Miguel Urioste

Summary

Country: Spain

Publications

  1. ncbi request reprint Identification of ins(8;21) with AML1/ETO fusion in acute myelogenous leukemia M2 by molecular cytogenetics
    M Urioste
    Departamento de Genetica Humana, Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas, Instituto de Salud Carlos III, Madrid, Spain
    Cancer Genet Cytogenet 133:83-6. 2002
  2. ncbi request reprint Malignant degeneration of presacral teratoma in the Currarino anomaly
    Miguel Urioste
    Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Med Genet A 128:299-304. 2004
  3. ncbi request reprint Complex cytogenetic abnormalities including telomeric associations and MEN1 mutation in a pediatric ependymoma
    M Urioste
    Departamento de Genetica Humana, Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas CNIO, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    Cancer Genet Cytogenet 138:107-10. 2002
  4. doi request reprint Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility
    Ana Osorio
    Group of Human Genetics, Human Cancer Genetics Programme, C Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Breast Cancer Res Treat 113:371-6. 2009
  5. ncbi request reprint About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family
    Laura Valle
    Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
    Eur J Hum Genet 13:570-8. 2005
  6. doi request reprint Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families
    Maria J Garcia
    Group of Human Genetics, Human Cancer Genetics Program, Spanish National Cancer Centre, CNIO, Madrid, Spain
    Breast Cancer Res Treat 113:545-51. 2009
  7. ncbi request reprint Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array
    Angel Martinez-Ramirez
    Department of Human Genetics, Spanish National Cancer Centre CNIO, Madrid, Spain
    Genes Chromosomes Cancer 42:287-98. 2005
  8. doi request reprint Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Roger L Milne
    Grupo de Epidemiología Genética y Molecular, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas CNIO, C Melchor Fernández Almagro, Madrid, Spain
    Breast Cancer Res Treat 119:221-32. 2010
  9. ncbi request reprint Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, 28029, Spain
    Hum Mol Genet 13:983-90. 2004
  10. ncbi request reprint Molecular cytogenetic characterization of rhabdomyosarcoma cell lines
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Genet Cytogenet 148:35-43. 2004

