Jose Vina

Summary

Affiliation: University of Valencia
Country: Spain

Publications

  1. pmc RasGrf1 deficiency delays aging in mice
    Consuelo Borras
    Department of Physiology, School of Medicine, University of Valencia, Spain
    Aging (Albany NY) 3:262-76. 2011
  2. ncbi request reprint Pharmacological properties of physical exercise in the elderly
    Jose Vina
    Department of Physiology Faculty of Medicine University of Valencia, Av Blasco Ibanez, 15, Valencia, E46010 Spain
    Curr Pharm Des 20:3019-29. 2014
  3. pmc Centenarians, but not octogenarians, up-regulate the expression of microRNAs
    Eva Serna
    Unidad Central de Investigación en Medicina INCLIVA, Universitat de Valencia, Valencia, Spain
    Sci Rep 2:961. 2012
  4. pmc Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: role of p38 MAPKinase and E3 ubiquitin ligases
    Frederic Derbré
    Laboratory Movement Sport and Health Sciences, University Rennes 2 ENS Cachan, Rennes, France
    PLoS ONE 7:e46668. 2012
  5. pmc The free radical theory of aging revisited: the cell signaling disruption theory of aging
    Jose Vina
    Department of Physiology, University of Valencia and Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia 46010, Spain
    Antioxid Redox Signal 19:779-87. 2013
  6. pmc Exercise acts as a drug; the pharmacological benefits of exercise
    J Vina
    Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia, Spain
    Br J Pharmacol 167:1-12. 2012
  7. ncbi request reprint Why females live longer than males: control of longevity by sex hormones
    Jose Vina
    Departamento de Fisiologia, Facultad de Medicina, Avenida Blasco Ibañez 17, 46010 Valencia, Spain
    Sci Aging Knowledge Environ 2005:pe17. 2005
  8. ncbi request reprint Part of the series: from dietary antioxidants to regulators in cellular signalling and gene expression. Role of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress
    Jose Vina
    Universidad de Valencia, Departamento de Fisiologia, 46010, Valencia, Spain
    Free Radic Res 40:111-9. 2006
  9. doi request reprint Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds
    Jose Vina
    Department of Physiology, University of Valencia, Spain
    Antioxid Redox Signal 13:269-78. 2010
  10. doi request reprint Mitochondrial biogenesis in exercise and in ageing
    Jose Vina
    Department of Physiology, University of Valencia, Spain
    Adv Drug Deliv Rev 61:1369-74. 2009

Collaborators

Detail Information

Publications80

  1. pmc RasGrf1 deficiency delays aging in mice
    Consuelo Borras
    Department of Physiology, School of Medicine, University of Valencia, Spain
    Aging (Albany NY) 3:262-76. 2011
    ..Our observations link Ras signaling to lifespan and suggest that RasGrf1 is an evolutionary conserved gene which could be targeted for the development of therapies to delay age-related processes...
  2. ncbi request reprint Pharmacological properties of physical exercise in the elderly
    Jose Vina
    Department of Physiology Faculty of Medicine University of Valencia, Av Blasco Ibanez, 15, Valencia, E46010 Spain
    Curr Pharm Des 20:3019-29. 2014
    ..If old adults adopted a more active lifestyle, there would be a significant delay in frailty and dependency with clear benefits to individual well-being and to the public's health. ..
  3. pmc Centenarians, but not octogenarians, up-regulate the expression of microRNAs
    Eva Serna
    Unidad Central de Investigación en Medicina INCLIVA, Universitat de Valencia, Valencia, Spain
    Sci Rep 2:961. 2012
    ..We suggest that the small non-coding RNAs signature in centenarians may provide insights into the underlying molecular mechanisms endowing centenarians with extreme longevity...
  4. pmc Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: role of p38 MAPKinase and E3 ubiquitin ligases
    Frederic Derbré
    Laboratory Movement Sport and Health Sciences, University Rennes 2 ENS Cachan, Rennes, France
    PLoS ONE 7:e46668. 2012
    ..Thus, allopurinol may have clinical benefits to combat skeletal muscle atrophy in bedridden, astronauts, sarcopenic, and cachexic patients...
