Laura Valle

Summary

Country: Spain

Publications

  1. ncbi Clinicopathologic and pedigree differences in amsterdam I-positive hereditary nonpolyposis colorectal cancer families according to tumor microsatellite instability status
    Laura Valle
    Familial Cancer Unit, Spanish National Cancer Centre, Melchor Fernandez Almagro, Madrid, Spain
    J Clin Oncol 25:781-6. 2007
  2. ncbi About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family
    Laura Valle
    Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
    Eur J Hum Genet 13:570-8. 2005
  3. ncbi Generation of the BCR/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22
    Laura Valle
    Familial Cancer Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hematol Oncol 24:86-8. 2006
  4. ncbi Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array
    Angel Martinez-Ramirez
    Department of Human Genetics, Spanish National Cancer Centre CNIO, Madrid, Spain
    Genes Chromosomes Cancer 42:287-98. 2005
  5. ncbi Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, 28029, Spain
    Hum Mol Genet 13:983-90. 2004
  6. ncbi Molecular cytogenetic characterization of rhabdomyosarcoma cell lines
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Genet Cytogenet 148:35-43. 2004
  7. ncbi Malignant degeneration of presacral teratoma in the Currarino anomaly
    Miguel Urioste
    Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Med Genet A 128:299-304. 2004
  8. ncbi A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
  9. pmc Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
    Esteban Ballestar
    Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    EMBO J 22:6335-45. 2003
  10. pmc Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer
    Laura Valle
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Science 321:1361-5. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Clinicopathologic and pedigree differences in amsterdam I-positive hereditary nonpolyposis colorectal cancer families according to tumor microsatellite instability status
    Laura Valle
    Familial Cancer Unit, Spanish National Cancer Centre, Melchor Fernandez Almagro, Madrid, Spain
    J Clin Oncol 25:781-6. 2007
    ....
  2. ncbi About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family
    Laura Valle
    Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
    Eur J Hum Genet 13:570-8. 2005
    ..We have not found new candidate regions along 3p by using a 1-Mb resolution array-based CGH. (4) The tumorigenesis mechanism of a second gastric tumor developed in the probandus is different from that of CRCC...
  3. ncbi Generation of the BCR/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22
    Laura Valle
    Familial Cancer Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hematol Oncol 24:86-8. 2006
    ..There is no transference of 22q material to chromosome 9 or to any other chromosomes. Clinical features and evolution of the patient are similar to those cases with classic Ph chromosome...
  4. ncbi Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array
    Angel Martinez-Ramirez
    Department of Human Genetics, Spanish National Cancer Centre CNIO, Madrid, Spain
    Genes Chromosomes Cancer 42:287-98. 2005
    ..3 and 19p13.3 were detected by HR-CGH. Array CGH analysis of the subtelomeric regions in some samples was able to confirm a number of these alterations and found some additional alterations not detected by conventional CGH...
  5. ncbi Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, 28029, Spain
    Hum Mol Genet 13:983-90. 2004
    ....
  6. ncbi Molecular cytogenetic characterization of rhabdomyosarcoma cell lines
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Genet Cytogenet 148:35-43. 2004
    ....
  7. ncbi Malignant degeneration of presacral teratoma in the Currarino anomaly
    Miguel Urioste
    Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Med Genet A 128:299-304. 2004
    ....
  8. ncbi A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
    ..This fact suggests that somatic BRCA1 inactivation could modify the profile of tumor progression in most of the BRCAX cases...
  9. pmc Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
    Esteban Ballestar
    Epigenetics Laboratory, Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    EMBO J 22:6335-45. 2003
    ..Our results support an essential role for MBDs in gene silencing and, when combined with genomic strategies, their potential to 'catch' new hypermethylated genes in cancer...
  10. pmc Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer
    Laura Valle
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Science 321:1361-5. 2008
    ..Conservative estimates suggest that ASE confers a substantially increased risk of CRC (odds ratio, 8.7; 95% confidence interval, 2.6 to 29.1), but these estimates require confirmation and will probably show ethnic differences...