying Zhang
Department of Medicine, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, Texas, USA
Cancer Res 67:8580-7. 2007
..Thus, we have elucidated a mechanism whereby acid can exert disparate effects on proliferation in neoplastic and non-neoplastic BAR-T cells...
- Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
Hui Ying Zhang
Department of Medcine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, MC 111B1, Dallas VA Medical Ctr, 4500 South Lancaster Rd, Dallas, TX 75216, USA
Am J Physiol Gastrointest Liver Physiol 295:G470-8. 2008
..We speculate that these differences might underlie the development of Barrett's metaplasia...
- Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway
Kathy Hormi-Carver
Department of Medicine, VA North Texas Health Care System, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
Cancer Res 69:672-7. 2009
..This capacity to avoid apoptosis despite genotoxic damage may underlie the persistence and malignant predisposition of Barrett's metaplasia...
- In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks
Hui Ying Zhang
Department of Medicine, VA North Texas Health Care System, Dallas, Texas 75216, USA
Cancer Res 69:9083-9. 2009
..Acid exposure causes DSBs in Barrett's epithelial cells through ROS produced as a consequence of intracellular acidification. These findings suggest that acid can be considered a carcinogen in Barrett's esophagus...
- Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus
Xiaofang Huo
Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas, USA
Gastroenterology 139:194-203.e1. 2010
..We hypothesized that differences among individuals in molecular pathways activated when esophageal squamous epithelium is exposed to reflux underlie the development of Barrett's metaplasia...
- Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells
Linda A Feagins
Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
Am J Gastroenterol 102:10-20. 2007
..We studied the effects of acid on proliferation and apoptosis in a nonneoplastic, telomerase-immortalized Barrett's epithelial cell line...
- All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells
Kathy Hormi-Carver
1Departments of Medicine, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
Am J Physiol Gastrointest Liver Physiol 292:G18-27. 2007
..This study elucidates molecular pathways whereby retinoid treatment might prevent carcinogenesis in Barrett's metaplasia and suggests a potential role for the use of safer retinoids for chemoprevention in Barrett's esophagus...
- Gastric and esophageal pH in patients with Barrett's esophagus treated with three esomeprazole dosages: a randomized, double-blind, crossover trial
Stuart J Spechler
Dallas Department of Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
Am J Gastroenterol 101:1964-71. 2006
..These results suggest that the apparent "PPI resistance" described in patients with BE may be caused by their profound reflux diathesis rather than by gastric resistance to the antisecretory effects of PPIs...
- Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus
Linda A Feagins
Dept of Gastrointestinology, MC 111B1, Dallas Veterans Affairs Medical Center, 4500 S Lancaster Road, Dallas, TX 75216, USA
Am J Physiol Gastrointest Liver Physiol 290:G871-5. 2006
..We conclude that in patients with Barrett's esophagus, GOAGE for IGF-II is found frequently in the metaplastic esophageal epithelium as well as in normal gastric and duodenal epithelia...
- Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus
Rhonda F Souza
Department of Medicine, Dallas VA Medical Center, University of Texas-Southwestern Medical School, Dallas, Texas, USA
Am J Gastroenterol 100:551-9. 2005
..To our knowledge, this is the first description of a molecular, phenotypic feature that distinguishes the esophageal squamous mucosa of GERD patients with and without Barrett's esophagus...
- Biomarkers and photodynamic therapy for Barrett's esophagus: time to FISH or cut bait?
Stuart Jon Spechler
Gastroenterology 135:354-7. 2008
- Managing Barrett's oesophagus
Stuart Jon Spechler
BMJ 326:892-4. 2003
- Carcinogenesis at the gastroesophageal junction: free radicals at the frontier
Stuart Jon Spechler
Gastroenterology 122:1518-20. 2002
- Should patients with GERD be screened once at least for Barrett's epithelium? A balancing view: To screen or not to screen: scoping out the issues
Stuart Jon Spechler
Dallas Department of Veterans Affairs, Texas, USA
Am J Gastroenterol 99:2295-6. 2004
- Therapeutic approaches to reflux disease: newer approaches and strategies to columnar-lined esophagus
Stuart Jon Spechler
Division of Gastroenterology (111B1, Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
J Gastroenterol 38:20-4. 2003
- Barrett's esophagus and esophageal adenocarcinoma: pathogenesis, diagnosis, and therapy
Stuart Jon Spechler
Division of Gastroenterology, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Med Clin North Am 86:1423-45, vii. 2002
..This article examines such issues as the treatment, endoscopic surveillance, and chemoprevention of Barrett's esophagus. Also included are published guidelines and recommendations...
- Screening for Barrett's esophagus
Stuart Jon Spechler
Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Rev Gastroenterol Disord 2:S25-9. 2002
..It is important for physicians to recognize that such models do not provide a single, definitive answer...