  5. pmc The free radical theory of aging revisited: the cell signaling disruption theory of aging
    Jose Vina
    Department of Physiology, University of Valencia and Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia 46010, Spain
    Antioxid Redox Signal 19:779-87. 2013
    ..Up to the turn of the century, the theory received abundant support from observations coming from fields as far apart as comparative physiology or molecular biology...
  6. pmc Exercise acts as a drug; the pharmacological benefits of exercise
    J Vina
    Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia, Spain
    Br J Pharmacol 167:1-12. 2012
    ..Our general conclusion is that exercise is so effective that it should be considered as a drug, but that more attention should be paid to the dosing and to individual variations between patients...
  7. ncbi request reprint Why females live longer than males: control of longevity by sex hormones
    Jose Vina
    Departamento de Fisiologia, Facultad de Medicina, Avenida Blasco Ibañez 17, 46010 Valencia, Spain
    Sci Aging Knowledge Environ 2005:pe17. 2005
    ..Study of gender differences in longevity may help us to understand the basic processes of aging and to devise practical strategies to increase the longevity of both females and males...
  8. ncbi request reprint Part of the series: from dietary antioxidants to regulators in cellular signalling and gene expression. Role of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress
    Jose Vina
    Universidad de Valencia, Departamento de Fisiologia, 46010, Valencia, Spain
    Free Radic Res 40:111-9. 2006
    ..The relevance of these findings is discussed in the context with observations made in transgenic animals overexpressing MnSOD or catalase...
  9. doi request reprint Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds
    Jose Vina
    Department of Physiology, University of Valencia, Spain
    Antioxid Redox Signal 13:269-78. 2010
    ..Phytoestrogens or other selective estrogen receptor modulators lower age-related diseases and prolong life span, at least in experimental animals. This provides rational bases to study their action in humans further...
  10. doi request reprint Mitochondrial biogenesis in exercise and in ageing
    Jose Vina
    Department of Physiology, University of Valencia, Spain
    Adv Drug Deliv Rev 61:1369-74. 2009
    ..In this chapter we consider the interrelationship between mitochondrial biogenesis stimulated by exercise and the possible impairment of this pathway in ageing leading to mitochondrial deficiency and eventually muscle sarcopenia...
  11. ncbi request reprint Role of mitochondrial oxidative stress to explain the different longevity between genders: protective effect of estrogens
    J Vina
    Departamento de Fisiologia, Universidad de Valencia, 46010, Valencia, Spain
    Free Radic Res 40:1359-65. 2006
    ..Phytoestrogens mimic the protective effect of oestradiol using the same signalling pathway. The critical importance of up-regulating antioxidant genes, by hormonal and dietary manipulations, to increase longevity is discussed...
  12. doi request reprint Modulation of longevity-associated genes by estrogens or phytoestrogens
    Jose Vina
    Departamento de Fisiologia, Universidad de Valencia, E 46010 Valencia, Spain
    Biol Chem 389:273-7. 2008
    ..The challenge for the future is to find molecules that have the beneficial effects of estradiol, but without its feminizing effects. Phytoestrogens or phytoestrogen-related molecules may be good candidates to meet this challenge...
  13. ncbi request reprint Theories of ageing
    Jose Vina
    Department of Physiology, School of Medicine, University of Valencia
    IUBMB Life 59:249-54. 2007
    ..It was further developed by one of us (JM) in what has become known as the mitochondrial theory of ageing. These theories provide new experimental approaches to further develop our understanding of the phenomenon of ageing...
  14. ncbi request reprint Mitochondrial oxidant signalling in Alzheimer's disease
    Jose Vina
    Departamento de Fisiologia, Facultad de Medicina, Valencia, Spain
    J Alzheimers Dis 11:175-81. 2007
    ..Experiments reported here indicate that phytoestrogens might have a role in the prevention of Alzheimer's disease...
  15. ncbi request reprint Effect of gender on mitochondrial toxicity of Alzheimer's Abeta peptide
    Jose Vina
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
    Antioxid Redox Signal 9:1677-90. 2007
    ..These ideas open up the possibility of using phytoestrogens to prevent the onset of Alzheimer's disease. More studies are required to determine whether estrogens and/or phytoestrogens fulfill these expectations...
