Eduard Vieta

Summary

Country: Spain

Publications

  1. doi Developing an individualized treatment plan for patients with schizoaffective disorder: from pharmacotherapy to psychoeducation
    Eduard Vieta
    Bipolar Disorders Program and the Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
    J Clin Psychiatry 71:14-9. 2010
  2. pmc Acute and long-term treatment of mania
    Eduard Vieta
    Bipolar Disorders Program, University of Barcelona, Hospital Clinic, IDIBAPS, CIBER SAM, Barcelona, Catalonia, Spain
    Dialogues Clin Neurosci 10:165-79. 2008
  3. doi Efficacy and tolerability of flexibly-dosed adjunct TC-5214 (dexmecamylamine) in patients with major depressive disorder and inadequate response to prior antidepressant
    Eduard Vieta
    Department of Psychiatry, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170 Rossello 140, 08036 Barcelona, Catalonia, Spain Electronic address
    Eur Neuropsychopharmacol 24:564-74. 2014
  4. pmc Functional remediation for bipolar disorder
    Anabel Martinez-Aran
    Early Onset Psychosis Program and Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    Clin Pract Epidemiol Ment Health 7:112-6. 2011
  5. ncbi Phenomenology of manic episodes according to the presence or absence of depressive features as defined in DSM-5: Results from the IMPACT self-reported online survey
    Eduard Vieta
    Bipolar Disorder Programme, Institute of Neuroscience, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, C Villarroel 170, Barcelona 08036, Catalonia, Spain Electronic address
    J Affect Disord 156:206-13. 2014
  6. doi Clinical management and burden of bipolar disorder: results from a multinational longitudinal study (WAVE-bd)
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, 170 Villaroel, Barcelona, Spain
    Int J Neuropsychopharmacol 16:1719-32. 2013
  7. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
  8. ncbi Pooled analysis of sustained response rates for extended release quetiapine fumarate as monotherapy or adjunct to antidepressant therapy in patients with major depressive disorder
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    J Affect Disord 150:639-43. 2013
  9. doi Pharmacological management of bipolar depression: acute treatment, maintenance, and prophylaxis
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel St, 08036 Barcelona, Catalonia, Spain
    CNS Drugs 27:515-29. 2013
  10. doi Mixed states in DSM-5: implications for clinical care, education, and research
    Eduard Vieta
    Bipolar Disorder Programme, Institute of Neuroscience, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, C Villarroel 170, Barcelona 08036, Catalonia, Spain
    J Affect Disord 148:28-36. 2013

Detail Information

Publications156 found, 100 shown here

  1. doi Developing an individualized treatment plan for patients with schizoaffective disorder: from pharmacotherapy to psychoeducation
    Eduard Vieta
    Bipolar Disorders Program and the Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
    J Clin Psychiatry 71:14-9. 2010
    ..In refractory cases, electroconvulsive therapy is an option...
  2. pmc Acute and long-term treatment of mania
    Eduard Vieta
    Bipolar Disorders Program, University of Barcelona, Hospital Clinic, IDIBAPS, CIBER SAM, Barcelona, Catalonia, Spain
    Dialogues Clin Neurosci 10:165-79. 2008
    ..Psychoeducation of patients and caregivers is a powerful tool that should be used in combination with medication for optimal long-term outcome. Functional recovery should be the ultimate goal...
  3. doi Efficacy and tolerability of flexibly-dosed adjunct TC-5214 (dexmecamylamine) in patients with major depressive disorder and inadequate response to prior antidepressant
    Eduard Vieta
    Department of Psychiatry, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170 Rossello 140, 08036 Barcelona, Catalonia, Spain Electronic address
    Eur Neuropsychopharmacol 24:564-74. 2014
    ..In conclusion, no antidepressant effect of TC-5214 was observed in these studies...
  4. pmc Functional remediation for bipolar disorder
    Anabel Martinez-Aran
    Early Onset Psychosis Program and Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    Clin Pract Epidemiol Ment Health 7:112-6. 2011
    ..Early intervention using functional remediation, involves neurocognitive techniques and training, but also psychoeducation on cognition-related issues and problem-solving within an ecological framework...
  5. ncbi Phenomenology of manic episodes according to the presence or absence of depressive features as defined in DSM-5: Results from the IMPACT self-reported online survey
    Eduard Vieta
    Bipolar Disorder Programme, Institute of Neuroscience, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, C Villarroel 170, Barcelona 08036, Catalonia, Spain Electronic address
    J Affect Disord 156:206-13. 2014
    ..The aim of this study was to describe the phenomenology of mania and depression in bipolar patients experiencing a manic episode with mixed features as defined in the new Diagnostic and Statistical Manual of Mental Disorders (DSM-5)...