Detail Information

Publications30

  1. ncbi request reprint Identification of ins(8;21) with AML1/ETO fusion in acute myelogenous leukemia M2 by molecular cytogenetics
    M Urioste
    Departamento de Genetica Humana, Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas, Instituto de Salud Carlos III, Madrid, Spain
    Cancer Genet Cytogenet 133:83-6. 2002
    ..The use of other FISH probes (CEP8, c-myc and TEL21) and spectral karyotyping indicated that AML1/ETO fusion occurred as a consequence of a previously undescribed ins(8;21)(q22;q22.1q22.3)...
  2. ncbi request reprint Malignant degeneration of presacral teratoma in the Currarino anomaly
    Miguel Urioste
    Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Med Genet A 128:299-304. 2004
    ....
  3. ncbi request reprint Complex cytogenetic abnormalities including telomeric associations and MEN1 mutation in a pediatric ependymoma
    M Urioste
    Departamento de Genetica Humana, Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas CNIO, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    Cancer Genet Cytogenet 138:107-10. 2002
    ..The chromosomal instability produced by the telomeric alterations and the mutation in the MEN1 gene could be important events in the tumorigenesis of ependymomas...
  4. doi request reprint Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility
    Ana Osorio
    Group of Human Genetics, Human Cancer Genetics Programme, C Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Breast Cancer Res Treat 113:371-6. 2009
    ..Our analysis suggests that RAP80 and CCDC98 do not play an important role as high penetrance breast cancer susceptibility genes...
  5. ncbi request reprint About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family
    Laura Valle
    Department of Human Genetics, Spanish National Cancer Centre, Madrid, Spain
    Eur J Hum Genet 13:570-8. 2005
    ..We have not found new candidate regions along 3p by using a 1-Mb resolution array-based CGH. (4) The tumorigenesis mechanism of a second gastric tumor developed in the probandus is different from that of CRCC...
  6. doi request reprint Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families
    Maria J Garcia
    Group of Human Genetics, Human Cancer Genetics Program, Spanish National Cancer Centre, CNIO, Madrid, Spain
    Breast Cancer Res Treat 113:545-51. 2009
    ....
  7. ncbi request reprint Analysis of myelodysplastic syndromes with complex karyotypes by high-resolution comparative genomic hybridization and subtelomeric CGH array
    Angel Martinez-Ramirez
    Department of Human Genetics, Spanish National Cancer Centre CNIO, Madrid, Spain
    Genes Chromosomes Cancer 42:287-98. 2005
    ..3 and 19p13.3 were detected by HR-CGH. Array CGH analysis of the subtelomeric regions in some samples was able to confirm a number of these alterations and found some additional alterations not detected by conventional CGH...
  8. doi request reprint Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Roger L Milne
    Grupo de Epidemiología Genética y Molecular, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas CNIO, C Melchor Fernández Almagro, Madrid, Spain
    Breast Cancer Res Treat 119:221-32. 2010
    ..Whether later age at first birth is also protective for ovarian cancer in mutation carriers requires further confirmation...
  9. ncbi request reprint Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, 28029, Spain
    Hum Mol Genet 13:983-90. 2004
    ....
  10. ncbi request reprint Molecular cytogenetic characterization of rhabdomyosarcoma cell lines
    Sandra Rodriguez-Perales
    Cytogenetics Unit, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Genet Cytogenet 148:35-43. 2004
    ....
  11. doi request reprint The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain
    Roger L Milne
    Unidad de Genotipación CEGEN and Grupo de Genética Humana, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 14:2861-9. 2008
    ..We aimed to estimate these penetrances for women attending genetic counseling units in Spain...
  12. doi request reprint Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    J Med Genet 49:341-4. 2012
    ..The present study analysed TL in peripheral blood leucocytes of hereditary and sporadic ovarian cancer cases, as well as in female controls, to evaluate whether TL contributes to ovarian cancer risk...
  13. ncbi request reprint Cytogenetic profile of myelodysplastic syndromes with complex karyotypes: an analysis using spectral karyotyping
    Angel Martinez-Ramirez
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Genet Cytogenet 153:39-47. 2004
    ..Fluorescence in situ hybridization analysis showed amplification of genes previously identified in myeloid and/or hematological processes, such as HER2neu, MLL, and AML1, which could represent frequent events in MDS with CK...
  14. pmc Genetic anticipation is associated with telomere shortening in hereditary breast cancer
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS Genet 7:e1002182. 2011
    ..Our results provide evidence that telomere shortening is associated with earlier age of cancer onset in successive generations, suggesting that it might be a mechanism of genetic anticipation in hereditary breast cancer...
  15. ncbi request reprint Genetic characterization and structural analysis of VHL Spanish families to define genotype-phenotype correlations
    Sergio Ruiz-Llorente
    Hereditary Endocrine Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hum Mutat 23:160-9. 2004
    ..Structural stability data in the genotype-phenotype correlations therefore provides us with a better understanding of VHL clinical implications. It is also a suitable approach to the evaluation of unknown significance changes...