  16. ncbi request reprint Mechanism of free radical production in exhaustive exercise in humans and rats; role of xanthine oxidase and protection by allopurinol
    J Vina
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia
    IUBMB Life 49:539-44. 2000
    ..These findings also suggest that mitochondria play a minor role as a source of free radicals during exhaustive physical exercise...
  17. ncbi request reprint Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds
    Jose Vina
    Departamento de Fisiologia, Facultad de Medicina, Valencia, Spain
    FEBS Lett 579:2541-5. 2005
    ..Phytoestrogens mimic the protective effect of oestradiol using the same signalling pathway. The critical importance of upregulating antioxidant genes, by hormonal and dietary manipulations, in order to increase longevity is discussed...
  18. ncbi request reprint Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation?
    Jose Vina
    Department of Physiology, Faculty of Medicine, University of Valencia, Spain
    Br J Nutr 98:S36-40. 2007
    ....
  19. ncbi request reprint Antioxidant pathways in Alzheimer's disease: possibilities of intervention
    J Vina
    Department of Physiology, Faculty of Medicine, University of Valencia, Avda Blasco Ibanez, 15 46010 Valencia, Spain
    Curr Pharm Des 17:3861-4. 2011
    ..Thus, the issue of whether antioxidant treatment is of use in AD is not settled and more research is warranted to clarify this point...
  20. ncbi request reprint Females live longer than males: role of oxidative stress
    Jose Vina
    Department of Physiology, Valencia, Spain
    Curr Pharm Des 17:3959-65. 2011
    ....
  21. ncbi request reprint Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress
    Jose Vina
    Department of Physiology, Faculty of Medicine, University of Valencia, Avda Blasco Ibanez 17, E 46010 Valencia, Spain
    Mol Aspects Med 25:117-23. 2004
    ....
  22. ncbi request reprint Mitochondrial theory of aging: importance to explain why females live longer than males
    Jose Vina
    Departamento de Fisiologia, Facultad de Medicina, Valencia, Spain
    Antioxid Redox Signal 5:549-56. 2003
    ..The challenge for the future is to find molecules that have the beneficial effects of estradiol, but without its feminizing effects. Phytoestrogens or phytoestrogen-related molecules may be good candidates to meet this challenge...
  23. ncbi request reprint Free radicals in exhaustive physical exercise: mechanism of production, and protection by antioxidants
    J Vina
    Departamento de Fisiologia, Facultad de Medicina, Valencia, Spain
    IUBMB Life 50:271-7. 2000
    ..Knowledge of the mechanism of free-radical formation in exercise is important because it will be useful to prevent oxidative stress and damage associated with exhaustive physical activity...
  24. ncbi request reprint 17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade
    Consuelo Borras
    Department of Physiology, School of Medicine, University of Valencia, Spain
    Aging Cell 4:113-8. 2005
    ....
  25. ncbi request reprint Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
    Consuelo Borras
    Department of Physiology, School of Medicine, University of Valencia, Valencia, Spain
    Free Radic Biol Med 34:546-52. 2003
    ..The facts reported here provide molecular evidence to explain the different life span in males and females...
  26. ncbi request reprint Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38
    Soraya L Valles
    Department of Physiology, University of Valencia, School of Medicine, Valencia, Spain
    Aging Cell 7:112-8. 2008
    ....
  27. ncbi request reprint Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Am J Clin Nutr 87:142-9. 2008
    ..There is, however, considerable debate regarding the beneficial health effects of vitamin C supplementation...
  28. ncbi request reprint Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol
    Marí Carmen Desco
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Diabetes 51:1118-24. 2002
    ..These results may have clinical significance in the prevention of late-onset vascular complications of diabetes...
  29. ncbi request reprint Oxidative stress in asphyxiated term infants resuscitated with 100% oxygen
    Maximo Vento
    School of Medicine, University of Alicante, Department of Pediatrics and Neonatology and Division of Neonatology, Hospital Virgen del Consuelo, Valencia, Spain
    J Pediatr 142:240-6. 2003
    ..Assays performed included: blood gases; reduced glutathione (GSH) and oxidized glutathione (GSSG) in whole blood; glutathione-related enzyme activities; and superoxide dismutase activity (SOD) in erythrocytes...
  30. doi request reprint Effects of acute exercise and xanthine oxidase inhibition on novel cardiovascular biomarkers
    Fabian Sanchis-Gomar
    Department of Physiology, Faculty of Medicine, University of Valencia, Spain
    Transl Res 162:102-9. 2013
    ....