  6. doi Clinical management and burden of bipolar disorder: results from a multinational longitudinal study (WAVE-bd)
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, 170 Villaroel, Barcelona, Spain
    Int J Neuropsychopharmacol 16:1719-32. 2013
    ..These results provide a description of treatment patterns for bipolar disorder across different countries and indicate factors related to relapse and recurrence. ..
  7. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
    ..We present here the study protocol of a trial intended to study the efficacy and safety of methylphenidate in the initial treatment of acute mania...
  8. ncbi Pooled analysis of sustained response rates for extended release quetiapine fumarate as monotherapy or adjunct to antidepressant therapy in patients with major depressive disorder
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    J Affect Disord 150:639-43. 2013
    ..Clinical trials are not generally powered to analyze outcomes such as sustained response. We evaluated sustained response rates for patients with major depressive disorder receiving quetiapine XR as monotherapy or adjunct therapy...
  9. doi Pharmacological management of bipolar depression: acute treatment, maintenance, and prophylaxis
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel St, 08036 Barcelona, Catalonia, Spain
    CNS Drugs 27:515-29. 2013
    ..Lithium, lamotrigine, valproate, olanzapine, quetiapine, and aripiprazole are the recommended first-line maintenance options. ..
  10. doi Mixed states in DSM-5: implications for clinical care, education, and research
    Eduard Vieta
    Bipolar Disorder Programme, Institute of Neuroscience, University of Barcelona Hospital Clinic, IDIBAPS, CIBERSAM, C Villarroel 170, Barcelona 08036, Catalonia, Spain
    J Affect Disord 148:28-36. 2013
    ..The medications that are effective in treating mixed episodes per the DSM-IV-TR definition may also be effective in treating mixed features per the DSM-5, but new studies are needed to demonstrate it...
  11. doi Pros and cons of specialised care in bipolar disorder: an international perspective
    Eduard Vieta
    Hospital Clinic, 170 Villarroel St, 08036 Barcelona, Catalonia, Spain
    Br J Psychiatry 202:170-1. 2013
    ..Rather than trying to solve the false dichotomy between specialised v. community care, the rational integration of both approaches may enhance quality of care and cost-effectiveness...
  12. doi The clinical implications of cognitive impairment and allostatic load in bipolar disorder
    E Vieta
    Bipolar Disorders Program, Clinical Institute of Neuroscience, University Clinic Hospital of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, 08036 Barcelona, Spain
    Eur Psychiatry 28:21-9. 2013
    ..This paper aims to provide clinicians with a comprehensive overview of the role of AL in patophysiology of bipolar disorder (BD) and its practical implications...
  13. doi Psychiatrists' perceptions of potential reasons for non- and partial adherence to medication: results of a survey in bipolar disorder from eight European countries
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ENBREC, 08036 Barcelona, Spain
    J Affect Disord 143:125-30. 2012
    ..Understanding psychiatrists' views on the causes and management of non-adherence are vital to address adherence problems effectively...
  14. ncbi Long-term efficacy of quetiapine in combination with lithium or divalproex on mixed symptoms in bipolar I disorder
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    J Affect Disord 142:36-44. 2012
    ..To evaluate quetiapine in patients with bipolar I disorder with mixed symptoms...
  15. doi Head to head comparisons as an alternative to placebo-controlled trials
    Eduara Vieta
    Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, Barcelona 08036, Catalonia, Spain
    Eur Neuropsychopharmacol 22:800-3. 2012
    ..The inclusion of active comparators in regulatory trials should not be seen as an alternative, but as a useful complement to the information that can be obtained from placebo-controlled studies...
  16. doi A randomized, double-blind, placebo-controlled trial to assess prevention of mood episodes with risperidone long-acting injectable in patients with bipolar I disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, 12 0, Barcelona 08036, Spain
    Eur Neuropsychopharmacol 22:825-35. 2012
    ..In conclusion, risperidone LAI significantly delayed time to recurrence of elevated mood episodes, with a safety profile consistent with previous studies...
  17. pmc Number of prior episodes and the presence of depressive symptoms are associated with longer length of stay for patients with acute manic episodes
    Manuel Martín-Carrasco
    AstraZeneca Medical Department, Madrid, Spain
    Ann Gen Psychiatry 11:7. 2012
    ..abstract:..
  18. pmc Clinical usefulness of the screen for cognitive impairment in psychiatry (SCIP-S) scale in patients with type I bipolar disorder
    Georgina Guilera
    Department of Methodology, Faculty of Psychology, University of Barcelona, Barcelona, Spain
    Health Qual Life Outcomes 7:28. 2009
    ..This investigation assessed the psychometric properties of the Spanish version of the Screen for Cognitive Impairment in Psychiatry (SCIP-S) for the detection of cognitive impairment in BD...