- Dysplasia in Barrett's esophagus: limitations of current management strategies
Stuart Jon Spechler
Dallas Department of Veterans Affairs Medical Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
Am J Gastroenterol 100:927-35. 2005
..Specific recommendations for management based on these considerations are proposed at the end of this report...
- Clinical practice. Barrett's Esophagus
Stuart Jon Spechler
Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas 75216, USA
N Engl J Med 346:836-42. 2002
- Stem cells in Barrett's esophagus: HALOs or horns?
Stuart Jon Spechler
Gastrointest Endosc 68:41-3. 2008
- Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
Rhonda F Souza
Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008
..The role of stem cells in the development of metaplasia and in carcinogenesis and the potential for therapies directed at those stem cells also is addressed...
- GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus
Rhonda F Souza
Department of Medicine, University of Texas Southwestern Medical Center at Dallas, and the Veterans Affairs North Texas Health Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Am J Physiol Gastrointest Liver Physiol 293:G19-24. 2007
..Telomeres in the squamous epithelium of the distal esophagus of patients who have GERD, with and without Barrett's esophagus, are significantly shorter than those of patients without GERD despite similar levels of telomerase activity...
- Re-examination of the cost-effectiveness of surgical versus medical therapy in patients with gastroesophageal reflux disease: the value of long-term data collection
Miguel R Arguedas
Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Gastroenterol 99:1023-8. 2004
..Our study highlights the importance of using primary, patient-derived data rather than expert opinion...
- Banding without resection (endoscopic mucosal ligation) as a novel approach for the ablation of short-segment Barrett's epithelium: results of a pilot study
Edgardo Diaz Cervantes
Saint Joseph s Hospital, Gastroenterology, Endoscopy and Motility Unit, Zacatecas, Mexico
Am J Gastroenterol 102:1640-5. 2007
..During an endoscopic variceal ligation, we banded a varix with an overlying tongue of Barrett's epithelium (BE). One month later, the tongue was no longer visible, suggesting that banding could be used to eradicate BE...
- High-frequency probe ultrasonography has limited accuracy for detecting invasive adenocarcinoma in patients with Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma: a case series
Irving Waxman
University Chicago Section of Endoscopy and Therapeutics and the Cancer Research Center, Chicago, Illinois 60637, USA
Am J Gastroenterol 101:1773-9. 2006
..Pending further refinements in technology, clinical management decisions in such patients should not be based solely on the results of HFPUS...
- The management of patients who have "failed" antireflux surgery
Stuart Jon Spechler
Dallas Department of Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
Am J Gastroenterol 99:552-61. 2004
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- Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis
Stuart Jon Spechler
Department of Medicine, Dallas Department of Veterans Affairs Medical Center, and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
Am J Gastroenterol 102:1301-6. 2007
..Furthermore, we suggest that a favorable response to PPI therapy does not preclude a diagnosis of eosinophilic esophagitis...
- Integrated approach to treatment of children and adults with eosinophilic esophagitis
Seema S Aceves
Division of Allergy, Immunology, Rady Children s Hospital, San Diego, Pediatrics University of California, 3020 Childrens Way, San Diego, CA 92123, USA
Gastrointest Endosc Clin N Am 18:195-217; xi. 2008
..In this article, three authors from diverse backgrounds combine their resources to propose treatment paths with justification based on their clinical experience and interpretation of the literature...
- Intestinal metaplasia at the gastroesophageal junction: Barrett's, bacteria, and biomarkers
Carmela P Morales
Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA
Am J Gastroenterol 98:759-62. 2003
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- Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus
G Sarosi
Dallas VA Medical Center, Dallas, Texas 75216, USA
Dis Esophagus 21:43-50. 2008
..These observations suggest that multi-potential progenitor cells of bone marrow origin contribute to esophageal regeneration and metaplasia in this rat model of Barrett's esophagus...
- Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus
Rhonda F Souza
Department of Medicine, Dallas VA Medical Center and University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
Gastroenterology 122:299-307. 2002
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- Upper gastrointestinal bleeding in a patient with AIDS
Valeska Balderas
University of Texas Southwestern Medical Center, Dallas, TX, USA
Nat Clin Pract Gastroenterol Hepatol 3:349-53; quiz following 353. 2006
..DIAGNOSIS: Non-Hodgkin's lymphoma of the stomach (diffuse large B-cell type) with associated gastric ulceration and bleeding. MANAGEMENT: Injection of epinephrine and bipolar coagulation for the bleeding malignant ulcer, and PPI therapy...
- Laryngopharyngeal reflux: a cause of faulty phonation or a faulted, phony diagnosis?
Stuart Jon Spechler
Clin Gastroenterol Hepatol 4:431-2. 2006
- Irreversible ototoxicity associated with difluoromethylornithine
Christopher D Lao
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, 48109, USA
Cancer Epidemiol Biomarkers Prev 13:1250-2. 2004
..This is the first case reported of irreversible ototoxicity in a clinical trial participant receiving DFMO and, thus, trial participants should be made aware of this small but important risk...