  31. doi request reprint Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's disease
    Ana Lloret
    Departamento de Fisiologia, Facultad de Medicina, Avda Blasco Ibanez 15, 46010 Valencia, Spain
    Free Radic Biol Med 44:2019-25. 2008
    ..Gender and age-related differences seen in the development of AD can also be partially explained...
  32. pmc Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease
    Ana Lloret
    Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, Valencia, Spain
    J Alzheimers Dis 27:701-9. 2011
    ..Thus upregulation of RCAN1 may be a valuable biomarker for AD risk...
  33. doi request reprint Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study
    Amparo Gimeno
    Department of Anatomy and Human Embryology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez, 15, E46010 Valencia, Spain Fundación Investigación Hospital Clínico Universitario de Valencia, Instituto de Investigación INCLIVA, Avda Blasco Ibanez 17, E46010 Valencia, Spain Electronic address
    Biochim Biophys Acta 1842:116-25. 2014
    ..Our preliminary results may explain the proneness to a progeroid phenotype. ..
  34. pmc Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases
    Javier Pereda
    Department of Physiology, University of Valencia, Spain
    Ann Surg 240:108-16. 2004
    ....
  35. doi request reprint Mitochondria as sources and targets of damage in cellular aging
    Mari Carmen Gomez-Cabrera
    Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia, Spain
    Clin Chem Lab Med 50:1287-95. 2012
    ..The promotion of mitochondriogenesis is critical to prevent aging. In skeletal muscle it has relevance to prevent sarcopenia and frailty...
  36. doi request reprint Direct antioxidant and protective effect of estradiol on isolated mitochondria
    Consuelo Borras
    Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibañez 17, 46010 Valencia, Spain
    Biochim Biophys Acta 1802:205-11. 2010
    ..Genistein, a phytoestrogen present at high concentration in soy, mimics the protective effect of estradiol by both decreasing the rate of formation of reactive oxygen species and preventing the release of cytochrome c from mitochondria...
  37. pmc Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
    Frederic Derbré
    Laboratory Movement Sport and Health Sciences, University Rennes, France
    Age (Dordr) 34:669-79. 2012
    ....
  38. doi request reprint Free [NADH]/[NAD(+)] regulates sirtuin expression
    Juan Gambini
    Department of Physiology, Faculty of Medicine, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Spain
    Arch Biochem Biophys 512:24-9. 2011
    ..We conclude that the expression of sirtuins is subject to tight redox regulation by the [NADH]/[NAD(+)] ratio, which is a major sensor for metabolite availability conserved from invertebrates to vertebrates...
  39. doi request reprint Reductive stress in young healthy individuals at risk of Alzheimer disease
    Mari Carmen Badía
    Department of Physiology, Facultad de Medicina, Universidad de Valencia, and Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia 46010, Spain
    Free Radic Biol Med 63:274-9. 2013
    ..These results provide insights into the early events of the progression of the disease that may allow us to find biomarkers of AD at its very early stages. ..
  40. ncbi request reprint Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver
    Juan Sastre
    Departamento de Fisiologia, Facultad de Medicina, Universitat de Valencia, Spain
    Cell Mol Biol (Noisy-le-grand) 48:685-92. 2002
    ..These antioxidants may also delay the physiological impairment associated with aging...
  41. ncbi request reprint The role of mitochondrial oxidative stress in aging
    Juan Sastre
    Department of Physiology, University of Valencia, Avenida Blasco Ibañez 17, 46010 Valencia, Spain
    Free Radic Biol Med 35:1-8. 2003
    ....
  42. pmc Vitamin C supplementation does not improve hypoxia-induced erythropoiesis
    Vladimir E Martinez-Bello
    Faculty of Medicine, Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia, Spain
    High Alt Med Biol 13:269-74. 2012
    ..However, we found an increase in plasma protein oxidation in both hypoxic groups. Vitamin C does not affect erythropoiesis and protein oxidation in rats submitted to intermittent hypoxic exposure...
  43. pmc The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts
    Jelena Markovic
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    PLoS ONE 4:e6413. 2009
    ..The presence of a nuclear pool of glutathione has been demonstrated but its role in cellular proliferation and differentiation is still a matter of debate...