  19. pmc Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases
    Olatz Garin
    Health Services Research Unit, IMIM Hospital del Mar, Barcelona, Spain
    Health Qual Life Outcomes 8:51. 2010
    ..The aim of this study was to assess WHODAS-2 conceptual model and metric properties in a set of chronic and prevalent clinical conditions accounting for a wide scope of disability in Europe...
  20. pmc Anticonvulsants in the treatment of aggression in the demented elderly: an update
    Benedikt Amann
    Benito Menni, CASM, Research Unit, CIBERSAM, St Boi de Llobregat, Barcelona, Spain
    Clin Pract Epidemiol Ment Health 5:14. 2009
    ..At least 50% of the dramatically growing number of patients with dementia exerts aggressive and agitated symptoms during the course of clinical progression, particularly at moderate clinical severity...
  21. pmc Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd study)
    Eduard Vieta
    Bipolar Disorders Programme, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, 08036 Barcelona, Spain
    BMC Psychiatry 11:58. 2011
    ..It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD...
  22. pmc The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia
    Gabriel Selva-Vera
    Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Blasco Ibanez 17, 46010 Valencia, Spain
    BMC Psychiatry 10:47. 2010
    ....
  23. pmc Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 8:27. 2009
    ..42, 0.63 and 0.48, respectively). CONCLUSION: The data analysed for the current study support the usefulness of aripiprazole against psychotic symptoms during the acute manic and maintenance phases of bipolar illness...
  24. pmc Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
    Konstantinos N Fountoulakis
    Third Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Ann Gen Psychiatry 8:16. 2009
    ..The current article is a systematic review concerning the efficacy and safety of aripiprazole in the treatment of bipolar disorder...
  25. ncbi Subsyndromal depressive symptoms in patients with bipolar and unipolar disorder during clinical remission
    E Vieta
    Bipolar Disorder Programme, Institut Clínic de Neurociències, Hospital Clinic, Universitat de Barcelona, IDIBAPS, REM TAP, Barcelona, Spain
    J Affect Disord 107:169-74. 2008
    ..This study sought to evaluate the presence of subsyndromal depressive symptoms in bipolar and unipolar patients in clinical remission...
  26. ncbi Bipolar II disorder: arguments for and against a distinct diagnostic entity
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER SAM, Barcelona, Spain
    Bipolar Disord 10:163-78. 2008
    ..As a commitment to the International Society for Bipolar Disorders (ISBD), a Task Force was developed to investigate the diagnostic value of bipolar II disorder...
  27. doi A double-blind, randomized, placebo-controlled prophylaxis trial of oxcarbazepine as adjunctive treatment to lithium in the long-term treatment of bipolar I and II disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER SAM, Barcelona, Spain
    Int J Neuropsychopharmacol 11:445-52. 2008
    ....
  28. ncbi Olanzapine monotherapy and olanzapine combination therapy in the treatment of mania: 12-week results from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) observational study
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona IDIBAPS, Barcelona, Spain
    J Affect Disord 106:63-72. 2008
    ....
  29. doi Efficacy of adjunctive aripiprazole to either valproate or lithium in bipolar mania patients partially nonresponsive to valproate/lithium monotherapy: a placebo-controlled study
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Villarroel 170 Rossello 140, 08036 Barcelona, Spain
    Am J Psychiatry 165:1316-25. 2008
    ..The authors evaluated the efficacy and safety of adjunctive aripiprazole in bipolar I patients with mania partially nonresponsive to lithium/valproate monotherapy...
  30. pmc Deconstructing bipolar disorder: a critical review of its diagnostic validity and a proposal for DSM-V and ICD-11
    Eduard Vieta
    Bipolar Disorders Program, Institute of Neuroscience, University of Barcelona Hospital Clinic, Barcelona, Spain
    Schizophr Bull 33:886-92. 2007
    ....
  31. ncbi Maintenance therapy for bipolar disorder: current and future management options
    Eduard Vieta
    Clinical Institute of Psychiatry and Psychology, University of Barcelona, Hospital Clinic, Villarroel 170, Rossello 140, 08036 Barcelona, Spain
    Expert Rev Neurother 4:S35-42. 2004
    ..Particular emphasis is given to the atypical agents and psychosocial strategies aimed at optimizing treatment adherence and long-term outcomes...
  32. ncbi Evidence-based research on the efficacy of psychologic interventions in bipolar disorders: a critical review
    Eduard Vieta
    Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Villarroel 170, Barcelona 08036, Barcelona, Spain
    Curr Psychiatry Rep 7:449-55. 2005
    ..Further research should focus on determining the therapeutic value of each ingredient of the tested psychologic interventions...
  33. ncbi A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychiatry 67:473-7. 2006
    ..To conduct the first randomized, controlled trial assessing the prophylactic efficacy of gabapentin in bipolar disorder...
