- Clinicopathologic and pedigree differences in amsterdam I-positive hereditary nonpolyposis colorectal cancer families according to tumor microsatellite instability statusLaura Valle
Familial Cancer Unit, Spanish National Cancer Centre, Melchor Fernandez Almagro, Madrid, Spain
J Clin Oncol 25:781-6. 2007....
- About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) familyLaura Valle
Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
Eur J Hum Genet 13:570-8. 2005..We have not found new candidate regions along 3p by using a 1-Mb resolution array-based CGH. (4) The tumorigenesis mechanism of a second gastric tumor developed in the probandus is different from that of CRCC...
- Generation of the BCR/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22Laura Valle
Familial Cancer Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Hematol Oncol 24:86-8. 2006..There is no transference of 22q material to chromosome 9 or to any other chromosomes. Clinical features and evolution of the patient are similar to those cases with classic Ph chromosome...
- Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH arrayAngel Martinez-Ramirez
Department of Human Genetics, Spanish National Cancer Centre CNIO, Madrid, Spain
Genes Chromosomes Cancer 42:287-98. 2005..3 and 19p13.3 were detected by HR-CGH. Array CGH analysis of the subtelomeric regions in some samples was able to confirm a number of these alterations and found some additional alterations not detected by conventional CGH...
- Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangementSandra Rodriguez-Perales
Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, 28029, Spain
Hum Mol Genet 13:983-90. 2004....
- Molecular cytogenetic characterization of rhabdomyosarcoma cell linesSandra Rodriguez-Perales
Cytogenetics Unit, Department of Human Genetics, , C/ Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Cancer Genet Cytogenet 148:35-43. 2004....
- Malignant degeneration of presacral teratoma in the Currarino anomalyMiguel Urioste
Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Am J Med Genet A 128:299-304. 2004....
- A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylationSara Alvarez
Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
Clin Cancer Res 11:1146-53. 2005..This fact suggests that somatic BRCA1 inactivation could modify the profile of tumor progression in most of the BRCAX cases...
- Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancerEsteban Ballestar
Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
EMBO J 22:6335-45. 2003..Our results support an essential role for MBDs in gene silencing and, when combined with genomic strategies, their potential to 'catch' new hypermethylated genes in cancer...
- Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancerLaura Valle
Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Science 321:1361-5. 2008..Conservative estimates suggest that ASE confers a substantially increased risk of CRC (odds ratio, 8.7; 95% confidence interval, 2.6 to 29.1), but these estimates require confirmation and will probably show ethnic differences...