  44. doi request reprint Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental
    Ana Lloret
    Departamento de Fisiologia, Facultad de Medicina, University of Valencia, Valencia, Spain
    J Alzheimers Dis 17:143-9. 2009
    ..Therefore, supplementation of AD patients with vitamin E cannot be recommended without determination of its antioxidant effect in each patient...
  45. ncbi request reprint Mitochondrial damage in aging and apoptosis
    Juan Sastre
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    Ann N Y Acad Sci 959:448-51. 2002
    ..Administration of antioxidants, such as vitamins C and E, or a Ginkgo biloba extract, protects against age-associated oxidative damage to mitochondrial DNA, oxidation of glutathione, and other signs of oxidative damage to mitochondria...
  46. doi request reprint Interplay of oxidants and antioxidants during exercise: implications for muscle health
    Maria Carmen Gomez-Cabrera
    University of Valencia, Valencia, Spain
    Phys Sportsmed 37:116-23. 2009
    ..Adaptation of muscle to increased oxidative stress and the potential mechanisms involved will be highlighted. The role of redox-controlled cell signaling in skeletal muscle health and function is also described...
  47. doi request reprint Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes
    Soraya L Valles
    Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez 15, 46010 Valencia, Spain
    Brain Res 1312:138-44. 2010
    ..Thus, some of the anti-inflammatory effects of estrogenic compounds may be mediated and activated by PPARs suppressing a diverse array of inflammatory responses caused by A beta in astrocytes in primary culture...
  48. ncbi request reprint Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB
    Consuelo Borras
    Catholic University of Valencia, Valencia, Spain
    FASEB J 20:2136-8. 2006
    ..Our molecular studies may provide a basis to determine the effects of genistein and other soy protein-derived products on longevity in both animals and the human population...
  49. ncbi request reprint Interaction between cytokines and oxidative stress in acute pancreatitis
    Javier Pereda
    Department of Physiology, School of Medicine, University of Valencia, Spain
    Curr Med Chem 13:2775-87. 2006
    ..This cross-talk that arises between pro-inflammatory cytokines and oxidative stress greatly contributes to amplification of the uncontrolled inflammatory cascade through MAPK and NF-kappaB...
  50. doi request reprint Moderate exercise is an antioxidant: upregulation of antioxidant genes by training
    Mari Carmen Gomez-Cabrera
    Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez, 15, 46010 Valencia, Spain
    Free Radic Biol Med 44:126-31. 2008
    ..We have found that interfering with free radical metabolism with antioxidants may hamper useful adaptations to training...
  51. ncbi request reprint Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis
    Juan Sastre
    Department of Physiology, School of Medicine, University of Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    Free Radic Biol Med 38:575-82. 2005
    ..In conclusion, the lack of gamma-cystathionase activity in over 50% of old lenses is due to decreased gene expression and proteolytic degradation of the oxidized enzyme. This results in a high risk for the development of senile cataract...
  52. doi request reprint Three weeks of erythropoietin treatment hampers skeletal muscle mitochondrial biogenesis in rats
    Vladimir E Martinez-Bello
    Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia, Spain
    J Physiol Biochem 68:593-601. 2012
    ..Our findings suggest that 3 weeks of rHuEpo treatment, which generates an increase of oxygen carrying capacity, can affect mitochondrial biogenesis in a muscle fibre-specific dependent manner...
  53. pmc Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy
    Raul López-Grueso
    1 Department of Physiology, School of Medicine, University of Valencia INCLIVA, Valencia, Spain
    Antioxid Redox Signal 20:236-46. 2014
    ..We aimed to study if there is a critical time window for effective treatment of the effects of ovariectomy with estrogens at the molecular, metabolic, and cellular level...
  54. ncbi request reprint AZT induces oxidative damage to cardiac mitochondria: protective effect of vitamins C and E
    José García de la Asunción
    Departament of Anesthesiology and Critical Care, University Clinical Hospital, Valencia, Spain
    Life Sci 76:47-56. 2004
    ....
  55. doi request reprint Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis
    Javier Pereda
    Department of Physiology, University of Valencia, 46100 Burjasot Valencia, Spain
    Free Radic Biol Med 44:1599-609. 2008
    ..This mechanism would abrogate a rapid recovery of glutathione levels...