  34. ncbi Cross validation with the mood disorder questionnaire (MDQ) of an instrument for the detection of hypomania in Spanish: the 32 item hypomania symptom check list (HCL-32)
    E Vieta
    Bipolar Disorder Programme, Institut Clínic de Neurociències, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona Stanley Foundation Centrem, Villarroel, 170, 08036 Barcelona, Spain
    J Affect Disord 101:43-55. 2007
    ..Our aim was to develop and validate the psychometric properties of the HCL-32 scale in Spain in patients with bipolar disorder and to compare its properties with other instruments available for the detection of bipolar II disorder...
  35. ncbi Evolving trends in the long-term treatment of bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    World J Biol Psychiatry 8:4-11. 2007
    ..The role of psychoeducation in improving adherence to medication in long-term treatment and overall patient outcomes is also crucial...
  36. ncbi Quetiapine in the treatment of acute mania: target dose for efficacious treatment
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Affect Disord 100:S23-31. 2007
    ..To analyze the available evidence from randomized clinical trials regarding the effective dose range and optimal dose of quetiapine when treating bipolar I disorder patients with acute mania...
  37. ncbi Developing core sets for persons with bipolar disorder based on the International Classification of Functioning, Disability and Health
    E Vieta
    Bipolar Disorders Programme, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Bipolar Disord 9:16-24. 2007
    ..Within a given disorder, both Brief and Comprehensive Core Sets can be established to serve specific purposes...
  38. ncbi Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: a randomized, double-blind, placebo-controlled study
    E Vieta
    Bipolar Disorders Programme, Clinical Institute of Neuroscience, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Bipolar Disord 9:413-25. 2007
    ..To investigate the efficacy and tolerability of quetiapine monotherapy in patients with bipolar I or II disorder with a rapid-cycling disease course...
  39. ncbi [Advances in the treatment of mania: aripiprazole]
    E Vieta
    Programa de Trastornos Bipolares, Instituto Clínico de Neurociencias, Hospital Clinic, Universitat de Barcelona, IDIBAPS, CIBER SAM, Barcelona
    Actas Esp Psiquiatr 36:158-64. 2008
    ....
  40. ncbi A long-term prospective study on the outcome of bipolar patients treated with long-acting injectable risperidone
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    World J Biol Psychiatry 9:219-24. 2008
    ..Risperidone is the first atypical antipsychotic to become available in a long-acting, injectable formulation. This is the first prospective study to assess the effectiveness of long-acting risperidone in a cohort of bipolar patients...
  41. doi Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    Int J Neuropsychopharmacol 14:1029-49. 2011
    ..Efficacy of all maintenance interventions needs to be balanced against the safety and tolerability profiles of individual agents...
  42. doi Therapeutic options in treatment-resistant depression
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, Catalonia, Spain
    Ann Med 43:512-30. 2011
    ..The use of cognitive behaviour therapy is recommended for unipolar TRD, but there is no evidence supporting its use in bipolar TRD...
  43. doi Detection of subclinical depression in bipolar disorder: a cross-sectional, 4-month prospective follow-up study at community mental health services (SIN-DEPRES)
    Eduard Vieta
    Bipolar Disorder Programme, Institut Clínic de Neurosciences, Hospital Clinic, IDIBAPS, University of Barcelona, CIBERSAM, Spain
    J Clin Psychiatry 71:1465-74. 2010
    ..The aim of this study was to assess the prevalence and the impact of depressive symptoms on the functional outcome of bipolar disorder outpatients in remission...
  44. doi Treatment options for bipolar depression: a systematic review of randomized, controlled trials
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
    J Clin Psychopharmacol 30:579-90. 2010
    ..Quetiapine and the olanzapine-fluoxetine combination showed the greatest symptomatic improvement. Efficacy considerations will need to be balanced against safety and tolerability of the individual agents...
  45. ncbi Prevalence of mixed mania using 3 definitions
    E Vieta
    Bipolar Disorder Programme, Institut Clínic de Neurociències, Hospital Clinic, IDIBAPS, Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain
    J Affect Disord 125:61-73. 2010
    ..We want to identify the proportion of patients who have depressive symptoms during an acute episode and also the validity of current methods for its diagnosis...
  46. doi Staging bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Institute of Neuroscience, Hospital Clinic Barcelona, University of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, 08036 Barcelona, Spain
    Neurotox Res 19:279-85. 2011
    ..Staging may assist in bipolar disorder treatment planning and prognosis, and emphasize the importance of early intervention. Further research is required in this exciting and novel area...
  47. ncbi Assessment of safety, tolerability and effectiveness of adjunctive aripiprazole to lithium/valproate in bipolar mania: a 46-week, open-label extension following a 6-week double-blind study
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    Curr Med Res Opin 26:1485-96. 2010
    ..This study evaluated the long-term tolerability and effectiveness of aripiprazole adjunctive to lithium or valproate in partial responders with bipolar mania...
