Vanessa Valdiglesias

Summary

Country: Spain

Publications

  1. pmc Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    BMC Genomics 13:46. 2012
  2. pmc Okadaic acid: more than a diarrheic toxin
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruña E15071, Spain
    Mar Drugs 11:4328-49. 2013
  3. doi request reprint Comparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cells
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Food Chem Toxicol 57:352-61. 2013
  4. doi request reprint In vivo genotoxicity assessment in rats exposed to Prestige-like oil by inhalation
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 75:756-64. 2012
  5. doi request reprint Alterations in metabolism-related genes induced in SHSY5Y cells by okadaic acid exposure
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 75:844-56. 2012
  6. doi request reprint Evaluation of okadaic acid-induced genotoxicity in human cells using the micronucleus test and γH2AX analysis
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 74:980-92. 2011
  7. doi request reprint Assays to determine DNA repair ability
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 74:1094-109. 2011
  8. doi request reprint Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071, A Coruna, Spain
    Environ Int 55:92-100. 2013
  9. doi request reprint Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Toxicon 57:882-8. 2011
  10. ncbi request reprint Follow-up study of genotoxic effects in individuals exposed to oil from the tanker Prestige, seven years after the accident
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 760:10-6. 2014

Detail Information

Publications20

  1. pmc Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    BMC Genomics 13:46. 2012
    ....
  2. pmc Okadaic acid: more than a diarrheic toxin
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruña E15071, Spain
    Mar Drugs 11:4328-49. 2013
    ....
  3. doi request reprint Comparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cells
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Food Chem Toxicol 57:352-61. 2013
    ..Furthermore, all these effects were not associated with oxidative damage production and, consequently, further investigations on the specific mechanisms underlying the effects observed in this study are required...
  4. doi request reprint In vivo genotoxicity assessment in rats exposed to Prestige-like oil by inhalation
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 75:756-64. 2012
    ..Data support previous positive genotoxicity results reported in humans exposed to Prestige oil during cleanup tasks...
  5. doi request reprint Alterations in metabolism-related genes induced in SHSY5Y cells by okadaic acid exposure
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 75:844-56. 2012
    ..However, other OA-induced affected genes can not be ruled out, and further studies are required to more comprehensively characterize in the mechanisms of OA-induced interaction on cell metabolism...
  6. doi request reprint Evaluation of okadaic acid-induced genotoxicity in human cells using the micronucleus test and γH2AX analysis
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 74:980-92. 2011
    ..Taking together these data, in addition to the comet assay results obtained in a previous study in this issue, OA was found to exert a either a clastogenic or aneugenic effect dependent upon the cell types examined...
  7. doi request reprint Assays to determine DNA repair ability
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, A Coruna, Spain
    J Toxicol Environ Health A 74:1094-109. 2011
    ....
  8. doi request reprint Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071, A Coruna, Spain
    Environ Int 55:92-100. 2013
    ....
  9. doi request reprint Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Toxicon 57:882-8. 2011
    ..However, the extent of these effects are cell type dependent...
  10. ncbi request reprint Follow-up study of genotoxic effects in individuals exposed to oil from the tanker Prestige, seven years after the accident
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 760:10-6. 2014
    ..Nevertheless, the need to plan biomonitoring studies on people participating in clean-up activities in case a new oil spill occurs should be established. ..
  11. doi request reprint Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Mutat Res 689:74-9. 2010
    ..Furthermore, we found that OA can induce modulations in DNA repair processes when exposure was performed prior to BLM treatment, in co-exposure, or during the subsequent DNA repair process...
  12. doi request reprint The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Ecotoxicol Environ Saf 92:303-11. 2013
    ..Nevertheless, given the complexity of this process, more exhaustive studies are required before drawing any final conclusion...
  13. ncbi request reprint Cytogenetic effects induced by Prestige oil on human populations: the role of polymorphisms in genes involved in metabolism and DNA repair
    Beatriz Pérez-Cadahía
    Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Mutat Res 653:117-23. 2008
    ....
  14. doi request reprint Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types
    Vanessa Valdiglesias
    Toxicology Unit, Psychobiology Department, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    J Environ Monit 13:1831-40. 2011
    ..Nevertheless, in the presence of S9 fraction no apoptosis was detected, indicating a metabolic detoxifying activity, although necrosis was observed in neuroblastoma cells...
  15. doi request reprint In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review
    Vanessa Valdiglesias
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Arch Toxicol 84:337-51. 2010
    ..Results from these studies provide a better knowledge on the selenium activity and help to elucidate the reasons underlying its duality in order to regulate its correct use in nutrition and clinic...
  16. doi request reprint The organic selenium compound selenomethionine modulates bleomycin-induced DNA damage and repair in human leukocytes
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071, A Coruna, Spain
    Biol Trace Elem Res 133:12-9. 2010
    ..Our results showed antigenotoxic effect of SeMet on BLM-induced DNA and also on repair and persistence of this damage when applied before and simultaneously with BLM...
  17. pmc Okadaic acid meet and greet: an insight into detection methods, response strategies and genotoxic effects in marine invertebrates
    María Verónica Prego-Faraldo
    XENOMAR Group, Department of Cellular and Molecular Biology, University of A Coruna, E15071 A Coruña, Spain
    Mar Drugs 11:2829-45. 2013
    ....
  18. doi request reprint Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure
    Blanca Laffon
    Toxicology Unit, Department of Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, Campus Elviña s n, 15071 A Coruna, Spain
    Environ Int 59:103-11. 2013
    ..Surveillance of the exposed individuals for early detection of possible health problems related to the endocrine or immunological systems is recommended. ..
  19. ncbi request reprint Genetic polymorphism in cytochrome P450 1B1 in a Spanish population
    Beatriz Pérez-Cadahía
    Toxicology Unit, University of A Coruna, Spain
    Basic Clin Pharmacol Toxicol 101:70-2. 2007
  20. ncbi request reprint Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories
    Roger W L Godschalk
    Department of Toxicology, Maastricht University, Universiteitssingel 50, Maastricht, Limburg 6200MD, The Netherlands, Department of Biosciences and Nutrition, Karolinska Institutet, Halsovagen 7 9, Huddinge 14183, Stockholm, Sweden, Toxicology and Carcinogenesis Department, Nofer Institute of Occupational Medicine, 91 348 Łódź, Poland, Environmental Health Department, National Institute of Health, Rua Alexandre Herculano 321, Porto 4000 055, Portugal, Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK, Department of Public Health, University of Copenhagen, Section of Environmental Health, Øster Farimagsgade 5, Copenhagen K 1014, Denmark, Department of Nutrition, Faculty of Medicine, University of Oslo, PB1046 Blindern, Oslo 0316, Norway, DICOMOSA Group, Department of Psychology, Area of Psychobiology, Edificio de Servicios Centrales de Investigación, Universidade da Coruna, Campus Elviña s n
    Mutagenesis 29:241-9. 2014
    ..41-0.45 lesions/10(6) bp). In contrast, there was no difference between the levels of FPG sensitive sites in PBMC samples from healthy donors in the different centres (0.41-0.52 lesion/10(6) bp). ..