  56. ncbi request reprint Induction of mitochondrial xanthine oxidase activity during apoptosis in the rat mammary gland
    Diana A Rus
    Department of Physiology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez 15, E46010 Valencia, Spain
    Front Biosci 12:1184-9. 2007
    ..Oxidative stress generated during apoptosis by mitochondria is not only due to the respiratory chain...
  57. ncbi request reprint Mitochondrial function in liver disease
    Juan Sastre
    Dept of Physiology, School of Medicine, University of Valencia, Spain
    Front Biosci 12:1200-9. 2007
    ....
  58. ncbi request reprint Glutathione is recruited into the nucleus in early phases of cell proliferation
    Jelena Markovic
    Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibañez 17, 46010 Valencia, Spain
    J Biol Chem 282:20416-24. 2007
    ....
  59. doi request reprint Role of glutathione in cell nucleus
    Jelena Markovic
    Department of Physiology, University of Valencia, Spain
    Free Radic Res 44:721-33. 2010
    ..Glutathionylation and oxidation of nuclear proteins appear as a reversible physiological mechanism able to regulate DNA compaction, cell cycle and DNA repair...
  60. doi request reprint The loss of muscle mass and sarcopenia: non hormonal intervention
    Fabian Sanchis-Gomar
    Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Spain
    Exp Gerontol 46:967-9. 2011
    ..Moreover, any significant improvement in the loss of muscle function will be a major breakthrough in the health and welfare of the population...
  61. doi request reprint Low in vivo brain glucose consumption and high oxidative stress in accelerated aging
    Consuelo Borras
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    FEBS Lett 583:2287-93. 2009
    ..Our results support the role of the free radical theory of aging in critical tissues involved in aging and that this correlates with glucose consumption...
  62. ncbi request reprint Effects of acute exercise and allopurinol administration on soluble urokinase plasminogen activator receptor (suPAR)
    Fabian Sanchis-Gomar
    Department of Physiology, Faculty of Medicine, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Valencia, Spain
    Clin Lab 59:207-10. 2013
    ....
  63. ncbi request reprint Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism
    Juan B Minana
    Departamento de Fisiologia, Facultad de Medicina, Universitat de Valencia, Valencia, Spain
    Hepatology 35:1205-14. 2002
    ..The overproduction of ROS by mitochondria, driven by acetaldehyde metabolism, is a common trigger of both mechanisms...
  64. ncbi request reprint Glutathione regulates telomerase activity in 3T3 fibroblasts
    Consuelo Borras
    Department of Physiology, School of Medicine, University of Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    J Biol Chem 279:34332-5. 2004
    ..when the reduced/oxidized glutathione ratio is high. Consequently glutathione concentration parallels telomerase activity. These results underscore the main role of glutathione in the control of telomerase activity and of the cell cycle...
  65. ncbi request reprint Age-related increase in xanthine oxidase activity in human plasma and rat tissues
    Rafael Aranda
    Department of Sports and Physical Education, University of Valencia, Valencia, Spain
    Free Radic Res 41:1195-200. 2007
    ..These results give a possible explanation for this correlation and underscore the role of xanthine oxidase in ageing...
  66. ncbi request reprint Hyperoxemia caused by resuscitation with pure oxygen may alter intracellular redox status by increasing oxidized glutathione in asphyxiated newly born infants
    Maximo Vento
    Servicio de Pediatria y Neonatologia, Hospital Virgen del Consuelo, Valencia, Spain
    Semin Perinatol 26:406-10. 2002
    ..Moreover, an increased antioxidant enzyme activity, which reflects an oxidative stress, indicates that the antioxidant capacity of the newly born infant may have been surpassed...
  67. doi request reprint [Aging and ovariectomy cause a decrease in brain glucose consumption in vivo in Wistar rats]
    Raul López-Grueso
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, Valencia, Espana
    Rev Esp Geriatr Gerontol 45:136-40. 2010
    ..Differences can be explained by the effects of estrogens because ovariectomy cancels out the benefits shown in females compared to males...
  68. doi request reprint Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide
    Jose Vina
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    J Alzheimers Dis 20:S527-33. 2010
    ..As such, more experiments and clinical trials are indeed warranted to find conditions in which estrogenic compounds may be useful to prevent or treat AD...