  48. ncbi A critical update on psychological interventions for bipolar disorders
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, Villarroel 170, 08036 Barcelona, Spain
    Curr Psychiatry Rep 11:494-502. 2009
    ..Group psychoeducation seems to have long-lasting effects and to be cost-effective. Future studies should focus on neurobiological markers of response to psychotherapy and tailor interventions to specific subtypes...
  49. ncbi Predominant previous polarity as an outcome predictor in a controlled treatment trial for depression in bipolar I disorder patients
    E Vieta
    Bipolar Disorders Program, University of Barcelona Hospital Clinic, Institut d Investigacions Biomediques Agusti Pi Sunyer, CIBER SAM, Barcelona, Spain
    J Affect Disord 119:22-7. 2009
    ....
  50. doi Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)
    Eduard Vieta
    Department of Psychiatry, Hospital Clinic, University of Barcelona IDIBAPS, CIBER SAM, Barcelona, Spain
    J Affect Disord 118:118-23. 2009
    ..Large observational studies may be useful in identifying variables that predict switch to depression after mania and provide data on medication use and outcomes in "real world" patients...
  51. ncbi Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study
    E Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    J Psychopharmacol 24:547-58. 2010
    ..0 mg/day and 16.1 mg/day, respectively. Ziprasidone was shown to be effective monotherapy for acute treatment of bipolar mania. Although haloperidol showed greater efficacy, ziprasidone showed a superior tolerability profile...
  52. doi Impact of geographical and cultural factors on clinical trials in acute mania: lessons from a ziprasidone and haloperidol placebo-controlled study
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    Int J Neuropsychopharmacol 14:1017-27. 2011
    ....
  53. ncbi Case for caution, case for action
    Eduard Vieta
    Clinical Institute of Psychiatry and Psychology, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Bipolar Disord 5:434-5. 2003
  54. ncbi Risperidone in the treatment of mania: efficacy and safety results from a large, multicentre, open study in Spain
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Affect Disord 72:15-9. 2002
    ..A number of open studies and preliminary results of unpublished double-blind trials have suggested that the novel antipsychotic risperidone may be effective and well tolerated in the treatment of acute mania in bipolar disorder...
  55. ncbi Bipolar mixed states and their treatment
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Villarroel 170 Rossello 140, 08036, Barcelona, Spain
    Expert Rev Neurother 5:63-8. 2005
    ..On the other hand, atypical antipsychotics may be effective and safe either in monotherapy or in combination with lithium or valproate. Further research is urgently needed in this neglected area of psychiatry...
  56. ncbi The treatment of mixed states and the risk of switching to depression
    Eduard Vieta
    Department of Psychiatry, Hospital Clinic, IDIBAPS, Clinical Institute of Neuroscience, University of Barcelona, Villarroel 170 Rossello 140, 8036 Barcelona, Spain
    Eur Psychiatry 20:96-100. 2005
    ....
  57. ncbi Mood stabilization in the treatment of bipolar disorder: focus on quetiapine
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Spain
    Hum Psychopharmacol 20:225-36. 2005
    ..Further data suggest that quetiapine has promise across all phases of bipolar disorder with the potential to meet even the most stringent definitions of a mood stabilizer...
  58. ncbi The somatics of psyche: structural neuromorphometry of bipolar disorder
    A Benabarre
    Bipolar Disorders Program and Nuclear Medicine Department, Barcelona Stanley Foundation Research Center, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Psychother Psychosom 71:180-9. 2002
    ..It seems clear that for many brain regions, the structural changes from normal may be subtle, and that the differences in the reported studies may be due to differences in research methodologies between studies and across centers...
  59. ncbi Atypical antipsychotics: newer options for mania and maintenance therapy
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Villarroel 170 Rossello 140, 08036 Barcelona, Spain
    Bipolar Disord 7:21-33. 2005
    ..A brief assessment of tolerability issues surrounding the use of atypical agents in bipolar disorder and other aspects of treatment that have impact on the clinical effectiveness of the therapy are considered...
  60. ncbi A randomized trial comparing paroxetine and venlafaxine in the treatment of bipolar depressed patients taking mood stabilizers
    Eduard Vieta
    Bipolar Disorders Program, Barcelona Stanley Foundation Research Center, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    J Clin Psychiatry 63:508-12. 2002
    ..This study was aimed to assess and compare the efficacy and safety of 2 different antidepressant drugs, paroxetine and venlafaxine, in this indication...
  61. ncbi Clinical correlates of psychiatric comorbidity in bipolar I patients
    E Vieta
    Barcelona Stanley Foundation Research Center, Hospital Clinic, University of Barcelona, Spain
    Bipolar Disord 3:253-8. 2001
    ..To ascertain the clinical implications of psychiatric comorbidity in the course and outcome of bipolar I patients...