  16. doi request reprint Early-onset colorectal cancer is an easy and effective tool to identify retrospectively Lynch syndrome
    Jose Perea
    Surgery Department, Hospital Universitario 12 de Octubre, Madrid, Spain
    Ann Surg Oncol 18:3285-91. 2011
    ..We evaluated whether early age of onset is a good marker to identify Lynch syndrome, especially retrospectively, and if there is any other feature that could improve this identification...
  17. ncbi request reprint Clinicopathologic and pedigree differences in amsterdam I-positive hereditary nonpolyposis colorectal cancer families according to tumor microsatellite instability status
    Laura Valle
    Familial Cancer Unit, Spanish National Cancer Centre, Melchor Fernandez Almagro, Madrid, Spain
    J Clin Oncol 25:781-6. 2007
    ....
  18. ncbi request reprint Generation of the BCR/ABL fusion gene in a Philadelphia chromosome-negative chronic myeloid leukaemia: insertion of 5.6 Mb of 9q34 into the BCR region of chromosome 22
    Laura Valle
    Familial Cancer Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hematol Oncol 24:86-8. 2006
    ..There is no transference of 22q material to chromosome 9 or to any other chromosomes. Clinical features and evolution of the patient are similar to those cases with classic Ph chromosome...
  19. ncbi request reprint Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma
    Sergio Ruiz-Llorente
    Hereditary Endocrine Cancer Group, Human Genetics Group, Biomedical Research Institute, CSIC, UAM, Madrid, Spain
    Cancer Res 67:9561-7. 2007
    ..These results highlight the utility of association studies using homogeneous series of cases for better understanding complex diseases...
  20. doi request reprint Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition
    Maria J Garcia
    Group of Human Genetics, Human Cancer Genetics Program, Spanish National Cancer Centre CNIO, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Carcinogenesis 30:1898-902. 2009
    ..Our results rule out a major role of FANCI, FANCL and FANCM in familial breast cancer susceptibility, suggesting that among the 13 known FA genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition...
  21. ncbi request reprint A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
    ..This fact suggests that somatic BRCA1 inactivation could modify the profile of tumor progression in most of the BRCAX cases...
  22. ncbi request reprint Molecular study of a new family with hereditary renal cell carcinoma and a translocation t(3;8)(p13;q24.1)
    Barbara Melendez
    Department of Human Genetics, Spanish National Cancer Center CNIO, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Hum Genet 112:178-85. 2003
    ..In the present work, we have confirmed the proposed mechanism for the development of clear-cell RCC in this family, although we cannot discard the existence of other genes, in addition to VHL, being involved in hereditary RCC...
  23. ncbi request reprint De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19
    Juan C Cigudosa
    Cytogenetics Unit, Department of Human Genetics, Spanish National Cancer Center, Melchior Fernandez Almagro, 3 28029 Madrid, Spain
    Genes Chromosomes Cancer 36:406-12. 2003
    ..1, 20q11.2, and 21q11.2. This is the first molecular cytogenetic description of the karyotype abnormalities present in patients with ERL. It should assist in the identification of genes involved in erythroleukemogenesis...
  24. ncbi request reprint Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
    Emiliano Honrado
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Mod Pathol 20:1298-306. 2007
    ..In addition we have defined a subset of them that have somatic inactivation of the BRCA1 gene...
  25. pmc Approach to early-onset colorectal cancer: clinicopathological, familial, molecular and immunohistochemical characteristics
    Jose Perea
    Department of Surgery, Hospital Universitario 12 de Octubre, Avda de Cordoba s n, Madrid, Spain
    World J Gastroenterol 16:3697-703. 2010
    ..To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI)...
  26. doi request reprint Detection of APC gene deletions using quantitative multiplex PCR of short fluorescent fragments
    Ester Castellsagué
    Translational Research Laboratory, IDIBELL Institut Català d Oncologia, Barcelona, Spain
    Clin Chem 54:1132-40. 2008
    ..We used QMPSF for the APC gene to screen FAP APC/MUTYH mutation-negative families to improve their diagnostic surveillance...
  27. ncbi request reprint Cytogenetic characterization reveals that the SAM-1 erythroid cell line is derived from K-562 cells
    Sara Alvarez
    Blood 100:3435-6. 2002
  28. pmc Epigenetic differences arise during the lifetime of monozygotic twins
    Mario F Fraga
    Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 102:10604-9. 2005
    ..These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype...
  29. ncbi request reprint Retrorectal cystic hamartoma as benign cause of CA 19-9 elevation
    Jesus Garcia-Donas
    Department of Medical Oncology, Fundacion Hospital Alcorcon, Alcorcon, Spain
    J Clin Oncol 25:4012-4. 2007
  30. ncbi request reprint Mutations in the DNA mismatch repair gene MLH1 associated with early-onset colon cancer
    Irene Marcos
    Unidad Clínica de Genética y Reproducción, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
    J Pediatr 148:837-9. 2006
    ..We present a HNPCC family with CRC at age 12 years. Our observations suggest that the germline mutation of the both copies of the MLH1 gene may play a role in the early onset of CRC...