Angeles Villanueva

Summary

Country: Spain

Publications

  1. ncbi request reprint Photokilling mechanisms induced by zinc(II)-phthalocyanine on cultured tumor cells
    A Villanueva
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Canto Blanco, Spain
    Oncol Res 11:447-53. 1999
  2. ncbi request reprint Photokilling of cultured tumour cells by the porphyrin derivative CF3
    A Villanueva
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Anticancer Drug Des 16:279-90. 2001
  3. doi request reprint A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers
    Angeles Villanueva
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Darwin 2, Edificio de Biología E 28049, Madrid, Spain
    Photochem Photobiol Sci 9:295-7. 2010
  4. doi request reprint The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells
    Angeles Villanueva
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
    Nanotechnology 20:115103. 2009
  5. doi request reprint Vehiculization determines the endocytic internalization mechanism of Zn(II)-phthalocyanine
    Jorge Soriano
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Histochem Cell Biol 139:149-60. 2013
  6. ncbi request reprint The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: a morphological approach
    Magdalena Cañete
    Departamento de Biologia, Universidad Autónoma de Madrid C Darwin 2, Cantoblanco, Madrid, Spain
    Int J Mol Med 26:533-9. 2010
  7. ncbi request reprint Mitotic catastrophe induced in HeLa cells by photodynamic treatment with Zn(II)-phthalocyanine
    Santiago Rello-Varona
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, C Darwin 2, E 28049 Madrid, Spain
    Int J Oncol 32:1189-96. 2008
  8. doi request reprint Liposomal temocene (m-THPPo) photodynamic treatment induces cell death by mitochondria-independent apoptosis
    Jorge Soriano
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
    Biochim Biophys Acta 1830:4611-20. 2013
  9. ncbi request reprint Metaphase arrest and cell death induced by etoposide on HeLa cells
    Santiago Rello-Varona
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, C Darwin 2, Citología A 115, E 28049 Madrid, Spain
    Int J Biochem Cell Biol 38:2183-95. 2006
  10. doi request reprint Cell uptake of Zn(II)-phthalocyanine-containing liposomes by clathrin-mediated endocytosis
    Jorge Soriano
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Darwin 2, 28049, Madrid, Spain
    Histochem Cell Biol 133:449-54. 2010

Collaborators

  • Magdalena Cañete
  • Juan C Stockert
  • Santiago Rello-Varona
  • Angeles Juarranz
  • Jorge Soriano
  • A Morales
  • Javier Cristóbal
  • S Rello
  • M Pacheco
  • G Cabello
  • María García-Díaz
  • Santi Nonell
  • Margarita Mora
  • Maria Lluïsa Sagristá
  • L Llacuna
  • J C Fernandez-Checa
  • C Garcia-Ruiz
  • R Paris
  • A Bartolome
  • A Gamez
  • V Moreno
  • G Calaf
  • L Botella
  • S Galaz
  • M J Bartolome
  • I Sánchez de las Matas
  • E Fraile
  • J González-Alenda
  • M Perez-Romero