  62. ncbi Quetiapine in the treatment of rapid cycling bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, Barcelona Spain
    Bipolar Disord 4:335-40. 2002
    ..This prospective open-label study assessed the impact of add-on quetiapine in the treatment of rapid cycling bipolar patients...
  63. ncbi Improving treatment adherence in bipolar disorder through psychoeducation
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    J Clin Psychiatry 66:24-9. 2005
    ..As an adjunct to pharmacotherapy of bipolar disorder, psychoeducation is a promising management component that increases treatment adherence and quality of life for patients...
  64. ncbi Acute and continuation risperidone monotherapy in mania
    Eduard Vieta
    Bipolar Disorders Programme, Clinical Institute of Psychiatry and Psychology, Hospital Clinic, University of Barcelona, IDIBAPS, Spain
    Hum Psychopharmacol 19:41-5. 2004
    ..The aim of this study was to assess the effectiveness and safety of risperidone monotherapy for acute and continuation treatment of mania...
  65. ncbi Adjunctive topiramate in bipolar II disorder
    Eduard Vieta
    Bipolar Disorders Programme, Barcelona Stanley Research Medical Institute, Centre Hospital Clinic, University of Barcelona, Barcelona, Spain
    World J Biol Psychiatry 4:172-6. 2003
    ..Topiramate was generally well tolerated. One third of the patients experienced weight loss. These preliminary results suggest that adjunctive topiramate may be useful in treating bipolar II disorder...
  66. ncbi Olanzapine in bipolar disorder
    Eduard Vieta
    University of Barcelona, Bipolar Disorders Program, Hospital Clinic, Villarroel 170, Rossello 140, 08036 Barcelona, Spain
    Expert Opin Pharmacother 5:1613-9. 2004
    ..However, there are some concerns about the safety and tolerability of olanzapine in this population, as far as weight gain and metabolic syndrome are concerned, which may be addressed in future pharmacovigilance studies...
  67. ncbi Effects on weight and outcome of long-term olanzapine-topiramate combination treatment in bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychopharmacol 24:374-8. 2004
    ..Given the limitations of the open, uncontrolled design, further trials are warranted with this combination...
  68. ncbi 1-year follow-up of patients treated with risperidone and topiramate for a manic episode
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques Agusti Pi Sunyer, Barcelona, Spain
    J Clin Psychiatry 64:834-9. 2003
    ..The safety and efficacy of the combination of risperidone and topiramate in the long-term treatment of mania were assessed in a 12-month, multicenter open study...
  69. ncbi Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled data
    Eduard Vieta
    Bipolar Disorders Program, Department of Psychiatry, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychiatry 65:1420-8. 2004
    ..We report on the first controlled study comparing acute and continuous clinical outcomes in RC and non-RC manic patients treated with olanzapine...
  70. ncbi [Treatment of bipolar II disorder with lamotrigine]
    E Vieta
    Programa de Transtornos Bipolares, Centro del Stanley Medical Research Insstitute de Barcelona Hospital Clínico, IDIBAPS, Barcelona, Spain
    Actas Esp Psiquiatr 31:65-8. 2003
    ..Th ey we re followed-up for 6 months and assessed with the Young Mania Scale (YMRS), Hamilton Depression Rating Scale (HDRS-17) and the modified version of the Global Clinic Impresion Scale for Bipolar Disorder ( CG I-BP-M)...
  71. ncbi The use of placebo in clinical trials on bipolar disorder: a new approach for an old debate
    Eduard Vieta
    Clinical Institute of Psychiatry and Psychology, Hospital Clinic, IDIBAPS, Stanley Medical Research Institute, University of Barcelona, IDIBAPS, Villarroel 170, ES 08036 Barcelona, Spain
    Psychother Psychosom 74:10-6. 2005
    ..This is a challenge for researchers and an enigma for clinicians. This article will attempt to aid in the comprehension of the ethical questions and methodologies related to the use of placebo in bipolar disorder...
  72. ncbi Role of risperidone in bipolar II: an open 6-month study
    E Vieta
    Bipolar Disorders Program, IDIBAPS, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Affect Disord 67:213-9. 2001
    ....
  73. ncbi Risperidone safety and efficacy in the treatment of bipolar and schizoaffective disorders: results from a 6-month, multicenter, open study
    E Vieta
    Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
    J Clin Psychiatry 62:818-25. 2001
    ..The goal of this study was to assess the efficacy and safety of risperidone in bipolar and schizoaffective disorders...
