Isabel Varela-Nieto

Summary

Country: Spain

Publications

  1. pmc A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice
    Raquel Riquelme
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM Madrid, Spain
    Front Neuroanat 4:27. 2010
  2. pmc The role of insulin-like growth factor-I in the physiopathology of hearing
    Silvia Murillo-Cuesta
    Servicio de Evaluación Neurofuncional no Invasiva, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid Madrid, Spain
    Front Mol Neurosci 4:11. 2011
  3. pmc AKT signaling mediates IGF-I survival actions on otic neural progenitors
    María R Aburto
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    PLoS ONE 7:e30790. 2012
  4. pmc Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation
    M R Aburto
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    Cell Death Dis 3:e394. 2012
  5. ncbi request reprint IGF-I deficiency and hearing loss: molecular clues and clinical implications
    Isabel Varela-Nieto
    Institute for Biomedical Research Alberto Sols, CSIC UAM, Madrid, Spain
    Pediatr Endocrinol Rev 10:460-72. 2013
  6. pmc Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I
    Inma Castilla-Cortazar
    Department of Physiology, Clinica Universitaria, University of Navarra, Pamplona, Spain
    BMC Gastroenterol 4:12. 2004
  7. ncbi request reprint Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation
    Isabel Varela-Nieto
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Curr Pharm Des 13:687-703. 2007
  8. ncbi request reprint Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear
    Isabel Varela-Nieto
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Alberto Sols, Arturo Duperier 4, 28029 Madrid, Spain
    Hear Res 196:19-25. 2004
  9. ncbi request reprint Cell death in the nervous system: lessons from insulin and insulin-like growth factors
    Isabel Varela-Nieto
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, Arturo Duperier 4, E 28029 Madrid, Spain
    Mol Neurobiol 28:23-50. 2003
  10. pmc RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors
    Hortensia Sanchez-Calderon
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    PLoS ONE 5:e8699. 2010