Detail Information

Publications18

  1. ncbi request reprint Photokilling mechanisms induced by zinc(II)-phthalocyanine on cultured tumor cells
    A Villanueva
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Canto Blanco, Spain
    Oncol Res 11:447-53. 1999
    ..Both apoptotic and necrotic mechanisms for cell death occur in HeLa cells in dependence on the experimental protocol of ZnPc photodynamic treatments...
  2. ncbi request reprint Photokilling of cultured tumour cells by the porphyrin derivative CF3
    A Villanueva
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Anticancer Drug Des 16:279-90. 2001
    ..1%). Forty-eight hours after this metaphase blockage, cultures showed a great number of apoptotic cells. Taking into account these results, CF3 could be a valuable photosensitizer for the photodynamic therapy of cancer...
  3. doi request reprint A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers
    Angeles Villanueva
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Darwin 2, Edificio de Biología E 28049, Madrid, Spain
    Photochem Photobiol Sci 9:295-7. 2010
    ..Thus, the proper combination of PSs may constitute a new strategy to improve the efficacy of clinical photodynamic therapy...
  4. doi request reprint The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells
    Angeles Villanueva
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
    Nanotechnology 20:115103. 2009
    ....
  5. doi request reprint Vehiculization determines the endocytic internalization mechanism of Zn(II)-phthalocyanine
    Jorge Soriano
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Histochem Cell Biol 139:149-60. 2013
    ..We conclude that using different drug vehiculization systems, it is possible to modify the internalization mechanism of a therapeutic compound, which could be of great interest in clinical research...
  6. ncbi request reprint The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: a morphological approach
    Magdalena Cañete
    Departamento de Biologia, Universidad Autónoma de Madrid C Darwin 2, Cantoblanco, Madrid, Spain
    Int J Mol Med 26:533-9. 2010
    ..We determined the potential internalization mechanism of nanoparticles into cells using endocytosis inhibitors. The results suggest that nanoparticles used in this study penetrate A-549 cells mainly through a macropinocytosis process...
  7. ncbi request reprint Mitotic catastrophe induced in HeLa cells by photodynamic treatment with Zn(II)-phthalocyanine
    Santiago Rello-Varona
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, C Darwin 2, E 28049 Madrid, Spain
    Int J Oncol 32:1189-96. 2008
    ..These features are components of the cell death mechanism known as mitotic catastrophe and represent, to our knowledge, the first description of this cell death modality after PDT with ZnPc...
  8. doi request reprint Liposomal temocene (m-THPPo) photodynamic treatment induces cell death by mitochondria-independent apoptosis
    Jorge Soriano
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
    Biochim Biophys Acta 1830:4611-20. 2013
    ..The present study aims to characterize a suitable m-THPPo liposomal formulation, to determine its subcellular localization in HeLa cells and to establish the cell death mechanisms that are activated after photodynamic treatments...
  9. ncbi request reprint Metaphase arrest and cell death induced by etoposide on HeLa cells
    Santiago Rello-Varona
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, C Darwin 2, Citología A 115, E 28049 Madrid, Spain
    Int J Biochem Cell Biol 38:2183-95. 2006
    ....
  10. doi request reprint Cell uptake of Zn(II)-phthalocyanine-containing liposomes by clathrin-mediated endocytosis
    Jorge Soriano
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Darwin 2, 28049, Madrid, Spain
    Histochem Cell Biol 133:449-54. 2010
    ..These results indicate that ZnPc is internalized into cells preferentially by a mechanism of clathrin-mediated endocytosis...
  11. ncbi request reprint Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment
    Javier Cristóbal
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Int J Oncol 28:1057-63. 2006
    ..From this results we assume that following the photodynamic treatment of A-549 cells with ZnPc, the activation of caspase-2 in the Golgi apparatus could begin to initiate immediately the apoptotic process...
  12. ncbi request reprint Porphycenes: facts and prospects in photodynamic therapy of cancer
    J C Stockert
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Curr Med Chem 14:997-1026. 2007
    ..Taking into account all these features, porphycene PSs should be very useful for PDT of cancer and other biomedical applications...
  13. ncbi request reprint Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments
    S Rello
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Ciudad Universitaria de Cantoblanco, E 28049, Madrid, Spain
    Apoptosis 10:201-8. 2005
    ....
  14. ncbi request reprint Necrotic cell death induced by photodynamic treatment of human lung adenocarcinoma A-549 cells with palladium(II)-tetraphenylporphycene
    M Canete
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Int J Oncol 24:1221-8. 2004
    ..Present results show that the cell type plays a fundamental role in relation to the apoptotic or necrotic response to photosensitization, and that cytoskeletal components are important targets implicated in cell death processes...
  15. ncbi request reprint Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo
    A Morales
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic i Provincial, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Oncogene 26:905-16. 2007
    ..Thus, acid CDase promotes hepatocarcinogenesis and its antagonism may be a promising strategy in the treatment of liver cancer...
  16. ncbi request reprint The pesticide malathion induces alterations in actin cytoskeleton and in cell adhesion of cultured breast carcinoma cells
    G Cabello
    Centro de Investigaciones del Hombre en el Desierto, Facultad de Ciencias, Departamento de Biologia y Salud, Universidad de Tarapaca, Arica, Chile
    Int J Oncol 23:697-704. 2003
    ..Conversely, we observed an increase in the expression of Rho and Rac1 GTPases, modulators of actin cytoskeleton and cell adhesion...
  17. ncbi request reprint Fixation and permanent mounting of fluorescent probes after vital labelling of cultured cells
    M Canete
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Canto Blanco, Spain
    Acta Histochem 103:117-26. 2001
    ..The method of vapour fixation and DPX mounting is simple, rapid and reproducible, allowing definitive preservation of the fluorescence pattern observed in unfixed cell cultures...
  18. ncbi request reprint [Study of the brachial plexus by magnetic resonance]
    A Bartolome
    Unidad de RM y CT, Clínica La Milagrosa San Francisco de Asis, Madrid, Espana
    Rev Neurol 26:983-8. 1998
    ..Magnetic resonance (MR) is considered to be the best method available at present for diagnosis of lesions of the brachial plexus. In this study we analyze our experience in patients with pathology of the brachial plexus...