  74. ncbi A European perspective on the Canadian guidelines for bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Bipolar Disord 7:73-6. 2005
  75. ncbi [Effectiveness and safety of topiramate in treatment-resistant bipolar disorder]
    E Vieta
    Programa de Trastornos Bipolares Centro de la Stanley Foundation de Barcelona, Hospital Clinic, IDIBAPS, Barcelona
    Actas Esp Psiquiatr 29:148-52. 2001
    ..This study was conducted to evaluate the effectiveness and safety of topiramate as add-on therapy for treatment-resistant bipolar disorder...
  76. ncbi An open-label study of amisulpride in the treatment of mania
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    J Clin Psychiatry 66:575-8. 2005
    ..However, no prospective study to date has assessed the effectiveness and tolerability of this compound in mania...
  77. ncbi Use of topiramate in treatment-resistant bipolar spectrum disorders
    Eduard Vieta
    Clinical Institute of Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain
    J Clin Psychopharmacol 22:431-5. 2002
    ..These preliminary results indicate that adjunctive topiramate may be useful in the long-term treatment of bipolar spectrum disorders, even in the most difficult-to-treat patients...
  78. ncbi Olanzapine as long-term adjunctive therapy in treatment-resistant bipolar disorder
    E Vieta
    Department of Psychiatry, Hospital Clinic, University of Barcelona, Spain
    J Clin Psychopharmacol 21:469-73. 2001
    ..These results suggest mood-stablizing properties of olanzapine...
  79. ncbi The package of care for patients with bipolar depression
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Clin Psychiatry 66:34-9. 2005
    ..Further randomized, clinical trials will help to define which components of psychosocial intervention are most effective in patients with bipolar disorder...
  80. ncbi Efficacy and safety of risperidone in the treatment of schizoaffective disorder: initial results from a large, multicenter surveillance study. Group for the Study of Risperidone in Affective Disorders (GSRAD)
    E Vieta
    Hospital Clinic, University of Barcelona, Spain
    J Clin Psychiatry 62:623-30. 2001
    ..We present data on a 6-week trial of risperidone for the treatment of schizoaffective disorder that was part of a larger, 6-month surveillance study of patients with affective disorders...
  81. ncbi Quetiapine monotherapy for mania associated with bipolar disorder: combined analysis of two international, double-blind, randomised, placebo-controlled studies
    Eduard Vieta
    Hospital Clinic, August Pi i Sunyer Biomedical Research Institute IDIBAPS, University of Barcelona, Spain
    Curr Med Res Opin 21:923-34. 2005
    ..To evaluate the efficacy and safety of quetiapine monotherapy for mania in bipolar disorder by an a priori defined combined analysis of data from two placebo-controlled studies...
  82. doi Effects of atypical antipsychotics on neurocognition in euthymic bipolar patients
    Carla Torrent
    Bipolar Disorders Program, Clinical Institute of Neuroscience, University Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain
    Compr Psychiatry 52:613-22. 2011
    ..The effect of pharmacologic treatment on cognition is still uncertain because of an insufficient number of studies examining this issue...
  83. doi Gender differences in a cohort study of 604 bipolar patients: the role of predominant polarity
    Alessandra M A Nivoli
    Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    J Affect Disord 133:443-9. 2011
    ..Some clinical differences between gender regarding the course and outcome of bipolar disorders have already been described and some others remain still controversial...
  84. ncbi Treatment nonadherence and neurocognitive impairment in bipolar disorder
    Anabel Martinez-Aran
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain
    J Clin Psychiatry 70:1017-23. 2009
    ..This study aimed to investigate whether poor treatment adherence is associated with cognitive impairment in euthymic bipolar patients and whether other factors may be associated with both adherence and cognitive functioning...
  85. doi Neurocognitive dysfunctions in euthymic bipolar patients with and without prior history of alcohol use
    Jose Sanchez-Moreno
    Bipolar Disorders Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Spain
    J Clin Psychiatry 70:1120-7. 2009
    ....
  86. doi Clinical predictors of functional outcome of bipolar patients in remission
    Adriane R Rosa
    Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona 08036, Spain
    Bipolar Disord 11:401-9. 2009
    ..This study was carried out to assess the level of functioning as well as to identify potential predictors of functioning in a well-defined, euthymic bipolar sample...
  87. ncbi A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders
    Jan Scott
    Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK, and Stanley Center for Bipolar Disorders, Hospital Clinic University of Barcelona, IDIBAPS, Spain
    Int J Neuropsychopharmacol 10:123-9. 2007
    ....
  88. ncbi Clinical and therapeutic implications of predominant polarity in bipolar disorder
    F Colom
    Bipolar Disorders Program, Institut d Investigacions Biomediques Agusti Pi Sunyer, Barcelona Stanley Foundation Center, Spain
    J Affect Disord 93:13-7. 2006
    ..To determine the clinical and therapeutic relevance of longitudinally predominant polarity for bipolar disorders long-term outcome...