Collaborators

Detail Information

Publications26

  1. pmc A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice
    Raquel Riquelme
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM Madrid, Spain
    Front Neuroanat 4:27. 2010
    ..Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss...
  2. pmc The role of insulin-like growth factor-I in the physiopathology of hearing
    Silvia Murillo-Cuesta
    Servicio de Evaluación Neurofuncional no Invasiva, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid Madrid, Spain
    Front Mol Neurosci 4:11. 2011
    ..This review will discuss these findings and their implications in new IGF-I-based treatments for the protection or repair of hearing loss...
  3. pmc AKT signaling mediates IGF-I survival actions on otic neural progenitors
    María R Aburto
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    PLoS ONE 7:e30790. 2012
    ..Here we have investigated the role of IGF-dependent activation of the PI3K-AKT pathway in maintenance of otic neuroblasts...
  4. pmc Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation
    M R Aburto
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    Cell Death Dis 3:e394. 2012
    ..Taken together, our results show for the first time that autophagy is an active and essential process during early inner ear development...
  5. ncbi request reprint IGF-I deficiency and hearing loss: molecular clues and clinical implications
    Isabel Varela-Nieto
    Institute for Biomedical Research Alberto Sols, CSIC UAM, Madrid, Spain
    Pediatr Endocrinol Rev 10:460-72. 2013
    ..Here we will discuss the basic mechanisms underlying IGF-I actions in the auditory system and their clinical implications to pursue novel treatments to ameliorate hearing loss...
  6. pmc Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I
    Inma Castilla-Cortazar
    Department of Physiology, Clinica Universitaria, University of Navarra, Pamplona, Spain
    BMC Gastroenterol 4:12. 2004
    ..Thus, jejunal structure and nutrient transport (D-galactose, L-leucine, L-proline, L-glutamic acid and L-cystine) were studied in rats with ascitic cirrhosis...
  7. ncbi request reprint Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation
    Isabel Varela-Nieto
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Curr Pharm Des 13:687-703. 2007
    ..Here, we review the contribution of IGF-I in developmental processes with a focus on the development of the inner ear, as well as pathological implications resulting from IGF-I deregulation during cancer...
  8. ncbi request reprint Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear
    Isabel Varela-Nieto
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Alberto Sols, Arturo Duperier 4, 28029 Madrid, Spain
    Hear Res 196:19-25. 2004
    ..IGF-I is thus necessary for normal development and maintenance of the inner ear. The trophic actions of IGF-I in the inner ear suggest that this factor may have therapeutic potential for the treatment of hearing loss...
  9. ncbi request reprint Cell death in the nervous system: lessons from insulin and insulin-like growth factors
    Isabel Varela-Nieto
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, Arturo Duperier 4, E 28029 Madrid, Spain
    Mol Neurobiol 28:23-50. 2003
    ....
  10. pmc RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors
    Hortensia Sanchez-Calderon
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    PLoS ONE 5:e8699. 2010
    ..Nevertheless, little is known about the molecular basis of IGF-I activity in hearing and deafness...
  11. pmc RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development
    Marta Magarinos
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    PLoS ONE 5:e14435. 2010
    ..However, the regulation of RAF kinase activity by growth factors during development is complex and still not fully understood...
  12. ncbi request reprint A network of growth and transcription factors controls neuronal differentation and survival in the developing ear
    Hortensia Sanchez-Calderon
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    Int J Dev Biol 51:557-70. 2007
    ..Understanding and defining the key factors and gene networks in the development and function of the inner ear represents an important step towards defeating deafness...
  13. ncbi request reprint Cochlear abnormalities in insulin-like growth factor-1 mouse mutants
    Guadalupe Camarero
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, 28029, Madrid, Spain
    Hear Res 170:2-11. 2002
    ..In addition, the myelin sheath was severely affected in ganglion neurons. In conclusion, IGF-1 deficit in mice severely affects postnatal survival, differentiation and maturation of the cochlear ganglion cells...
  14. ncbi request reprint Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I
    Laura M Frago
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Cell Sci 116:475-86. 2003
    ..Taken together, these results strongly suggest that regulation of nerve-growth-factor-induced apoptosis in the otocysts occurs via p75 receptor binding and is strictly controlled by the interaction with survival signalling pathways...
  15. doi request reprint Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice
    Silvia Murillo-Cuesta
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC, Universidad Autonoma de Madrid UAM, Madrid, Spain
    Pigment Cell Melanoma Res 23:72-83. 2010
    ..These results demonstrate that melanin precursors, such as L-DOPA, have a protective role in the mammalian cochlea in age-related and noise-induced hearing loss...
  16. pmc Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function
    Silvia Murillo-Cuesta
    Institute of Biomedical Research Alberto Sols IIBM, Spanish National Research Council Autonomous University of Madrid CSIC UAM, Madrid, Spain
    Mol Med 18:260-9. 2012
    ..We show for the first time that IRS2 is essential for hearing and that PTP1B inhibition may be useful for treating deafness associated with hyperglycemia and type 2 diabetes...
  17. doi request reprint Early development of the vertebrate inner ear
    Marta Magarinos
    Instituto de Investigaciones Biomedicas, Alberto Sols, CSIC UAM, Madrid, Spain
    Anat Rec (Hoboken) 295:1775-90. 2012
    ..Understanding the molecular clues that direct otic development is fundamental for the design of novel treatments for the protection and repair of hearing loss and balance disorders...
  18. doi request reprint Direct drug application to the round window: a comparative study of ototoxicity in rats
    Silvia Murillo-Cuesta
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Otolaryngol Head Neck Surg 141:584-90. 2009
    ..To assess the validity of inducing ototoxicity in rats by applying a sponge soaked in kanamycin and furosemide on the round window...
  19. ncbi request reprint Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation
    Covadonga Paneda
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Hepatology 35:1381-91. 2002
    ..In conclusion, our results show that MAT2A expression not only correlates with liver cell proliferation but is required for this process...
  20. ncbi request reprint Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action
    Amelia Diaz-Casares
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Spain
    Adv Exp Med Biol 567:221-42. 2005
  21. pmc Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice
    Lourdes Rodriguez-de la Rosa
    Instituto de Investigaciones Biomedicas Alberto Sols, Centro Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Madrid, Spain Unidad 761, Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain
    PLoS ONE 9:e87536. 2014
    ..Collectively, these findings indicate that PTHrP (1-36) and osteostatin can exert several osteogenic actions even in the absence of IGF-I in the mouse bone. ..
  22. ncbi request reprint Drug delivery to the inner ear: strategies and their therapeutic implications for sensorineural hearing loss
    Teresa Rivera
    University Hospital Prince of Asturias, University of Alcala, Madrid, Spain
    Curr Drug Deliv 9:231-42. 2012
    ..In this article, we review the different techniques under evaluation in animal models of deafness, and their potential use for drug delivery and treatment of human inner ear diseases...
  23. doi request reprint Spatial and temporal segregation of auditory and vestibular neurons in the otic placode
    Donald Bell
    Department of Craniofacial Development, King s College London, London SE1 9RT, UK
    Dev Biol 322:109-20. 2008
    ..In addition, positional information is integrated with temporal cues that coordinate neurogenesis and sensory differentiation...
  24. ncbi request reprint Hematotesticular barrier is altered from early stages of liver cirrhosis: effect of insulin-like growth factor 1
    Inma Castilla-Cortazar
    Department of Human Physiology, School of Medicine, University of Navarra, Pamplona, Spain
    World J Gastroenterol 10:2529-34. 2004
    ....
  25. ncbi request reprint Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals
    Berta Alsina
    DCEXS Universitat Pomepu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Curr Top Dev Biol 57:177-206. 2003
  26. ncbi request reprint Expression and function of phospholipase A(2) in brain
    María A Balboa
    Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0601, USA
    FEBS Lett 531:12-7. 2002
    ..This cell system emerges as a model to study injury/inflammation-related activation of the new PLA(2) forms GIVB and GIVC...