  69. doi request reprint The dual role of p53: DNA protection and antioxidant
    Consuelo Borras
    Department of Physiology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez, 15 46010 Valencia, Spain
    Free Radic Res 45:643-52. 2011
    ..On the contrary, high-intensity activation of p53 will result in an increase of oxidative stress by activation of p53-mediated pro-oxidant targets, thus increasing the rate of ageing, but protecting against cancer...
  70. doi request reprint Role of nuclear glutathione as a key regulator of cell proliferation
    Federico V Pallardo
    Department of Physiology, Faculty of Medicine, University of Valencia, Av Blasco Ibanez 15, E 46010 Valencia, Spain CIBERER, Av Blasco Ibanez 15, E 46010 Valencia, Spain
    Mol Aspects Med 30:77-85. 2009
    ..The information provided in the present review suggests an important role of nuclear glutathione as a key regulator of epigenetic events that may be critical in the regulation of cell proliferation...
  71. doi request reprint [Resveratrol: distribution, properties and perspectives]
    Juan Gambini
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, INCLIVA, Valencia, Spain
    Rev Esp Geriatr Gerontol 48:79-88. 2013
    ..This opens a new potential approach, seeking derivatives of resveratrol that can be measured in the desired tissues...
  72. doi request reprint Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions
    Alessandro Arduini
    Department of Physiology, University of Valencia, Spain
    Am J Physiol Gastrointest Liver Physiol 301:G119-27. 2011
    ..In conclusion, the lack of stimulation of mitochondrial biogenesis leads to mtDNA severe depletion and deletions in long-term cholestasis. Hence, long-term cholestasis should be considered a secondary mitochondrial hepatopathy...
  73. ncbi request reprint Room-air resuscitation causes less damage to heart and kidney than 100% oxygen
    Maximo Vento
    Neonatal Research Unit, Servicio de Neonatologia, Hospital Universitario Materno Infantil La Fe, Avenida de Campanar 21, 46009 Valencia, Spain
    Am J Respir Crit Care Med 172:1393-8. 2005
    ..Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage...
  74. doi request reprint Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon
    Beatriz Baño Otálora
    Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
    Chronobiol Int 29:822-34. 2012
    ..Therefore, care should be taken when extending the results obtained in Tg mice to develop new therapies in humans. This study also revealed the complexity in the therapeutic actions of melatonin and ramelteon in this mouse model of AD...
  75. doi request reprint Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats
    Vladimir Essau Martinez-Bello
    Department of Physiology, Faculty of Medicine, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Blasco Ibañez, 15, 46010 Valencia, Spain
    Eur J Appl Physiol 111:1147-56. 2011
    ..However, contrary to our starting hypothesis, the combination of normobaric hypoxia and sprint training did not improve MAV in our animals...
  76. doi request reprint Current limitations of the Athlete's Biological Passport use in sports
    Fabian Sanchis-Gomar
    Department of Physiology, Faculty of Medicine, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Spain
    Clin Chem Lab Med 49:1413-5. 2011
    ....
  77. pmc Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration
    Jose L Rodriguez
    Departamento de Bioquimica y Biologia Molecular, Universidad de Valencia, Valencia, Spain
    Biochem J 398:431-7. 2006
    ..Our results may suggest a control role for Id2 in hepatocyte priming, through a p130 dissociation-independent regulation of c-myc...
  78. doi request reprint [Effects of physical exercise on cognitive alterations and oxidative stress in an APP/PSN1 transgenic model of Alzheimer's disease]
    Helios Pareja-Galeano
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
    Rev Esp Geriatr Gerontol 47:198-204. 2012
    ..This model is mainly based on the cerebral deposition of amyloid β plaques...
  79. doi request reprint Intermittent hypobaric hypoxia applicability in myocardial infarction prevention and recovery
    Fabian Sanchis-Gomar
    Faculty of Medicine, Department of Physiology, University of Valencia, Valencia, Spain
    J Cell Mol Med 16:1150-4. 2012
    ..As such, further research is needed before IHH can be widely advocated in myocardial infarction prevention and recovery...
  80. doi request reprint Biogerontology in Spain: the most significant studies
    Consuelo Borras
    Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain
    Biogerontology 12:77-81. 2011
    ..Finally, molecular biologists have found new age-associated genes by showing changes in longevity of genetically manipulated mice...