  89. ncbi Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis
    Nuria Cruz
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
    Int J Neuropsychopharmacol 13:5-14. 2010
    ..Some modern antipsychotics (quetiapine and olanzapine) have demonstrated efficacy in bipolar depressive patients from week 1 onwards. Rapid onset of action seems to be a common feature of atypical antipsychotics in bipolar depression...
  90. doi Treatment-resistant bipolar depression: towards a new definition
    I Pacchiarotti
    Bipolar Disorders Programme, Institute of Clinical Neuroscience, Hospital Clinic, University of Barcelona, CIBERSAM, 08036 Barcelona, Spain
    Acta Psychiatr Scand 120:429-40. 2009
    ..To summarize the conceptual and operational definitions of treatment-resistant bipolar depression and to review the evidence-based therapeutic options...
  91. ncbi Psychoeducation efficacy in bipolar disorders: beyond compliance enhancement
    Francesc Colom
    Bipolar Disorders Program, IDIBAPS Hospital Clinic Barcelona, Barcelona Stanley Research Center, Barcelona, Spain
    J Clin Psychiatry 64:1101-5. 2003
    ..To date, studies assessing the usefulness of psychoeducation in fully compliant patients are lacking...
  92. ncbi Why do clinicians maintain antidepressants in some patients with acute mania? Hints from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM), a large naturalistic study
    Adriane R Rosa
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, CIBERSAM, Barcelona, Spain
    J Clin Psychiatry 71:1000-6. 2010
    ..Antidepressants are supposed to be withdrawn during a manic episode. The aim of this study was to analyze the characteristics of manic patients who received antidepressants during a manic phase in a large, naturalistic study...
  93. ncbi Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial
    Eduard Vieta
    Director of Research, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, Spain
    Br J Psychiatry 187:235-42. 2005
    ..Despite several treatmentoptions, adherenceto therapy is poor in patients with bipolar disorder...
  94. ncbi Psychoeducation in bipolar patients with comorbid personality disorders
    Francesc Colom
    Bipolar Disorders Program, Hospital Clinic University of Barcelona, IDIBAPS, Spain
    Bipolar Disord 6:294-8. 2004
    ..Psychoeducation has shown its efficacy in the prevention of relapses in the bipolar population but, to date, no data is available on its efficacy in the management of bipolar patients with personality disorders...
  95. ncbi Observational, pragmatic, and clinical trials in bipolar disorder
    Eduard Vieta
    Bipolar Disorders Program, IDIBAPS Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain
    J Clin Psychiatry 69:e27. 2008
    ..Observational studies can complement randomized trials because they provide valuable insight into the course, treatment response, and outcomes of patients who would generally be excluded from clinical trials...
  96. doi Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study
    C M Bonnin
    Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
    J Affect Disord 121:156-60. 2010
    ..To identify clinical and neurocognitive predictors of long-term functional outcome in patients with bipolar disorder..
  97. ncbi Evidence for three distinct classes of 'typical', 'psychotic' and 'dual' mania: results from the EMBLEM study
    J M Haro
    Sant Joan de Deu SSM, Fundació Sant Joan de Déu, St Boi de Llobregat, Barcelona, Spain
    Acta Psychiatr Scand 113:112-20. 2006
    ..To describe patients included in the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) study and to assess and clinically validate the presence of clinical subtypes of patients with acute mania...
  98. ncbi Validity and reliability of the Spanish versions of the Bech-Rafaelsen's mania and melancholia scales for bipolar disorders
    E Vieta
    Clinic Hospital, University of Barcelona, IDIBAPS, CIBER SAM, Barcelona, Spain
    Acta Psychiatr Scand 117:207-15. 2008
    ..To assess classical psychometric properties of the Spanish versions of the Bech-Rafaelsen's mania (MAS) and melancholia (MES) scales...
  99. doi The impact of staging bipolar disorder on treatment outcome of family psychoeducation
    Maria Reinares
    Bipolar Disorders Program, Institut of Neuroscience, Hospital Clinic, University of Barcelona, CIBERSAM, Barcelona, Spain
    J Affect Disord 123:81-6. 2010
    ..The aim of this study was to assess whether a staging model in bipolar disorder was related to patients' response to psychoeducation delivered to caregivers...
  100. ncbi [Improving the outcome of bipolar disorder through non-pharmacological strategies: the role of psychoeducation]
    Francesc Colom
    IDIBAPS, Centro de Pesquisa Médica Stanley de Barcelona, Barcelona, Spain
    Rev Bras Psiquiatr 26:47-50. 2004
    ..Nowadays, several treatment guidelines include psychoeducation as a crucial prophylactic tool. Clinicians should be aware of this and start performing psychoeducation in their everyday clinical practice...
  101. doi Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126)
    Eduard Vieta
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER SAM, Barcelona, Spain
    J Affect Disord 109:251-63. 2008
    ....